(Q35773997)

10 August 2017

title

Group VIA PLA2 (iPLA2β) is activated upstream of p38 mitogen-activated protein kinase (MAPK) in pancreatic islet β-cell signaling (English)

1 reference

10 August 2017

Haowei Song

1

1 reference

10 August 2017

Mary Wohltmann

2

1 reference

10 August 2017

Min Tan

3

1 reference

10 August 2017

Shunzhong Bao

4

1 reference

10 August 2017

Jack H Ladenson

5

1 reference

10 August 2017

John Turk

6

1 reference

10 August 2017

language of work or name

English

0 references

publication date

22 December 2011

1 reference

Journal of Biological Chemistry

10 August 2017

published in

1 reference

10 August 2017

volume

287

1 reference

10 August 2017

issue

8

1 reference

10 August 2017

page(s)

5528-5541

1 reference

Activation and function of the MAPKs and their substrates, the MAPK-activated protein kinases

10 August 2017

cites work

1 reference

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Calcium-independent phospholipase A2 (iPLA2 beta)-mediated ceramide generation plays a key role in the cross-talk between the endoplasmic reticulum (ER) and mitochondria during ER stress-induced insulin-secreting cell apoptosis

12 July 2018

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12 July 2018

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12 July 2018

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The group VIA calcium-independent phospholipase A2 participates in ER stress-induced INS-1 insulinoma cell apoptosis by promoting ceramide generation via hydrolysis of sphingomyelins by neutral sphingomyelinase.

12 July 2018

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Attenuated free cholesterol loading-induced apoptosis but preserved phospholipid composition of peritoneal macrophages from mice that do not express group VIA phospholipase A2.

12 July 2018

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Group VIA phospholipase A2 (iPLA2beta) participates in angiotensin II-induced transcriptional up-regulation of regulator of g-protein signaling-2 in vascular smooth muscle cells

12 July 2018

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12 July 2018

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12 July 2018

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12 July 2018

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Modulation of the pancreatic islet beta-cell-delayed rectifier potassium channel Kv2.1 by the polyunsaturated fatty acid arachidonate.

12 July 2018

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12 July 2018

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Graded regulation of the Kv2.1 potassium channel by variable phosphorylation.

12 July 2018

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Insulin secretory responses and phospholipid composition of pancreatic islets from mice that do not express Group VIA phospholipase A2 and effects of metabolic stress on glucose homeostasis.

12 July 2018

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Calcium-independent phospholipase A2 localizes in and protects mitochondria during apoptotic induction by staurosporine

12 July 2018

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A bromoenol lactone suicide substrate inactivates group VIA phospholipase A2 by generating a diffusible bromomethyl keto acid that alkylates cysteine thiols

12 July 2018

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Effects of stable suppression of Group VIA phospholipase A2 expression on phospholipid content and composition, insulin secretion, and proliferation of INS-1 insulinoma cells

12 July 2018

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Arachidonic acid inhibits the insulin induction of glucose-6-phosphate dehydrogenase via p38 MAP kinase

12 July 2018

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12 July 2018

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Genetic and pharmacologic evidence that calcium-independent phospholipase A2beta regulates virus-induced inducible nitric-oxide synthase expression by macrophages

12 July 2018

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Activation and signaling of the p38 MAP kinase pathway

12 July 2018

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The expression and function of a group VIA calcium-independent phospholipase A2 (iPLA2beta) in beta-cells

12 July 2018

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Inhibition of Ca2+-independent phospholipase A2 results in insufficient insulin secretion and impaired glucose tolerance

12 July 2018

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Coupling endoplasmic reticulum stress to the cell death program

12 July 2018

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Apoptosis of insulin-secreting cells induced by endoplasmic reticulum stress is amplified by overexpression of group VIA calcium-independent phospholipase A2 (iPLA2 beta) and suppressed by inhibition of iPLA2 beta

12 July 2018

1 reference

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Pancreatic islets and insulinoma cells express a novel isoform of group VIA phospholipase A2 (iPLA2 beta) that participates in glucose-stimulated insulin secretion and is not produced by alternate splicing of the iPLA2 beta transcript

12 July 2018

1 reference

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Impact of Endoplasmic Reticulum Stress Pathway on Pancreatic β-Cells and Diabetes Mellitus

12 July 2018

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Phosphorylation-dependent regulation of Kv2.1 Channel activity at tyrosine 124 by Src and by protein-tyrosine phosphatase epsilon

12 July 2018

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Beta-cell deficit and increased beta-cell apoptosis in humans with type 2 diabetes

12 July 2018

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Endoplasmic reticulum stress-mediated apoptosis in pancreatic beta-cells

12 July 2018

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Identification of calcium-independent phospholipase A2 (iPLA2) beta, and not iPLA2gamma, as the mediator of arginine vasopressin-induced arachidonic acid release in A-10 smooth muscle cells. Enantioselective mechanism-based discrimination of mammali

12 July 2018

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Trophic factor withdrawal: p38 mitogen-activated protein kinase activates NHE1, which induces intracellular alkalinization

12 July 2018

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Cellular mechanisms of insulin resistance

12 July 2018

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Perk is essential for translational regulation and cell survival during the unfolded protein response

12 July 2018

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Phospholipase A2 and its potential regulation of islet function

12 July 2018

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Beta-cell mitochondria in the regulation of insulin secretion: a new culprit in type II diabetes

12 July 2018

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The natural history of insulin secretory dysfunction and insulin resistance in the pathogenesis of type 2 diabetes mellitus

12 July 2018

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12 July 2018

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12 July 2018

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Human Pancreatic Islets Express mRNA Species Encoding Two Distinct Catalytically Active Isoforms of Group VI Phospholipase A2 (iPLA2) [etc.]

12 July 2018

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12 July 2018

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Type 2 diabetes: when insulin secretion fails to compensate for insulin resistance

12 July 2018

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Pancreatic islets express a Ca2+-independent phospholipase A2 enzyme that contains a repeated structural motif homologous to the integral membrane protein binding domain of ankyrin

12 July 2018

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MLK-3 activates the SAPK/JNK and p38/RK pathways via SEK1 and MKK3/6

12 July 2018

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Depletion of intracellular calcium stores activates smooth muscle cell calcium-independent phospholipase A2. A novel mechanism underlying arachidonic acid mobilization

12 July 2018

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A brain serine/threonine protein kinase activated by Cdc42 and Rac1

12 July 2018

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Glucosylation of Rho proteins by Clostridium difficile toxin B.

12 July 2018

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A novel serine kinase activated by rac1/CDC42Hs-dependent autophosphorylation is related to PAK65 and STE20

12 July 2018

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Adipose expression of tumor necrosis factor-alpha: direct role in obesity-linked insulin resistance

12 July 2018

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Rho Family GTPases Regulate p38 Mitogen-activated Protein Kinase through the Downstream Mediator Pak1

12 July 2018

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Cdc42 and PAK-mediated signaling leads to Jun kinase and p38 mitogen-activated protein kinase activation

12 July 2018

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Glucoreceptor mechanisms and the control of insulin release and biosynthesis

12 July 2018

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Islet pathology and the pathogenesis of type 1 and type 2 diabetes mellitus revisited.

12 July 2018

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Pancreatic islet glucose metabolism and regulation of insulin secretion

12 July 2018

1 reference

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Ca2+, cAMP, and phospholipid-derived messengers in coupling mechanisms of insulin secretion

12 July 2018

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Glucokinase as glucose sensor and metabolic signal generator in pancreatic beta-cells and hepatocytes

12 July 2018

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The Pancreatic Islet as Rubik's Cube: Is Phospholipid Hydrolysis a piece of the Puzzle?

12 July 2018

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The role of ATP and free ADP in metabolic coupling during fuel-stimulated insulin release from islet beta-cells in the isolated perfused rat pancreas

12 July 2018

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Arachidonic acid metabolism in isolated pancreatic islets. VI. Carbohydrate insulin secretagogues must be metabolized to induce eicosanoid release

12 July 2018

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Glucose transport and NIDDM

12 July 2018

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Stimulus-secretion coupling in beta-cells of transplantable human islets of Langerhans. Evidence for a critical role for Ca2+ entry

12 July 2018

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Stress kinase p38 mediates EGFR transactivation by hyperosmolar concentrations of sorbitol

12 July 2018

1 reference

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Structural studies on ceramides as lithiated adducts by low energy collisional-activated dissociation tandem mass spectrometry with electrospray ionization

25 September 2018

1 reference

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Characterization of ceramides by low energy collisional-activated dissociation tandem mass spectrometry with negative-ion electrospray ionization

25 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3285329

The genetic basis of type 2 diabetes mellitus: impaired insulin secretion versus impaired insulin sensitivity.

25 September 2018

1 reference

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Inhibition of glucose-induced insulin secretion by the diacylglycerol lipase inhibitor RHC 80267 and the phospholipase A2 inhibitor ACA through stimulation of K+ permeability without diminution by exogenous arachidonic acid.

25 September 2018

1 reference

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Sequence of rat mitochondrial glycerol-3-phosphate dehydrogenase cDNA. Evidence for EF-hand calcium-binding domains.

25 September 2018

1 reference

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Inhibition of ATP-regulated K+ channels precedes depolarization-induced increase in cytoplasmic free Ca2+ concentration in pancreatic beta-cells.

25 September 2018

1 reference

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Prevalence of High Body Mass Index in US Children and Adolescents, 2007-2008

25 September 2018

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Intracellular ATP directly blocks K+ channels in pancreatic B-cells

21 January 2018

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Mortality from heart disease in a cohort of 23,000 patients with insulin-treated diabetes

21 January 2018

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12 December 2020

Phospholipase A2 activity in pancreatic islets is calcium-dependent and stimulated by glucose

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12 December 2020

Quantitation of Endocrine Cell Content in the Pancreas of Nondiabetic and Diabetic Humans

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12 December 2020

Activity of endogenous phospholipase C and phospholipase A2 in glucose stimulated pancreatic islets

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12 December 2020

Intracellular Ca2+ mobilization by arachidonic acid. Comparison with myo-inositol 1,4,5-trisphosphate in isolated pancreatic islets

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12 December 2020

The ATP-sensitivity of K+ channels in rat pancreatic B-cells is modulated by ADP

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12 December 2020

Suicide inhibition of canine myocardial cytosolic calcium-independent phospholipase A2. Mechanism-based discrimination between calcium-dependent and -independent phospholipases A2

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12 December 2020

Free fatty acid accumulation in secretagogue-stimulated pancreatic islets and effects of arachidonate on depolarization-induced insulin secretion

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12 December 2020

Mass spectrometric evidence that agents that cause loss of Ca2+ from intracellular compartments induce hydrolysis of arachidonic acid from pancreatic islet membrane phospholipids by a mechanism that does not require a rise in cytosolic Ca2+ concentr

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12 December 2020

Glucose decreases Na+,K+-ATPase activity in pancreatic beta-cells. An effect mediated via Ca2+-independent phospholipase A2 and protein kinase C-dependent phosphorylation of the alpha-subunit

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12 December 2020

Role of NADH shuttle system in glucose-induced activation of mitochondrial metabolism and insulin secretion

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12 December 2020

Arachidonic acid induces an increase in the cytosolic calcium concentration in single pancreatic islet beta cells

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12 December 2020

Glucose regulation of insulin secretion independent of the opening or closure of adenosine triphosphate-sensitive K+ channels in beta cells

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12 December 2020

Studies of the role of group VI phospholipase A2 in fatty acid incorporation, phospholipid remodeling, lysophosphatidylcholine generation, and secretagogue-induced arachidonic acid release in pancreatic islets and insulinoma cells

1 reference

12 December 2020

cAMP enhances insulin secretion by an action on the ATP-sensitive K+ channel-independent pathway of glucose signaling in rat pancreatic islets

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12 December 2020

Uptake and release of Ca2+ by the endoplasmic reticulum contribute to the oscillations of the cytosolic Ca2+ concentration triggered by Ca2+ influx in the electrically excitable pancreatic B-cell

1 reference

12 December 2020

The Oscillatory Behavior of Pancreatic Islets from Mice with Mitochondrial Glycerol-3-phosphate Dehydrogenase Knockout

1 reference

12 December 2020

Studies of insulin secretory responses and of arachidonic acid incorporation into phospholipids of stably transfected insulinoma cells that overexpress group VIA phospholipase A2 (iPLA2beta ) indicate a signaling rather than a housekeeping role for

1 reference

12 December 2020

Rat and human pancreatic islet cells contain a calcium ion independent phospholipase A2 activity selective for hydrolysis of arachidonate which is stimulated by adenosine triphosphate and is specifically localized to islet beta-cells

1 reference

12 December 2020

Inhibition of arachidonate release by secretagogue-stimulated pancreatic islets suppresses both insulin secretion and the rise in beta-cell cytosolic calcium ion concentration

1 reference

12 December 2020

Structural determinants of haloenol lactone-mediated suicide inhibition of canine myocardial calcium-independent phospholipase A2

1 reference

12 December 2020

Characterization of an ATP-stimulatable Ca(2+)-independent phospholipase A2 from clonal insulin-secreting HIT cells and rat pancreatic islets: a possible molecular component of the beta-cell fuel sensor

1 reference

12 December 2020

Feasibility of a mitochondrial pyruvate malate shuttle in pancreatic islets. Further implication of cytosolic NADPH in insulin secretion

1 reference

12 December 2020

Glucose-responsitivity and expression of an ATP-stimulatable, Ca(2+)-independent phospholipase A2 enzyme in clonal insulinoma cell lines

1 reference

12 December 2020

Two distinct stress signaling pathways converge upon the CHOP promoter during the mammalian unfolded protein response

1 reference

12 December 2020

Cutting edge: proliferating fibroblasts respond to collagenous C1q with phosphorylation of p38 mitogen-activated protein kinase and apoptotic features

1 reference

12 December 2020

Identifiers

DOI

10.1074/JBC.M111.285114

1 reference

10 August 2017

1 reference

10 August 2017

1 reference