(Q35788447)

10 August 2017

title

Amsacrine as a topoisomerase II poison: importance of drug-DNA interactions (English)

1 reference

10 August 2017

4

Neil Osheroff

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10 August 2017

2

William A Denny

1 reference

10 August 2017

Adam C Ketron

1

1 reference

10 August 2017

David E Graves

series ordinal

3

1 reference

10 August 2017

language of work or name

English

0 references

publication date

10 February 2012

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10 August 2017

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10 August 2017

volume

51

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10 August 2017

issue

8

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10 August 2017

page(s)

1730-1739

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Structural basis of type II topoisomerase inhibition by the anticancer drug etoposide

10 August 2017

cites work

1 reference

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12 July 2018

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DNA topoisomerases and their poisoning by anticancer and antibacterial drugs

12 July 2018

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Late relapses in acute myeloid leukemia: analysis of characteristics and outcome

12 July 2018

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Targeting DNA topoisomerase II in cancer chemotherapy

12 July 2018

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The DNA cleavage reaction of topoisomerase II: wolf in sheep's clothing

12 July 2018

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Treatment of relapsed acute myeloid leukaemia

12 July 2018

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Substituents on etoposide that interact with human topoisomerase IIalpha in the binary enzyme-drug complex: contributions to etoposide binding and activity.

12 July 2018

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Using 3'-bridging phosphorothiolates to isolate the forward DNA cleavage reaction of human topoisomerase IIalpha

12 July 2018

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(-)-Epigallocatechin gallate, a major constituent of green tea, poisons human type II topoisomerases

12 July 2018

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DNA topoisomerase II, genotoxicity, and cancer

12 July 2018

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Topoisomerase II - drug interaction domains: identification of substituents on etoposide that interact with the enzyme.

12 July 2018

1 reference

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Quinone-induced enhancement of DNA cleavage by human topoisomerase IIalpha: adduction of cysteine residues 392 and 405.

12 July 2018

1 reference

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The geometry of DNA supercoils modulates topoisomerase-mediated DNA cleavage and enzyme response to anticancer drugs

12 July 2018

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Etoposide, topoisomerase II and cancer

12 July 2018

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N-acetyl-p-benzoquinone imine, the toxic metabolite of acetaminophen, is a topoisomerase II poison

12 July 2018

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Cobalt enhances DNA cleavage mediated by human topoisomerase II alpha in vitro and in cultured cells

12 July 2018

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Site-specific DNA cleavage by Chlorella virus topoisomerase II.

12 July 2018

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DNA topoisomerases as targets for the anticancer drug TAS-103: DNA interactions and topoisomerase catalytic inhibition.

12 July 2018

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Absence of topoisomerase IIbeta in an amsacrine-resistant human leukemia cell line with mutant topoisomerase IIalpha.

12 July 2018

1 reference

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Merbarone inhibits the catalytic activity of human topoisomerase IIalpha by blocking DNA cleavage

12 July 2018

1 reference

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Role of topoisomerase II beta in the resistance of 9-OH-ellipticine-resistant Chinese hamster fibroblasts to topoisomerase II inhibitors

12 July 2018

1 reference

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Differential expression of DNA topoisomerase II alpha and -beta in P-gp and MRP-negative VM26, mAMSA and mitoxantrone-resistant sublines of the human SCLC cell line GLC4.

12 July 2018

1 reference

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Localization of an aminoacridine antitumor agent in a type II topoisomerase-DNA complex

12 July 2018

1 reference

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Protein-associated deoxyribonucleic acid strand breaks in L1210 cells treated with the deoxyribonucleic acid intercalating agents 4'-(9-acridinylamino) methanesulfon-m-anisidide and adriamycin

12 July 2018

1 reference

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Mechanism of antitumor drug action: poisoning of mammalian DNA topoisomerase II on DNA by 4'-(9-acridinylamino)-methanesulfon-m-anisidide

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3289736

Potential antitumor agents. 14. Acridylmethanesulfonanilides.

12 July 2018

1 reference

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Cooperative binding of m-AMSA to nucleic acids

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3289736

In vivo mapping of DNA topoisomerase II-specific cleavage sites on SV40 chromatin.

12 July 2018

1 reference

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DNA binding by epipodophyllotoxins and N-acyl anthracyclines: implications for mechanism of topoisomerase II inhibition

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3289736

Calcium-promoted DNA cleavage by eukaryotic topoisomerase II: trapping the covalent enzyme-DNA complex in an active form.

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3289736

Thermodynamics of the interactions of m-AMSA and o-AMSA with nucleic acids: influence of ionic strength and DNA base composition

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3289736

Stabilization of the topoisomerase II-DNA cleavage complex by antineoplastic drugs: inhibition of enzyme-mediated DNA religation by 4'-(9-acridinylamino)methanesulfon-m-anisidide.

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3289736

New drugs in the treatment of acute and chronic leukemia with some emphasis on m-AMSA.

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3289736

Effects of antineoplastic drugs on the post-strand-passage DNA cleavage/religation equilibrium of topoisomerase II.

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3289736

Mode of action of topoisomerase II-targeting agents at a specific DNA sequence. Uncoupling the DNA binding, cleavage and religation events

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3289736

Polychlorinated biphenyl quinone metabolites poison human topoisomerase IIalpha: altering enzyme function by blocking the N-terminal protein gate.

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3289736

Stimulation of topoisomerase II-mediated DNA cleavage by benzene metabolites

25 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3289736

A unique type II topoisomerase mutant that is hypersensitive to a broad range of cleavage-inducing antitumor agents

25 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3289736

Murine transgenic cells lacking DNA topoisomerase IIbeta are resistant to acridines and mitoxantrone: analysis of cytotoxicity and cleavable complex formation.

25 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3289736

DNA-binding characteristics of acridinylmethanesulphonanilide drugs: comparison with antitumour properties

25 September 2018

1 reference

12 December 2020

Potential antitumor agents. 16. 4'-(Acridin-9-ylamino)methanesulfonanilides

1 reference

12 December 2020

Role of topoisomerase II in mediating epipodophyllotoxin-induced DNA cleavage

1 reference

12 December 2020

Inducible overexpression, purification, and active site mapping of DNA topoisomerase II from the yeast Saccharomyces cerevisiae

1 reference

12 December 2020

Properties of the nucleic acid photoaffinity labeling agent 3-azidoamsacrine

1 reference

12 December 2020

Interactions of anilinoacridines with nucleic acids: effects of substituent modifications on DNA-binding properties

1 reference

12 December 2020

Expression, domain structure, and enzymatic properties of an active recombinant human DNA topoisomerase II beta

1 reference

12 December 2020

Amsacrine-promoted DNA cleavage site determinants for the two human DNA topoisomerase II isoforms alpha and beta

1 reference

12 December 2020

Spontaneous DNA lesions poison human topoisomerase IIalpha and stimulate cleavage proximal to leukemic 11q23 chromosomal breakpoints

1 reference

12 December 2020

Identifiers

DOI

10.1021/BI201159B

1 reference

10 August 2017

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10 August 2017

1 reference