(Q35795880)

English

Computational studies of difference in binding modes of peptide and non-peptide inhibitors to MDM2/MDMX based on molecular dynamics simulations

scientific article published on 17 February 2012

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scholarly article

1 reference

Europe PubMed Central

PubMed publication ID

10 August 2017

Computational studies of difference in binding modes of peptide and non-peptide inhibitors to MDM2/MDMX based on molecular dynamics simulations (English)

1 reference

Europe PubMed Central

PubMed publication ID

10 August 2017

author name string

Jianzhong Chen

1

1 reference

Europe PubMed Central

PubMed publication ID

10 August 2017

Dinglin Zhang

2

1 reference

Europe PubMed Central

PubMed publication ID

10 August 2017

Yuxin Zhang

3

1 reference

Europe PubMed Central

PubMed publication ID

10 August 2017

Guohui Li

4

1 reference

Europe PubMed Central

PubMed publication ID

10 August 2017

language of work or name

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publication date

17 February 2012

1 reference

Europe PubMed Central

PubMed publication ID

10 August 2017

International Journal of Molecular Sciences

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Europe PubMed Central

PubMed publication ID

10 August 2017

13

1 reference

Europe PubMed Central

PubMed publication ID

10 August 2017

2

1 reference

Europe PubMed Central

PubMed publication ID

10 August 2017

2176-2195

1 reference

Europe PubMed Central

PubMed publication ID

10 August 2017

copyright license

Creative Commons Attribution 4.0 International

17 February 2012

1 reference

April 2022 Public Data File from Crossref

copyright status

0 references

Generalized Born model with a simple, robust molecular volume correction

1 reference

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Molecular interaction fields and 3D-QSAR studies of p53-MDM2 inhibitors suggest additional features of ligand-target interaction

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11 July 2018

A computational analysis of the binding model of MDM2 with inhibitors

1 reference

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Electrostatic polarization makes a substantial contribution to the free energy of avidin-biotin binding

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Systematic Mutational Analysis of Peptide Inhibition of the p53–MDM2/MDMX Interactions

1 reference

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Differential binding of p53 and nutlin to MDM2 and MDMX: computational studies

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The p53 orchestra: Mdm2 and Mdmx set the tone

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Identification and characterization of the first small molecule inhibitor of MDMX

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Structure-based Design of High Affinity Peptides Inhibiting the Interaction of p53 with MDM2 and MDMX

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Insights into drug resistance of mutations D30N and I50V to HIV-1 protease inhibitor TMC-114: free energy calculation and molecular dynamic simulation

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Trypsin-ligand binding free energies from explicit and implicit solvent simulations with polarizable potential

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Structural basis for high-affinity peptide inhibition of p53 interactions with MDM2 and MDMX

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Small-molecule inhibitors of the MDM2-p53 protein-protein interaction to reactivate p53 function: a novel approach for cancer therapy

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The pre-clinical development of MDM2 inhibitors in chronic lymphocytic leukemia uncovers a central role for p53 status in sensitivity to MDM2 inhibitor-mediated apoptosis.

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Molecular basis for the inhibition of p53 by Mdmx

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Targeting protein-protein interactions: lessons from p53/MDM2.

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p53 in health and disease

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Senescence and tumour clearance is triggered by p53 restoration in murine liver carcinomas

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Restoration of p53 function leads to tumour regression in vivo

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MDMX: from bench to bedside

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Modeling the therapeutic efficacy of p53 restoration in tumors

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An essential function of the extreme C-terminus of MDM2 can be provided by MDMX

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MDM2 inhibitors for cancer therapy

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Ultra-high resolution crystal structure of HIV-1 protease mutant reveals two binding sites for clinical inhibitor TMC114

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MDMX overexpression prevents p53 activation by the MDM2 inhibitor Nutlin.

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Effectiveness of nonpeptide clinical inhibitor TMC-114 on HIV-1 protease with highly drug resistant mutations D30N, I50V, and L90M.

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Core domain interactions in full-length p53 in solution

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Hdmx protein stability is regulated by the ubiquitin ligase activity of Mdm2.

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Identifiers

10.3390/IJMS13022176

1 reference

Europe PubMed Central

PubMed publication ID

10 August 2017

PMC publication ID

1 reference

Europe PubMed Central

PubMed publication ID

10 August 2017

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

10 August 2017

ResearchGate publication ID

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