(Q35825997)

10 August 2017

An extra allele of Chk1 limits oncogene-induced replicative stress and promotes transformation (English)

1 reference

10 August 2017

Andres J López-Contreras

1

1 reference

10 August 2017

Paula Gutierrez-Martinez

2

1 reference

10 August 2017

Julia Specks

3

1 reference

10 August 2017

Sara Rodrigo-Perez

4

1 reference

10 August 2017

Oscar Fernandez-Capetillo

5

1 reference

10 August 2017

language of work or name

English

0 references

publication date

27 February 2012

1 reference

Journal of Experimental Medicine

10 August 2017

1 reference

10 August 2017

209

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10 August 2017

3

1 reference

10 August 2017

455-461

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Oncogenic stress sensitizes murine cancers to hypomorphic suppression of ATR

10 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3302228

Exploiting oncogene-induced replicative stress for the selective killing of Myc-driven tumors

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3302228

Mechanisms and pathways of growth failure in primordial dwarfism.

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3302228

Therapeutic implications for the induced levels of Chk1 in Myc-expressing cancer cells

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3302228

A continuum model for tumour suppression

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3302228

A cell-based screen identifies ATR inhibitors with synthetic lethal properties for cancer-associated mutations.

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3302228

Nucleotide deficiency promotes genomic instability in early stages of cancer development

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3302228

Combining ATR suppression with oncogenic Ras synergistically increases genomic instability, causing synthetic lethality or tumorigenesis in a dosage-dependent manner

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3302228

The ATR barrier to replication-born DNA damage.

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3302228

The DNA-damage response in human biology and disease

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3302228

Tissue regenerative delays and synthetic lethality in adult mice after combined deletion of Atr and Trp53.

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3302228

A mouse model of ATR-Seckel shows embryonic replicative stress and accelerated aging

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3302228

ATR: an essential regulator of genome integrity

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3302228

Deletion of the developmentally essential gene ATR in adult mice leads to age-related phenotypes and stem cell loss

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3302228

An oncogene-induced DNA damage model for cancer development

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3302228

The E2F-regulated gene Chk1 is highly expressed in triple-negative estrogen receptor /progesterone receptor /HER-2 breast carcinomas

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3302228

ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3302228

ATM regulates ATR chromatin loading in response to DNA double-strand breaks

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3302228

ATM- and cell cycle-dependent regulation of ATR in response to DNA double-strand breaks

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3302228

Increased gene dosage of Ink4a/Arf results in cancer resistance and normal aging.

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3302228

Chk1 is haploinsufficient for multiple functions critical to tumor suppression

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3302228

A splicing mutation affecting expression of ataxia-telangiectasia and Rad3-related protein (ATR) results in Seckel syndrome

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3302228

"Super p53" mice exhibit enhanced DNA damage response, are tumor resistant and age normally

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3302228

ATR and ATRIP: partners in checkpoint signaling

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3302228

Chk1 is an essential kinase that is regulated by Atr and required for the G(2)/M DNA damage checkpoint

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3302228

Aberrant cell cycle checkpoint function and early embryonic death in Chk1(-/-) mice

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3302228

Targeted disruption of the cell-cycle checkpoint gene ATR leads to early embryonic lethality in mice

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3302228

ATR disruption leads to chromosomal fragmentation and early embryonic lethality

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3302228

Atm-deficient mice: a paradigm of ataxia telangiectasia

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3302228

A single ataxia telangiectasia gene with a product similar to PI-3 kinase

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3302228

The impact of a negligent G2/M checkpoint on genomic instability and cancer induction.

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3302228

24 September 2018

Identifiers

DOI

10.1084/JEM.20112147

1 reference

release_jdzsw2usdnaefe7lr6fktfeltu

10 August 2017

1 reference

Fatcat

https://api.fatcat.wiki/v0/release/jdzsw2usdnaefe7lr6fktfeltu

mapped directly with Wikidata item

24 November 2022

based on heuristic

1 reference

10 August 2017

PubMed publication ID

22370720

1 reference