(Q35838889)

English

Heparanase induces signal transducer and activator of transcription (STAT) protein phosphorylation: preclinical and clinical significance in head and neck cancer

scientific article published on 22 December 2011

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Statements

scholarly article

1 reference

Europe PubMed Central

PMC publication ID

10 August 2017

Heparanase induces signal transducer and activator of transcription (STAT) protein phosphorylation: preclinical and clinical significance in head and neck cancer (English)

1 reference

Europe PubMed Central

PMC publication ID

10 August 2017

phosphorylation

1 reference

based on heuristic

inferred from title

head and neck cancer

1 reference

based on heuristic

inferred from title

1 reference

based on heuristic

inferred from title

head and neck carcinoma

1 reference

based on heuristic

inferred from title

author name string

Victoria Cohen-Kaplan

1

1 reference

Europe PubMed Central

PMC publication ID

10 August 2017

Jenny Jrbashyan

2

1 reference

Europe PubMed Central

PMC publication ID

10 August 2017

Yoav Yanir

3

1 reference

Europe PubMed Central

PMC publication ID

10 August 2017

Inna Naroditsky

4

1 reference

Europe PubMed Central

PMC publication ID

10 August 2017

Ofer Ben-Izhak

5

1 reference

Europe PubMed Central

PMC publication ID

10 August 2017

Neta Ilan

6

1 reference

Europe PubMed Central

PMC publication ID

10 August 2017

Ilana Doweck

7

1 reference

Europe PubMed Central

PMC publication ID

10 August 2017

Israel Vlodavsky

8

1 reference

Europe PubMed Central

PMC publication ID

10 August 2017

language of work or name

0 references

publication date

22 December 2011

1 reference

Europe PubMed Central

PMC publication ID

10 August 2017

Journal of Biological Chemistry

1 reference

Europe PubMed Central

PMC publication ID

10 August 2017

287

1 reference

Europe PubMed Central

PMC publication ID

10 August 2017

9

1 reference

Europe PubMed Central

PMC publication ID

10 August 2017

6668-6678

1 reference

Europe PubMed Central

PMC publication ID

10 August 2017

Heparanase powers a chronic inflammatory circuit that promotes colitis-associated tumorigenesis in mice

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3307274

27 July 2018

Heparanase plays a dual role in driving hepatocyte growth factor (HGF) signaling by enhancing HGF expression and activity

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3307274

27 July 2018

Heparanase enhances local and systemic osteolysis in multiple myeloma by upregulating the expression and secretion of RANKL

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3307274

27 July 2018

Proteoglycans in health and disease: new concepts for heparanase function in tumor progression and metastasis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3307274

27 July 2018

Heparanase 2 interacts with heparan sulfate with high affinity and inhibits heparanase activity

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3307274

27 July 2018

Emerging drugs to treat squamous cell carcinomas of the head and neck

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3307274

27 July 2018

Defining the role of the JAK-STAT pathway in head and neck and thoracic malignancies: implications for future therapeutic approaches

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3307274

27 July 2018

Nuclear localization of signal transducer and activator of transcription 3 in head and neck squamous cell carcinoma is associated with a better prognosis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3307274

27 July 2018

NF-kappaB and STAT3 signaling in glioma: targets for future therapies

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3307274

27 July 2018

STATs in cancer inflammation and immunity: a leading role for STAT3

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3307274

27 July 2018

Heparanase: busy at the cell surface

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3307274

27 July 2018

Cancer statistics, 2009

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3307274

27 July 2018

The PG500 series: novel heparan sulfate mimetics as potent angiogenesis and heparanase inhibitors for cancer therapy

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3307274

27 July 2018

Structure-function approach identifies a COOH-terminal domain that mediates heparanase signaling

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3307274

27 July 2018

Heparanase augments epidermal growth factor receptor phosphorylation: correlation with head and neck tumor progression

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3307274

27 July 2018

Heparanase induces VEGF C and facilitates tumor lymphangiogenesis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3307274

27 July 2018

Paradigm shifts in the cell biology of STAT signaling

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3307274

27 July 2018

Heparanase facilitates cell adhesion and spreading by clustering of cell surface heparan sulfate proteoglycans

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3307274

27 July 2018

Function of heparanase in prostate tumorigenesis: potential for therapy

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3307274

27 July 2018

Targeting the cytoplasmic and nuclear functions of signal transducers and activators of transcription 3 for cancer therapy

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3307274

27 July 2018

Heparanase induces Akt phosphorylation via a lipid raft receptor

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3307274

27 July 2018

Mammalian heparanase: what is the message?

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3307274

27 July 2018

Heparanase: structure, biological functions, and inhibition by heparin-derived mimetics of heparan sulfate

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3307274

27 July 2018

Heparanase: a target for drug discovery in cancer and inflammation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3307274

27 July 2018

Heparanase localization and expression by head and neck cancer: correlation with tumor progression and patient survival

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3307274

27 July 2018

STAT3 as a central mediator of neoplastic cellular transformation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3307274

27 July 2018

The generation and regulation of functional diversity of malignant plasma cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3307274

27 July 2018

Development of heparanase inhibitors for anti-cancer therapy

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3307274

27 July 2018

Regulation, function and clinical significance of heparanase in cancer metastasis and angiogenesis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3307274

27 July 2018

STAT3 as a therapeutic target in head and neck cancer

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3307274

27 July 2018

Heparanase induces vascular endothelial growth factor expression: correlation with p38 phosphorylation levels and Src activation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3307274

27 July 2018

Heparanase is involved in angiogenesis in esophageal cancer through induction of cyclooxygenase-2.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3307274

27 July 2018

Enzymatic remodeling of heparan sulfate proteoglycans within the tumor microenvironment: growth regulation and the prospect of new cancer therapies.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3307274

27 July 2018

Malignant transformation but not normal cell growth depends on signal transducer and activator of transcription 3.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3307274

27 July 2018

STATs as critical mediators of signal transduction and transcription: lessons learned from STAT5.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3307274

27 July 2018

Processing and activation of latent heparanase occurs in lysosomes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3307274

27 July 2018

Heparanase induces endothelial cell migration via protein kinase B/Akt activation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3307274

27 July 2018

The STATs of cancer--new molecular targets come of age

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3307274

27 July 2018

Heparanase: a key enzyme involved in cell invasion

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3307274

27 July 2018

Heparanase, a potential regulator of cell-matrix interactions

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3307274

27 July 2018

STAT signaling in head and neck cancer

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3307274

27 July 2018

Pre-clinical and clinical significance of heparanase in Ewing's sarcoma.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M111.271346

21 January 2018

Non-anticoagulant heparins and inhibition of cancer

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M111.271346

21 January 2018

Tumorigenic and adhesive properties of heparanase

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M111.271346

21 January 2018

A novel human heparanase splice variant, T5, endowed with protumorigenic characteristics

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M111.271346

21 January 2018

In vivo detection of head and neck cancer orthotopic xenografts by immunofluorescence

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M111.271346

21 January 2018

Tracking STAT nuclear traffic

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M111.271346

21 January 2018

Activated signal transducer and activator of transcription (STAT) 3: localization in focal adhesions and function in ovarian cancer cell motility

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M111.271346

21 January 2018

Immunohistochemical analysis of phosphotyrosine signal transducer and activator of transcription 3 and epidermal growth factor receptor autocrine signaling pathways in head and neck cancers and metastatic lymph nodes.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M111.271346

21 January 2018

STAT3: a critical transcription activator in angiogenesis.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M111.271346

21 January 2018

Constitutive activation of signal transducer and activator of transcription 5 contributes to tumor growth, epithelial-mesenchymal transition, and resistance to epidermal growth factor receptor targeting

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M111.271346

21 January 2018

Constitutive activation of Stat5b contributes to carcinogenesis in vivo

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3307274

24 September 2018

Molecular properties and involvement of heparanase in cancer metastasis and angiogenesis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3307274

24 September 2018

Epidermal growth factor receptor gene amplification and expression in head and neck cancer cell lines

1 reference

https://pubmed.ncbi.nlm.nih.gov/22194600

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

MEK is a negative regulator of Stat5b in PDGF-stimulated cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/22194600

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Activation of signal transducer and activator of transcription-5 in prostate cancer predicts early recurrence

1 reference

https://pubmed.ncbi.nlm.nih.gov/22194600

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1074/JBC.M111.271346

1 reference

Europe PubMed Central

PMC publication ID

10 August 2017

PMC publication ID

1 reference

Europe PubMed Central

PMC publication ID

10 August 2017

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

10 August 2017

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