(Q35841561)

10 August 2017

1 reference

title

Idiopathic pulmonary fibrosis: emerging concepts on pharmacotherapy (English)

1 reference

idiopathic pulmonary fibrosis

10 August 2017

0 references

1 reference

1 reference

3

Fernando J Martinez

1 reference

10 August 2017

Victor J Thannickal

1

1 reference

10 August 2017

Kevin R Flaherty

series ordinal

2

1 reference

10 August 2017

Joseph P Lynch

series ordinal

4

1 reference

10 August 2017

language of work or name

English

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publication date

1 August 2004

1 reference

Expert Opinion on Pharmacotherapy

10 August 2017

1 reference

10 August 2017

5

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10 August 2017

8

1 reference

10 August 2017

1671-1686

1 reference

https://api.crossref.org/works/10.1517%2F14656566.5.8.1671

10 August 2017

1 reference

Mechanisms of pulmonary fibrosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14656566.5.8.1671

Idiopathic pulmonary fibrosis: prevailing and evolving hypotheses about its pathogenesis and implications for therapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14656566.5.8.1671

Demystifying idiopathic interstitial pneumonia

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14656566.5.8.1671

Points of control in inflammation

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14656566.5.8.1671

Possible new role for NF-kappaB in the resolution of inflammation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14656566.5.8.1671

Role of transforming growth factor-beta in tissue injury and repair

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14656566.5.8.1671

Clinical significance of histological classification of idiopathic interstitial pneumonia

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14656566.5.8.1671

A clinical, radiographic, and physiologic scoring system for the longitudinal assessment of patients with idiopathic pulmonary fibrosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14656566.5.8.1671

Steroids in idiopathic pulmonary fibrosis: a prospective assessment of adverse reactions, response to therapy, and survival.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14656566.5.8.1671

A placebo-controlled trial of interferon gamma-1b in patients with idiopathic pulmonary fibrosis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14656566.5.8.1671

Signaling and transcription in T helper development

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14656566.5.8.1671

Inhibition of transforming growth factor-beta/SMAD signalling by the interferon-gamma/STAT pathway.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14656566.5.8.1671

Mice lacking Smad3 are protected against cutaneous injury induced by ionizing radiation

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14656566.5.8.1671

Is Smad3 a major player in signal transduction pathways leading to fibrogenesis?

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14656566.5.8.1671

Proteoglycan expression in bleomycin lung fibroblasts: role of transforming growth factor-beta(1) and interferon-gamma

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14656566.5.8.1671

Attenuation of lung inflammation and fibrosis in interferon-gamma-deficient mice after intratracheal bleomycin

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14656566.5.8.1671

A preliminary study of long-term treatment with interferon gamma-1b and low-dose prednisolone in patients with idiopathic pulmonary fibrosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14656566.5.8.1671

Acute respiratory failure after interferon-gamma therapy of end-stage pulmonary fibrosis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14656566.5.8.1671

Effect of pirfenidone on rat hepatic stellate cell proliferation and collagen production

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14656566.5.8.1671

Anti-inflammatory effect of pirfenidone in the bleomycin-hamster model of lung inflammation

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14656566.5.8.1671

Pirfenidone suppresses tumor necrosis factor-alpha, enhances interleukin-10 and protects mice from endotoxic shock

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14656566.5.8.1671

Pirfenidone blocks the in vitro and in vivo effects of staphylococcal enterotoxin B

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14656566.5.8.1671

A novel anti-fibrotic agent pirfenidone suppresses tumor necrosis factor-alpha at the translational level

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14656566.5.8.1671

Pirfenidone: a novel antifibrotic agent with implications for the treatment of obliterative bronchiolitis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14656566.5.8.1671

Pirfenidone improves renal function and fibrosis in the post-obstructed kidney

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14656566.5.8.1671

Effect of pirfenidone against vanadate-induced kidney fibrosis in rats

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14656566.5.8.1671

Pirfenidone inhibits dimethylnitrosamine-induced hepatic fibrosis in rats

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14656566.5.8.1671

Pirfenidone effectively reverses experimental liver fibrosis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14656566.5.8.1671

Effects of pirfenidone on vascular smooth muscle cell proliferation and intimal hyperplasia following arterial balloon injury

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14656566.5.8.1671

Reversal of cardiac and renal fibrosis by pirfenidone and spironolactone in streptozotocin-diabetic rats

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14656566.5.8.1671

Effect of pirfenidone on the pulmonary fibrosis of Hermansky-Pudlak syndrome

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14656566.5.8.1671

Pirfenidone in the treatment of primary sclerosing cholangitis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14656566.5.8.1671

Vascular and cardiac benefits of angiotensin receptor blockers

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14656566.5.8.1671

Angiotensin II is mitogenic for human lung fibroblasts via activation of the type 1 receptor.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14656566.5.8.1671

Transforming growth factor-beta and angiotensin II: the missing link from glomerular hyperfiltration to glomerulosclerosis?

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14656566.5.8.1671

Captopril inhibits proliferation of human lung fibroblasts in culture: a potential antifibrotic mechanism

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14656566.5.8.1671

Captopril inhibits the pulmonary toxicity of paraquat in rats

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14656566.5.8.1671

Therapeutic strategies to halt renal fibrosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14656566.5.8.1671

Elevated expression of endothelin-1 and endothelin-converting enzyme-1 in idiopathic pulmonary fibrosis: possible involvement of proinflammatory cytokines

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14656566.5.8.1671

Endothelin-1 and endothelin-3 induce chemotaxis and replication of pulmonary artery fibroblasts

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14656566.5.8.1671

Sarcomeric gene expression and contractility in myofibroblasts

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14656566.5.8.1671

Human myofibroblastic hepatic stellate cells express Ca(2+)-activated K(+) channels that modulate the effects of endothelin-1 and nitric oxide

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14656566.5.8.1671

Fibroblast matrix gene expression and connective tissue remodeling: role of endothelin-1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14656566.5.8.1671

LU135252, an endothelin(A) receptor antagonist did not prevent pulmonary vascular remodelling or lung fibrosis in a rat model of myocardial infarction

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14656566.5.8.1671

Transforming growth factor beta in tissue fibrosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14656566.5.8.1671

TGFbeta signaling in growth control, cancer, and heritable disorders

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14656566.5.8.1671

Targeted disruption of the mouse transforming growth factor-beta 1 gene results in multifocal inflammatory disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14656566.5.8.1671

Transforming growth factor type beta regulation of actin mRNA.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14656566.5.8.1671

Upregulated expression of fibroblast growth factor (FGF) receptors by transforming growth factor-beta1 (TGF-beta1) mediates enhanced mitogenic responses to FGFs in cultured human lung fibroblasts

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14656566.5.8.1671

Activation of the pro-survival phosphatidylinositol 3-kinase/AKT pathway by transforming growth factor-beta1 in mesenchymal cells is mediated by p38 MAPK-dependent induction of an autocrine growth factor.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14656566.5.8.1671

Transforming growth factor-beta 1 induces alpha-smooth muscle actin expression in granulation tissue myofibroblasts and in quiescent and growing cultured fibroblasts

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14656566.5.8.1671

Myofibroblast differentiation by transforming growth factor-beta1 is dependent on cell adhesion and integrin signaling via focal adhesion kinase.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14656566.5.8.1671

Activation of an H2O2-generating NADH oxidase in human lung fibroblasts by transforming growth factor beta 1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14656566.5.8.1671

Myofibroblasts and mechano-regulation of connective tissue remodelling

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14656566.5.8.1671

Transforming growth factor beta 1 (TGF-beta 1) induced neutrophil recruitment to synovial tissues: implications for TGF-beta-driven synovial inflammation and hyperplasia

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14656566.5.8.1671

Stimulation of the chemotactic migration of human fibroblasts by transforming growth factor beta

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14656566.5.8.1671

Intratracheal gene transfer of decorin reduces subpleural fibroproliferation induced by bleomycin

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14656566.5.8.1671

Smad-dependent and Smad-independent pathways in TGF-beta family signalling

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14656566.5.8.1671

Smad3 deficiency attenuates bleomycin-induced pulmonary fibrosis in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14656566.5.8.1671

Inhibitory effects of tranilast on expression of transforming growth factor-beta isoforms and receptors in injured arteries.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14656566.5.8.1671

Relaxin peptides are new global players.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14656566.5.8.1671

Activation of orphan receptors by the hormone relaxin

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14656566.5.8.1671

Relaxin signalling links tyrosine phosphorylation to phosphodiesterase and adenylyl cyclase activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14656566.5.8.1671

Human relaxin decreases collagen accumulation in vivo in two rodent models of fibrosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14656566.5.8.1671

Relaxin, a pregnancy hormone, is a functional endothelin-1 antagonist: attenuation of endothelin-1-mediated vasoconstriction by stimulation of endothelin type-B receptor expression via ERK-1/2 and nuclear factor-kappaB.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14656566.5.8.1671

Airway fibrosis in a mouse model of airway inflammation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14656566.5.8.1671

Increased risk of fibrosing alveolitis associated with interleukin-1 receptor antagonist and tumor necrosis factor-alpha gene polymorphisms.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14656566.5.8.1671

Transfer of tumor necrosis factor-alpha to rat lung induces severe pulmonary inflammation and patchy interstitial fibrogenesis with induction of transforming growth factor-beta1 and myofibroblasts

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14656566.5.8.1671

Tumor necrosis factor alpha inhibits type I collagen synthesis through repressive CCAAT/enhancer-binding proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14656566.5.8.1671

Cooperation between SMAD and NF-kappaB in growth factor regulated type VII collagen gene expression

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14656566.5.8.1671

Tumor necrosis factor alpha suppresses the induction of connective tissue growth factor by transforming growth factor-beta in normal and scleroderma fibroblasts

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14656566.5.8.1671

Tumor necrosis factor/cachectin plays a key role in bleomycin-induced pneumopathy and fibrosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14656566.5.8.1671

Upregulation of the p75 but not the p55 TNF-alpha receptor mRNA after silica and bleomycin exposure and protection from lung injury in double receptor knockout mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14656566.5.8.1671

TNF-alpha receptor knockout mice are protected from the fibroproliferative effects of inhaled asbestos fibers

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14656566.5.8.1671

Overexpression of tumor necrosis factor-alpha diminishes pulmonary fibrosis induced by bleomycin or transforming growth factor-beta

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14656566.5.8.1671

Anti-TNF alpha therapy of rheumatoid arthritis: what have we learned?

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14656566.5.8.1671

Pathogenesis of fibrosis: role of TGF-beta and CTGF.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14656566.5.8.1671

Adenoviral gene transfer of connective tissue growth factor in the lung induces transient fibrosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14656566.5.8.1671

The role of connective tissue growth factor, a multifunctional matricellular protein, in fibroblast biology

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14656566.5.8.1671

Elevation of glutathione levels in bovine pulmonary artery endothelial cells by N-acetylcysteine

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14656566.5.8.1671

Effect of glutathione aerosol on oxidant-antioxidant imbalance in idiopathic pulmonary fibrosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14656566.5.8.1671

The Wilson disease gene is a copper transporting ATPase with homology to the Menkes disease gene

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14656566.5.8.1671

Tetrathiomolybdate therapy protects against bleomycin-induced pulmonary fibrosis in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14656566.5.8.1671

Augmentation of functional prostaglandin E levels on the respiratory epithelial surface by aerosol administration of prostaglandin E.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14656566.5.8.1671

Prostaglandin E2 synthesis and suppression of fibroblast proliferation by alveolar epithelial cells is cyclooxygenase-2-dependent.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14656566.5.8.1671

Prostaglandin E2 inhibits fibroblast to myofibroblast transition via E. prostanoid receptor 2 signaling and cyclic adenosine monophosphate elevation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14656566.5.8.1671

Roles of cysteinyl leukotrienes in airway inflammation, smooth muscle function, and remodeling

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14656566.5.8.1671

Protection from pulmonary fibrosis in leukotriene-deficient mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14656566.5.8.1671

Alveolar epithelial cell inhibition of fibroblast proliferation is regulated by MCP-1/CCR2 and mediated by PGE2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14656566.5.8.1671

Protection from pulmonary fibrosis in the absence of CCR2 signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14656566.5.8.1671

Impaired synthesis of prostaglandin E2 by lung fibroblasts and alveolar epithelial cells from GM-CSF-/- mice: implications for fibroproliferation

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14656566.5.8.1671

Imatinib mesylate--a new oral targeted therapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14656566.5.8.1671

The origins of protein phosphorylation

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14656566.5.8.1671

Protein kinases--the major drug targets of the twenty-first century?

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14656566.5.8.1671

A highly specific inhibitor of human p38 MAP kinase binds in the ATP pocket

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14656566.5.8.1671

Alternative splicing yields novel BMAL2 variants: tissue distribution and functional characterization

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14656566.5.8.1671

Hepatic stellate cell proliferation is an early platelet-derived growth factor-mediated cellular event in rat cholestatic liver injury

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14656566.5.8.1671

Prognostic implications of physiologic and radiographic changes in idiopathic interstitial pneumonia

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14656566.5.8.1671

Pulmonary Fibrosis and Chronic Lung Inflammation in ET-1 Transgenic Mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14656566.5.8.1671

Systemic and pulmonary oxidative stress in idiopathic pulmonary fibrosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14656566.5.8.1671

Requirement of tumour necrosis factor for development of silica-induced pulmonary fibrosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14656566.5.8.1671

10.1517/14656566.5.8.1671

21 January 2018

Identifiers

DOI

1 reference

10 August 2017

1 reference