(Q35860759)

English

Unbiased Cell-based Screening in a Neuronal Cell Model of Batten Disease Highlights an Interaction between Ca2+ Homeostasis, Autophagy, and CLN3 Protein Function

scientific article published on 15 April 2015

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scholarly article

1 reference

Europe PubMed Central

10 August 2017

Unbiased Cell-based Screening in a Neuronal Cell Model of Batten Disease Highlights an Interaction between Ca2+ Homeostasis, Autophagy, and CLN3 Protein Function (English)

1 reference

Europe PubMed Central

10 August 2017

0 references

Ceroid lipofuscinosis, neuronal 3, juvenile (Batten, Spielmeyer-Vogt disease)

1 reference

GOA release 2020-03-11

1 reference

based on heuristic

inferred from title

Anton Petcherski

5

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9 June 2020

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Susan L Cotman

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9 June 2020

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Uma Chandrachud

1

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9 June 2020

Mathew W Walker

2

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9 June 2020

Alexandra M Simas

3

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9 June 2020

Sasja Heetveld

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Madeleine Klein

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Hyejin Oh

7

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9 June 2020

Pavlina Wolf

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9 June 2020

Wen-Ning Zhao

9

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9 June 2020

Stephanie Norton

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9 June 2020

Stephen J Haggarty

11

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9 June 2020

Emyr Lloyd-Evans

12

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9 June 2020

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15 April 2015

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Journal of Biological Chemistry

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9 June 2020

290

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9 June 2020

23

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9 June 2020

14361-14380

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9 June 2020

describes a project that uses

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11 June 2022

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based on heuristic

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X-ray fluorescence imaging reveals subcellular biometal disturbances in a childhood neurodegenerative disorder

1 reference

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CLN3 deficient cells display defects in the ARF1-Cdc42 pathway and actin-dependent events

1 reference

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11 July 2018

The Batten disease gene CLN3 confers resistance to endoplasmic reticulum stress induced by tunicamycin.

1 reference

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1 reference

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11 July 2018

Parkinson's disease-associated human ATP13A2 (PARK9) deficiency causes zinc dyshomeostasis and mitochondrial dysfunction

1 reference

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Zn²⁺ dyshomeostasis caused by loss of ATP13A2/PARK9 leads to lysosomal dysfunction and alpha-synuclein accumulation

1 reference

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11 July 2018

Human iPSC models of neuronal ceroid lipofuscinosis capture distinct effects of TPP1 and CLN3 mutations on the endocytic pathway

1 reference

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CLN3 loss disturbs membrane microdomain properties and protein transport in brain endothelial cells

1 reference

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1 reference

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11 July 2018

Modulation of intracellular calcium homeostasis blocks autophagosome formation

1 reference

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11 July 2018

Altered biometal homeostasis is associated with CLN6 mRNA loss in mouse neuronal ceroid lipofuscinosis

1 reference

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Neuronal ceroid lipofuscinosis: impact of recent genetic advances and expansion of the clinicopathologic spectrum

1 reference

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11 July 2018

Amlodipine prevents apoptotic cell death by correction of elevated intracellular calcium in a primary neuronal model of Batten disease (CLN3 disease).

1 reference

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11 July 2018

Genetic basis and phenotypic correlations of the neuronal ceroid lipofusinoses.

1 reference

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11 July 2018

Batten disease is linked to altered expression of mitochondria-related metabolic molecules.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4505505

11 July 2018

Alterations in ROS activity and lysosomal pH account for distinct patterns of macroautophagy in LINCL and JNCL fibroblasts

1 reference

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11 July 2018

Cell biology and function of neuronal ceroid lipofuscinosis-related proteins

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11 July 2018

The role of calcium stores in apoptosis and autophagy

1 reference

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11 July 2018

Guidelines for the use and interpretation of assays for monitoring autophagy

1 reference

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11 July 2018

NIH Image to ImageJ: 25 years of image analysis

1 reference

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1 reference

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11 July 2018

The juvenile Batten disease protein, CLN3, and its role in regulating anterograde and retrograde post-Golgi trafficking

1 reference

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11 July 2018

Neuronal ceroid lipofuscinosis protein CLN3 interacts with motor proteins and modifies location of late endosomal compartments

1 reference

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11 July 2018

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1 reference

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11 July 2018

Distinct early molecular responses to mutations causing vLINCL and JNCL presage ATP synthase subunit C accumulation in cerebellar cells

1 reference

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11 July 2018

Screening for calcium channel modulators in CLN3 siRNA knock down SH-SY5Y neuroblastoma cells reveals a significant decrease of intracellular calcium levels by selected L-type calcium channel blockers

1 reference

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11 July 2018

GM1-ganglioside accumulation at the mitochondria-associated ER membranes links ER stress to Ca(2+)-dependent mitochondrial apoptosis

1 reference

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11 July 2018

Niemann-Pick disease type C1 is a sphingosine storage disease that causes deregulation of lysosomal calcium

1 reference

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11 July 2018

Novel interactions of CLN3 protein link Batten disease to dysregulation of fodrin-Na+, K+ ATPase complex.

1 reference

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Regulation of autophagy by the inositol trisphosphate receptor

1 reference

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11 July 2018

Control of macroautophagy by calcium, calmodulin-dependent kinase kinase-beta, and Bcl-2.

1 reference

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Neuronal vulnerability of CLN3 deletion to calcium-induced cytotoxicity is mediated by calsenilin

1 reference

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Autophagy is disrupted in a knock-in mouse model of juvenile neuronal ceroid lipofuscinosis

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Membrane trafficking and mitochondrial abnormalities precede subunit c deposition in a cerebellar cell model of juvenile neuronal ceroid lipofuscinosis

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Interconnections of CLN3, Hook1 and Rab proteins link Batten disease to defects in the endocytic pathway

1 reference

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Elevated lysosomal pH in neuronal ceroid lipofuscinoses (NCLs)

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CLN3 protein regulates lysosomal pH and alters intracellular processing of Alzheimer's amyloid-beta protein precursor and cathepsin D in human cells

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Studies of pH regulation by Btn1p, the yeast homolog of human Cln3p

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11 July 2018

Isolation of a novel gene underlying Batten disease, CLN3. The International Batten Disease Consortium

1 reference

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1 reference

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11 July 2018

Deregulation of biometal homeostasis: the missing link for neuronal ceroid lipofuscinoses?

1 reference

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24 September 2018

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1 reference

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24 September 2018

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1 reference

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24 September 2018

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1 reference

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24 September 2018

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24 September 2018

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24 September 2018

Isolation of a novel gene underlying batten disease, CLN3

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21 January 2018

CA074 methyl ester: a proinhibitor for intracellular cathepsin B

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12 December 2020

based on heuristic

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Cln3(Deltaex7/8) knock-in mice with the common JNCL mutation exhibit progressive neurologic disease that begins before birth

1 reference

https://pubmed.ncbi.nlm.nih.gov/25878248

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

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1 reference

https://pubmed.ncbi.nlm.nih.gov/25878248

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Dependence of hepatocytic autophagy on intracellularly sequestered calcium

1 reference

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12 December 2020

based on heuristic

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1 reference

https://pubmed.ncbi.nlm.nih.gov/25878248

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1074/JBC.M114.621706

1 reference

Europe PubMed Central

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9 June 2020

1 reference

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9 June 2020

1 reference

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9 June 2020

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