(Q35877182)

10 August 2017

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title

Gene-promoter hypermethylation as a biomarker in lung cancer (English)

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10 August 2017

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1

Steven A Belinsky

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PubMed ID

15343277

10 August 2017

language of work or name

English

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publication date

1 September 2004

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10 August 2017

Nature Reviews Cancer

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10 August 2017

4

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10 August 2017

9

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10 August 2017

707-717

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https://scigraph.springernature.com/pub.10.1038/nrc1432

10 August 2017

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cites work

Cancer burden in the year 2000. The global picture

1 reference

Comparison of four chemotherapy regimens for advanced non-small-cell lung cancer

21 January 2018

1 reference

Phase III randomized trial comparing three platinum-based doublets in advanced non-small-cell lung cancer.

21 January 2018

1 reference

Gefitinib in combination with paclitaxel and carboplatin in advanced non-small-cell lung cancer: a phase III trial--INTACT 2.

21 January 2018

1 reference

Gefitinib in combination with gemcitabine and cisplatin in advanced non-small-cell lung cancer: a phase III trial--INTACT 1.

21 January 2018

1 reference

Small-cell lung cancer: a review of clinical trials

21 January 2018

1 reference

Teen smoking, field cancerization, and a "critical period" hypothesis for lung cancer susceptibility

21 January 2018

1 reference

Smoking, smoking cessation, and lung cancer in the UK since 1950: combination of national statistics with two case-control studies

21 January 2018

1 reference

Lung carcinoma in former smokers.

21 January 2018

1 reference

Mass screening for lung cancer with mobile spiral computed tomography scanner

21 January 2018

1 reference

CT evaluation for pulmonary metastases in patients with extrathoracic malignancy

21 January 2018

1 reference

Early Lung Cancer Action Project: overall design and findings from baseline screening.

21 January 2018

1 reference

Computerized tomography screening for lung cancer: new findings and diagnostic work-up

21 January 2018

1 reference

Peripheral lung cancer: screening and detection with low-dose spiral CT versus radiography

21 January 2018

1 reference

Screening for lung cancer: in pursuit of pre-metastatic disease

21 January 2018

1 reference

Autofluorescence bronchoscopy in the detection of squamous metaplasia and dysplasia in current and former smokers

21 January 2018

1 reference

Detection of bronchial preneoplastic lesions and early lung cancer with fluorescence bronchoscopy: a study about its ambulatory feasibility under local anaesthesis.

21 January 2018

1 reference

Comparison of K-ras gene mutations in tumour and sputum DNA of patients with lung cancer.

21 January 2018

1 reference

Microsatellite alterations in serum DNA of head and neck cancer patients

21 January 2018

1 reference

Microsatellite alterations in plasma DNA of small cell lung cancer patients.

21 January 2018

1 reference

Methylation patterns and K-ras mutations in tumor and paired serum of resected non-small-cell lung cancer patients

21 January 2018

1 reference

Detecting lung cancer in plasma with the use of multiple genetic markers

21 January 2018

1 reference

The fundamental role of epigenetic events in cancer

21 January 2018

1 reference

Gene silencing in cancer in association with promoter hypermethylation

21 January 2018

1 reference

DNA hypermethylation in tumorigenesis: epigenetics joins genetics

21 January 2018

1 reference

Cancer epigenetics comes of age

21 January 2018

1 reference

DNA methylation analysis: a powerful new tool for lung cancer diagnosis

21 January 2018

1 reference

5' CpG island methylation is associated with transcriptional silencing of the tumour suppressor p16/CDKN2/MTS1 in human cancers.

21 January 2018

1 reference

Methylation-specific PCR: a novel PCR assay for methylation status of CpG islands

21 January 2018

1 reference

Aberrant methylation of p16(INK4a) is an early event in lung cancer and a potential biomarker for early diagnosis

21 January 2018

1 reference

The retinoblastoma protein and cell cycle control

21 January 2018

1 reference

Inactivation of p16 in human mammary epithelial cells by CpG island methylation

21 January 2018

1 reference

Progressive region-specific de novo methylation of the p16 CpG island in primary human mammary epithelial cell strains during escape from M(0) growth arrest

21 January 2018

1 reference

Chromosomal localization of seven PAX genes and cloning of a novel family member, PAX-9

21 January 2018

1 reference

Deregulation of PAX-5 by translocation of the Emu enhancer of the IgH locus adjacent to two alternative PAX-5 promoters in a diffuse large-cell lymphoma

21 January 2018

1 reference

The promoter of the CD19 gene is a target for the B-cell-specific transcription factor BSAP

21 January 2018

1 reference

Chfr defines a mitotic stress checkpoint that delays entry into metaphase

21 January 2018

1 reference

Frequent hypermethylation of the 5' CpG island of the mitotic stress checkpoint gene Chfr in colorectal and non-small cell lung cancer

21 January 2018

1 reference

Aberrant hypermethylation of the CHFR prophase checkpoint gene in human lung cancers

21 January 2018

1 reference

Methylation of O(6)-methylguanine-DNA methyltransferase gene is associated significantly with K-ras mutation, lymph node invasion, tumor staging, and disease free survival in patients with gastric carcinoma.

21 January 2018

1 reference

DAP-kinase is a Ca2+/calmodulin-dependent, cytoskeletal-associated protein kinase, with cell death-inducing functions that depend on its catalytic activity

21 January 2018

1 reference

Promoter methylation of DAP-kinase: association with advanced stage in non-small cell lung cancer

21 January 2018

1 reference

DAP kinase activates a p19ARF/p53-mediated apoptotic checkpoint to suppress oncogenic transformation

21 January 2018

1 reference

Increased apoptosis in metastatic human colonic adenocarcinomas.

21 January 2018

1 reference

Silencing of death receptor and caspase-8 expression in small cell lung carcinoma cell lines and tumors by DNA methylation.

21 January 2018

1 reference

Increasing complexity of Ras signaling.

21 January 2018

1 reference

The ins and outs of signalling

21 January 2018

1 reference

Epigenetic inactivation of a RAS association domain family protein from the lung tumour suppressor locus 3p21.3.

21 January 2018

1 reference

Epigenetic inactivation of RASSF1A in lung and breast cancers and malignant phenotype suppression

21 January 2018

1 reference

Identification of a novel Ras-regulated proapoptotic pathway

21 January 2018

1 reference

Changing views of the role of matrix metalloproteinases in metastasis

21 January 2018

1 reference

Form and function: the laminin family of heterotrimers

21 January 2018

1 reference

Biological and clinical relevance of Laminin-5 in cancer

21 January 2018

1 reference

In situ detection of the hypermethylation-induced inactivation of the p16 gene as an early event in oncogenesis

21 January 2018

1 reference

Transcriptional silencing of the RUNX3 gene by CpG hypermethylation is associated with lung cancer.

21 January 2018

1 reference

Global methylation profiling of lung cancer identifies novel methylated genes

21 January 2018

1 reference

Adenomatous polyposis coli gene promoter hypermethylation in non-small cell lung cancer is associated with survival.

21 January 2018

1 reference

Tobacco smoke carcinogens and lung cancer

21 January 2018

1 reference

Effect of oxidative DNA damage in promoter elements on transcription factor binding

21 January 2018

1 reference

DNA methylation, chromatin inheritance, and cancer

21 January 2018

1 reference

K-ras and p16(INK4A)alterations in sputum of NSCLC patients and in heavy asymptomatic chronic smokers.

21 January 2018

1 reference

Aberrant methylation of multiple genes in the upper aerodigestive tract epithelium of heavy smokers

21 January 2018

1 reference

Molecular damage in the bronchial epithelium of current and former smokers

21 January 2018

1 reference

The case for early detection

21 January 2018

1 reference

Histone-deacetylase inhibitors: novel drugs for the treatment of cancer

21 January 2018

1 reference

Inhibition of DNA methylation and reactivation of silenced genes by zebularine

21 January 2018

1 reference

Synergy of demethylation and histone deacetylase inhibition in the re-expression of genes silenced in cancer

21 January 2018

1 reference

Continuous zebularine treatment effectively sustains demethylation in human bladder cancer cells

21 January 2018

1 reference

Molecular mechanisms of cancer prevention by selenium compounds

21 January 2018

1 reference

Promoter Methylation and Silencing of the Retinoic Acid Receptor- Gene in Lung Carcinomas

21 January 2018

1 reference

Retinoblastoma-protein-dependent cell-cycle inhibition by the tumour suppressor p16

21 January 2018

1 reference

21 January 2018

Cancer statistics, 2002

1 reference

Small-cell lung cancer at the millennium: radiotherapy innovations improve survival while new chemotherapy treatments remain unproven

31 March 2020

1 reference

Diameter, cell type, and survival in stage I primary non-small-cell lung cancer

31 March 2020

1 reference

Lung cancer screening with CT: Mayo Clinic experience.

31 March 2020

1 reference

Detection and localization of early lung cancer by imaging techniques

31 March 2020

1 reference

Autofluorescence of normal and malignant bronchial tissue

31 March 2020

1 reference

Localization of bronchial intraepithelial neoplastic lesions by fluorescence bronchoscopy.

31 March 2020

1 reference

Molecular detection of early lung cancer

31 March 2020

1 reference

Development of carcinoma of the lung as reflected in exfoliated cells.

31 March 2020

1 reference

Microsatellite alterations as clonal markers for the detection of human cancer

31 March 2020

1 reference

Quantitation and characterization of plasma DNA in normals and patients with systemic lupus erythematosus

31 March 2020

1 reference

Determination of circulating DNA levels in patients with benign or malignant gastrointestinal disease

31 March 2020

1 reference

Histone deacetylase inhibitors: from target to clinical trials

31 March 2020

1 reference

Abnormalities in structure and expression of the human retinoblastoma gene in SCLC.

31 March 2020

1 reference

Hypermethylation of the death-associated protein (DAP) kinase promoter and aggressiveness in stage I non-small-cell lung cancer

31 March 2020

1 reference

Differential inactivation of caspase-8 in lung cancers.

31 March 2020

1 reference

NORE1A, a homologue of RASSF1A tumour suppressor gene is inactivated in human cancers

31 March 2020

1 reference

Cadherin cell adhesion receptors as a morphogenetic regulator

31 March 2020

1 reference

Aberrant promoter hypermethylation of the death-associated protein kinase gene is early and frequent in murine lung tumors induced by cigarette smoke and tobacco carcinogens

31 March 2020

1 reference

Promoter hypermethylation of tumor suppressor and tumor-related genes in non-small cell lung cancers.

31 March 2020

1 reference

Elucidation of epigenetic inactivation of SMAD8 in cancer using targeted expressed gene display.

31 March 2020

1 reference

Differential frequencies of p16(INK4a) promoter hypermethylation, p53 mutation, and K-ras mutation in exfoliative material mark the development of lung cancer in symptomatic chronic smokers

31 March 2020

1 reference

Detection of RASSF1A aberrant promoter hypermethylation in sputum from chronic smokers and ductal carcinoma in situ from breast cancer patients

31 March 2020

1 reference

Detection of p16 hypermethylation in circulating plasma DNA of non-small cell lung cancer patients

31 March 2020

1 reference

Histologic findings in the tracheobronchial tree of uranium miners and non-miners with lung cancer

31 March 2020

1 reference

Changes in bronchial epithelium in relation to cigarette smoking, 1955-1960 vs. 1970-1977

31 March 2020

1 reference

The smoking gun and the damage done: genetic alterations in the lungs of smokers

31 March 2020

1 reference

Effects of selenium supplementation for cancer prevention in patients with carcinoma of the skin. A randomized controlled trial. Nutritional Prevention of Cancer Study Group.

31 March 2020

1 reference

Inhibition of DNA cytosine methyltransferase by chemopreventive selenium compounds, determined by an improved assay for DNA cytosine methyltransferase and DNA cytosine methylation

31 March 2020

1 reference

Selenium-dependent peroxidases suppress 5-lipoxygenase activity in B-lymphocytes and immature myeloid cells. The presence of peroxidase-insensitive 5-lipoxygenase activity in differentiated myeloid cells

31 March 2020

1 reference

31 March 2020

Identifiers

DOI

10.1038/NRC1432

1 reference

10 August 2017

1 reference

PubMed ID

15343277