(Q35880053)

10 August 2017

Protein misfolding detected early in pathogenesis of transgenic mouse model of Huntington disease using amyloid seeding assay (English)

1 reference

10 August 2017

0 references

Sharad Gupta

1

1 reference

10 August 2017

Shy'Ann Jie

series ordinal

2

1 reference

10 August 2017

David W Colby

series ordinal

3

1 reference

10 August 2017

language of work or name

English

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publication date

20 December 2011

1 reference

10 August 2017

8

1 reference

Journal of Biological Chemistry

inferred from page(s)

published in

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10 August 2017

287

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10 August 2017

13

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10 August 2017

9982-9989

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Huntington's disease: can mice lead the way to treatment?

10 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3323021

Ultrasensitive human prion detection in cerebrospinal fluid by real-time quaking-induced conversion.

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3323021

A kinetic aggregation assay allowing selective and sensitive amyloid-β quantification in cells and tissues

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3323021

Rapid end-point quantitation of prion seeding activity with sensitivity comparable to bioassays

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3323021

Brief ampakine treatments slow the progression of Huntington's disease phenotypes in R6/2 mice

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3323021

Mutant huntingtin fragments form oligomers in a polyglutamine length-dependent manner in vitro and in vivo

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3323021

Protease-sensitive synthetic prions

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3323021

A causative link between the structure of aberrant protein oligomers and their toxicity.

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3323021

Distinct conformations of in vitro and in vivo amyloids of huntingtin-exon1 show different cytotoxicity

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3323021

Neuroanatomic profile of polyglutamine immunoreactivity in Huntington disease brains.

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3323021

Tiagabine is neuroprotective in the N171-82Q and R6/2 mouse models of Huntington's disease

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3323021

Prion detection by an amyloid seeding assay.

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3323021

Neuronal intranuclear and neuropil inclusions for pathological assessment of Huntington's disease

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3323021

RNA interference improves motor and neuropathological abnormalities in a Huntington's disease mouse model

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3323021

Potent inhibition of huntingtin aggregation and cytotoxicity by a disulfide bond-free single-domain intracellular antibody

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3323021

Inclusion body formation reduces levels of mutant huntingtin and the risk of neuronal death

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3323021

Time course of early motor and neuropathological anomalies in a knock-in mouse model of Huntington's disease with 140 CAG repeats

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3323021

Huntington's disease age-of-onset linked to polyglutamine aggregation nucleation

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3323021

Neuroprotective effects of creatine in a transgenic mouse model of Huntington's disease.

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3323021

Long glutamine tracts cause nuclear localization of a novel form of huntingtin in medium spiny striatal neurons in HdhQ92 and HdhQ111 knock-in mice

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3323021

Ultrastructural localization and progressive formation of neuropil aggregates in Huntington's disease transgenic mice

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3323021

Huntington's disease intranuclear inclusions contain truncated, ubiquitinated huntingtin protein

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3323021

Neuronal distribution of intranuclear inclusions in Huntington's disease with adult onset.

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3323021

Aggregation of huntingtin in neuronal intranuclear inclusions and dystrophic neurites in brain

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3323021

Formation of neuronal intranuclear inclusions underlies the neurological dysfunction in mice transgenic for the HD mutation

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3323021

Exon 1 of the HD gene with an expanded CAG repeat is sufficient to cause a progressive neurological phenotype in transgenic mice

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3323021

A novel gene containing a trinucleotide repeat that is expanded and unstable on Huntington's disease chromosomes.

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3323021

Huntingtin acts in the nucleus to induce apoptosis but death does not correlate with the formation of intranuclear inclusions.

11 July 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M111.305417

Aggregated polyglutamine peptides delivered to nuclei are toxic to mammalian cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M111.305417

Beneficial effects of rolipram in the R6/2 mouse model of Huntington's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M111.305417

Intranuclear inclusions and neuritic aggregates in transgenic mice expressing a mutant N-terminal fragment of huntingtin

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M111.305417

Creatine increase survival and delays motor symptoms in a transgenic animal model of Huntington's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M111.305417

Neuroprotective effects of a novel kynurenic acid analogue in a transgenic mouse model of Huntington's disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M111.305417

A YAC mouse model for Huntington's disease with full-length mutant huntingtin, cytoplasmic toxicity, and selective striatal neurodegeneration.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M111.305417

Selective striatal neuronal loss in a YAC128 mouse model of Huntington disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M111.305417

Cognitive dysfunction precedes neuropathology and motor abnormalities in the YAC128 mouse model of Huntington's disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M111.305417

Phenotypic abnormalities in the YAC128 mouse model of Huntington disease are penetrant on multiple genetic backgrounds and modulated by strain

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M111.305417

Biochemical, ultrastructural, and reversibility studies on huntingtin filaments isolated from mouse and human brain.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M111.305417

Polyglutamine aggregation behavior in vitro supports a recruitment mechanism of cytotoxicity

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M111.305417

Huntingtin-encoded polyglutamine expansions form amyloid-like protein aggregates in vitro and in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M111.305417

Distinct behavioral and neuropathological abnormalities in transgenic mouse models of HD and DRPLA.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M111.305417

Selective degeneration and nuclear localization of mutant huntingtin in the YAC128 mouse model of Huntington disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M111.305417

Stochastic kinetics of intracellular huntingtin aggregate formation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M111.305417

Therapeutic effects of cystamine in a murine model of Huntington's disease.

21 January 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3323021

Thioflavin-T for Amyloid Detection

24 September 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/22187438

12 December 2020

inferred from PubMed ID database lookup

Kinetics and thermodynamics of amyloid assembly using a high-performance liquid chromatography-based sedimentation assay

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/22187438

12 December 2020

inferred from PubMed ID database lookup

Interference by huntingtin and atrophin-1 with cbp-mediated transcription leading to cellular toxicity

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/22187438

12 December 2020

inferred from PubMed ID database lookup

Identifiers

DOI

10.1074/JBC.M111.305417

1 reference

10 August 2017

1 reference

10 August 2017

PubMed publication ID

22187438

1 reference