(Q45299022)

11 December 2017

Selective degeneration and nuclear localization of mutant huntingtin in the YAC128 mouse model of Huntington disease (English)

1 reference

11 December 2017

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5

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11 December 2017

4

Blair R Leavitt

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11 December 2017

3

Elizabeth J Slow

1 reference

PubMed ID

16278236

11 December 2017

Jeremy M Van Raamsdonk

series ordinal

1

object named as

Jeremy M Van Raamsdonk

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11 December 2017

Zoe Murphy

2

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11 December 2017

8 November 2005

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11 December 2017

Human Molecular Genetics

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11 December 2017

14

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11 December 2017

24

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11 December 2017

3823-3835

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Glutamine repeats and neurodegeneration

11 December 2017

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDI407

Evidence for more widespread cerebral pathology in early HD: an MRI-based morphometric analysis

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDI407

Onset and rate of striatal atrophy in preclinical Huntington disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDI407

Regional specificity of brain atrophy in Huntington's disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDI407

Pyramidal cell loss in motor cortices in Huntington's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDI407

Preferential loss of striato-external pallidal projection neurons in presymptomatic Huntington's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDI407

Widespread expression of Huntington's disease gene (IT15) protein product

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDI407

Widespread expression of the human and rat Huntington's disease gene in brain and nonneural tissues

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDI407

Cellular localization of the Huntington's disease protein and discrimination of the normal and mutated form

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDI407

Huntington's disease gene (IT15) is widely expressed in human and rat tissues

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDI407

Huntington's disease gene: regional and cellular expression in brain of normal and affected individuals

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDI407

Selective striatal neuronal loss in a YAC128 mouse model of Huntington disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDI407

Cognitive dysfunction precedes neuropathology and motor abnormalities in the YAC128 mouse model of Huntington's disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDI407

Loss of wild-type huntingtin influences motor dysfunction and survival in the YAC128 mouse model of Huntington disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDI407

Exon 1 of the HD gene with an expanded CAG repeat is sufficient to cause a progressive neurological phenotype in transgenic mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDI407

Intranuclear inclusions and neuritic aggregates in transgenic mice expressing a mutant N-terminal fragment of huntingtin

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDI407

Behavioural abnormalities and selective neuronal loss in HD transgenic mice expressing mutated full-length HD cDNA.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDI407

Huntingtin is a cytoplasmic protein associated with vesicles in human and rat brain neurons

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDI407

Nuclear targeting of mutant Huntingtin increases toxicity

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDI407

Huntingtin acts in the nucleus to induce apoptosis but death does not correlate with the formation of intranuclear inclusions.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDI407

Long glutamine tracts cause nuclear localization of a novel form of huntingtin in medium spiny striatal neurons in HdhQ92 and HdhQ111 knock-in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDI407

Amino-terminal fragments of mutant huntingtin show selective accumulation in striatal neurons and synaptic toxicity

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDI407

Absence of behavioral abnormalities and neurodegeneration in vivo despite widespread neuronal huntingtin inclusions

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDI407

In vivo evidence of cerebellar atrophy and cerebral white matter loss in Huntington disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDI407

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDI407

Neurobiology of Huntington's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDI407

A YAC mouse model for Huntington's disease with full-length mutant huntingtin, cytoplasmic toxicity, and selective striatal neurodegeneration.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDI407

Huntingtin is required for neurogenesis and is not impaired by the Huntington's disease CAG expansion

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDI407

A Huntington's disease CAG expansion at the murine Hdh locus is unstable and associated with behavioural abnormalities in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDI407

Recent advances on the pathogenesis of Huntington's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDI407

Formation of neuronal intranuclear inclusions underlies the neurological dysfunction in mice transgenic for the HD mutation

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDI407

Huntingtin localization in brains of normal and Huntington's disease patients

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDI407

Analysis of the subcellular localization of huntingtin with a set of rabbit polyclonal antibodies in cultured mammalian cells of neuronal origin: comparison with the distribution of huntingtin in Huntington's disease autopsy brain

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDI407

Huntingtin contains a highly conserved nuclear export signal

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDI407

Polyglutamine expansion of huntingtin impairs its nuclear export

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDI407

Nucleocytoplasmic transport signals affect the age at onset of abnormalities in knock-in mice expressing polyglutamine within an ectopic protein context

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDI407

Testosterone reduction prevents phenotypic expression in a transgenic mouse model of spinal and bulbar muscular atrophy

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDI407

Leuprorelin rescues polyglutamine-dependent phenotypes in a transgenic mouse model of spinal and bulbar muscular atrophy

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDI407

Huntingtin is present in the nucleus, interacts with the transcriptional corepressor C-terminal binding protein, and represses transcription

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDI407

The Huntington's disease protein interacts with p53 and CREB-binding protein and represses transcription

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDI407

Intranuclear huntingtin increases the expression of caspase-1 and induces apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDI407

Time course of early motor and neuropathological anomalies in a knock-in mouse model of Huntington's disease with 140 CAG repeats

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDI407

Neurological abnormalities in a knock-in mouse model of Huntington's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDI407

Neuronal intranuclear inclusions and neuropil aggregates in HdhCAG(150) knockin mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDI407

Inclusion body formation reduces levels of mutant huntingtin and the risk of neuronal death

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDI407

Neuronal loss in layers V and VI of cerebral cortex in Huntington's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDI407

Cortical and striatal neurone number in Huntington's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDI407

21 January 2018

Identifiers

DOI

10.1093/HMG/DDI407

1 reference

11 December 2017

1 reference

PubMed ID

16278236