(Q35896048)

English

Subretinal AAV2.COMP-Ang1 suppresses choroidal neovascularization and vascular endothelial growth factor in a murine model of age-related macular degeneration.

scientific article published on 13 January 2016

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5 March 2020

Subretinal AAV2.COMP-Ang1 suppresses choroidal neovascularization and vascular endothelial growth factor in a murine model of age-related macular degeneration (English)

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5 March 2020

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neovascularization

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based on heuristic

inferred from title

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based on heuristic

inferred from title

Nathan G Lambert

1

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5 March 2020

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Xiaohui Zhang

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Ruju R Rai

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Hironori Uehara

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Susie Choi

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Lara S Carroll

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Judd M Cahoon

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Brian H Kirk

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Blaine M Bentley

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Balamurali K Ambati

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13 January 2016

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Experimental Eye Research

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248-257

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5 March 2020

Intravitreal AAV2.COMP-Ang1 Prevents Neurovascular Degeneration in a Murine Model of Diabetic Retinopathy

1 reference

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Human embryonic stem cell-derived retinal pigment epithelium in patients with age-related macular degeneration and Stargardt's macular dystrophy: follow-up of two open-label phase 1/2 studies

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AAV2 delivery of Flt23k intraceptors inhibits murine choroidal neovascularization

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Anti-vascular endothelial growth factor for neovascular age-related macular degeneration

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Treating the untreatable patient: current options for the management of treatment-resistant neovascular age-related macular degeneration

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Angiopoietin-1 suppresses choroidal neovascularization and vascular leakage

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Adenovirus-delivered angiopoietin-1 suppresses NF-κB and p38 MAPK and attenuates inflammatory responses in phosgene-induced acute lung injury

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Anti-VEGF-refractory exudative age-related macular degeneration: differential response according to features on optical coherence tomography.

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Biosafety of recombinant adeno-associated virus vectors.

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Laser-induced choroidal neovascularization model to study age-related macular degeneration in mice.

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Resistance to antivascular endothelial growth factor treatment in age-related macular degeneration

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Potential protective effect of angiopoietin-1 on the leakage of rat choroidal neovascularization

1 reference

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Prevalence of neutralizing factors against adeno-associated virus types 2 in age-related macular degeneration and polypoidal choroidal vasculopathy

1 reference

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Three-year follow-up after unilateral subretinal delivery of adeno-associated virus in patients with Leber congenital Amaurosis type 2

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Suppression of laser-induced choroidal neovascularization by a CCR3 antagonist

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Orchestral actions of angiopoietin-1 in vascular regeneration

1 reference

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Dual suppression of hemangiogenesis and lymphangiogenesis by splice-shifting morpholinos targeting vascular endothelial growth factor receptor 2 (KDR)

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Clinical and differential utility of VEGF inhibitors in wet age-related macular degeneration: focus on aflibercept

1 reference

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Adverse events with intravitreal injection of vascular endothelial growth factor inhibitors: nested case-control study.

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Angiopoietin-1 and vascular endothelial growth factor regulation of leukocyte adhesion to endothelial cells: role of nuclear receptor-77

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Ranibizumab and bevacizumab for treatment of neovascular age-related macular degeneration: two-year results

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Embryonic stem cell trials for macular degeneration: a preliminary report

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Novel interventional approaches for ALI/ARDS: cell-based gene therapy

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Pericyte requirement for anti-leak action of angiopoietin-1 and vascular remodeling in sustained inflammation

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AAV-mediated gene supply for treatment of degenerative and neovascular retinal diseases.

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Suppression of laser-induced choroidal neovascularization by nontargeted siRNA.

1 reference

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Angiopoietin-1/Tie2 receptor signaling in vascular quiescence and angiogenesis

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Role of PI3K/Akt and MEK/ERK in mediating hypoxia-induced expression of HIF-1alpha and VEGF in laser-induced rat choroidal neovascularization

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Gene therapy using adeno-associated virus vectors

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5862038

24 September 2018

Enhancement of rAAV2-mediated transgene expression in retina cells in vitro and in vivo by coadministration of low-dose chemotherapeutic drugs

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5862038

24 September 2018

Preclinical safety evaluation of subretinal AAV2.sFlt-1 in non-human primates.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5862038

24 September 2018

Regulation of VEGF expression in human retinal cells by cytokines: implications for the role of inflammation in age-related macular degeneration.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5862038

24 September 2018

Neovascular age-related macular degeneration: intraocular cytokines and growth factors and the influence of therapy with ranibizumab.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5862038

24 September 2018

Central retinal sensitivity after intravitreal injection of bevacizumab for myopic choroidal neovascularization

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5862038

24 September 2018

Small hairpin loop RNA targeting HIF-1alpha down-regulates VEGF and up-regulates PEDF in human retinal pigment epithelial cells under hypoxic condition

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5862038

24 September 2018

High-level expression and purification of a designed angiopoietin-1 chimeric protein, COMP-Ang1, produced in Chinese hamster ovary cells.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5862038

24 September 2018

Angiopoietin-1 prevents VEGF-induced endothelial permeability by sequestering Src through mDia.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5862038

24 September 2018

Inhibition of VEGF expression by targeting HIF-1 alpha with small interference RNA in human RPE cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5862038

24 September 2018

Safety of recombinant adeno-associated virus type 2-RPE65 vector delivered by ocular subretinal injection

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5862038

24 September 2018

Angiopoietin-1 decreases plasma leakage by reducing number and size of endothelial gaps in venules.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5862038

24 September 2018

Angiopoietin 1 prevents retinal detachment in an aggressive model of proliferative retinopathy, but has no effect on established neovascularization

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5862038

24 September 2018

Pegaptanib for neovascular age-related macular degeneration

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5862038

24 September 2018

Photoreceptor protection by iris pigment epithelial transplantation transduced with AAV-mediated brain-derived neurotrophic factor gene.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5862038

24 September 2018

Causes and prevalence of visual impairment among adults in the United States

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5862038

24 September 2018

Comparison of adenoviral and adeno-associated viral vectors for pancreatic gene delivery in vivo

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5862038

24 September 2018

Angiopoietin 1 inhibits ocular neovascularization and breakdown of the blood-retinal barrier.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5862038

24 September 2018

Transforming growth factor‐β induces expression of vascular endothelial growth factor in human retinal pigment epithelial cells: Involvement of mitogen‐activated protein kinases

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5862038

24 September 2018

Expressions of angiopoietins and Tie2 in human choroidal neovascular membranes

1 reference

https://pubmed.ncbi.nlm.nih.gov/26775053

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Adenovirus-mediated gene transfer to murine retinal cells in vitro and in vivo

1 reference

https://pubmed.ncbi.nlm.nih.gov/26775053

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Expression and regulation of vascular endothelial growth factor in choroidal fibroblasts

1 reference

https://pubmed.ncbi.nlm.nih.gov/26775053

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Age-related macular degeneration is the leading cause of blindness...

1 reference

https://pubmed.ncbi.nlm.nih.gov/26775053

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Impact of availability of anti-vascular endothelial growth factor therapy on visual impairment and blindness due to neovascular age-related macular degeneration

1 reference

https://pubmed.ncbi.nlm.nih.gov/26775053

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The potential angiogenic role of macrophages in the formation of choroidal neovascular membranes

1 reference

https://pubmed.ncbi.nlm.nih.gov/26775053

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Vitrectomy and subretinal injection of tissue plasminogen activator for large submacular hemorrhage secondary to AMD

1 reference

https://pubmed.ncbi.nlm.nih.gov/26775053

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1016/J.EXER.2016.01.009

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26775053%20AND%20SRC:MED&resulttype=core&format=json

5 March 2020

PMC publication ID

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26775053%20AND%20SRC:MED&resulttype=core&format=json

5 March 2020

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26775053%20AND%20SRC:MED&resulttype=core&format=json

5 March 2020

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