(Q35906074)

11 August 2017

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title

Connecting proliferation and apoptosis in development and disease (English)

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11 August 2017

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David R Hipfner

1

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11 August 2017

Stephen M Cohen

series ordinal

2

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11 August 2017

language of work or name

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1 October 2004

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Nature Reviews Molecular Cell Biology

11 August 2017

published in

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11 August 2017

volume

5

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11 August 2017

issue

10

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11 August 2017

page(s)

805-815

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https://scigraph.springernature.com/pub.10.1038/nrm1491

11 August 2017

exact match

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cites work

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Identification of CDK4 as a target of c-MYC.

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A large scale genetic analysis of c-Myc-regulated gene expression patterns

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Identification of positively and negatively acting elements regulating expression of the E2F2 gene in response to cell growth signals

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Drosophila myc regulates cellular growth during development.

21 January 2018

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Coordination of growth and cell division in the Drosophila wing

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Cyclin E ablation in the mouse

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A role for transcriptional repression of p21CIP1 by c-Myc in overcoming transforming growth factor beta -induced cell-cycle arrest

21 January 2018

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Expression analysis with oligonucleotide microarrays reveals that MYC regulates genes involved in growth, cell cycle, signaling, and adhesion

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Repression of transcription of the p27(Kip1) cyclin-dependent kinase inhibitor gene by c-Myc.

21 January 2018

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Repression of p15INK4b expression by Myc through association with Miz-1

21 January 2018

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Loss of p27(Kip1) but not p21(Cip1) decreases survival and synergizes with MYC in murine lymphomagenesis

21 January 2018

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A syndrome of multiorgan hyperplasia with features of gigantism, tumorigenesis, and female sterility in p27(Kip1)-deficient mice

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Enhanced growth of mice lacking the cyclin-dependent kinase inhibitor function of p27(Kip1).

21 January 2018

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Mice lacking p27(Kip1) display increased body size, multiple organ hyperplasia, retinal dysplasia, and pituitary tumors

21 January 2018

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c-Myc regulates mammalian body size by controlling cell number but not cell size

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Myc and Max homologs in Drosophila

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A P-insertion screen identifying novel X-linked essential genes in Drosophila.

21 January 2018

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Drosophila myc regulates organ size by inducing cell competition

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An encore for ribosome biogenesis in the control of cell proliferation

21 January 2018

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Differences in the way a mammalian cell and yeast cells coordinate cell growth and cell-cycle progression

21 January 2018

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Why size matters: altering cell size

21 January 2018

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Negative regulation of dE2F1 by cyclin-dependent kinases controls cell cycle timing

21 January 2018

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Induction of apoptosis in fibroblasts by c-myc protein

21 January 2018

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Suppression of Myc-induced apoptosis in beta cells exposes multiple oncogenic properties of Myc and triggers carcinogenic progression.

21 January 2018

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Myc pathways provoking cell suicide and cancer

21 January 2018

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c-Myc Augments Gamma Irradiation-Induced Apoptosis by Suppressing Bcl-XL

21 January 2018

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c-Myc induces cytochrome c release in Rat1 fibroblasts by increasing outer mitochondrial membrane permeability in a Bid-dependent manner

21 January 2018

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Apoptosis triggered by Myc-induced suppression of Bcl-X(L) or Bcl-2 is bypassed during lymphomagenesis

21 January 2018

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Bcl-2 is an apoptotic target suppressed by both c-Myc and E2F-1.

21 January 2018

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c-Myc functionally cooperates with Bax to induce apoptosis

21 January 2018

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c-MYC apoptotic function is mediated by NRF-1 target genes

21 January 2018

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Requirement for the CD95 receptor-ligand pathway in c-Myc-induced apoptosis

21 January 2018

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Deregulated c-Myc prematurely recruits both Type I and II CD95/Fas apoptotic pathways associated with terminal myeloid differentiation

21 January 2018

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c-Myc augments the apoptotic activity of cytosolic death receptor signaling proteins by engaging the mitochondrial apoptotic pathway

21 January 2018

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E2F1 and c-Myc potentiate apoptosis through inhibition of NF-kappaB activity that facilitates MnSOD-mediated ROS elimination

21 January 2018

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INK4a/ARF mutations accelerate lymphomagenesis and promote chemoresistance by disabling p53.

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Multiple docking sites on substrate proteins form a modular system that mediates recognition by ERK MAP kinase

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Novel primitive lymphoid tumours induced in transgenic mice by cooperation between myc and bcl-2.

21 January 2018

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Bax loss impairs Myc-induced apoptosis and circumvents the selection of p53 mutations during Myc-mediated lymphomagenesis

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ARF differentially modulates apoptosis induced by E2F1 and Myc.

21 January 2018

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Disruption of the ARF-Mdm2-p53 tumor suppressor pathway in Myc-induced lymphomagenesis

21 January 2018

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Mdm2 haplo-insufficiency profoundly inhibits Myc-induced lymphomagenesis

21 January 2018

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Arf tumor suppressor promoter monitors latent oncogenic signals in vivo

21 January 2018

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Role of the INK4a locus in tumor suppression and cell mortality.

21 January 2018

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Tumor suppression at the mouse INK4a locus mediated by the alternative reading frame product p19ARF

21 January 2018

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Drosophila p53 preserves genomic stability by regulating cell death

21 January 2018

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Depletion of epithelial stem-cell compartments in the small intestine of mice lacking Tcf-4

21 January 2018

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Canonical Wnt signals are essential for homeostasis of the intestinal epithelium

21 January 2018

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The beta-catenin/TCF-4 complex imposes a crypt progenitor phenotype on colorectal cancer cells

21 January 2018

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Identification of c-MYC as a target of the APC pathway

21 January 2018

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Wnt signaling promotes oncogenic transformation by inhibiting c-Myc-induced apoptosis

21 January 2018

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Validating survivin as a cancer therapeutic target

21 January 2018

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Survivin and molecular pathogenesis of colorectal cancer.

21 January 2018

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The Drosophila Sterile-20 Kinase Slik Controls Cell Proliferation and Apoptosis during Imaginal Disc Development

21 January 2018

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hippo encodes a Ste-20 family protein kinase that restricts cell proliferation and promotes apoptosis in conjunction with salvador and warts

21 January 2018

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Hippo promotes proliferation arrest and apoptosis in the Salvador/Warts pathway

21 January 2018

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The Salvador partner Hippo promotes apoptosis and cell-cycle exit in Drosophila.

21 January 2018

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The Drosophila Mst ortholog, hippo, restricts growth and cell proliferation and promotes apoptosis

21 January 2018

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bantam encodes a developmentally regulated microRNA that controls cell proliferation and regulates the proapoptotic gene hid in Drosophila

21 January 2018

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Interactions between Ras1, dMyc, and dPI3K signaling in the developing Drosophila wing

21 January 2018

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Ras enhances Myc protein stability.

21 January 2018

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The Drosophila gene hid is a direct molecular target of Ras-dependent survival signaling

21 January 2018

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Ras promotes cell survival in Drosophila by downregulating hid expression

21 January 2018

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MEK kinase activity is not necessary for Raf-1 function

21 January 2018

1 reference

Cell cycle withdrawal, progression, and cell survival regulation by EGFR and its effectors in the differentiating Drosophila eye.

21 January 2018

1 reference

Control of growth and organ size in Drosophila

21 January 2018

1 reference

Insulin/IGF and target of rapamycin signaling: a TOR de force in growth control

21 January 2018

1 reference

The Drosophila cyclin D-Cdk4 complex promotes cellular growth

21 January 2018

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Drosophila Cdk4 is required for normal growth and is dispensable for cell cycle progression

21 January 2018

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Drosophila cyclin D/Cdk4 requires Hif-1 prolyl hydroxylase to drive cell growth

21 January 2018

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Shar-pei mediates cell proliferation arrest during imaginal disc growth in Drosophila

21 January 2018

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salvador Promotes both cell cycle exit and apoptosis in Drosophila and is mutated in human cancer cell lines

21 January 2018

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NDR family of AGC kinases--essential regulators of the cell cycle and morphogenesis

21 January 2018

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The Ste20 group kinases as regulators of MAP kinase cascades

21 January 2018

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A genetic screen for modifiers of the lats tumor suppressor gene identifies C-terminal Src kinase as a regulator of cell proliferation in Drosophila

21 January 2018

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Apoptotic phosphorylation of histone H2B is mediated by mammalian sterile twenty kinase

21 January 2018

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Size control in animal development

21 January 2018

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dMyc transforms cells into super-competitors

21 January 2018

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Methyl jasmonate induces traumatic resin ducts, terpenoid resin biosynthesis, and terpenoid accumulation in developing xylem of Norway spruce stems

21 January 2018

1 reference

Wingless promotes cell survival but constrains growth during Drosophila wing development.

21 January 2018

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Wingless and Notch signaling provide cell survival cues and control cell proliferation during wing development.

21 January 2018

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Direct and long-range action of a DPP morphogen gradient.

21 January 2018

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Two distinct mechanisms for long-range patterning by Decapentaplegic in the Drosophila wing.

21 January 2018

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Cells compete for decapentaplegic survival factor to prevent apoptosis in Drosophila wing development.

21 January 2018

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Hedgehog regulates cell growth and proliferation by inducing Cyclin D and Cyclin E.

21 January 2018

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Developmental parameters of cell death in the wing disc of Drosophila.

21 January 2018

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Human homologue of the Drosophila melanogaster lats tumour suppressor modulates CDC2 activity

21 January 2018

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Mice deficient of Lats1 develop soft-tissue sarcomas, ovarian tumours and pituitary dysfunction

21 January 2018

1 reference

Molecular alterations of h-warts/LATS1 tumor suppressor in human soft tissue sarcoma

21 January 2018

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The EGF receptor provides an essential survival signal for SOS-dependent skin tumor development

21 January 2018

1 reference

Use of MMTV-Wnt-1 transgenic mice for studying the genetic basis of breast cancer

21 January 2018

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Basal cell carcinomas in mice overexpressing sonic hedgehog

21 January 2018

1 reference

The Hedgehog and Wnt signalling pathways in cancer

21 January 2018

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Hedgehog is an early and late mediator of pancreatic cancer tumorigenesis

21 January 2018

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Widespread requirement for Hedgehog ligand stimulation in growth of digestive tract tumours

21 January 2018

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Functions of FGF signalling from the apical ectodermal ridge in limb development

21 January 2018

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Distortion of proximodistal information causes JNK-dependent apoptosis in Drosophila wing

21 January 2018

1 reference

Minutes: Mutants of Drosophila autonomously affecting cell division rate

21 January 2018

1 reference

Myc activation of cyclin E/Cdk2 kinase involves induction of cyclin E gene transcription and inhibition of p27(Kip1) binding to newly formed complexes

31 March 2020

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Ras1 promotes cellular growth in the Drosophila wing

31 March 2020

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Dynamic expression pattern of the myc protooncogene in midgestation mouse embryos

31 March 2020

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A null c-myc mutation causes lethality before 10.5 days of gestation in homozygotes and reduced fertility in heterozygous female mice

31 March 2020

1 reference

The minute genes in Drosophila and their molecular functions.

31 March 2020

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c-Myc-induced apoptosis in fibroblasts is inhibited by specific cytokines.

31 March 2020

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c-Myc-induced sensitization to apoptosis is mediated through cytochrome c release

31 March 2020

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c-Myc can induce DNA damage, increase reactive oxygen species, and mitigate p53 function: a mechanism for oncogene-induced genetic instability

31 March 2020

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A matter of life and death

31 March 2020

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A matter of life and cell death

31 March 2020

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Myc signaling via the ARF tumor suppressor regulates p53-dependent apoptosis and immortalization

31 March 2020

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Role of Raf in vascular protection from distinct apoptotic stimuli

31 March 2020

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The Drosophila tumor suppressor gene warts encodes a homolog of human myotonic dystrophy kinase and is required for the control of cell shape and proliferation

31 March 2020

1 reference

Differential mitotic rates and patterns of growth in compartments in the Drosophila wing

31 March 2020

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The Drosophila phosphoinositide 3-kinase Dp110 promotes cell growth.

31 March 2020

1 reference

31 March 2020

Identifiers

DOI

10.1038/NRM1491

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Dimensions Publication ID

11 August 2017

1024207810

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