(Q35924680)

11 August 2017

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title

Novel approaches to vaccine delivery (English)

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11 August 2017

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2

Rino Rappuoli

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11 August 2017

Derek T O'Hagan

1

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11 August 2017

1 September 2004

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11 August 2017

Pharmaceutical Research

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11 August 2017

21

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11 August 2017

9

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11 August 2017

1519-1530

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Macrophage stimulation with Murabutide, an HIV-suppressive muramyl peptide derivative, selectively activates extracellular signal-regulated kinases 1 and 2, C/EBPbeta and STAT1: role of CD14 and Toll-like receptors 2 and 4.

11 August 2017

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12 December 2020

Stabilization of alum-adjuvanted vaccine dry powder formulations: mechanism and application

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12 December 2020

Enhancement of protective efficacy following intranasal immunization with vaccine plus a nontoxic LTK63 mutant delivered with nanoparticles

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12 December 2020

Microparticles as vaccine adjuvants and delivery systems

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12 December 2020

Skin immunization made possible by cholera toxin

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12 December 2020

Activation patterns of murine B cells after oral administration of an encapsulated soluble antigen

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12 December 2020

Biodegradable and biocompatible poly(DL-lactide-co-glycolide) microspheres as an adjuvant for staphylococcal enterotoxin B toxoid which enhances the level of toxin-neutralizing antibodies.

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12 December 2020

Transcutaneous immunization with bacterial ADP-ribosylating exotoxins, subunits, and unrelated adjuvants

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12 December 2020

A month-long effect from a single injection of microencapsulated human growth hormone

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12 December 2020

Safety and antigenicity of non-adjuvanted and MF59-adjuvanted influenza A/Duck/Singapore/97 (H5N3) vaccine: a randomised trial of two potential vaccines against H5N1 influenza.

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12 December 2020

Transcutaneous immunization with tetanus toxoid and mutants of Escherichia coli heat-labile enterotoxin as adjuvants elicits strong protective antibody responses.

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12 December 2020

Toll-like receptors and innate immunity

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12 December 2020

The cost-effectiveness of policies for the safe and appropriate use of injection in healthcare settings.

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12 December 2020

Cationic microparticles are an effective delivery system for immune stimulatory cpG DNA.

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12 December 2020

Protective levels of diphtheria-neutralizing antibody induced in healthy volunteers by unilateral priming-boosting intranasal immunization associated with restricted ipsilateral mucosal secretory immunoglobulin a

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12 December 2020

Safety and immunogenicity of varying dosages of trivalent inactivated influenza vaccine administered by needle-free jet injectors

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12 December 2020

Plasmid vectors encoding cholera toxin or the heat-labile enterotoxin from Escherichia coli are strong adjuvants for DNA vaccines.

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12 December 2020

Transcutaneous immunization: a human vaccine delivery strategy using a patch

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12 December 2020

DNA vaccination with the human immunodeficiency virus type 1 SF162DeltaV2 envelope elicits immune responses that offer partial protection from simian/human immunodeficiency virus infection to CD8(+) T-cell-depleted rhesus macaques

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12 December 2020

Induction of antigen-specific cytotoxic T lymphocytes in humans by a malaria DNA vaccine

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12 December 2020

A novel bioadhesive intranasal delivery system for inactivated influenza vaccines

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12 December 2020

Macrophage phagocytosis of biodegradable microspheres composed of L-lactic acid/glycolic acid homo- and copolymers

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12 December 2020

MF59-adjuvanted vaccines: increased immunogenicity with an optimal safety profile

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12 December 2020

Cellular and humoral immune responses to a canarypox vaccine containing human immunodeficiency virus type 1 Env, Gag, and Pro in combination with rgp120.

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12 December 2020

The preparation, characterization, and evaluation of cationic microparticles for DNA vaccine delivery.

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12 December 2020

Immunization with the adjuvant MF59 induces macrophage trafficking and apoptosis

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12 December 2020

Antigen localisation regulates immune responses in a dose- and time-dependent fashion: a geographical view of immune reactivity

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12 December 2020

Induction of potent immune responses by cationic microparticles with adsorbed human immunodeficiency virus DNA vaccines

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12 December 2020

Genetically detoxified mutants of heat-labile toxin from Escherichia coli are able to act as oral adjuvants

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12 December 2020

MF59 adjuvant enhances antibody responses of infant baboons immunized with Haemophilus influenzae type b and Neisseria meningitidis group C oligosaccharide-CRM197 conjugate vaccine

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12 December 2020

Innate immunity and biodefence vaccines

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12 December 2020

Improved genetic immunization via micromechanical disruption of skin-barrier function and targeted epidermal delivery.

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12 December 2020

Survey of human-use adjuvants

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12 December 2020

Safety and immunogenicity of a prototype enterotoxigenic Escherichia coli vaccine administered transcutaneously

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12 December 2020

Epidermal immunization by a needle-free powder delivery technology: Immunogenicity of influenza vaccine and protection in mice

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12 December 2020

Clinical and immunologic responses to human immunodeficiency virus (HIV) type 1SF2 gp120 subunit vaccine combined with MF59 adjuvant with or without muramyl tripeptide dipalmitoyl phosphatidylethanolamine in non-HIV-infected human volunteers

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12 December 2020

Intranasal immunization with pneumococcal conjugate vaccines with LT-K63, a nontoxic mutant of heat-Labile enterotoxin, as adjuvant rapidly induces protective immunity against lethal pneumococcal infections in neonatal mice

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12 December 2020

A randomized trial demonstrating successful boosting responses following simultaneous aerosols of measles and rubella (MR) vaccines in school age children

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12 December 2020

Induction of mucosal and systemic immune responses by immunization with ovalbumin entrapped in poly(lactide-co-glycolide) microparticles.

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12 December 2020

Immunostimulant patch containing heat-labile enterotoxin from Escherichia coli enhances immune responses to injected influenza virus vaccine through activation of skin dendritic cells

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12 December 2020

Safety and immunogenicity of an oral inactivated enterotoxigenic Escherichia coli vaccine.

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12 December 2020

Biodegradable microparticles as controlled release antigen delivery systems.

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12 December 2020

Recent advances in vaccine adjuvants

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12 December 2020

Microspheres containing plasmid-encoded antigens elicit cytotoxic T-cell responses

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12 December 2020

Mechanisms of increased immunogenicity for DNA-based vaccines adsorbed onto cationic microparticles

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12 December 2020

Route and method of delivery of DNA vaccine influence immune responses in mice and non-human primates

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12 December 2020

The effect of CTAB concentration in cationic PLG microparticles on DNA adsorption and in vivo performance

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12 December 2020

A cationic sub-micron emulsion (MF59/DOTAP) is an effective delivery system for DNA vaccines

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12 December 2020

Macroflux microprojection array patch technology: a new and efficient approach for intracutaneous immunization

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12 December 2020

Clinical immunogenicity and tolerance studies of liquid vaccines delivered by jet-injector and a new single-use cartridge (Imule): comparison with standard syringe injection. Imule Investigators Group

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12 December 2020

Efficacy and safety of oral immunotherapy with short ragweed extract

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12 December 2020

Targeting antigen into the phagocytic pathway in vivo induces protective tumour immunity

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12 December 2020

DNA immunization circumvents deficient induction of T helper type 1 and cytotoxic T lymphocyte responses in neonates and during early life

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12 December 2020

Adjuvants of immunity: harnessing innate immunity to promote adaptive immunity

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12 December 2020

Safety of 2 recombinant human immunodeficiency virus type 1 (HIV-1) envelope vaccines in neonates born to HIV-1-infected women

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12 December 2020

Novel anionic microparticles are a potent adjuvant for the induction of cytotoxic T lymphocytes against recombinant p55 gag from HIV-1.

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12 December 2020

Response to different measles vaccine strains given by aerosol and subcutaneous routes to schoolchildren: a randomised trial

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12 December 2020

Mutants of the Escherichia coli heat-labile enterotoxin as safe and strong adjuvants for intranasal delivery of vaccines

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12 December 2020

Potency of a genetically detoxified mucosal adjuvant derived from the heat-labile enterotoxin of Escherichia coli (LTK63) is not adversely affected by the presence of preexisting immunity to the adjuvant.

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12 December 2020

An outbreak of hepatitis B associated with jet injections in a weight reduction clinic

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12 December 2020

Safety, tolerability and humoral immune responses after intramuscular administration of a malaria DNA vaccine to healthy adult volunteers

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12 December 2020

An ancient system of host defense

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12 December 2020

Induction of Broad and Potent Anti-Human Immunodeficiency Virus Immune Responses in Rhesus Macaques by Priming with a DNA Vaccine and Boosting with Protein-Adsorbed Polylactide Coglycolide Microparticles

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12 December 2020

Epidermal powder immunization of mice and monkeys with an influenza vaccine

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12 December 2020

A new MF59-adjuvanted influenza vaccine enhances the immune response in the elderly with chronic diseases: results from an immunogenicity meta-analysis

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12 December 2020

Induction of antigen-specific CD8+ T cells, T helper cells, and protective levels of antibody in humans by particle-mediated administration of a hepatitis B virus DNA vaccine

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12 December 2020

Field trial of oral cholera vaccines in Bangladesh: results from three-year follow-up

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12 December 2020

Successful immunization of children with and without maternal antibody by aerosolized measles vaccine. I. Different results with undiluted human diploid cell and chick embryo fibroblast vaccines

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12 December 2020

Immunization with a soluble recombinant HIV protein entrapped in biodegradable microparticles induces HIV-specific CD8+ cytotoxic T lymphocytes and CD4+ Th1 cells.

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12 December 2020

Plasmid DNA adsorbed onto cationic microparticles mediates target gene expression and antigen presentation by dendritic cells

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12 December 2020

Immunogenicity of a recombinant human cytomegalovirus gB vaccine in seronegative toddlers

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12 December 2020

Pilot evaluation of influenza virus vaccine (IVV) combined with adjuvant

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12 December 2020

Synergistic adjuvant activity of immunostimulatory DNA and oil/water emulsions for immunization with HIV p55 gag antigen

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12 December 2020

Recent advances in the discovery and delivery of vaccine adjuvants

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12 December 2020

Anionic microparticles are a potent delivery system for recombinant antigens from Neisseria meningitidis serotype B.

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12 December 2020

Mucosal immunisation and adjuvants: a brief overview of recent advances and challenges

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12 December 2020

Oral administration of influenza vaccine in combination with the adjuvants LT-K63 and LT-R72 induces potent immune responses comparable to or stronger than traditional intramuscular immunization

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12 December 2020

Structure and mucosal adjuvanticity of cholera and Escherichia coli heat-labile enterotoxins

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12 December 2020

A randomized, controlled study in adults of the immunogenicity of a novel hepatitis B vaccine containing MF59 adjuvant

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12 December 2020

Safety and immunogenicity of a genetically engineered human immunodeficiency virus vaccine.

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12 December 2020

Oral immunization of adult volunteers with microencapsulated enterotoxigenic Escherichia coli (ETEC) CS6 antigen

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12 December 2020

PLGA microspheres containing plasmid DNA: preservation of supercoiled DNA via cryopreparation and carbohydrate stabilization

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12 December 2020

Virus-based vectors for human vaccine applications

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12 December 2020

Measles elimination: progress and challenges

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12 December 2020

Minimal structural requirements for adjuvant activity of bacterial peptidoglycan derivatives

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12 December 2020

Cationic microparticles: A potent delivery system for DNA vaccines

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12 December 2020

Safety and immunogenicity of Env 2-3, a human immunodeficiency virus type 1 candidate vaccine, in combination with a novel adjuvant, MTP-PE/MF59. NIAID AIDS Vaccine Evaluation Group

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12 December 2020

Safety, tolerability, and lack of antibody responses after administration of a PfCSP DNA malaria vaccine via needle or needle-free jet injection, and comparison of intramuscular and combination intramuscular/intradermal routes.

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12 December 2020

Differentiation of phagocytic monocytes into lymph node dendritic cells in vivo

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12 December 2020

The concomitant use of the LTK63 mucosal adjuvant and of chitosan-based delivery system enhances the immunogenicity and efficacy of intranasally administered vaccines.

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12 December 2020

Uptake of poly(D,L-lactic-co-glycolic acid) microspheres by antigen-presenting cells in vivo

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12 December 2020

Microparticles and polymers for the mucosal delivery of vaccines

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12 December 2020

Ensuring vaccine safety in immunization programmes--a WHO perspective

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12 December 2020

Mucosal vaccines: non toxic derivatives of LT and CT as mucosal adjuvants.

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12 December 2020

Recent advances in the stabilization of proteins encapsulated in injectable PLGA delivery systems

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12 December 2020

10.1023/B:PHAM.0000041443.17935.33

Identifiers

DOI

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11 August 2017

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PubMed ID

15497674