(Q35976359)

11 August 2017

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title

Therapeutic potential of target of rapamycin inhibitors (English)

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11 August 2017

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John B Easton

1

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11 August 2017

Peter J Houghton

series ordinal

2

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11 August 2017

language of work or name

English

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publication date

1 December 2004

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Expert Opinion on Therapeutic Targets

11 August 2017

published in

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11 August 2017

volume

8

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11 August 2017

issue

6

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11 August 2017

page(s)

551-564

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Targets for Cell Cycle Arrest by the Immunosuppressant Rapamycin in Yeast

11 August 2017

cites work

1 reference

https://api.crossref.org/works/10.1517%2F14728222.8.6.551

Rapamycin sensitivity in Saccharomyces cerevisiae is mediated by a peptidyl-prolyl cis-trans isomerase related to human FK506-binding protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.8.6.551

HEAT repeats mediate plasma membrane localization of Tor2p in yeast

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.8.6.551

Tor-mediated induction of autophagy via an Apg1 protein kinase complex

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.8.6.551

A mammalian protein targeted by G1-arresting rapamycin-receptor complex

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.8.6.551

RAFT1: a mammalian protein that binds to FKBP12 in a rapamycin-dependent fashion and is homologous to yeast TORs

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.8.6.551

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.8.6.551

Cell cycle checkpoint signaling through the ATM and ATR kinases

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.8.6.551

Identification of an 11-kDa FKBP12-rapamycin-binding domain within the 289-kDa FKBP12-rapamycin-associated protein and characterization of a critical serine residue

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.8.6.551

Structure of the FKBP12-rapamycin complex interacting with the binding domain of human FRAP

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.8.6.551

Evidence of insulin-stimulated phosphorylation and activation of the mammalian target of rapamycin mediated by a protein kinase B signaling pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.8.6.551

4E-BP1, a repressor of mRNA translation, is phosphorylated and inactivated by the Akt(PKB) signaling pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.8.6.551

PDGF- and insulin-dependent pp70S6k activation mediated by phosphatidylinositol-3-OH kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.8.6.551

Signal transduction by receptors with tyrosine kinase activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.8.6.551

Positive and negative regulation of phosphoinositide 3-kinase-dependent signaling pathways by three different gene products of the p85alpha regulatory subunit

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.8.6.551

Type I phosphatidylinositol kinase makes a novel inositol phospholipid, phosphatidylinositol-3-phosphate

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.8.6.551

AKT/PKB and other D3 phosphoinositide-regulated kinases: kinase activation by phosphoinositide-dependent phosphorylation

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.8.6.551

Phosphoinositide-3-OH kinase-dependent regulation of glycogen synthase kinase 3 and protein kinase B/AKT by the integrin-linked kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.8.6.551

Regulation of protein kinase B/Akt-serine 473 phosphorylation by integrin-linked kinase: critical roles for kinase activity and amino acids arginine 211 and serine 343

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.8.6.551

Identification of a PKB/Akt hydrophobic motif Ser-473 kinase as DNA-dependent protein kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.8.6.551

TSC2 is phosphorylated and inhibited by Akt and suppresses mTOR signalling

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.8.6.551

Akt regulates growth by directly phosphorylating Tsc2

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.8.6.551

Tuberous sclerosis complex gene products, Tuberin and Hamartin, control mTOR signaling by acting as a GTPase-activating protein complex toward Rheb

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.8.6.551

Rheb is a direct target of the tuberous sclerosis tumour suppressor proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.8.6.551

Rheb promotes cell growth as a component of the insulin/TOR signalling network

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.8.6.551

Rheb is an essential regulator of S6K in controlling cell growth in Drosophila

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.8.6.551

Rheb GTPase is a direct target of TSC2 GAP activity and regulates mTOR signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.8.6.551

Phosphorylation of the translational repressor PHAS-I by the mammalian target of rapamycin

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.8.6.551

RAFT1 phosphorylation of the translational regulators p70 S6 kinase and 4E-BP1

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.8.6.551

Identification of a conserved motif required for mTOR signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.8.6.551

Raptor, a binding partner of target of rapamycin (TOR), mediates TOR action

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.8.6.551

TOS motif-mediated raptor binding regulates 4E-BP1 multisite phosphorylation and function

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.8.6.551

The mammalian target of rapamycin (mTOR) partner, raptor, binds the mTOR substrates p70 S6 kinase and 4E-BP1 through their TOR signaling (TOS) motif

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.8.6.551

GbetaL, a positive regulator of the rapamycin-sensitive pathway required for the nutrient-sensitive interaction between raptor and mTOR

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.8.6.551

Insulin-dependent stimulation of protein synthesis by phosphorylation of a regulator of 5'-cap function

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.8.6.551

Eukaryotic translation initiation factor 4E regulates expression of cyclin D1 at transcriptional and post-transcriptional levels

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.8.6.551

Rapamycin inhibition of the G1 to S transition is mediated by effects on cyclin D1 mRNA and protein stability

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.8.6.551

Rapamycin suppresses 5'TOP mRNA translation through inhibition of p70s6k.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.8.6.551

Rapamycin selectively inhibits translation of mRNAs encoding elongation factors and ribosomal proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.8.6.551

Rapamycin selectively represses translation of the "polypyrimidine tract" mRNA family

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.8.6.551

Amino acid-induced translation of TOP mRNAs is fully dependent on phosphatidylinositol 3-kinase-mediated signaling, is partially inhibited by rapamycin, and is independent of S6K1 and rpS6 phosphorylation

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.8.6.551

S6K1(-/-)/S6K2(-/-) mice exhibit perinatal lethality and rapamycin-sensitive 5'-terminal oligopyrimidine mRNA translation and reveal a mitogen-activated protein kinase-dependent S6 kinase pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.8.6.551

Phosphorylation of eucaryotic translation initiation factor 4B Ser422 is modulated by S6 kinases

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.8.6.551

A novel mTOR-regulated phosphorylation site in elongation factor 2 kinase modulates the activity of the kinase and its binding to calmodulin

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.8.6.551

Interleukin-2-mediated elimination of the p27Kip1 cyclin-dependent kinase inhibitor prevented by rapamycin

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.8.6.551

Interleukin-7 promotes survival and cell cycle progression of T-cell acute lymphoblastic leukemia cells by down-regulating the cyclin-dependent kinase inhibitor p27(kip1).

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.8.6.551

Expression of constitutively active 4EBP-1 enhances p27Kip1 expression and inhibits proliferation of MCF7 breast cancer cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.8.6.551

Rapamycin specifically interferes with GM-CSF signaling in human dendritic cells, leading to apoptosis via increased p27KIP1 expression

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.8.6.551

Mammalian TOR: a homeostatic ATP sensor

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.8.6.551

TSC2 mediates cellular energy response to control cell growth and survival

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.8.6.551

Tsc tumour suppressor proteins antagonize amino-acid-TOR signalling

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.8.6.551

Rapamycin selectively inhibits interleukin-2 activation of p70 S6 kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.8.6.551

Rapamycin inhibits IL-4--induced dendritic cell maturation in vitro and dendritic cell mobilization and function in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.8.6.551

Rapamycin impairs antigen uptake of human dendritic cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.8.6.551

Influence of immunosuppressive drugs on dendritic cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.8.6.551

Long-term improvement in renal function with sirolimus after early cyclosporine withdrawal in renal transplant recipients: 2-year results of the Rapamune Maintenance Regimen Study

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.8.6.551

Comparison of sirolimus-based calcineurin inhibitor-sparing and calcineurin inhibitor-free regimens in cadaveric renal transplantation

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.8.6.551

Sustained efficacy of percutaneous transluminal coronary angioplasty

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.8.6.551

A randomized comparison of a sirolimus-eluting stent with a standard stent for coronary revascularization

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.8.6.551

Prediction of mortality in heart transplant recipients by stress technetium-99m tetrofosmin myocardial perfusion imaging

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.8.6.551

Everolimus for the prevention of allograft rejection and vasculopathy in cardiac-transplant recipients

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.8.6.551

Enhanced sensitivity of PTEN-deficient tumors to inhibition of FRAP/mTOR.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.8.6.551

An inhibitor of mTOR reduces neoplasia and normalizes p70/S6 kinase activity in Pten+/- mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.8.6.551

AKT activity determines sensitivity to mammalian target of rapamycin (mTOR) inhibitors by regulating cyclin D1 and c-myc expression

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.8.6.551

AKT2, a putative oncogene encoding a member of a subfamily of protein-serine/threonine kinases, is amplified in human ovarian carcinomas

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.8.6.551

Peutz-Jeghers syndrome is caused by mutations in a novel serine threonine kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.8.6.551

A serine/threonine kinase gene defective in Peutz-Jeghers syndrome

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.8.6.551

The LKB1 tumor suppressor negatively regulates mTOR signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.8.6.551

Progression of eIF4e gene amplification and overexpression in benign and malignant tumors of the head and neck.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.8.6.551

Upregulation of protein synthesis initiation factor eIF-4E is an early event during colon carcinogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.8.6.551

Eukaryotic initiation factor-4E in superficial and muscle invasive bladder cancer and its correlation with vascular endothelial growth factor expression and tumour progression

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.8.6.551

mTOR controls cell cycle progression through its cell growth effectors S6K1 and 4E-BP1/eukaryotic translation initiation factor 4E

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.8.6.551

4E-binding proteins, the suppressors of eukaryotic initiation factor 4E, are down-regulated in cells with acquired or intrinsic resistance to rapamycin

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.8.6.551

Overexpression of the eukaryotic translation initiation factor 4G (eIF4G-1) in squamous cell lung carcinoma.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.8.6.551

Activation of translation complex eIF4F is essential for the genesis and maintenance of the malignant phenotype in human mammary epithelial cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.8.6.551

The translation factor eIF-4E promotes tumor formation and cooperates with c-Myc in lymphomagenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.8.6.551

Myc: a weapon of mass destruction

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.8.6.551

Serine phosphorylation of death agonist BAD in response to survival factor results in binding to 14-3-3 not BCL-X(L)

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.8.6.551

Survival signalling by Akt and eIF4E in oncogenesis and cancer therapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.8.6.551

Sustained activation of the JNK cascade and rapamycin-induced apoptosis are suppressed by p53/p21(Cip1)

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.8.6.551

FAT: a novel domain in PIK-related kinases

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.8.6.551

21 January 2018

Identifiers

DOI

10.1517/14728222.8.6.551

1 reference

release_ge2t25akoveprjrwcunvve3nxe

11 August 2017

Fatcat ID

1 reference

Fatcat

https://api.fatcat.wiki/v0/release/ge2t25akoveprjrwcunvve3nxe

mapped directly with Wikidata item

24 November 2022

based on heuristic

1 reference