(Q36008229)

11 August 2017

The amino acid sensor GCN2 inhibits inflammatory responses to apoptotic cells promoting tolerance and suppressing systemic autoimmunity (English)

1 reference

11 August 2017

0 references

Jillian Bradley

6

0 references

Rahul Shinde

object named as

Rahul Shinde

3

0 references

Marianne Koritzinsky

object named as

Marianne Koritzinsky

7

0 references

Tracy L. McGaha

object named as

Tracy L McGaha

9

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author name string

Buvana Ravishankar

1

1 reference

11 August 2017

Haiyun Liu

2

1 reference

11 August 2017

Kapil Chaudhary

4

1 reference

11 August 2017

Wei Xiao

5

1 reference

11 August 2017

Michael P Madaio

8

1 reference

11 August 2017

language of work or name

English

0 references

publication date

10 August 2015

1 reference

Proceedings of the National Academy of Sciences of the United States of America

11 August 2017

1 reference

11 August 2017

112

1 reference

11 August 2017

34

1 reference

11 August 2017

10774-10779

1 reference

describes a project that uses

11 August 2017

ImageJ

1 reference

11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC4553766/fullTextXML

inferred from PubMed Central ID database lookup

cites work

Suppression of systemic autoimmunity by the innate immune adaptor STING.

1 reference

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Lymphocyte Activation Gene-3 (LAG-3) negatively regulates environmentally-induced autoimmunity

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4553766

Beyond apoptosis in lupus

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4553766

Marginal zone CD169+ macrophages coordinate apoptotic cell-driven cellular recruitment and tolerance

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4553766

Vaccine activation of the nutrient sensor GCN2 in dendritic cells enhances antigen presentation

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4553766

GCN2-dependent metabolic stress is essential for endotoxemic cytokine induction and pathology

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4553766

The eIF2α/ATF4 pathway is essential for stress-induced autophagy gene expression

2 October 2017

1 reference

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O death where is thy sting? Immunologic tolerance to apoptotic self

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4553766

MAPK phosphatase-1 is required for regulatory natural autoantibody-mediated inhibition of TLR responses

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4553766

Amino acid catabolism: a pivotal regulator of innate and adaptive immunity.

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4553766

Eukaryotic initiation factor 2 phosphorylation and translational control in metabolism.

2 October 2017

1 reference

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Engineering DNA nanoparticles as immunomodulatory reagents that activate regulatory T cells

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4553766

Leucyl-tRNA synthetase is an intracellular leucine sensor for the mTORC1-signaling pathway

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4553766

Tolerance to apoptotic cells is regulated by indoleamine 2,3-dioxygenase.

2 October 2017

1 reference

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Halofuginone and other febrifugine derivatives inhibit prolyl-tRNA synthetase

2 October 2017

1 reference

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Multiple sclerosis, seizures, and antiepileptics: role of IL-18, IDO, and melatonin.

2 October 2017

1 reference

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IDO activates regulatory T cells and blocks their conversion into Th17-like T cells

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4553766

Halofuginone inhibits TH17 cell differentiation by activating the amino acid starvation response

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4553766

Indoleamine 2,3-dioxygenase controls conversion of Foxp3+ Tregs to TH17-like cells in tumor-draining lymph nodes.

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4553766

Indoleamine 2,3-dioxygenase is a critical regulator of acute graft-versus-host disease lethality

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4553766

Plasmacytoid dendritic cells from mouse tumor-draining lymph nodes directly activate mature Tregs via indoleamine 2,3-dioxygenase

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4553766

Regulated translation initiation controls stress-induced gene expression in mammalian cells

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4553766

Autoantigens as substrates for apoptotic proteases: implications for the pathogenesis of systemic autoimmune disease

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4553766

The male-specific histocompatibility antigen, H-Y: a history of transplantation, immune response genes, sex determination and expression cloning

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4553766

Autoantigens targeted in systemic lupus erythematosus are clustered in two populations of surface structures on apoptotic keratinocytes

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4553766

Magnesium precipitation of ribonucleoprotein complexes. Expedient techniques for the isolation of undergraded polysomes and messenger ribonucleic acid

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4553766

In Vitro Assessment of In Vivo Absorption of Drug Complexes

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4553766

Marginal zone macrophages suppress innate and adaptive immunity to apoptotic cells in the spleen.

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4553766

Indolamine 2,3-dioxygenase is expressed in the CNS and down-regulates autoimmune inflammation

23 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4553766

GCN2 kinase in T cells mediates proliferative arrest and anergy induction in response to indoleamine 2,3-dioxygenase.

23 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4553766

Inhibition of indoleamine 2,3-dioxygenase augments trinitrobenzene sulfonic acid colitis in mice

23 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4553766

Halofuginone, an inhibitor of type-I collagen synthesis and skin sclerosis, blocks transforming-growth-factor-beta-mediated Smad3 activation in fibroblasts.

23 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4553766

Restoration of tolerance in lupus by targeted inhibitory receptor expression

23 September 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/26261340

12 December 2020

inferred from PubMed ID database lookup

FcgammaRIIB deficiency leads to autoimmunity and a defective response to apoptosis in Mrl-MpJ mice

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/26261340

12 December 2020

inferred from PubMed ID database lookup

Effects of adalimumab therapy on disease activity and interferon-γ-mediated biochemical pathways in patients with rheumatoid arthritis

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/26261340

12 December 2020

inferred from PubMed ID database lookup

Identifiers

DOI

10.1073/PNAS.1504276112

1 reference

11 August 2017

0 references

1 reference

11 August 2017

PubMed publication ID

26261340

1 reference