(Q36023613)

11 August 2017

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title

Potential role of drug transporters in the pathogenesis of medically intractable epilepsy (English)

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11 August 2017

Patrick Kwan

1

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Martin J Brodie

series ordinal

2

object named as

Martin J Brodie

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author name string

Martin J Brodie

series ordinal

2

1 reference

11 August 2017

publication date

1 February 2005

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11 August 2017

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11 August 2017

volume

46

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11 August 2017

issue

2

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11 August 2017

page(s)

224-235

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Remission of epilepsy: results from the National General Practice Study of Epilepsy.

11 August 2017

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Do seizures beget seizures? An assessment of the clinical evidence in humans

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Permanently altered hippocampal structure, excitability, and inhibition after experimental status epilepticus in the rat: The ?dormant basket cell? hypothesis and its possible relevance to temporal lobe epilepsy

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Selective changes in single cell GABA(A) receptor subunit expression and function in temporal lobe epilepsy

21 January 2018

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Distribution of glutamate transporters in the hippocampus of patients with pharmaco-resistant temporal lobe epilepsy

21 January 2018

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Mechanisms of antiepileptic drug resistance

21 January 2018

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Role of multidrug transporters in pharmacoresistance to antiepileptic drugs

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Multidrug resistance in cancer: role of ATP-dependent transporters

21 January 2018

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Multidrug transporters from bacteria to man: similarities in structure and function

21 January 2018

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The human ATP-binding cassette (ABC) transporter superfamily

21 January 2018

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An inventory of the human ABC proteins

21 January 2018

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Localization of the human multiple drug resistance gene, MDR1, to 7q21.1

21 January 2018

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Multidrug resistant proteins

21 January 2018

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The structure and function of drug pumps: an update

21 January 2018

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How does P-glycoprotein recognize its substrates?

21 January 2018

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Disruption of the mouse mdr1a P-glycoprotein gene leads to a deficiency in the blood-brain barrier and to increased sensitivity to drugs

21 January 2018

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Normal viability and altered pharmacokinetics in mice lacking mdr1-type (drug-transporting) P-glycoproteins

21 January 2018

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The physiological function of drug-transporting P-glycoproteins

21 January 2018

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The P-glycoprotein efflux pump: how does it transport drugs?

21 January 2018

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A general pattern for substrate recognition by P-glycoprotein.

21 January 2018

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P-Glycoprotein in clinical cardiology.

21 January 2018

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https://api.crossref.org/works/10.1111%2FJ.0013-9580.2005.31904.X

Pharmacologic circumvention of multidrug resistance

21 January 2018

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Inhibitors of multidrug resistance to antitumor agents (MDR).

21 January 2018

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Search for specific inhibitors of multidrug resistance in cancer

21 January 2018

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https://api.crossref.org/works/10.1111%2FJ.0013-9580.2005.31904.X

Multidrug resistance transporters and modulation

21 January 2018

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Expression of the multidrug resistance gene product (P-glycoprotein) in human normal and tumor tissues

21 January 2018

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P-glycoprotein is strongly expressed in the luminal membranes of the endothelium of blood vessels in the brain

21 January 2018

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Limited oral bioavailability and active epithelial excretion of paclitaxel (Taxol) caused by P-glycoprotein in the intestine

21 January 2018

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Choroid plexus epithelial expression of MDR1 P glycoprotein and multidrug resistance-associated protein contribute to the blood-cerebrospinal-fluid drug-permeability barrier

21 January 2018

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https://api.crossref.org/works/10.1111%2FJ.0013-9580.2005.31904.X

Disruption of mdr1a p-glycoprotein gene results in dysfunction of blood-inner ear barrier in mice

21 January 2018

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P-glycoprotein: a major determinant of rifampicin-inducible expression of cytochrome P4503A in mice and humans

21 January 2018

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Functional expression and localization of P-glycoprotein at the blood brain barrier

21 January 2018

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Drug transport to the brain: key roles for the efflux pump P-glycoprotein in the blood-brain barrier

21 January 2018

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Neurotrophic and neuroprotective actions of estrogens and their therapeutic implications

21 January 2018

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P-Glycoprotein on astrocyte foot processes of unfixed isolated human brain capillaries

21 January 2018

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Glial cells express multiple ATP binding cassette proteins which are involved in ATP release

21 January 2018

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Expression of the multidrug transporter P-glycoprotein in brain capillary endothelial cells and brain parenchyma of amygdala-kindled rats

21 January 2018

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Differential expression of multidrug resistance genes in naïve rat brain

21 January 2018

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21 January 2018

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New insights into the biology and pharmacology of the multidrug resistance protein (MRP) from gene knockout models

21 January 2018

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Regulation of expression of the multidrug resistance-associated protein 2 (MRP2) and its role in drug disposition

21 January 2018

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The multidrug resistance protein family.

21 January 2018

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Real-time reverse transcription-PCR expression profiling of the complete human ATP-binding cassette transporter superfamily in various tissues.

21 January 2018

1 reference

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Response to antiretroviral treatment in HIV-1-infected individuals with allelic variants of the multidrug resistance transporter 1: a pharmacogenetics study

21 January 2018

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The effects of the human MDR1 genotype on the expression of duodenal P-glycoprotein and disposition of the probe drug talinolol.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0013-9580.2005.31904.X

Deposition of Alzheimer's beta-amyloid is inversely correlated with P-glycoprotein expression in the brains of elderly non-demented humans

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0013-9580.2005.31904.X

Identification of functionally variant MDR1 alleles among European Americans and African Americans

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0013-9580.2005.31904.X

Role of human MDR1 gene polymorphism in bioavailability and interaction of digoxin, a substrate of P-glycoprotein.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0013-9580.2005.31904.X

Genetic polymorphisms in MDR1 and CYP3A4 genes in Asians and the influence of MDR1 haplotypes on cyclosporin disposition in heart transplant recipients

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0013-9580.2005.31904.X

MDR1 haplotypes do not affect the steady-state pharmacokinetics of cyclosporine in renal transplant patients.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0013-9580.2005.31904.X

Frequency of C3435T polymorphism of MDR1 gene in African people

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0013-9580.2005.31904.X

MDR1 pharmacogenetics: frequency of the C3435T mutation in exon 26 is significantly influenced by ethnicity

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0013-9580.2005.31904.X

Polymorphism of the ABC transporter genes, MDR1, MRP1 and MRP2/cMOAT, in healthy Japanese subjects

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0013-9580.2005.31904.X

Long term outcome of temporal lobe epilepsy surgery: analyses of 140 consecutive patients

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0013-9580.2005.31904.X

Overexpression of multiple drug resistance genes in endothelial cells from patients with refractory epilepsy.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0013-9580.2005.31904.X

Expression and cellular distribution of multidrug resistance-related proteins in the hippocampus of patients with mesial temporal lobe epilepsy

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0013-9580.2005.31904.X

Multidrug-resistance protein 1 in focal cortical dysplasia

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0013-9580.2005.31904.X

Expression and cellular distribution of multidrug transporter proteins in two major causes of medically intractable epilepsy: focal cortical dysplasia and glioneuronal tumors

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0013-9580.2005.31904.X

Tuberous sclerosis associated with MDR1 gene expression and drug-resistant epilepsy

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0013-9580.2005.31904.X

Widespread upregulation of drug-resistance proteins in fatal human status epilepticus

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0013-9580.2005.31904.X

Induction of P-glycoprotein expression in astrocytes following intracerebroventricular kainate injections

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0013-9580.2005.31904.X

Neuronal expression of the drug efflux transporter P-glycoprotein in the rat hippocampus after limbic seizures.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0013-9580.2005.31904.X

Regional expression of multidrug resistance genes in genetically epilepsy-prone rat brain after a single audiogenic seizure

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0013-9580.2005.31904.X

Lack of effects of prolonged treatment with phenobarbital or phenytoin on the expression of P-glycoprotein in various rat brain regions

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0013-9580.2005.31904.X

A kindling model of pharmacoresistant temporal lobe epilepsy in Sprague-Dawley rats induced by Coriaria lactone and its possible mechanism

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0013-9580.2005.31904.X

Carbamazepine is not a substrate for P-glycoprotein

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0013-9580.2005.31904.X

P-glycoprotein-mediated efflux of antiepileptic drugs: preliminary studies in mdr1a knockout mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0013-9580.2005.31904.X

In vivo evidence for P-glycoprotein-mediated transport of phenytoin at the blood-brain barrier of rats

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0013-9580.2005.31904.X

P-glycoprotein and multidrug resistance-associated protein are involved in the regulation of extracellular levels of the major antiepileptic drug carbamazepine in the brain

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0013-9580.2005.31904.X

P-Glycoprotein-mediated efflux of phenobarbital, lamotrigine, and felbamate at the blood-brain barrier: evidence from microdialysis experiments in rats

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0013-9580.2005.31904.X

Multidrug resistance-associated protein is involved in the regulation of extracellular levels of phenytoin in the brain

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0013-9580.2005.31904.X

Multidrug resistance protein MRP2 contributes to blood-brain barrier function and restricts antiepileptic drug activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0013-9580.2005.31904.X

Relationship between expression of multiple drug resistance proteins and p53 tumor suppressor gene proteins in human brain astrocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0013-9580.2005.31904.X

Antiepileptogenesis and seizure prevention trials with antiepileptic drugs: meta-analysis of controlled trials

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0013-9580.2005.31904.X

Treatment of first tonic-clonic seizure does not improve the prognosis of epilepsy. First Seizure Trial Group (FIRST Group).

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0013-9580.2005.31904.X

Models for epilepsy and epileptogenesis: report from the NIH workshop, Bethesda, Maryland.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0013-9580.2005.31904.X

Growth hormone deficiency (GHD) from birth to 2 years of age: diagnostic specifics of GHD during the early phase of life

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0013-9580.2005.31904.X

Success or failure with antiepileptic drug therapy: Beyond empiricism?

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0013-9580.2005.31904.X

Internal duplication and homology with bacterial transport proteins in the mdr1 (P-glycoprotein) gene from multidrug-resistant human cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0013-9580.2005.31904.X

Association of Multidrug Resistance in Epilepsy with a Polymorphism in the Drug-Transporter GeneABCB1

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0013-9580.2005.31904.X

10.1111/J.0013-9580.2005.31904.X

21 January 2018

Identifiers

DOI

1 reference

11 August 2017

1 reference