(Q36028393)

11 August 2017

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title

Generation of loss of heterozygosity and its dependency on p53 status in human lymphoblastoid cells (English)

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11 August 2017

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Masamitsu Honma

1

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11 August 2017

language of work or name

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1 March 2005

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Environmental and Molecular Mutagenesis

11 August 2017

published in

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11 August 2017

volume

45

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11 August 2017

issue

2-3

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11 August 2017

page(s)

162-176

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Chromosome changes caused by alterations of p53 expression

11 August 2017

cites work

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A comparison of induced mutation at homologous alleles of the tk locus in human cells. II. Molecular analysis of mutants

21 January 2018

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Different cytotoxic and mutagenic responses induced by X-rays in two human lymphoblastoid cell lines derived from a single donor

21 January 2018

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Validation and characterization of the L5178Y/TK+/- mouse lymphoma mutagen assay system

21 January 2018

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Assay for gene mutation in a human lymphoblast line, AHH-1, competent for xenobiotic metabolism

21 January 2018

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Tk+/- mouse model for detecting in vivo mutation in an endogenous, autosomal gene

21 January 2018

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Allelic losses in mutations at the aprt locus of human lymphoblastoid cells

21 January 2018

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DNA-sequence specificity of mutations at the human thymidine kinase locus

21 January 2018

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Pathways for mitotic homologous recombination in mammalian cells

21 January 2018

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Cytotoxic and mutagenic responses to X-rays and chemical mutagens in normal and p53-mutated human lymphoblastoid cells

21 January 2018

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Illegitimate recombination leading to allelic loss and unbalanced translocation in p53-mutated human lymphoblastoid cells

21 January 2018

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Chromosomal instability in B-lymphoblasotoid cell lines from Werner and Bloom syndrome patients

21 January 2018

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Characterization of p53 in Chinese hamster cell lines CHO-K1, CHO-WBL, and CHL: implications for genotoxicity testing

21 January 2018

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The 1993 Walter Hubert Lecture: the role of the p53 tumour-suppressor gene in tumorigenesis.

21 January 2018

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A comparison of mutation induction at the tk and hprt loci in human lymphoblastoid cells; quantitative differences are due to an additional class of mutations at the autosomal tk locus.

21 January 2018

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A mutation in the p53 tumor suppressor gene of AHH-1 tk+/- human lymphoblastoid cells

21 January 2018

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Mutagenesis and carcinogenesis in nucleotide excision repair-deficient XPA knock out mice

21 January 2018

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Loss of heterozygosity in somatic cells of the mouse. An important step in cancer initiation?

21 January 2018

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Different capacities for recombination in closely related human lymphoblastoid cell lines with different mutational responses to X-irradiation

21 January 2018

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The tumor suppressor p53 modifies mutational processes in a human lymphoblastoid cell line

21 January 2018

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Proliferating cell nuclear antigen and p21 are components of multiple cell cycle kinase complexes

21 January 2018

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DNA substrate dependence of p53-mediated regulation of double-strand break repair

21 January 2018

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7 January 2021

Increase of spontaneous intrachromosomal homologous recombination in mammalian cells expressing a mutant p53 protein

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7 January 2021

p53's double life: transactivation-independent repression of homologous recombination.

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7 January 2021

Human in vivo somatic mutation measured at two loci: individuals with stably elevated background erythrocyte glycophorin A (gpa) variant frequencies exhibit normal T-lymphocyte hprt mutant frequencies

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7 January 2021

Expression of recessive alleles by chromosomal mechanisms in retinoblastoma

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7 January 2021

Genetic origin of mutations predisposing to retinoblastoma

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7 January 2021

How many mutant p53 molecules are needed to inactivate a tetramer?

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7 January 2021

The p53 status of Chinese hamster V79 cells frequently used for studies on DNA damage and DNA repair

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7 January 2021

Identification and chromosomal assignment of two heterozygous mutations in the Trp53 gene in L5178Y/Tk(+/-)-3.7.2C mouse lymphoma cells

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7 January 2021

Expression of fragile sites triggers intrachromosomal mammalian gene amplification and sets boundaries to early amplicons

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7 January 2021

Mice lacking p21CIP1/WAF1 undergo normal development, but are defective in G1 checkpoint control

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7 January 2021

Extensive loss of heterozygosity accounts for differential mutation rate on chromosome 17q in human lymphoblasts

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7 January 2021

The influence of cellular apoptotic capacity on N-nitrosodimethylamine-induced loss of heterozygosity mutations in human cells

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7 January 2021

Development of a novel mouse tk+/- embryonic stem cell line for use in mutagenicity studies

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7 January 2021

Abnormal centrosome amplification in the absence of p53.

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7 January 2021

Homologous and nonhomologous recombination resulting in deletion: effects of p53 status, microhomology, and repetitive DNA length and orientation

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7 January 2021

Mutational spectrum of X-ray induced TK- human cell mutants

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7 January 2021

Mutations of the VHL tumour suppressor gene in renal carcinoma

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7 January 2021

Efficient rescue of integrated shuttle vectors from transgenic mice: a model for studying mutations in vivo

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7 January 2021

Absence of p53 permits propagation of mutant cells following genotoxic damage

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7 January 2021

Requirement of wild-type p53 protein for maintenance of chromosomal integrity

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7 January 2021

Deletion, rearrangement, and gene conversion; genetic consequences of chromosomal double-strand breaks in human cells

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7 January 2021

Sensing and repairing DNA double-strand breaks

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7 January 2021

Screening the p53 status of human cell lines using a yeast functional assay

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7 January 2021

Microsatellite instability in human hepatocellular carcinoma: relationship to p53 abnormalities

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7 January 2021

Impaired function of p53R2 in Rrm2b-null mice causes severe renal failure through attenuation of dNTP pools

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7 January 2021

Lessons from hereditary colorectal cancer

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7 January 2021

Spectra of spontaneous and mutagen-induced mutations in the lacI gene in transgenic mice

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7 January 2021

A chemical inhibitor of p53 that protects mice from the side effects of cancer therapy

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7 January 2021

Wild-type p53 is a cell cycle checkpoint determinant following irradiation

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7 January 2021

NK-mediated elimination of mutant lymphocytes that have lost expression of MHC class I molecules

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7 January 2021

Cancer. p53, guardian of the genome

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7 January 2021

Loss of constitutional heterozygosity in human cancer.

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7 January 2021

Genetic instabilities in human cancers

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7 January 2021

Molecular mechanisms of spontaneous and induced loss of heterozygosity in human cells in vitro

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7 January 2021

Radiation-induced genetic instability in vivo depends on p53 status

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7 January 2021

Mutation assay at the thymidine kinase locus in diploid human lymphoblasts

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7 January 2021

Molecular and biochemical analyses of spontaneous and X-ray-induced mutants in human lymphoblastoid cells

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7 January 2021

Absence of radiation-induced G1 arrest in two closely related human lymphoblast cell lines that differ in p53 status

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7 January 2021

Chromosome stability, in the absence of apoptosis, is critical for suppression of tumorigenesis in Trp53 mutant mice

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7 January 2021

Altered cell cycle arrest and gene amplification potential accompany loss of wild-type p53

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7 January 2021

Differential induction of transcriptionally active p53 following UV or ionizing radiation: defects in chromosome instability syndromes?

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7 January 2021

UV wavelength-dependent regulation of transcription-coupled nucleotide excision repair in p53-deficient human cells

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7 January 2021

Inactivation of p53 results in high rates of homologous recombination

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7 January 2021

A role for p53 in the frequency and mechanism of mutation

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7 January 2021

Induction of telomerase activity by irradiation in human lymphoblasts

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7 January 2021

The IARC TP53 database: new online mutation analysis and recommendations to users

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7 January 2021

Interstitial deletions and intrachromosomal amplification initiated from a double-strand break targeted to a mammalian chromosome

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7 January 2021

Frequent chromosomal translocations induced by DNA double-strand breaks

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7 January 2021

Pathways of DNA double-strand break repair during the mammalian cell cycle

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7 January 2021

Homologous recombination induced by replication inhibition, is stimulated by expression of mutant p53.

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7 January 2021

p53 deficiency does not affect the accumulation of point mutations in a transgene target

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7 January 2021

The E6 oncoprotein encoded by human papillomavirus types 16 and 18 promotes the degradation of p53

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7 January 2021

Chromosome instability contributes to loss of heterozygosity in mice lacking p53

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7 January 2021

Isolation of a human lymphoblastoid line heterozygous at the thymidine kinase locus: Possibility for a rapid human cell mutation assay

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7 January 2021

APRT: a versatile in vivo resident reporter of local mutation and loss of heterozygosity

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7 January 2021

Extensive loss of heterozygosity is suppressed during homologous repair of chromosomal breaks

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7 January 2021

A ribonucleotide reductase gene involved in a p53-dependent cell-cycle checkpoint for DNA damage

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7 January 2021

p53 mutation and mitotic infidelity

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7 January 2021

Functions of p53 suppress critical consequences of damage and repair in the initiation of cancer

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7 January 2021

Autosomal mutation in somatic cells of the mouse

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7 January 2021

Development of a mouse model for studying in vivo T-cell receptor mutations

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7 January 2021

Xpa and Xpa/p53+/- knockout mice: overview of available data

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7 January 2021

The role of nucleotide excision repair and loss of p53 in mutagenesis and carcinogenesis

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7 January 2021

Genetic Stabilization by p53 Involves Growth Regulatory and Repair Pathways

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7 January 2021

Abrogation of p53 function by HPV16 E6 gene delays apoptosis and enhances mutagenesis but does not alter radiosensitivity in TK6 human lymphoblast cells

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7 January 2021

The relative radiosensitivity of TK6 and WI-L2-NS lymphoblastoid cells derived from a common source is primarily determined by their p53 mutational status

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7 January 2021

The role of p53 in base excision repair following genotoxic stress

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7 January 2021

Identifiers

DOI

10.1002/EM.20113

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11 August 2017

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