(Q36037500)

English

Cancer drug pan-resistance: pumps, cancer stem cells, quiescence, epithelial to mesenchymal transition, blocked cell death pathways, persisters or what?

scientific article

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scholarly article

1 reference

Europe PubMed Central

PMC publication ID

11 August 2017

4 references

20 August 2019

19 September 2019

14 September 2020

26 October 2020

Cancer drug pan-resistance: pumps, cancer stem cells, quiescence, epithelial to mesenchymal transition, blocked cell death pathways, persisters or what? (English)

1 reference

Europe PubMed Central

PMC publication ID

11 August 2017

physiological phenomenon

1 reference

20 August 2019

biomedical investigative technique

1 reference

19 September 2019

1 reference

14 September 2020

antineoplastic resistance

1 reference

26 October 2020

neoplastic stem cells

1 reference

based on heuristic

inferred from title

1 reference

based on heuristic

inferred from title

stem-cell quiescence

1 reference

based on heuristic

inferred from title

author name string

Piet Borst

1

1 reference

Europe PubMed Central

PMC publication ID

11 August 2017

publication date

1 May 2012

5 references

Europe PubMed Central

PMC publication ID

11 August 2017

20 August 2019

19 September 2019

14 September 2020

26 October 2020

5 references

Europe PubMed Central

PMC publication ID

11 August 2017

20 August 2019

19 September 2019

14 September 2020

26 October 2020

2

1 reference

Europe PubMed Central

PMC publication ID

11 August 2017

5

1 reference

Europe PubMed Central

PMC publication ID

11 August 2017

120066

1 reference

Europe PubMed Central

PMC publication ID

11 August 2017

copyright license

Creative Commons Attribution 3.0 Unported

4 references

Europe PubMed Central

20 August 2019

Europe PubMed Central

19 September 2019

Europe PubMed Central

14 September 2020

Europe PubMed Central

26 October 2020

copyright status

0 references

Transient low doses of DNA-demethylating agents exert durable antitumor effects on hematological and epithelial tumor cells

1 reference

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Drug resistance in the mouse cancer clinic

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The intestinal stem cell markers Bmi1 and Lgr5 identify two functionally distinct populations

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Autophagy-dependent anticancer immune responses induced by chemotherapeutic agents in mice

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Programmed necrosis: backup to and competitor with apoptosis in the immune system

1 reference

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Breast cancer epithelial-to-mesenchymal transition: examining the functional consequences of plasticity

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Redefining the relevance of established cancer cell lines to the study of mechanisms of clinical anti-cancer drug resistance

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Harnessing the cell death pathway for targeted cancer treatment.

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Homeobox B9 induces epithelial-to-mesenchymal transition-associated radioresistance by accelerating DNA damage responses.

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Multidrug resistance proteins (MRPs/ABCCs) in cancer chemotherapy and genetic diseases

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Microenvironmental regulation of stem cells in intestinal homeostasis and cancer

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BCL6 enables Ph+ acute lymphoblastic leukaemia cells to survive BCR-ABL1 kinase inhibition

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Harnessing synthetic lethal interactions in anticancer drug discovery

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Strategies to improve radiotherapy with targeted drugs

1 reference

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The cancer stem cell: premises, promises and challenges

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Studying therapy response and resistance in mouse models for BRCA1-deficient breast cancer

1 reference

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Drug discovery approaches to target Wnt signaling in cancer stem cells

1 reference

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Phenotypic heterogeneity among tumorigenic melanoma cells from patients that is reversible and not hierarchically organized

1 reference

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2 October 2017

Clinical experience with Hedgehog pathway inhibitors

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3376736

2 October 2017

Tumor-initiating cells are not enriched in cisplatin-surviving BRCA1;p53-deficient mammary tumor cells in vivo

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3376736

2 October 2017

Multiple drug resistance mechanisms in cancer

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3376736

2 October 2017

Targeting leukemic stem cells by breaking their dormancy

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3376736

2 October 2017

EMT, cancer stem cells and drug resistance: an emerging axis of evil in the war on cancer

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3376736

2 October 2017

A temporarily distinct subpopulation of slow-cycling melanoma cells is required for continuous tumor growth

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3376736

2 October 2017

A chromatin-mediated reversible drug-tolerant state in cancer cell subpopulations

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3376736

2 October 2017

Induction of cell cycle entry eliminates human leukemia stem cells in a mouse model of AML.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3376736

2 October 2017

Prospective comparison of clinical and genomic multivariate predictors of response to neoadjuvant chemotherapy in breast cancer

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3376736

2 October 2017

The therapeutic promise of the cancer stem cell concept

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3376736

2 October 2017

Identification of compounds selectively killing multidrug-resistant cancer cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3376736

2 October 2017

Tumour-initiating cells: challenges and opportunities for anticancer drug discovery

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3376736

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Identification of selective inhibitors of cancer stem cells by high-throughput screening

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3376736

2 October 2017

Inhibition of Hedgehog signaling enhances delivery of chemotherapy in a mouse model of pancreatic cancer

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3376736

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Histone deacetylase inhibitors induce a very broad, pleiotropic anticancer drug resistance phenotype in acute myeloid leukemia cells by modulation of multiple ABC transporter genes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3376736

2 October 2017

Cancer stem cells: controversial or just misunderstood?

1 reference

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2 October 2017

ABC transporters, drug resistance, and cancer stem cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3376736

2 October 2017

Association of reactive oxygen species levels and radioresistance in cancer stem cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3376736

2 October 2017

Cancer stem cells in solid tumours: accumulating evidence and unresolved questions

1 reference

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2 October 2017

ATF6alpha-Rheb-mTOR signaling promotes survival of dormant tumor cells in vivo

1 reference

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2 October 2017

Topoisomerase levels determine chemotherapy responsein vitroandin vivo

1 reference

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How do real tumors become resistant to cisplatin?

1 reference

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1 reference

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2 October 2017

What makes tumors multidrug resistant?

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3376736

2 October 2017

Models, mechanisms and clinical evidence for cancer dormancy

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3376736

2 October 2017

Initiation of high frequency multi-drug resistance following kinase targeting by siRNAs

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3376736

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Sequential ABL kinase inhibitor therapy selects for compound drug-resistant BCR-ABL mutations with altered oncogenic potency

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3376736

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Selective induction of chemotherapy resistance of mammary tumors in a conditional mouse model for hereditary breast cancer

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3376736

2 October 2017

Chronic myeloid leukemia stem cells possess multiple unique features of resistance to BCR-ABL targeted therapies

1 reference

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Chemotherapy dose--response relationships in non-small cell lung cancer and implied resistance mechanisms

1 reference

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2 October 2017

Glioma stem cells promote radioresistance by preferential activation of the DNA damage response

1 reference

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2 October 2017

Characterization of gene rearrangements leading to activation of MDR-1.

1 reference

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2 October 2017

Transmembrane transport of endo- and xenobiotics by mammalian ATP-binding cassette multidrug resistance proteins

1 reference

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Targeting multidrug resistance in cancer

1 reference

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Generation of a functional mammary gland from a single stem cell

1 reference

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1 reference

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The concept of synthetic lethality in the context of anticancer therapy

1 reference

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1 reference

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ABCG2 -- a transporter for all seasons

1 reference

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1 reference

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Strategies for reversing drug resistance

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3376736

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Senescence, apoptosis and therapy--cutting the lifelines of cancer.

1 reference

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Mammalian ABC transporters in health and disease

1 reference

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Reversal of multidrug resistance: lessons from clinical oncology.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3376736

2 October 2017

Apoptosis is critical for drug response in vivo

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3376736

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1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3376736

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Clinical resistance to STI-571 cancer therapy caused by BCR-ABL gene mutation or amplification

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3376736

2 October 2017

Mutational analysis of the human nucleotide excision repair gene ERCC1

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3376736

2 October 2017

DNA repair and resistance to chemotherapy

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3376736

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1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3376736

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1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3376736

2 October 2017

Multifactorial approach to predicting resistance to anthracyclines

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3376736

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Cycling toward elimination of leukemic stem cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3376736

23 September 2018

Sensitivity and acquired resistance of BRCA1;p53-deficient mouse mammary tumors to the topoisomerase I inhibitor topotecan

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3376736

23 September 2018

IFNalpha activates dormant haematopoietic stem cells in vivo.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3376736

23 September 2018

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1 reference

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23 September 2018

Brain metastases after achieving local pathological complete responses with neoadjuvant chemotherapy.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3376736

23 September 2018

Changes in gene expression associated with response to neoadjuvant chemotherapy in breast cancer

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3376736

23 September 2018

The role of apoptosis in cancer development and treatment response

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3376736

23 September 2018

Central nervous system metastases in women who receive trastuzumab-based therapy for metastatic breast carcinoma

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3376736

23 September 2018

The genetic origin of drug resistance in neoplasms: implications for systemic therapy.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3376736

23 September 2018

Moderate Increase in Mdr1a/1b Expression Causes In vivo Resistance to Doxorubicin in a Mouse Model for Hereditary Breast Cancer

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3376736

5 December 2018

Combining targeted drugs to stop resistant tumors

1 reference

https://pubmed.ncbi.nlm.nih.gov/22724067

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Bcl-2 and accelerated DNA repair mediates resistance of hair follicle bulge stem cells to DNA-damage-induced cell death

1 reference

https://pubmed.ncbi.nlm.nih.gov/22724067

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Differentiated human colorectal cancer cells protect tumor-initiating cells from irinotecan

1 reference

https://pubmed.ncbi.nlm.nih.gov/22724067

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Translational medicine: Cancer lessons from mice to humans

1 reference

https://pubmed.ncbi.nlm.nih.gov/22724067

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Chemotherapy response of spontaneous mammary tumors is independent of the adaptive immune system

1 reference

https://pubmed.ncbi.nlm.nih.gov/22724067

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cancer: Clinical trials unite mice and humans

1 reference

https://pubmed.ncbi.nlm.nih.gov/22724067

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cell lines battle cancer

1 reference

https://pubmed.ncbi.nlm.nih.gov/22724067

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1098/RSOB.120066

1 reference

Europe PubMed Central

PMC publication ID

11 August 2017

PMC publication ID

1 reference

Europe PubMed Central

PMC publication ID

11 August 2017

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

11 August 2017

ResearchGate publication ID

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