(Q36047385)

11 August 2017

title

Asymmetric multicomponent reactions (AMCRs): the new frontier (English)

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11 August 2017

2

Miguel Yus

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11 August 2017

Diego J Ramón

1

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11 August 2017

language of work or name

English

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publication date

1 March 2005

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Angewandte Chemie International Edition

11 August 2017

published in

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volume

44

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11 August 2017

issue

11

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11 August 2017

page(s)

1602-1634

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Organic synthesis and chemical ecology

11 August 2017

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Target-oriented and diversity-oriented organic synthesis in drug discovery

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Pathway development and pilot library realization in diversity-oriented synthesis: exploring Ferrier and Pauson-Khand reactions on a glycal template

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Generating Diverse Skeletons of Small Molecules Combinatorially

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A planning strategy for diversity-oriented synthesis

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Chemical genetic approaches for the elucidation of signaling pathways

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The emerging power of chemical genetics

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Hit and lead generation: beyond high-throughput screening

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Electrospray ionization tandem mass spectrometry in high-throughput screening of homogeneous catalysts

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Immobilized nicotinic receptor stationary phases: going with the flow in high-throughput screening and pharmacological studies

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Quantitative high-throughput analysis of drugs in biological matrices by mass spectrometry.

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High-throughput approaches to catalyst discovery

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Maximizing synthetic efficiency: multi-component transformations lead the way

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Atom Economy—A Challenge for Organic Synthesis: Homogeneous Catalysis Leads the Way

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On inventing reactions for atom economy

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Chemistry in microstructured reactors

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Cascade Radical Cyclizations via Biradicals Generated from Enediynes, Enyne-Allenes, and Enyne-Ketenes

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Multicomponent reactions involving 2-methyleneaziridines: rapid synthesis of 1,3-disubstituted propanones.

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Highly diastereoselective addition of silyldihalomethyllithiums to chiral alkyl esters

21 January 2018

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3-Boronoacrolein as an exceptional heterodiene in the highly enantio- and diastereoselective Cr(III)-catalyzed three-component [4+2]/allylboration

21 January 2018

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Catalytic asymmetric [3+2] cycloaddition of azomethine ylides. Development of a versatile stepwise, three-component reaction for diversity-oriented synthesis

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Multicomponent linchpin couplings. Reaction of dithiane anions with terminal epoxides, epichlorohydrin, and vinyl epoxides: efficient, rapid, and stereocontrolled assembly of advanced fragments for complex molecule synthesis

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High-diversity combinatorial libraries

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Recent advances in the Biginelli dihydropyrimidine synthesis. New tricks from an old dog.

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The tethered Biginelli condensation in natural product synthesis

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Multiple-Component Condensation Strategies for Combinatorial Library Synthesis

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Multicomponent Reactions with Isocyanides.

21 January 2018

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The discovery of new isocyanide-based multi-component reactions

21 January 2018

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Recent advances in isocyanide-based multicomponent chemistry.

21 January 2018

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"Multi-component reactions : emerging chemistry in drug discovery" 'from xylocain to crixivan'.

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The Chemistry of Isocyanides, their MultiComponent Reactions and their Libraries

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Multicomponent Coupling Reactions for Organic Synthesis: Chemoselective Reactions with Amide–Aldehyde Mixtures

21 January 2018

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A process in need is a process indeed: scalable enantioselective synthesis of chiral compounds for the pharmaceutical industry

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Ueber die künstliche Bildung der Milchsäure und einen neuen, dem Glycocoll homologen Körper;

21 January 2018

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Recent developments in the stereoselective synthesis of α-aminoacids

21 January 2018

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Asymmetric Synthesis of α-Amino-acids by the Strecker Synthesis

21 January 2018

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New Naturally Occurring Amino Acids

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Phytoremediation: synergistic use of plants and bacteria to clean up the environment

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Catalytic Asymmetric Strecker Synthesis. Preparation of Enantiomerically Pure α-Amino Acid Derivatives from Aldimines and Tributyltin Cyanide or Achiral Aldehydes, Amines, and Hydrogen Cyanide Using a Chiral Zirconium Catalyst

21 January 2018

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Catalytic enantioselective Reissert-type reaction: development and application to the synthesis of a potent NMDA receptor antagonist (-)-L-689,560 using a solid-supported catalyst

21 January 2018

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4-Amido-2-carboxytetrahydroquinolines. Structure-activity relationships for antagonism at the glycine site of the NMDA receptor

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Ueber ein Kondensationsprodukt aus Formaldehyd, Ammoniak und Antipyrin

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The direct catalytic asymmetric mannich reaction.

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Proline-catalyzed asymmetric reactions

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The proline-catalyzed direct asymmetric three-component Mannich reaction: scope, optimization, and application to the highly enantioselective synthesis of 1,2-amino alcohols

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Application of high pressure induced by water-freezing to the direct catalytic asymmetric three-component List-Barbas-Mannich reaction.

21 January 2018

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The direct and enantioselective, one-pot, three-component, cross-mannich reaction of aldehydes.

21 January 2018

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The direct organocatalytic asymmetric mannich reaction: unmodified aldehydes as nucleophiles

21 January 2018

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The Direct catalytic asymmetric cross-Mannich reaction: a highly enantioselective route to 3-amino alcohols and alpha-amino acid derivatives

21 January 2018

1 reference

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Three-component Biginelli cyclocondensation reaction using C-glycosylated substrates. Preparation of a collection of dihydropyrimidinone glycoconjugates and the synthesis of C-glycosylated monastrol analogues

21 January 2018

1 reference

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Model studies toward the synthesis of dihydropyrimidinyl and pyridyl alpha-amino acids via three-component Biginelli and Hantzsch cyclocondensations.

21 January 2018

1 reference

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Analysis of cyanobacterial toxins by immunological methods

21 January 2018

1 reference

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The boronic acid mannich reaction: A new method for the synthesis of geometrically pure allylamines

21 January 2018

1 reference

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A New and Practical Synthesis of α-Amino Acids from Alkenyl Boronic Acids

21 January 2018

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A new synthesis of α-arylglycines from aryl boronic acids

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1 reference

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Asymmetry in the boronic acid Mannich reaction: diastereocontrolled addition to chiral iminium species derived from aldehydes and (S)-5-phenylmorpholin-2-one

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1 reference

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Chirally templated boronic acid Mannich reaction in the synthesis of optically active α-amino acids

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1 reference

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Highly Stereocontrolled One-Step Synthesis ofanti-β-Amino Alcohols from Organoboronic Acids, Amines, and α-Hydroxy Aldehydes

21 January 2018

1 reference

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Stereoselective synthesis of anti-alpha-(difluoromethyl)-beta-amino alcohols by boronic acid based three-component condensation. Stereoselective preparation of (2S,3R)-difluorothreonine

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1 reference

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Four-Component Reactions for a New Diastereoselective Synthesis of Chiral Quaternary Centers

21 January 2018

1 reference

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Three‐Component Enantioselective Synthesis of Propargylamines through Zr‐Catalyzed Additions of Alkyl Zinc Reagents to Alkynylimines

21 January 2018

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Catalytic three-component coupling of alkynes, imines, and organoboron reagents

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Ueber die Synthese pyridinartiger Verbindungen aus Acetessigäther und Aldehydammoniak

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Multicomponent reactions are accelerated in water

21 January 2018

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New synthetic technology for efficient construction of alpha-hydroxy-beta-amino amides via the Passerini reaction

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Protein structure similarity as guiding principle for combinatorial library design.

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Di/tri-peptide transporters as drug delivery targets: regulation of transport under physiological and patho-physiological conditions.

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Generation of C-Glycoside Peptide Ligands for Cell Surface Carbohydrate Receptors Using a Four-Component Condensation on Solid Support

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Identification of highly selective inhibitors of collagenase-1 from combinatorial libraries of diketopiperazines

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Design and therapeutic application of matrix metalloproteinase inhibitors

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Solid-supported synthesis of putative peptide beta-turn mimetics via Ugi reaction for diketopiperazine formation

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Total synthesis of ecteinascidin 743.

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Glycoconjugate libraries accessed by multicomponent reactions

21 January 2018

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Asymmetrically induced four component condensation with extremely high stereoselectivity and multiplication of stereoselectivity

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Organoplatinum(II) complexes as a color biomarker in solid-phase peptide chemistry and screening

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One-pot synthesis and biological evaluation of aspergillamides and analogues

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Formation of 1,1'-iminodicarboxylic acid derivatives, 2,6-diketo-piperazine and dibenzodiazocine-2,6-dione by variations of multicomponent reactions

21 January 2018

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Activation of a terminal carboxylic acid by an internal oxazole: a novel synthesis of macrocyclodepsipeptide.

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Chemistry and biology of biosynthetic Diels-Alder reactions

21 January 2018

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A three-component reaction for diversity-oriented synthesis of polysubstituted piperidines: solution and solid-phase optimization of the first tandem aza[4+2]/allylboration

21 January 2018

1 reference

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Recent advances in the activation of boron and silicon reagents for stereocontrolled allylation reactions

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Development of a new carbon-carbon bond forming reaction. new organic chemistry of sulfur dioxide. Asymmetric four-component synthesis of polyfunctional sulfones

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Organocatalytic Asymmetric Domino Knoevenagel/Diels–Alder Reactions: A Bioorganic Approach to the Diastereospecific and Enantioselective Construction of Highly Substituted Spiro[5,5]undecane‐1,5,9‐triones

21 January 2018

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Concise, Asymmetric Total Synthesis of Spirotryprostatin A

21 January 2018

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Synthesis of Cyclic and Acyclic β-Amino Acids via Chelation-Controlled 1,3-Dipolar Cycloaddition

21 January 2018

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Aziridines: epoxides' ugly cousins?

21 January 2018

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Asymmetric N1 unit transfer to olefins with a chiral nitridomanganese complex: novel stereoselective pathways to aziridines or oxazolines

21 January 2018

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The Pauson-Khand reaction: the catalytic age is here!

21 January 2018

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The Pauson-Khand reaction, a powerful synthetic tool for the synthesis of complex molecules

21 January 2018

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Regio- and diastereoselective tandem rhodium-catalyzed allylic alkylation/Pauson-Khand annulation reactions

21 January 2018

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Syntheses of γ,δ-unsaturated alcohols from allylsilanes and carbonyl compounds in the presence of titanium tetrachloride

21 January 2018

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Synthesis of optically pure arylsilylcarbinols and their use as chiral auxiliaries in oxacarbenium ion reactions

21 January 2018

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Synthesis of enantiopure homoallylic ethers by reagent controlled facial selective allylation of chiral ketones

21 January 2018

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Facial-selective allylation of methyl ketones for the asymmetric synthesis of alpha-substituted tertiary homoallylic ethers

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Total Synthesis of the Macrolide Antibiotic 5,6-Dihydrocineromycin B This work was supported by the DFG (SFB 416) and the Fonds der Chemischen Industrie. We thank Prof. Dr. A. Zeeck for supplying data of the title compound, as well as BASF, Degussa-

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1 reference

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Ueber die Einwirkung von Fettaldehyden auf Malonsäure und Aethylmalonat

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1 reference

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Formation of Quaternary Stereocenters by Copper‐Catalyzed Michael Reactions with L‐Valine Amides as Auxiliaries

21 January 2018

1 reference

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First asymmetric synthesis of chiral beta-iodo Baylis-Hillman esters via tandem 1,4-conjugate addition/carbonyl coupling reactions

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The Catalytic Asymmetric Aldol Reaction.

21 January 2018

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Current progress in the asymmetric aldol addition reaction

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New entries in Lewis acid-Lewis base bifunctional asymmetric catalyst: catalytic enantioselective Reissert reaction of pyridine derivatives.

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A three-component Mannich-type reaction for selective tyrosine bioconjugation.

21 January 2018

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Studies towards the total synthesis of batzelladine A.

21 January 2018

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alpha-Aminoallylation of aldehydes with ammonia: stereoselective synthesis of homoallylic primary amines

21 January 2018

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Practical highly enantioselective synthesis of terminal propargylamines. An expeditious synthesis of (S)-(+)-coniine

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Asymmetric catalytic coupling of organoboranes, alkynes, and imines with a removable (trialkylsilyloxy)ethyl group--direct access to enantiomerically pure primary allylic amines

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1 reference

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Three-component condensation leading to beta-amino acid diamides: convergent assembly of beta-peptide analogues.

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1 reference

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Stereochemical control of the Passerini reaction

21 January 2018

1 reference

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Glyco- and peptidomimetics from three-component Joullié-Ugi coupling show selective antiviral activity

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Design of a nonreductive method for chemoselective cleavage of hydrazines in the presence of unsaturations: application to a stereoconvergent three-component synthesis of (-)-methyl palustramate

21 January 2018

1 reference

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Sulfur dioxide mediated one-pot, three- and four-component syntheses of polyfunctional sulfonamides and sulfonic esters: study of the stereoselectivity of the ene reaction of sulfur dioxide.

21 January 2018

1 reference

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Expeditious asymmetric synthesis of a stereoheptad corresponding to the C(19)-C(27)-ansa chain of rifamycins: formal total synthesis of Rifamycin S.

21 January 2018

1 reference

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Direct organocatalytic asymmetric heterodomino reactions: the Knoevenagel/Diels-Alder/epimerization sequence for the highly diastereoselective synthesis of symmetrical and nonsymmetrical synthons of benzoannelated centropolyquinanes

21 January 2018

1 reference

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Towards organo-click chemistry: development of organocatalytic multicomponent reactions through combinations of aldol, Wittig, Knoevenagel, Michael, Diels-Alder and Huisgen cycloaddition reactions

21 January 2018

1 reference

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A library of spirooxindoles based on a stereoselective three-component coupling reaction.

21 January 2018

1 reference

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Combinatorial Libraries of Chiral Ligands for Enantioselective Catalysis

21 January 2018

1 reference

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The Scope of the Direct Proline-Catalyzed Asymmetric Addition of Ketones to Imines

21 January 2018

1 reference

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21 January 2018

Identifiers

DOI

10.1002/ANIE.200460548

1 reference

11 August 2017

1 reference