(Q36050816)

11 August 2017

A crucial requirement for Hedgehog signaling in small cell lung cancer (English)

1 reference

11 August 2017

1 reference

Moe R Mahjoub

6

0 references

Cory A Ocasio

Cory A Ocasio

18

0 references

Martin Peifer

Martin Peifer

3

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James K. Chen

James K Chen

19

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Luciano G. Martelotto

Luciano G Martelotto

2

0 references

Tim Stearns

Tim Stearns

20

0 references

Julien Sage

26

Julien Sage

1 reference

11 August 2017

Kwon-Sik Park

1

1 reference

11 August 2017

Martin L Sos

4

1 reference

11 August 2017

Anthony N Karnezis

5

1 reference

11 August 2017

Katie Bernard

7

1 reference

11 August 2017

Jamie F Conklin

8

1 reference

11 August 2017

Anette Szczepny

9

1 reference

11 August 2017

Jing Yuan

10

1 reference

11 August 2017

Ribo Guo

11

1 reference

11 August 2017

Beatrice Ospina

12

1 reference

11 August 2017

Jeanette Falzon

13

1 reference

11 August 2017

Samara Bennett

14

1 reference

11 August 2017

Tracey J Brown

15

1 reference

11 August 2017

Ana Markovic

16

1 reference

11 August 2017

Wendy L Devereux

17

1 reference

11 August 2017

Roman K Thomas

21

1 reference

11 August 2017

Marion Dorsch

22

1 reference

11 August 2017

Silvia Buonamici

23

1 reference

11 August 2017

D Neil Watkins

24

1 reference

11 August 2017

Craig D Peacock

25

1 reference

11 August 2017

language of work or name

English

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publication date

9 October 2011

1 reference

11 August 2017

1 reference

11 August 2017

17

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11 August 2017

11

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11 August 2017

1504-1508

1 reference

https://scigraph.springernature.com/pub.10.1038/nm.2473

11 August 2017

0 references

cites work

Discovery of NVP-LDE225, a Potent and Selective Smoothened Antagonist

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3380617

Characterization of the cell of origin for small cell lung cancer

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3380617

Hedgehog-producing cancer cells respond to and require autocrine Hedgehog activity

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3380617

Array comparative genomic hybridization-based characterization of genetic alterations in pulmonary neuroendocrine tumors.

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3380617

Loss of p130 accelerates tumor development in a mouse model for human small-cell lung carcinoma

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3380617

Hedgehog beyond medulloblastoma and basal cell carcinoma

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3380617

Human colon cancer epithelial cells harbour active HEDGEHOG-GLI signalling that is essential for tumour growth, recurrence, metastasis and stem cell survival and expansion

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3380617

Gli2 trafficking links Hedgehog-dependent activation of Smoothened in the primary cilium to transcriptional activation in the nucleus

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3380617

Lateral transport of Smoothened from the plasma membrane to the membrane of the cilium

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3380617

Small-molecule inhibitors reveal multiple strategies for Hedgehog pathway blockade

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3380617

Mechanisms of Hedgehog pathway activation in cancer and implications for therapy.

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3380617

A primary xenograft model of small-cell lung cancer reveals irreversible changes in gene expression imposed by culture in vitro

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3380617

A GLI1-p53 inhibitory loop controls neural stem cell and tumour cell numbers

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3380617

A paracrine requirement for hedgehog signalling in cancer

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3380617

Bronchopulmonary neuroendocrine tumors

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3380617

Novel systemic therapies for small cell lung cancer

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3380617

Inhibition of GLI-mediated transcription and tumor cell growth by small-molecule antagonists

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3380617

Melanomas require HEDGEHOG-GLI signaling regulated by interactions between GLI1 and the RAS-MEK/AKT pathways.

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3380617

Hedgehog signaling maintains a tumor stem cell compartment in multiple myeloma

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3380617

HEDGEHOG-GLI1 signaling regulates human glioma growth, cancer stem cell self-renewal, and tumorigenicity

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3380617

A novel somatic mouse model to survey tumorigenic potential applied to the Hedgehog pathway

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3380617

Hedgehog signaling in small-cell lung cancer: frequent in vivo but a rare event in vitro.

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3380617

Activation of the hedgehog pathway in a subset of lung cancers

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3380617

Inhibition of prostate cancer proliferation by interference with SONIC HEDGEHOG-GLI1 signaling

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3380617

Hedgehog is an early and late mediator of pancreatic cancer tumorigenesis

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3380617

Hedgehog signalling within airway epithelial progenitors and in small-cell lung cancer

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3380617

Analysis of lung tumor initiation and progression using conditional expression of oncogenic K-ras

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3380617

Effects of oncogenic mutations in Smoothened and Patched can be reversed by cyclopamine

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3380617

Altered neural cell fates and medulloblastoma in mouse patched mutants

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3380617

Treatment of medulloblastoma with hedgehog pathway inhibitor GDC-0449

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3380617

Cell of origin of small cell lung cancer: inactivation of Trp53 and Rb1 in distinct cell types of adult mouse lung.

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3380617

Interfering with resistance to smoothened antagonists by inhibition of the PI3K pathway in medulloblastoma.

23 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3380617

Reduced level of smoothened suppresses intestinal tumorigenesis by down-regulation of Wnt signaling.

23 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3380617

Medulloblastoma growth inhibition by hedgehog pathway blockade

23 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3380617

Teratogen-mediated inhibition of target tissue response to Shh signaling.

23 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3380617

Acute mutation of retinoblastoma gene function is sufficient for cell cycle re-entry

23 September 2018

1 reference

Crossref

https://api.crossref.org/works/10.1038%2FNM.2473

The output of Hedgehog signaling is controlled by the dynamic association between Suppressor of Fused and the Gli proteins

21 January 2018

1 reference

Crossref

https://api.crossref.org/works/10.1038%2FNM.2473

Frequent requirement of hedgehog signaling in non-small cell lung carcinoma

21 January 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/21983857

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Induction of small cell lung cancer by somatic inactivation of both Trp53 and Rb1 in a conditional mouse model

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/21983857

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1038/NM.2473

1 reference

11 August 2017

1 reference

11 August 2017

1 reference