(Q36057706)

11 August 2017

title

Artesunate induces ROS-dependent apoptosis via a Bax-mediated intrinsic pathway in Huh-7 and Hep3B cells (English)

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11 August 2017

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Yilin Pang

1

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11 August 2017

Guiqi Qin

2

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11 August 2017

Liping Wu

3

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11 August 2017

Xiaoping Wang

4

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11 August 2017

Tongsheng Chen

5

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11 August 2017

language of work or name

English

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publication date

17 June 2016

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Experimental Cell Research

11 August 2017

published in

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11 August 2017

volume

347

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11 August 2017

issue

2

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11 August 2017

page(s)

251-260

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Anticancer activities of artemisinin and its bioactive derivatives

11 August 2017

cites work

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Antitumor activity of artemisinin and its derivatives: from a well-known antimalarial agent to a potential anticancer drug

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Enhanced delivery of artemisinin and its analogues to cancer cells by their adducts with human serum transferrin

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The role of heme and the mitochondrion in the chemical and molecular mechanisms of mammalian cell death induced by the artemisinin antimalarials

7 January 2021

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Artesunate induces ROS-mediated apoptosis in doxorubicin-resistant T leukemia cells

7 January 2021

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Artesunate mitigates proliferation of tumor cells by alkylating heme-harboring nitric oxide synthase

7 January 2021

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Artesunate altered cellular mechanical properties leading to deregulation of cell proliferation and migration in esophageal squamous cell carcinoma

7 January 2021

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Artesunate induces oxidative DNA damage, sustained DNA double-strand breaks, and the ATM/ATR damage response in cancer cells

7 January 2021

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Artesunate induces necrotic cell death in schwannoma cells.

7 January 2021

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Artesunate induces oncosis-like cell death in vitro and has antitumor activity against pancreatic cancer xenografts in vivo

7 January 2021

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Repurposing the anti-malarial drug artesunate as a novel therapeutic agent for metastatic renal cell carcinoma due to its attenuation of tumor growth, metastasis, and angiogenesis.

7 January 2021

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Identification of artesunate as a specific activator of ferroptosis in pancreatic cancer cells

7 January 2021

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Artemisinins: their growing importance in medicine

7 January 2021

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The antiviral activities of artemisinin and artesunate.

7 January 2021

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Experimental Therapy of Hepatoma with Artemisinin and Its Derivatives: In vitro and In vivo Activity, Chemosensitization, and Mechanisms of Action

7 January 2021

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Inhibition of angiogenesis in vivo and growth of Kaposi's sarcoma xenograft tumors by the anti-malarial artesunate

7 January 2021

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Artesunate down-regulates immunosuppression from colorectal cancer Colon26 and RKO cells in vitro by decreasing transforming growth factor β1 and interleukin-10.

7 January 2021

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Artemisinin and a Series of Novel Endoperoxide Antimalarials Exert Early Effects on Digestive Vacuole Morphology

7 January 2021

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The molecular mechanism of action of artemisinin--the debate continues.

7 January 2021

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The anti-cancer activity of dihydroartemisinin is associated with induction of iron-dependent endoplasmic reticulum stress in colorectal carcinoma HCT116 cells

7 January 2021

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The antimalarial agent artesunate possesses anticancer properties that can be enhanced by combination strategies.

7 January 2021

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Artemisinin dimer anticancer activity correlates with heme-catalyzed reactive oxygen species generation and endoplasmic reticulum stress induction

7 January 2021

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The artemisinin derivative artesunate inhibits corneal neovascularization by inducing ROS-dependent apoptosis in vascular endothelial cells.

7 January 2021

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Artesunate activates mitochondrial apoptosis in breast cancer cells via iron-catalyzed lysosomal reactive oxygen species production

7 January 2021

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Anti-cancer effects of artesunate in a panel of chemoresistant neuroblastoma cell lines

7 January 2021

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Artesunate induces ROS- and p38 MAPK-mediated apoptosis and counteracts tumor growth in vivo in embryonal rhabdomyosarcoma cells

7 January 2021

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Artesunate induces apoptosis via a Bak-mediated caspase-independent intrinsic pathway in human lung adenocarcinoma cells

7 January 2021

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Artesunate induces apoptosis via a ROS-independent and Bax-mediated intrinsic pathway in HepG2 cells

7 January 2021

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The BCL-2 protein family: opposing activities that mediate cell death

7 January 2021

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Artesunate inhibits the growth and induces apoptosis of human gastric cancer cells by downregulating COX-2

7 January 2021

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Artesunate induces apoptosis and inhibits growth of Eca109 and Ec9706 human esophageal cancer cell lines in vitro and in vivo

7 January 2021

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Artesunate overcomes drug resistance in multiple myeloma by inducing mitochondrial stress and non-caspase apoptosis

7 January 2021

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Potent proapoptotic actions of dihydroartemisinin in gemcitabine-resistant A549 cells

7 January 2021

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https://api.crossref.org/works/10.1016%2FJ.YEXCR.2016.06.012

Artemisinin induces A549 cell apoptosis dominantly via a reactive oxygen species-mediated amplification activation loop among caspase-9, -8 and -3.

7 January 2021

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https://api.crossref.org/works/10.1016%2FJ.YEXCR.2016.06.012

Confirmation by FRET in individual living cells of the absence of significant amyloid beta -mediated caspase 8 activation

7 January 2021

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https://api.crossref.org/works/10.1016%2FJ.YEXCR.2016.06.012

The bile acid-activated phosphatidylinositol 3-kinase pathway inhibits Fas apoptosis upstream of bid in rodent hepatocytes

7 January 2021

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Enhancement of cytotoxicity of artemisinins toward cancer cells by ferrous iron

7 January 2021

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Mcl-1 down-regulation potentiates ABT-737 lethality by cooperatively inducing Bak activation and Bax translocation

7 January 2021

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A chemical inhibitor of p53 that protects mice from the side effects of cancer therapy

7 January 2021

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Randomized, multicenter, open-label study of oxaliplatin plus fluorouracil/leucovorin versus doxorubicin as palliative chemotherapy in patients with advanced hepatocellular carcinoma from Asia

7 January 2021

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Management of hepatocellular carcinoma

7 January 2021

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https://api.crossref.org/works/10.1016%2FJ.YEXCR.2016.06.012

Dihydroartemisinin exerts its anticancer activity through depleting cellular iron via transferrin receptor-1.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2016.06.012

Dihydroartemisinin induces apoptosis in HL-60 leukemia cells dependent of iron and p38 mitogen-activated protein kinase activation but independent of reactive oxygen species

7 January 2021

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Expression of hepcidin mRNA is uniformly suppressed in hepatocellular carcinoma

7 January 2021

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Modulation of iron-regulatory genes in human hepatocellular carcinoma and its physiological consequences.

7 January 2021

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Expression of hepcidin and other iron-regulatory genes in human hepatocellular carcinoma and its clinical implications.

7 January 2021

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Iron homeostasis, oxidative stress, and DNA damage

7 January 2021

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Distinct mechanisms of ferritin delivery to lysosomes in iron-depleted and iron-replete cells

7 January 2021

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p53-mediated cellular response to DNA damage in cells with replicative hepatitis B virus

7 January 2021

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Drug-induced apoptosis in hepatoma cells is mediated by the CD95 (APO-1/Fas) receptor/ligand system and involves activation of wild-type p53.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2016.06.012

In vitro antiproliferative and antioxidant effects of urolithin A, the colonic metabolite of ellagic acid, on hepatocellular carcinomas HepG2 cells

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2016.06.012

Protective Effect of Tyrosol and S-Adenosylmethionine against Ethanol-Induced Oxidative Stress of Hepg2 Cells Involves Sirtuin 1, P53 and Erk1/2 Signaling.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2016.06.012

p53, oxidative stress, and aging

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2016.06.012

The antioxidant function of the p53 tumor suppressor

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2016.06.012

Post-transcriptional modulation of iron homeostasis during p53-dependent growth arrest

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2016.06.012

Iron deprivation suppresses hepatocellular carcinoma growth in experimental studies.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2016.06.012

10.1016/J.YEXCR.2016.06.012

7 January 2021

Identifiers

DOI

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11 August 2017

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