(Q36085630)

12 August 2017

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title

Chemical approaches to the discovery and development of cancer therapies (English)

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12 August 2017

Stephen Neidle

1

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12 August 2017

David E Thurston

series ordinal

2

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12 August 2017

language of work or name

English

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publication date

1 April 2005

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12 August 2017

Nature Reviews Cancer

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12 August 2017

5

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12 August 2017

285-296

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12 August 2017

4

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https://scigraph.springernature.com/pub.10.1038/nrc1587

12 August 2017

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cites work

Plant antitumor agents. VI. The isolation and structure of taxol, a novel antileukemic and antitumor agent from Taxus brevifolia

1 reference

Antitumor imidazotetrazines. 1. Synthesis and chemistry of 8-carbamoyl-3-(2-chloroethyl)imidazo[5,1-d]-1,2,3,5-tetrazin-4(3 H)-one , a novel broad-spectrum antitumor agent

21 January 2018

1 reference

Platinum Compounds: a New Class of Potent Antitumour Agents

21 January 2018

1 reference

INHIBITION OF CELL DIVISION IN ESCHERICHIA COLI BY ELECTROLYSIS PRODUCTS FROM A PLATINUM ELECTRODE

21 January 2018

1 reference

Property distributions: differences between drugs, natural products, and molecules from combinatorial chemistry

21 January 2018

1 reference

High-throughput X-ray crystallography for drug discovery

21 January 2018

1 reference

Development of natural product-derived receptor tyrosine kinase inhibitors based on conservation of protein domain fold

21 January 2018

1 reference

Chemical and biological profile of dual Cdk1 and Cdk2 inhibitors

21 January 2018

1 reference

Protein kinase inhibitors: insights into drug design from structure.

21 January 2018

1 reference

Kinases, Homology Models, and High Throughput Docking

21 January 2018

1 reference

Glivec (STI571, imatinib), a rationally developed, targeted anticancer drug

21 January 2018

1 reference

Efficacy and safety of imatinib mesylate in advanced gastrointestinal stromal tumors

21 January 2018

1 reference

Structural basis for the autoinhibition and STI-571 inhibition of c-Kit tyrosine kinase

21 January 2018

1 reference

Strategies to overcome resistance to targeted protein kinase inhibitors

21 January 2018

1 reference

Discovery of N-(2-chloro-6-methyl- phenyl)-2-(6-(4-(2-hydroxyethyl)- piperazin-1-yl)-2-methylpyrimidin-4- ylamino)thiazole-5-carboxamide (BMS-354825), a dual Src/Abl kinase inhibitor with potent antitumor activity in preclinical assays.

21 January 2018

1 reference

Overriding imatinib resistance with a novel ABL kinase inhibitor

21 January 2018

1 reference

Molecular characterization of the hdm2-p53 interaction

21 January 2018

1 reference

Structure of the MDM2 oncoprotein bound to the p53 tumor suppressor transactivation domain

21 January 2018

1 reference

Isolation and structure elucidation of Chlorofusin, a novel p53-MDM2 antagonist from a Fusarium sp.

21 January 2018

1 reference

Binding of an inhibitor of the p53/MDM2 interaction to MDM2.

21 January 2018

1 reference

Solid-phase synthesis of the cyclic peptide portion of chlorofusin, an inhibitor of p53-MDM2 interactions.

21 January 2018

1 reference

A nonpeptidic sulfonamide inhibits the p53-mdm2 interaction and activates p53-dependent transcription in mdm2-overexpressing cells

21 January 2018

1 reference

In vivo activation of the p53 pathway by small-molecule antagonists of MDM2

21 January 2018

1 reference

Recognition of the DNA minor groove by pyrrole-imidazole polyamides

21 January 2018

1 reference

Nuclear localization of pyrrole–imidazole polyamide–fluorescein conjugates in cell culture

21 January 2018

1 reference

DNA crosslinking and biological activity of a hairpin polyamide-chlorambucil conjugate

21 January 2018

1 reference

Design, synthesis, and evaluation of a novel pyrrolobenzodiazepine DNA-interactive agent with highly efficient cross-linking ability and potent cytotoxicity

21 January 2018

1 reference

SJG-136 (NSC 694501), a novel rationally designed DNA minor groove interstrand cross-linking agent with potent and broad spectrum antitumor activity: part 1: cellular pharmacology, in vitro and initial in vivo antitumor activity

21 January 2018

1 reference

The novel sequence-specific DNA cross-linking agent SJG-136 (NSC 694501) has potent and selective in vitro cytotoxicity in human B-cell chronic lymphocytic leukemia cells with evidence of a p53-independent mechanism of cell kill

21 January 2018

1 reference

SJG-136 (NSC 694501), a novel rationally designed DNA minor groove interstrand cross-linking agent with potent and broad spectrum antitumor activity: part 2: efficacy evaluations

21 January 2018

1 reference

Linker length modulates DNA cross-linking reactivity and cytotoxic potency of C8/C8' ether-linked C2-exo-unsaturated pyrrolo[2,1-c][1,4]benzodiazepine (PBD) dimers.

21 January 2018

1 reference

Specific association of human telomerase activity with immortal cells and cancer

21 January 2018

1 reference

Inhibition of telomerase limits the growth of human cancer cells.

21 January 2018

1 reference

Inhibition of human telomerase in immortal human cells leads to progressive telomere shortening and cell death

21 January 2018

1 reference

Telomere maintenance as a target for anticancer drug discovery

21 January 2018

1 reference

Trisubstituted acridine derivatives as potent and selective telomerase inhibitors.

21 January 2018

1 reference

Structure-based design of selective and potent G quadruplex-mediated telomerase inhibitors

21 January 2018

1 reference

Crystal structure of parallel quadruplexes from human telomeric DNA

21 January 2018

1 reference

Cell senescence and telomere shortening induced by a new series of specific G-quadruplex DNA ligands.

21 January 2018

1 reference

The G-quadruplex-interactive molecule BRACO-19 inhibits tumor growth, consistent with telomere targeting and interference with telomerase function.

21 January 2018

1 reference

The process of structure-based drug design

21 January 2018

1 reference

Assessing scoring functions for protein-ligand interactions.

21 January 2018

1 reference

Calculation of ligand-nucleic acid binding free energies with the generalized-born model in DOCK.

21 January 2018

1 reference

The PDBbind database: collection of binding affinities for protein-ligand complexes with known three-dimensional structures

21 January 2018

1 reference

Prodrug strategies in cancer therapy

21 January 2018

1 reference

Monoclonal antibodies to the myeloid stem cells: therapeutic implications of CMA-676, a humanized anti-CD33 antibody calicheamicin conjugate

21 January 2018

1 reference

Selective activation of anticancer prodrugs by monoclonal antibody-enzyme conjugates

21 January 2018

1 reference

Nitroreductase-based GDEPT.

21 January 2018

1 reference

Receptor-mediated and enzyme-dependent targeting of cytotoxic anticancer drugs

21 January 2018

1 reference

Targeting enzymes to cancers--new developments.

21 January 2018

1 reference

Measurement of the critical DNA lesions produced by antibody-directed enzyme prodrug therapy (ADEPT) in vitro, in vivo and in clinical material

21 January 2018

1 reference

Predictive ADMET studies, the challenges and the opportunities

21 January 2018

1 reference

Chemoinformatics - predicting the physicochemical properties of 'drug-like' molecules

21 January 2018

1 reference

Of mice and men: values and liabilities of the athymic nude mouse model in anticancer drug development

21 January 2018

1 reference

Simple selection criteria for drug-like chemical matter

21 January 2018

1 reference

Experimental and computational approaches to estimate solubility and permeability in drug discovery and development settings

21 January 2018

1 reference

Characteristic physical properties and structural fragments of marketed oral drugs.

21 January 2018

1 reference

Synthesis of the thapsigargins

21 January 2018

1 reference

Chemical genetics: ligand-based discovery of gene function

21 January 2018

1 reference

High-throughput screening of small molecules in miniaturized mammalian cell-based assays involving post-translational modifications

21 January 2018

1 reference

Generating Diverse Skeletons of Small Molecules Combinatorially

21 January 2018

1 reference

Systematic discovery of multicomponent therapeutics

21 January 2018

1 reference

A census of human cancer genes

21 January 2018

1 reference

DNA and its associated processes as targets for cancer therapy

21 January 2018

1 reference

NMR-driven discovery of benzoylanthranilic acid inhibitors of far upstream element binding protein binding to the human oncogene c-myc promoter.

21 January 2018

1 reference

Crystal structures of human cytochrome P450 3A4 bound to metyrapone and progesterone

21 January 2018

1 reference

Timeline: Chemotherapy and the war on cancer.

21 January 2018

1 reference

Natural products in cancer chemotherapy: past, present and future

21 January 2018

1 reference

Synthesis of the chlorofusin cyclic peptide: assignment of the asparagine stereochemistry

31 March 2020

1 reference

A small molecule transcriptional activation domain

31 March 2020

1 reference

31 March 2020

Identifiers

DOI

10.1038/NRC1587

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release_ixchtpiwhbbc5kdxtzgqniappq

12 August 2017

1 reference

Fatcat

https://api.fatcat.wiki/v0/release/ixchtpiwhbbc5kdxtzgqniappq

mapped directly with Wikidata item

24 November 2022

based on heuristic

1 reference