(Q36099400)

12 August 2017

1 reference

title

Assessment of pharmacology and potential anti-obesity properties of H3 receptor antagonists/inverse agonists (English)

1 reference

12 August 2017

0 references

Arthur A Hancock

1

1 reference

PubMed ID

15833055

12 August 2017

Michael E Brune

series ordinal

2

1 reference

PubMed ID

15833055

12 August 2017

language of work or name

English

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publication date

1 March 2005

1 reference

Expert Opinion on Investigational Drugs

12 August 2017

1 reference

12 August 2017

14

1 reference

12 August 2017

3

1 reference

12 August 2017

223-241

1 reference

Actual Causes of Death in the United States, 2000

12 August 2017

1 reference

https://api.crossref.org/works/10.1517%2F13543784.14.3.223

Prevalence of overweight and obesity among US children, adolescents, and adults, 1999-2002.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.14.3.223

Increases in Clinically Severe Obesity in the United States, 1986-2000

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.14.3.223

New US Medicare policy changes ruling that obesity is not an illness

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.14.3.223

Medical Consequences of Obesity

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.14.3.223

Obesity and the impact of chronic pain.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.14.3.223

Economic costs of obesity and inactivity

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.14.3.223

Current management strategies for coexisting diabetes mellitus and obesity

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.14.3.223

Clinical implications of obesity with specific focus on cardiovascular disease: a statement for professionals from the American Heart Association Council on Nutrition, Physical Activity, and Metabolism: endorsed by the American College of Cardiology

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.14.3.223

Longitudinal study of moderate weight change and sleep-disordered breathing

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.14.3.223

Pharmacological therapy of obesity: past, present, and future

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.14.3.223

Towards the pharmacotherapy of eating disorders

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.14.3.223

Hypothalamic control of energy balance: different peptides, different functions

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.14.3.223

Multiple neural systems controlling food intake and body weight

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.14.3.223

Neuropharmacology of the histaminergic neuron system in the brain and its relationship with behavioral disorders

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.14.3.223

Functional heterogeneity of the responses of histaminergic neuron subpopulations to various stress challenges

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.14.3.223

Subcellular distribution of histamine, GABA and galanin in tuberomamillary neurons in vitro

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.14.3.223

The physiology of brain histamine.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.14.3.223

The histamine H3 receptor as a novel therapeutic target for cognitive and sleep disorders

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.14.3.223

Differential activation of dual signaling responses by human H1 and H2 histamine receptors

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.14.3.223

Genetic and pharmacological aspects of histamine H3 receptor heterogeneity

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.14.3.223

H1-histamine receptor affinity predicts short-term weight gain for typical and atypical antipsychotic drugs.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.14.3.223

A detailed mapping of the histamine H(3) receptor and its gene transcripts in rat brain

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.14.3.223

Distribution and modulation of histamine H(3) receptors in basal ganglia and frontal cortex of healthy controls and patients with Parkinson's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.14.3.223

Orexins activate histaminergic neurons via the orexin 2 receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.14.3.223

Hyperleptinemia, visceral adiposity, and decreased glucose tolerance in mice with a targeted disruption of the histidine decarboxylase gene.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.14.3.223

Histamine-immunoreactive neurons of the tuberomammillary nucleus are innervated by alpha-melanocyte stimulating hormone-containing axons. Generation of a new histamine antiserum for ultrastructural studies

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.14.3.223

Decreased brain histamine content in hypocretin/orexin receptor-2 mutated narcoleptic dogs

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.14.3.223

Biexponential kinetics of (R)-alpha-[3H]methylhistamine binding to the rat brain H3 histamine receptor.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.14.3.223

Distinct pharmacology of rat and human histamine H(3) receptors: role of two amino acids in the third transmembrane domain

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.14.3.223

Molecular modeling and pharmacological analysis of species-related histamine H(3) receptor heterogeneity

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.14.3.223

Cloning and pharmacological characterization of the monkey histamine H3 receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.14.3.223

Molecular cloning and pharmacology of functionally distinct isoforms of the human histamine H(3) receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.14.3.223

The rat H3 receptor: gene organization and multiple isoforms.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.14.3.223

High constitutive activity of native H3 receptors regulates histamine neurons in brain.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.14.3.223

Histamine H3-receptor-mediated [35S]GTP gamma[S] binding: evidence for constitutive activity of the recombinant and native rat and human H3 receptors.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.14.3.223

Central infusion of histamine reduces fat accumulation and upregulates UCP family in leptin-resistant obese mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.14.3.223

Hypothalamic neuronal histamine: implications of its homeostatic control of energy metabolism

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.14.3.223

Histaminergic control of energy balance in rats.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.14.3.223

Neuronal Histamine Regulates Food Intake, Adiposity, and Uncoupling Protein Expression in Agouti Yellow (Ay/a) Obese Mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.14.3.223

Involvement of hypothalamic histamine H1 receptor in the regulation of feeding rhythm and obesity

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.14.3.223

Leptin and the treatment of obesity: its current status

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.14.3.223

Chronic exercise lowers the defended body weight gain and adiposity in diet-induced obese rats

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.14.3.223

High leptin level is accompanied with decreased long leptin receptor transcript in histamine deficient transgenic mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.14.3.223

Involvement of the histaminergic system in leptin-induced suppression of food intake

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.14.3.223

The role of hypothalamic histamine in leptin-induced suppression of short-term food intake in fasted rats

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.14.3.223

Targeted disruption of histamine H1-receptor attenuates regulatory effects of leptin on feeding, adiposity, and UCP family in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.14.3.223

Hypothalamic neuronal histamine as a target of leptin in feeding behavior

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.14.3.223

Histamine H1 receptors in the ventromedial hypothalamus mediate the anorectic action of the pancreatic hormone amylin

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.14.3.223

Brain histamine and feeding behavior

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.14.3.223

Learning new tricks from old dogs: beta-adrenergic receptors teach new lessons on firing up adipose tissue metabolism

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.14.3.223

Comparison of gene expression profiles between white and brown adipose tissues of rat by microarray analysis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.14.3.223

Expression of the H3 receptor in the developing CNS and brown fat suggests novel roles for histamine

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.14.3.223

L-histidine stimulates sympathetic nerve activity to brown adipose tissue in rats

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.14.3.223

Hypothalamic neuronal histamine regulates sympathetic nerve activity and expression of uncoupling protein 1 mRNA in brown adipose tissue in rats

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.14.3.223

Histidine induces lipolysis through sympathetic nerve in white adipose tissue

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.14.3.223

Histamine and betahistine in the treatment of vertigo: elucidation of mechanisms of action

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.14.3.223

The H3 receptor is involved in cholecystokinin inhibition of food intake in rats

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.14.3.223

Thioperamide, a histamine H3 receptor antagonist, powerfully suppresses peptide YY-induced food intake in rats.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.14.3.223

Neuronal histamine in the hypothalamus suppresses food intake in rats

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.14.3.223

Relationship between histamine receptors in the brain and diazepam-induced hyperphagia in rats.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.14.3.223

The role of transmembrane helix 5 in agonist binding to the human H3 receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.14.3.223

Replacement of imidazole by a piperidine moiety differentially affects the potency of histamine H3-receptor antagonists

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.14.3.223

Coordination of histamine H3 receptor antagonists with human adrenal cytochrome P450 enzymes

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.14.3.223

Investigational drugs for eating disorders

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.14.3.223

Brain penetration of the histamine H3 receptor antagonists thioperamide and clobenpropit in rat and mouse, determined with ex vivo [125I]iodophenpropit binding.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.14.3.223

Synthesis of potent non-imidazole histamine H3-receptor antagonists.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.14.3.223

Two novel and selective nonimidazole histamine H3 receptor antagonists A-304121 and A-317920: I. In vitro pharmacological effects

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.14.3.223

Antiobesity effects of A-331440, a novel non-imidazole histamine H3 receptor antagonist

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.14.3.223

Central H3R activation by thioperamide does not affect energy balance

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.14.3.223

Behavioral characterization of mice lacking histamine H(3) receptors.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.14.3.223

Targeted disruption of H3 receptors results in changes in brain histamine tone leading to an obese phenotype

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.14.3.223

Weighing the role of hypothalamic feeding neurotransmitters

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.14.3.223

A concise review on the therapeutics of obesity

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.14.3.223

Two novel and selective nonimidazole H3 receptor antagonists A-304121 and A-317920: II. In vivo behavioral and neurophysiological characterization

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.14.3.223

H3 receptor blockade by thioperamide enhances cognition in rats without inducing locomotor sensitization

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.14.3.223

Efficacy as a vector: the relative prevalence and paucity of inverse agonism

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.14.3.223

4-(2-[2-(2(R)-methylpyrrolidin-1-yl)ethyl]benzofuran-5-yl)benzonitrile and related 2-aminoethylbenzofuran H3 receptor antagonists potently enhance cognition and attention

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.14.3.223

Acute wake-promoting actions of JNJ-5207852, a novel, diamine-based H3 antagonist

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.14.3.223

D-amino acid homopiperazine amides: discovery of A-320436, a potent and selective non-imidazole histamine H(3)-receptor antagonist

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.14.3.223

A new class of potent non-imidazole H(3) antagonists: 2-aminoethylbenzofurans

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.14.3.223

In vitro optimization of structure activity relationships of analogues of A-331440 combining radioligand receptor binding assays and micronucleus assays of potential antiobesity histamine H3 receptor antagonists

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.14.3.223

Perspectives on cognitive domains, H3 receptor ligands and neurological disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.14.3.223

21 January 2018

The Epidemic of Obesity

1 reference

https://api.crossref.org/works/10.1517%2F13543784.14.3.223

10.1517/13543784.14.3.223

21 January 2018

Identifiers

DOI

1 reference

12 August 2017

1 reference

PubMed ID

15833055