(Q36099440)

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Novel allosteric agonists of M1 muscarinic acetylcholine receptors induce brain region-specific responses that correspond with behavioral effects in animal models

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scholarly article

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12 August 2017

Novel allosteric agonists of M1 muscarinic acetylcholine receptors induce brain region-specific responses that correspond with behavioral effects in animal models (English)

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12 August 2017

Colleen M. Niswender

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Colleen M Niswender

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12 August 2017

Craig W. Lindsley

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Craig W Lindsley

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12 August 2017

P. Jeffrey Conn

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P Jeffrey Conn

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Hyekyung P Cho

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12 August 2017

Ryan R. Morrison

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Ryan Morrison

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12 August 2017

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Michael Bubser

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12 August 2017

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Zixiu Xiang

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12 August 2017

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Nellie E Byun

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12 August 2017

Meredith J Noetzel

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Meredith J Noetzel

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12 August 2017

Douglas J Sheffler

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Douglas J Sheffler

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12 August 2017

Kimberly Italiano

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Kimberly Italiano

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12 August 2017

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Jacob Bode

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12 August 2017

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Evan P Lebois

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12 August 2017

Gregory J Digby

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Gregory J Digby

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12 August 2017

M. Foster Olive

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M Foster Olive

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12 August 2017

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Carrie K Jones

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12 August 2017

author name string

Thomas J Utley

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12 August 2017

Adam G Walker

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12 August 2017

Albert A Davis

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12 August 2017

Natali E Nemirovsky

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12 August 2017

Sarah E Mennenga

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12 August 2017

Bryan W Camp

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12 August 2017

Heather A Bimonte-Nelson

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12 August 2017

J Scott Daniels

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12 August 2017

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publication date

1 June 2012

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12 August 2017

Journal of Neuroscience

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12 August 2017

32

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12 August 2017

25

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12 August 2017

8532-8544

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12 August 2017

Roles of the M1 muscarinic acetylcholine receptor subtype in the regulation of basal ganglia function and implications for the treatment of Parkinson's disease.

1 reference

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2 October 2017

Discovery and characterization of novel subtype-selective allosteric agonists for the investigation of M(1) receptor function in the central nervous system

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3398407

2 October 2017

Development of a highly selective, orally bioavailable and CNS penetrant M1 agonist derived from the MLPCN probe ML071.

1 reference

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2 October 2017

Striatal origin of the pathologic beta oscillations in Parkinson's disease

1 reference

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2 October 2017

Prefrontal cortical network connections: key site of vulnerability in stress and schizophrenia

1 reference

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2 October 2017

Facilitation of long-term potentiation by muscarinic M(1) receptors is mediated by inhibition of SK channels.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3398407

2 October 2017

Discovery of novel allosteric modulators of metabotropic glutamate receptor subtype 5 reveals chemical and functional diversity and in vivo activity in rat behavioral models of anxiolytic and antipsychotic activity

1 reference

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2 October 2017

Update on the Pharmacological Treatment of Alzheimers Disease

1 reference

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2 October 2017

A selective allosteric potentiator of the M1 muscarinic acetylcholine receptor increases activity of medial prefrontal cortical neurons and restores impairments in reversal learning

1 reference

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2 October 2017

Contrasting effects of allosteric and orthosteric agonists on m1 muscarinic acetylcholine receptor internalization and down-regulation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3398407

2 October 2017

Selective activation of the M1 muscarinic acetylcholine receptor achieved by allosteric potentiation

1 reference

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2 October 2017

mGluR5 positive allosteric modulators facilitate both hippocampal LTP and LTD and enhance spatial learning

1 reference

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2 October 2017

Subtype-selective allosteric modulators of muscarinic receptors for the treatment of CNS disorders

1 reference

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2 October 2017

Novel selective allosteric activator of the M1 muscarinic acetylcholine receptor regulates amyloid processing and produces antipsychotic-like activity in rats.

1 reference

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2 October 2017

Selective muscarinic receptor agonist xanomeline as a novel treatment approach for schizophrenia

1 reference

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2 October 2017

Characterization of a CNS penetrant, selective M1 muscarinic receptor agonist, 77-LH-28-1

1 reference

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2 October 2017

Schizophrenia: moving beyond monoamine antagonists

1 reference

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2 October 2017

Re-emergence of striatal cholinergic interneurons in movement disorders

1 reference

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2 October 2017

Alzheimer's disease and the basal forebrain cholinergic system: relations to beta-amyloid peptides, cognition, and treatment strategies

1 reference

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2 October 2017

Hyperactivity, elevated dopaminergic transmission, and response to amphetamine in M1 muscarinic acetylcholine receptor-deficient mice

1 reference

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2 October 2017

Therapeutic opportunities for muscarinic receptors in the central nervous system

1 reference

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2 October 2017

Cognition, schizophrenia, and the atypical antipsychotic drugs

1 reference

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2 October 2017

Activation of the genetically defined m1 muscarinic receptor potentiates N-methyl-D-aspartate (NMDA) receptor currents in hippocampal pyramidal cells

1 reference

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2 October 2017

Effects of xanomeline, a selective muscarinic receptor agonist, on cognitive function and behavioral symptoms in Alzheimer disease

1 reference

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2 October 2017

AC-260584, an orally bioavailable M(1) muscarinic receptor allosteric agonist, improves cognitive performance in an animal model

1 reference

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2 July 2018

Scopolamine selectively disrupts the acquisition of contextual fear conditioning in rats

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Differential receptor occupancy requirements for muscarinic cholinergic stimulation of inositol lipid hydrolysis in brain and in neuroblastomas.

1 reference

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2 July 2018

Antipsychotic-like behavioral effects and cognitive enhancement by a potent and selective muscarinic M-sub-1 receptor agonist, AC-260584.

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Multiple Gq-coupled receptors converge on a common protein synthesis-dependent long-term depression that is affected in fragile X syndrome mental retardation.

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Cholinergic modulation of Kir2 channels selectively elevates dendritic excitability in striatopallidal neurons.

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Coexistence of muscarinic long-term depression with electrically induced long-term potentiation and depression at CA3-CA1 synapses

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Sympathetic sprouting drives hippocampal cholinergic reinnervation that prevents loss of a muscarinic receptor-dependent long-term depression at CA3-CA1 synapses.

1 reference

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Modulation of synaptic plasticity by physiological activation of M1 muscarinic acetylcholine receptors in the mouse hippocampus.

1 reference

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Pharmacologic interactions between the muscarinic cholinergic and dopaminergic systems in the modulation of prepulse inhibition in rats

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The muscarinic M1/M4 receptor agonist xanomeline exhibits antipsychotic-like activity in Cebus apella monkeys

1 reference

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Selective cognitive dysfunction in acetylcholine M1 muscarinic receptor mutant mice

1 reference

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The muscarinic receptor agonist xanomeline has an antipsychotic-like profile in the rat.

1 reference

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Hyperactivity and intact hippocampus-dependent learning in mice lacking the M1 muscarinic acetylcholine receptor.

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The muscarinic agonist xanomeline increases monoamine release and immediate early gene expression in the rat prefrontal cortex

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Xanomeline, an M(1)/M(4) preferring muscarinic cholinergic receptor agonist, produces antipsychotic-like activity in rats and mice.

1 reference

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The selective muscarinic agonist xanomeline improves both the cognitive deficits and behavioral symptoms of Alzheimer disease.

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Differential regulation of molecular subtypes of muscarinic receptors in Alzheimer's disease.

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Cholinergic receptor blockade impairs spatial localization by use of distal cues in the rat.

1 reference

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G protein coupling and signaling pathway activation by m1 muscarinic acetylcholine receptor orthosteric and allosteric agonists.

1 reference

https://pubmed.ncbi.nlm.nih.gov/22723693

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Expression of m1-m4 muscarinic acetylcholine receptor proteins in rat hippocampus and regulation by cholinergic innervation

1 reference

https://pubmed.ncbi.nlm.nih.gov/22723693

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1523/JNEUROSCI.0337-12.2012

1 reference

Europe PubMed Central

PMC publication ID

12 August 2017

PMC publication ID

1 reference

Europe PubMed Central

PMC publication ID

12 August 2017

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

12 August 2017

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