(Q30474039)

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Discovery and characterization of novel subtype-selective allosteric agonists for the investigation of M(1) receptor function in the central nervous system

scientific article published on January 2010

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scholarly article

1 reference

Europe PubMed Central

PMC publication ID

4 September 2017

Discovery and characterization of novel subtype-selective allosteric agonists for the investigation of M(1) receptor function in the central nervous system (English)

1 reference

Europe PubMed Central

PMC publication ID

4 September 2017

10

1 reference

Europe PubMed Central

PubMed publication ID

21 June 2017

object named as

Zixiu Xiang

6

0 references

object named as

Huiyong Yin

8

0 references

Colleen M. Niswender

11

object named as

Colleen M Niswender

1 reference

Europe PubMed Central

PMC publication ID

4 September 2017

P. Jeffrey Conn

13

object named as

P Jeffrey Conn

1 reference

Europe PubMed Central

PMC publication ID

4 September 2017

Craig W. Lindsley

15

object named as

Craig W Lindsley

1 reference

Europe PubMed Central

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4 September 2017

1

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Evan P Lebois

1 reference

Europe PubMed Central

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4 September 2017

4

object named as

Eric S Dawson

1 reference

Europe PubMed Central

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4 September 2017

12

object named as

Carrie K Jones

1 reference

Europe PubMed Central

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4 September 2017

author name string

Thomas M Bridges

2

1 reference

Europe PubMed Central

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4 September 2017

L Michelle Lewis

3

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Europe PubMed Central

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4 September 2017

Alexander S Kane

5

1 reference

Europe PubMed Central

PMC publication ID

4 September 2017

Satyawan B Jadhav

7

1 reference

Europe PubMed Central

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4 September 2017

J Phillip Kennedy

9

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Europe PubMed Central

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4 September 2017

C David Weaver

14

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Europe PubMed Central

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4 September 2017

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publication date

1 January 2010

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Europe PubMed Central

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4 September 2017

ACS Chemical Neuroscience

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Europe PubMed Central

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4 September 2017

1

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Europe PubMed Central

PMC publication ID

4 September 2017

2

1 reference

Europe PubMed Central

PMC publication ID

4 September 2017

104-121

1 reference

Europe PubMed Central

PMC publication ID

4 September 2017

Discovery of the first highly M5-preferring muscarinic acetylcholine receptor ligand, an M5 positive allosteric modulator derived from a series of 5-trifluoromethoxy N-benzyl isatins

1 reference

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20 June 2018

A novel selective muscarinic acetylcholine receptor subtype 1 antagonist reduces seizures without impairing hippocampus-dependent learning

1 reference

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20 June 2018

Subtype-selective allosteric modulators of muscarinic receptors for the treatment of CNS disorders

1 reference

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20 June 2018

Pharmacological comparison of muscarinic ligands: historical versus more recent muscarinic M1-preferring receptor agonists

1 reference

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20 June 2018

Allosteric modulators of GPCRs: a novel approach for the treatment of CNS disorders

1 reference

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20 June 2018

Discovery and characterization of novel allosteric potentiators of M1 muscarinic receptors reveals multiple modes of activity

1 reference

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20 June 2018

Mutagenic mapping suggests a novel binding mode for selective agonists of M1 muscarinic acetylcholine receptors

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3180826

20 June 2018

Novel selective allosteric activator of the M1 muscarinic acetylcholine receptor regulates amyloid processing and produces antipsychotic-like activity in rats.

1 reference

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20 June 2018

Centrally active allosteric potentiators of the M4 muscarinic acetylcholine receptor reverse amphetamine-induced hyperlocomotor activity in rats

1 reference

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20 June 2018

Allosteric modulation of the muscarinic M4 receptor as an approach to treating schizophrenia

1 reference

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20 June 2018

G-protein-coupled receptors: from classical modes of modulation to allosteric mechanisms

1 reference

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20 June 2018

Selective muscarinic receptor agonist xanomeline as a novel treatment approach for schizophrenia

1 reference

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20 June 2018

Layer 2/3 synapses in monocular and binocular regions of tree shrew visual cortex express mAChR-dependent long-term depression and long-term potentiation

1 reference

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20 June 2018

Characterization of a CNS penetrant, selective M1 muscarinic receptor agonist, 77-LH-28-1

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3180826

20 June 2018

Allosteric modulation of kinases and GPCRs: design principles and structural diversity

1 reference

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20 June 2018

M1 muscarinic agonists target major hallmarks of Alzheimer's disease--the pivotal role of brain M1 receptors

1 reference

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20 June 2018

Application of combinatorial chemistry science on modern drug discovery

1 reference

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20 June 2018

Muscarinic acetylcholine receptors as CNS drug targets

1 reference

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20 June 2018

An allosteric potentiator of M4 mAChR modulates hippocampal synaptic transmission

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3180826

20 June 2018

High-resolution crystal structure of an engineered human beta2-adrenergic G protein-coupled receptor

1 reference

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20 June 2018

Muscarinic acetylcholine receptors: mutant mice provide new insights for drug development

1 reference

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20 June 2018

Altered hippocampal muscarinic M4, but not M1, receptor expression from subjects with schizophrenia.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3180826

20 June 2018

Towards a muscarinic hypothesis of schizophrenia.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3180826

20 June 2018

Muscarinic receptors: their distribution and function in body systems, and the implications for treating overactive bladder

1 reference

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20 June 2018

Current pharmacotherapy for Alzheimer's disease

1 reference

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20 June 2018

1 reference

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20 June 2018

Acetylcholinesterase inhibition in Alzheimer's Disease

1 reference

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20 June 2018

Muscarinic acetylcholine receptor subtypes in cerebral cortex and hippocampus

1 reference

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20 June 2018

N-desmethylclozapine, an allosteric agonist at muscarinic 1 receptor, potentiates N-methyl- d -aspartate receptor activity

1 reference

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20 June 2018

Xanomeline and the antipsychotic potential of muscarinic receptor subtype selective agonists.

1 reference

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20 June 2018

Discovery of an ectopic activation site on the M(1) muscarinic receptor

1 reference

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20 June 2018

Elucidating the role of muscarinic receptors in psychosis

1 reference

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20 June 2018

On neurodegenerative diseases, models, and treatment strategies: lessons learned and lessons forgotten a generation following the cholinergic hypothesis

1 reference

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20 June 2018

Activation of the genetically defined m1 muscarinic receptor potentiates N-methyl-D-aspartate (NMDA) receptor currents in hippocampal pyramidal cells

1 reference

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Effects of xanomeline, a selective muscarinic receptor agonist, on cognitive function and behavioral symptoms in Alzheimer disease

1 reference

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Immunological localization of m1-m5 muscarinic acetylcholine receptors in peripheral tissues and brain

1 reference

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Muscarinic acetylcholine receptor status in Alzheimer's disease assessed using (R, R) 123I-QNB SPECT.

1 reference

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26 November 2018

Muscarinic acetylcholine receptor knockout mice show distinct synaptic plasticity impairments in the visual cortex

1 reference

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26 November 2018

ROSETTALIGAND: protein-small molecule docking with full side-chain flexibility.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3180826

26 November 2018

M1 receptors play a central role in modulating AD-like pathology in transgenic mice

1 reference

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26 November 2018

Modulation of synaptic plasticity by physiological activation of M1 muscarinic acetylcholine receptors in the mouse hippocampus.

1 reference

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26 November 2018

Probing the molecular mechanism of interaction between 4-n-butyl-1-[4-(2-methylphenyl)-4-oxo-1-butyl]-piperidine (AC-42) and the muscarinic M(1) receptor: direct pharmacological evidence that AC-42 is an allosteric agonist

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3180826

26 November 2018

Selective cognitive dysfunction in acetylcholine M1 muscarinic receptor mutant mice

1 reference

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26 November 2018

Identifiers

10.1021/CN900003H

1 reference

Europe PubMed Central

PMC publication ID

4 September 2017

PMC publication ID

1 reference

Europe PubMed Central

PMC publication ID

4 September 2017

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

4 September 2017

ResearchGate publication ID

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