(Q24657785)

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A selective allosteric potentiator of the M1 muscarinic acetylcholine receptor increases activity of medial prefrontal cortical neurons and restores impairments in reversal learning

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A selective allosteric potentiator of the M1 muscarinic acetylcholine receptor increases activity of medial prefrontal cortical neurons and restores impairments in reversal learning (English)

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P. Jeffrey Conn

19

object named as

P Jeffrey Conn

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Craig W. Lindsley

18

object named as

Craig W Lindsley

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8

object named as

Usha N Menon

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Jana K Shirey-Rice

1

object named as

Jana K Shirey

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2

object named as

Ashley E Brady

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9

object named as

Zixiu Xiang

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Paulianda J Jones

3

object named as

Paulianda J Jones

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15

object named as

James J Lah

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16

object named as

Allan I Levey

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author name string

Albert A Davis

4

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Thomas M Bridges

5

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J Phillip Kennedy

6

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Satyawan B Jadhav

7

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Mona L Watson

10

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Edward P Christian

11

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James J Doherty

12

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Michael C Quirk

13

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Dean H Snyder

14

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Michelle M Nicolle

17

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language of work or name

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publication date

11 November 2009

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Journal of Neuroscience

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29

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45

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14271-86

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Subtype-selective allosteric modulators of muscarinic receptors for the treatment of CNS disorders

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Discovery and characterization of novel allosteric potentiators of M1 muscarinic receptors reveals multiple modes of activity

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Synaptic mechanisms modulated by acetylcholine in cerebral cortex.

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Discovery of an ectopic activation site on the M(1) muscarinic receptor

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Activation of muscarinic receptors inhibits beta-amyloid peptide-induced signaling in cortical slices.

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Selective cognitive dysfunction in acetylcholine M1 muscarinic receptor mutant mice

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Hyperactivity and intact hippocampus-dependent learning in mice lacking the M1 muscarinic acetylcholine receptor.

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The selective muscarinic M1 agonist AF102B decreases levels of total Abeta in cerebrospinal fluid of patients with Alzheimer's disease.

1 reference

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Muscarinic-induced modulation of potassium conductances is unchanged in mouse hippocampal pyramidal cells that lack functional M1 receptors

1 reference

https://pubmed.ncbi.nlm.nih.gov/19906975

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Selective activation of the M1 muscarinic acetylcholine receptor achieved by allosteric potentiation

1 reference

https://pubmed.ncbi.nlm.nih.gov/19906975

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Regulated secretion of beta-amyloid precursor protein in rat brain

1 reference

https://pubmed.ncbi.nlm.nih.gov/19906975

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1523/JNEUROSCI.3930-09.2009

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