(Q36123872)

12 August 2017

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title

SAC-ing mitotic errors: how the spindle assembly checkpoint (SAC) plays defense against chromosome mis-segregation (English)

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12 August 2017

Sheila Kadura

1

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PubMed ID

15887295

12 August 2017

Shelley Sazer

series ordinal

2

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12 August 2017

1 July 2005

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12 August 2017

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12 August 2017

61

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12 August 2017

145-160

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12 August 2017

3

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Mutations in the essential spindle checkpoint gene bub1 cause chromosome missegregation and fail to block apoptosis in Drosophila

12 August 2017

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The spindle checkpoint of budding yeast depends on a tight complex between the Mad1 and Mad2 proteins

21 January 2018

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HEC, a novel nuclear protein rich in leucine heptad repeats specifically involved in mitosis

21 January 2018

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Fission yeast Ste9, a homolog of Hct1/Cdh1 and Fizzy-related, is a novel negative regulator of cell cycle progression during G1-phase

21 January 2018

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Abnormal kinetochore structure activates the spindle assembly checkpoint in budding yeast

21 January 2018

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The Saccharomyces cerevisiae checkpoint gene BUB1 encodes a novel protein kinase

21 January 2018

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The dephosphorylated form of the anaphase-promoting complex protein Cdc27/Apc3 concentrates on kinetochores and chromosome arms in mitosis

21 January 2018

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Hec1p, an evolutionarily conserved coiled-coil protein, modulates chromosome segregation through interaction with SMC proteins

21 January 2018

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CENP-E as an essential component of the mitotic checkpoint in vitro.

21 January 2018

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7 January 2021

Mps1 is a kinetochore-associated kinase essential for the vertebrate mitotic checkpoint.

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7 January 2021

The anaphase promoting complex/cyclosome is recruited to centromeres by the spindle assembly checkpoint.

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7 January 2021

Sister chromatid separation and chromosome re-duplication are regulated by different mechanisms in response to spindle damage

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7 January 2021

AURORA-A amplification overrides the mitotic spindle assembly checkpoint, inducing resistance to Taxol

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7 January 2021

Rae1 is an essential mitotic checkpoint regulator that cooperates with Bub3 to prevent chromosome missegregation

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7 January 2021

BubR1 insufficiency causes early onset of aging-associated phenotypes and infertility in mice.

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7 January 2021

Men and sin: what's the difference?

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7 January 2021

Rough deal and Zw10 are required for the metaphase checkpoint in Drosophila

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7 January 2021

Localization of the Drosophila checkpoint control protein Bub3 to the kinetochore requires Bub1 but not Zw10 or Rod.

1 reference

7 January 2021

Fission yeast bub1 is a mitotic centromere protein essential for the spindle checkpoint and the preservation of correct ploidy through mitosis

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7 January 2021

Fission yeast Bub1 is essential in setting up the meiotic pattern of chromosome segregation

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7 January 2021

The spindle checkpoint, aneuploidy, and cancer

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7 January 2021

The budding yeast protein kinase Ipl1/Aurora allows the absence of tension to activate the spindle checkpoint

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7 January 2021

Complex formation between Mad1p, Bub1p and Bub3p is crucial for spindle checkpoint function

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7 January 2021

Complexity in the spindle checkpoint

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7 January 2021

Mutations of mitotic checkpoint genes in human cancers

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7 January 2021

Genetic instability and darwinian selection in tumours

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7 January 2021

Analysis of Bub3 spindle checkpoint function in Xenopus egg extracts.

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7 January 2021

Microinjection of mitotic cells with the 3F3/2 anti-phosphoepitope antibody delays the onset of anaphase

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7 January 2021

Survivin is required for stable checkpoint activation in taxol-treated HeLa cells

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7 January 2021

Human BUBR1 is a mitotic checkpoint kinase that monitors CENP-E functions at kinetochores and binds the cyclosome/APC

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7 January 2021

Human Zw10 and ROD are mitotic checkpoint proteins that bind to kinetochores

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7 January 2021

A conserved protein network controls assembly of the outer kinetochore and its ability to sustain tension

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7 January 2021

BubR1 is essential for kinetochore localization of other spindle checkpoint proteins and its phosphorylation requires Mad1.

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7 January 2021

Association of spindle assembly checkpoint component XMAD2 with unattached kinetochores

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7 January 2021

Spindle checkpoint protein Xmad1 recruits Xmad2 to unattached kinetochores

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7 January 2021

Phosphorylation of Cdc20 is required for its inhibition by the spindle checkpoint.

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7 January 2021

Centromeres and kinetochores: from epigenetics to mitotic checkpoint signaling

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7 January 2021

Monoclonal antibodies specific for thiophosphorylated proteins recognize Xenopus MPF.

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7 January 2021

Slippage of mitotic arrest and enhanced tumor development in mice with BubR1 haploinsufficiency

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7 January 2021

The 3F3/2 anti-phosphoepitope antibody binds the mitotically phosphorylated anaphase-promoting complex/cyclosome

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7 January 2021

Nuf2 and Hec1 are required for retention of the checkpoint proteins Mad1 and Mad2 to kinetochores

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7 January 2021

Aurora B couples chromosome alignment with anaphase by targeting BubR1, Mad2, and Cenp-E to kinetochores

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7 January 2021

Chromosome missegregation and apoptosis in mice lacking the mitotic checkpoint protein Mad2

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7 January 2021

Aurora kinases in spindle assembly and chromosome segregation

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7 January 2021

A Bub2p-dependent spindle checkpoint pathway regulates the Dbf2p kinase in budding yeast.

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7 January 2021

The mitotic arrest in response to hypoxia and of polar bodies during early embryogenesis requires Drosophila Mps1.

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7 January 2021

The mouse Mps1p-like kinase regulates centrosome duplication

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7 January 2021

Human Mps1 protein kinase is required for centrosome duplication and normal mitotic progression

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7 January 2021

Budding yeast Bub2 is localized at spindle pole bodies and activates the mitotic checkpoint via a different pathway from Mad2

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7 January 2021

Bub3 interaction with Mad2, Mad3 and Cdc20 is mediated by WD40 repeats and does not require intact kinetochores

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7 January 2021

Cut2 proteolysis required for sister-chromatid seperation in fission yeast

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7 January 2021

Byr4 and Cdc16 form a two-component GTPase-activating protein for the Spg1 GTPase that controls septation in fission yeast

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7 January 2021

Fission yeast ch-TOG/XMAP215 homologue Alp14 connects mitotic spindles with the kinetochore and is a component of the Mad2-dependent spindle checkpoint

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7 January 2021

Spindle checkpoint proteins and chromosome-microtubule attachment in budding yeast

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7 January 2021

Microinjection of antibody to Mad2 protein into mammalian cells in mitosis induces premature anaphase

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7 January 2021

Proper metaphase spindle length is determined by centromere proteins Mis12 and Mis6 required for faithful chromosome segregation

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7 January 2021

Human centromere chromatin protein hMis12, essential for equal segregation, is independent of CENP-A loading pathway

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7 January 2021

The control of septum formation in fission yeast

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7 January 2021

Regulation of cell division: stop the SIN!

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7 January 2021

Dma1 prevents mitotic exit and cytokinesis by inhibiting the septation initiation network (SIN)

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7 January 2021

Breast cancer-specific gene 1 interacts with the mitotic checkpoint kinase BubR1

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7 January 2021

Identification of a MAD2-binding protein, CMT2, and its role in mitosis

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7 January 2021

Constitutional aneuploidy and cancer predisposition caused by biallelic mutations in BUB1B.

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7 January 2021

The spindle checkpoint.

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7 January 2021

Mad1p, a phosphoprotein component of the spindle assembly checkpoint in budding yeast

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7 January 2021

Activation of the budding yeast spindle assembly checkpoint without mitotic spindle disruption.

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7 January 2021

MAD3 encodes a novel component of the spindle checkpoint which interacts with Bub3p, Cdc20p, and Mad2p

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7 January 2021

Cell cycle control and cancer

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7 January 2021

The small molecule Hesperadin reveals a role for Aurora B in correcting kinetochore-microtubule attachment and in maintaining the spindle assembly checkpoint

1 reference

7 January 2021

The Schizosaccharomyces pombe spindle checkpoint protein mad2p blocks anaphase and genetically interacts with the anaphase-promoting complex

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7 January 2021

Rb inactivation promotes genomic instability by uncoupling cell cycle progression from mitotic control.

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7 January 2021

Visualization of Mad2 dynamics at kinetochores, along spindle fibers, and at spindle poles in living cells

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7 January 2021

Cytoplasmic dynein/dynactin drives kinetochore protein transport to the spindle poles and has a role in mitotic spindle checkpoint inactivation

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7 January 2021

Spindle checkpoint protein dynamics at kinetochores in living cells.

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7 January 2021

S. cerevisiae genes required for cell cycle arrest in response to loss of microtubule function

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7 January 2021

Budding yeast Cdc20: a target of the spindle checkpoint.

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7 January 2021

The hBUB1 and hBUBR1 kinases sequentially assemble onto kinetochores during prophase with hBUBR1 concentrating at the kinetochore plates in mitosis

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7 January 2021

The budding yeast proteins Spc24p and Spc25p interact with Ndc80p and Nuf2p at the kinetochore and are important for kinetochore clustering and checkpoint control

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7 January 2021

Human T cell leukemia virus type 1 oncoprotein Tax targets the human mitotic checkpoint protein MAD1

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7 January 2021

Chemical genetics reveals a role for Mps1 kinase in kinetochore attachment during mitosis

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7 January 2021

The A78V mutation in the Mad3-like domain of Schizosaccharomyces pombe Bub1p perturbs nuclear accumulation and kinetochore targeting of Bub1p, Bub3p, and Mad3p and spindle assembly checkpoint function

1 reference

7 January 2021

Mammalian p55CDC mediates association of the spindle checkpoint protein Mad2 with the cyclosome/anaphase-promoting complex, and is involved in regulating anaphase onset and late mitotic events

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7 January 2021

Rapid microtubule-independent dynamics of Cdc20 at kinetochores and centrosomes in mammalian cells

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7 January 2021

Mad1p, a component of the spindle assembly checkpoint in fission yeast, suppresses a novel septation-defective mutant,sun1, in a cell-division cycle

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7 January 2021

Fission yeast Slp1: an effector of the Mad2-dependent spindle checkpoint

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7 January 2021

Components of the spindle-assembly checkpoint are essential in Caenorhabditis elegans

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7 January 2021

Activation of the human anaphase-promoting complex by proteins of the CDC20/Fizzy family

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7 January 2021

SIN and the art of splitting the fission yeast cell

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7 January 2021

Bipolar orientation of chromosomes in Saccharomyces cerevisiae is monitored by Mad1 and Mad2, but not by Mad3.

1 reference

7 January 2021

Survivin is required for a sustained spindle checkpoint arrest in response to lack of tension

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7 January 2021

The Spindle Assembly and Spindle Position Checkpoints

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7 January 2021

Bifurcation of the mitotic checkpoint pathway in budding yeast

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7 January 2021

Feedback control of mitosis in budding yeast

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7 January 2021

Mitotic forces control a cell-cycle checkpoint

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7 January 2021

Identification of a human mitotic checkpoint gene: hsMAD2

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7 January 2021

Human MPS1 kinase is required for mitotic arrest induced by the loss of CENP-E from kinetochores

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7 January 2021

NEK2A interacts with MAD1 and possibly functions as a novel integrator of the spindle checkpoint signaling

1 reference

7 January 2021

The dynamic kinetochore-microtubule interface

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7 January 2021

Activating and silencing the mitotic checkpoint through CENP-E-dependent activation/inactivation of BubR1.

1 reference

7 January 2021

Role of Hec1 in spindle checkpoint signaling and kinetochore recruitment of Mad1/Mad2

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7 January 2021

The highly conserved Ndc80 complex is required for kinetochore assembly, chromosome congression, and spindle checkpoint activity

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7 January 2021

The vertebrate Ndc80 complex contains Spc24 and Spc25 homologs, which are required to establish and maintain kinetochore-microtubule attachment

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7 January 2021

Timing is everything: regulation of mitotic exit and cytokinesis by the MEN and SIN.

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7 January 2021

Chromosome-microtubule interactions during mitosis

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7 January 2021

Aurora-A overexpression reveals tetraploidization as a major route to centrosome amplification in p53-/- cells

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7 January 2021

Timing and checkpoints in the regulation of mitotic progression

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7 January 2021

Aurora kinases link chromosome segregation and cell division to cancer susceptibility

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7 January 2021

MAD2 haplo-insufficiency causes premature anaphase and chromosome instability in mammalian cells

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7 January 2021

Fission yeast Mad3p is required for Mad2p to inhibit the anaphase-promoting complex and localizes to kinetochores in a Bub1p-, Bub3p-, and Mph1p-dependent manner

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7 January 2021

The awesome power of multiple model systems: interpreting the complex nature of spindle checkpoint signaling

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7 January 2021

Chromosome damage and progression into and through mitosis in vertebrates.

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7 January 2021

A conserved protein, Nuf2, is implicated in connecting the centromere to the spindle during chromosome segregation: a link between the kinetochore function and the spindle checkpoint

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7 January 2021

Control of the yeast cell cycle by the Cdc28 protein kinase

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7 January 2021

How cells get the right chromosomes

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7 January 2021

A conserved Mis12 centromere complex is linked to heterochromatic HP1 and outer kinetochore protein Zwint-1

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7 January 2021

Mammalian BUB1 protein kinases: map positions and in vivo expression

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7 January 2021

Hormone-induced chromosomal instability in p53-null mammary epithelium

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7 January 2021

S. pombe aurora kinase/survivin is required for chromosome condensation and the spindle checkpoint attachment response

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7 January 2021

An Mtw1 complex promotes kinetochore biorientation that is monitored by the Ipl1/Aurora protein kinase

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7 January 2021

Heart regeneration in zebrafish

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7 January 2021

Germ cell aneuploidy in zebrafish with mutations in the mitotic checkpoint gene mps1.

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7 January 2021

Stuck in division or passing through: what happens when cells cannot satisfy the spindle assembly checkpoint

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7 January 2021

Anaphase onset in vertebrate somatic cells is controlled by a checkpoint that monitors sister kinetochore attachment to the spindle

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7 January 2021

The checkpoint delaying anaphase in response to chromosome monoorientation is mediated by an inhibitory signal produced by unattached kinetochores

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7 January 2021

Yeast Hct1 is a regulator of Clb2 cyclin proteolysis

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7 January 2021

Loss of Sin3/Rpd3 histone deacetylase restores the DNA damage response in checkpoint-deficient strains of Saccharomyces cerevisiae

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7 January 2021

Phosphorylation of human MAD1 by the BUB1 kinase in vitro

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7 January 2021

Spindle checkpoint protein Bub1 is required for kinetochore localization of Mad1, Mad2, Bub3, and CENP-E, independently of its kinase activity

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7 January 2021

Principles of tumor suppression

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7 January 2021

Requirement of the spindle checkpoint for proper chromosome segregation in budding yeast meiosis

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7 January 2021

Exit from mitosis is triggered by Tem1-dependent release of the protein phosphatase Cdc14 from nucleolar RENT complex

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7 January 2021

Mammalian mad2 and bub1/bubR1 recognize distinct spindle-attachment and kinetochore-tension checkpoints

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7 January 2021

Lack of tension at kinetochores activates the spindle checkpoint in budding yeast

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7 January 2021

Kinetochore localization and microtubule interaction of the human spindle checkpoint kinase Mps1

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7 January 2021

Human Mps1 kinase is required for the spindle assembly checkpoint but not for centrosome duplication

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7 January 2021

Checkpoint inhibition of the APC/C in HeLa cells is mediated by a complex of BUBR1, BUB3, CDC20, and MAD2

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7 January 2021

Identification of frequent impairment of the mitotic checkpoint and molecular analysis of the mitotic checkpoint genes, hsMAD2 and p55CDC, in human lung cancers

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7 January 2021

Essential tension and constructive destruction: the spindle checkpoint and its regulatory links with mitotic exit

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7 January 2021

Evidence that the Ipl1-Sli15 (Aurora kinase-INCENP) complex promotes chromosome bi-orientation by altering kinetochore-spindle pole connections

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7 January 2021

Mad2-Independent inhibition of APCCdc20 by the mitotic checkpoint protein BubR1.

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7 January 2021

Phosphorylation of Cdc20 by Bub1 provides a catalytic mechanism for APC/C inhibition by the spindle checkpoint

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7 January 2021

Chromosome segregation: dual control ensures fidelity.

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7 January 2021

Kinetochore localization of murine Bub1 is required for normal mitotic timing and checkpoint response to spindle damage

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7 January 2021

The human homologue of Bub3 is required for kinetochore localization of Bub1 and a Mad3/Bub1-related protein kinase

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7 January 2021

The spindle checkpoint: a quality control mechanism which ensures accurate chromosome segregation

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7 January 2021

Sister-chromatid separation at anaphase onset is promoted by cleavage of the cohesin subunit Scc1

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7 January 2021

The fission yeast cut1+ gene regulates spindle pole body duplication and has homology to the budding yeast ESP1 gene

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7 January 2021

Kinetochore targeting of fission yeast Mad and Bub proteins is essential for spindle checkpoint function but not for all chromosome segregation roles of Bub1p

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7 January 2021

The fission yeast gamma-tubulin complex is required in G(1) phase and is a component of the spindle assembly checkpoint

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7 January 2021

Kinetochore localization of spindle checkpoint proteins: who controls whom?

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7 January 2021

CDC20 and CDH1: a family of substrate-specific activators of APC-dependent proteolysis.

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7 January 2021

The phosphatase Cdc14 triggers mitotic exit by reversal of Cdk-dependent phosphorylation

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7 January 2021

Cell cycle: Waiters serving the Destruction machinery

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7 January 2021

Human Zwint-1 specifies localization of Zeste White 10 to kinetochores and is essential for mitotic checkpoint signaling

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7 January 2021

BUBR1 deficiency results in abnormal megakaryopoiesis

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7 January 2021

The mitotic checkpoint protein hBUB3 and the mRNA export factor hRAE1 interact with GLE2p-binding sequence (GLEBS)-containing proteins

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7 January 2021

The Bfa1/Bub2 GAP complex comprises a universal checkpoint required to prevent mitotic exit.

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7 January 2021

Distinct chromosome segregation roles for spindle checkpoint proteins

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7 January 2021

Mitotic checkpoints: from yeast to cancer

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7 January 2021

Mad2 phosphorylation regulates its association with Mad1 and the APC/C.

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7 January 2021

Localization of Mad2 to kinetochores depends on microtubule attachment, not tension

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7 January 2021

Centromere-associated protein-E is essential for the mammalian mitotic checkpoint to prevent aneuploidy due to single chromosome loss

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7 January 2021

The Saccharomyces cerevisiae spindle pole body duplication gene MPS1 is part of a mitotic checkpoint

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7 January 2021

The spindle-assembly checkpoint: aiming for a perfect mitosis, every time

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7 January 2021

The Ndc80p complex from Saccharomyces cerevisiae contains conserved centromere components and has a function in chromosome segregation

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7 January 2021

Centrosomes and checkpoints: the MPS1 family of kinases

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7 January 2021

MPS1 and MPS2: novel yeast genes defining distinct steps of spindle pole body duplication

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7 January 2021

Three-dimensional ultrastructural analysis of the Saccharomyces cerevisiae mitotic spindle

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7 January 2021

Kinetochore dynein: its dynamics and role in the transport of the Rough deal checkpoint protein

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7 January 2021

CENP-E is a plus end-directed kinetochore motor required for metaphase chromosome alignment

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7 January 2021

Function of Cdc2p-dependent Bub1p phosphorylation and Bub1p kinase activity in the mitotic and meiotic spindle checkpoint

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7 January 2021

Pds1p, an inhibitor of anaphase in budding yeast, plays a critical role in the APC and checkpoint pathway(s).

1 reference

7 January 2021

Cell cycle mechanisms of sister chromatid separation; roles of Cut1/separin and Cut2/securin

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7 January 2021

CENP-E forms a link between attachment of spindle microtubules to kinetochores and the mitotic checkpoint

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7 January 2021

WD repeat-containing mitotic checkpoint proteins act as transcriptional repressors during interphase

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7 January 2021

Regulation of APC-Cdc20 by the spindle checkpoint

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7 January 2021

Attachment and tension in the spindle assembly checkpoint

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7 January 2021

Identifiers

DOI

10.1002/CM.20072

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12 August 2017

1 reference

PubMed ID

15887295