(Q36145741)

12 August 2017

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title

Practical formulation and process development of freeze-dried products (English)

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12 August 2017

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J Jeff Schwegman

1

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12 August 2017

Lisa M Hardwick

series ordinal

2

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12 August 2017

Michael J Akers

series ordinal

3

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12 August 2017

publication date

1 January 2005

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Pharmaceutical Development and Technology

12 August 2017

published in

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12 August 2017

volume

10

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12 August 2017

issue

2

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12 August 2017

page(s)

151-173

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Phase separation of excipients during lyophilization: effects on protein stability

12 August 2017

cites work

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Rational design of stable lyophilized protein formulations: some practical advice

21 January 2018

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Surface denaturation at solid-void interface--a possible pathway by which opalescent particulates form during the storage of lyophilized tissue-type plasminogen activator at high temperatures

21 January 2018

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Effect of process conditions on recovery of protein activity after freezing and freeze-drying

21 January 2018

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The ice nucleation temperature determines the primary drying rate of lyophilization for samples frozen on a temperature-controlled shelf

21 January 2018

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A study of the impact of freezing on the lyophilization of a concentrated formulation with a high fill depth

21 January 2018

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Maintenance of quaternary structure in the frozen state stabilizes lactate dehydrogenase during freeze-drying

21 January 2018

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Hydrogen bonding between sugar and protein is responsible for inhibition of dehydration-induced protein unfolding.

21 January 2018

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Maltodextrins as lyoprotectants in the lyophilization of a model protein, LDH.

21 January 2018

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Lyophilization of protein formulations in vials: investigation of the relationship between resistance to vapor flow during primary drying and small-scale product collapse

21 January 2018

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Physical chemistry of freeze-drying: measurement of sublimation rates for frozen aqueous solutions by a microbalance technique

21 January 2018

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Mass and heat transfer in vial freeze-drying of pharmaceuticals: role of the vial.

21 January 2018

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Optimizing the lyophilization cycle and the consequences of collapse on the pharmaceutical acceptability of Erwinia L-asparaginase

21 January 2018

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Development of an efficient single-step freeze-drying cycle for protein formulations.

21 January 2018

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Determining the water sorption monolayer of lyophilized pharmaceutical proteins.

21 January 2018

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Probing hydration and the stability of protein solutions--a colloid science approach

21 January 2018

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Effects of annealing lyophilized and spray-lyophilized formulations of recombinant human interferon-gamma.

21 January 2018

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Surface adsorption of recombinant human interferon-gamma in lyophilized and spray-lyophilized formulations

21 January 2018

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The effects of Tween 20 and sucrose on the stability of anti-L-selectin during lyophilization and reconstitution

21 January 2018

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Determination of molecular mobility of lyophilized bovine serum albumin and gamma-globulin by solid-state 1H NMR and relation to aggregation-susceptibility

21 January 2018

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The effect of excipients on the molecular mobility of lyophilized formulations, as measured by glass transition temperature and NMR relaxation-based critical mobility temperature

21 January 2018

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Molecular mobility of protein in lyophilized formulations linked to the molecular mobility of polymer excipients, as determined by high resolution 13C solid-state NMR.

21 January 2018

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Aggregation of a lyophilized pharmaceutical protein, recombinant human albumin: effect of moisture and stabilization by excipients

21 January 2018

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The relationship between protein aggregation and molecular mobility below the glass transition temperature of lyophilized formulations containing a monoclonal antibody.

21 January 2018

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Incorporation of lipophilic drugs in sugar glasses by lyophilization using a mixture of water and tertiary butyl alcohol as solvent.

21 January 2018

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The relevance of the amorphous state to pharmaceutical dosage forms: glassy drugs and freeze dried systems

21 January 2018

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Effect of collapse on the stability of freeze-dried recombinant factor VIII and alpha-amylase

21 January 2018

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The secondary structure and aggregation of lyophilized tetanus toxoid

21 January 2018

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The physical state of mannitol after freeze-drying: effects of mannitol concentration, freezing rate, and a noncrystallizing cosolute.

21 January 2018

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Crystallization behavior of mannitol in frozen aqueous solutions

21 January 2018

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Mannitol-sucrose mixtures--versatile formulations for protein lyophilization

21 January 2018

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Effect of mannitol crystallinity on the stabilization of enzymes during freeze-drying.

21 January 2018

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Effect of sucrose/raffinose mass ratios on the stability of co-lyophilized protein during storage above the Tg.

21 January 2018

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A new strategy for enhancing the stability of lyophilized protein: the effect of the reconstitution medium on keratinocyte growth factor.

21 January 2018

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A specific molar ratio of stabilizer to protein is required for storage stability of a lyophilized monoclonal antibody

21 January 2018

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Effects of types of sugar on the stabilization of protein in the dried state.

21 January 2018

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Freeze-drying of tert-butanol/water cosolvent systems: a case report on formation of a friable freeze-dried powder of tobramycin sulfate

21 January 2018

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Stabilization of the Restriction Enzyme EcoRI Dried with Trehalose and Other Selected Glass-Forming Solutes

21 January 2018

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21 January 2018

Identifiers

DOI

10.1081/PDT-56308

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12 August 2017

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