(Q36150834)

12 August 2017

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title

Treating the metabolic syndrome: acetyl-CoA carboxylase inhibition (English)

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12 August 2017

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H James Harwood

1

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12 August 2017

language of work or name

English

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publication date

1 April 2005

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Expert Opinion on Therapeutic Targets

12 August 2017

published in

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12 August 2017

volume

9

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12 August 2017

issue

2

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12 August 2017

page(s)

267-281

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Banting lecture 1988. Role of insulin resistance in human disease

12 August 2017

cites work

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.2.267

Prevalence of the metabolic syndrome among US adults: findings from the third National Health and Nutrition Examination Survey

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.2.267

Executive Summary of The Third Report of The National Cholesterol Education Program (NCEP) Expert Panel on Detection, Evaluation, And Treatment of High Blood Cholesterol In Adults (Adult Treatment Panel III)

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.2.267

New drug targets for type 2 diabetes and the metabolic syndrome

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.2.267

Definition of metabolic syndrome: Report of the National Heart, Lung, and Blood Institute/American Heart Association conference on scientific issues related to definition

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.2.267

Effect of increasing metabolic syndrome score on atherosclerotic risk profile and coronary artery disease angiographic severity.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.2.267

Prospective analysis of the insulin-resistance syndrome (syndrome X).

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.2.267

Metabolic disturbances in obesity versus sleep apnoea: the importance of visceral obesity and insulin resistance

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.2.267

Fat accumulation in the liver is associated with defects in insulin suppression of glucose production and serum free fatty acids independent of obesity in normal men.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.2.267

Metabolic syndrome with and without C-reactive protein as a predictor of coronary heart disease and diabetes in the West of Scotland Coronary Prevention Study

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.2.267

Central role of the adipocyte in the metabolic syndrome

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.2.267

Fatty acids, lipotoxicity and insulin secretion

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.2.267

AMP kinase and malonyl-CoA: targets for therapy of the metabolic syndrome

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.2.267

Lipid metabolic enzymes: emerging drug targets for the treatment of obesity

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.2.267

Hepatic expression of malonyl-CoA decarboxylase reverses muscle, liver and whole-animal insulin resistance

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.2.267

Regulation of mammalian acetyl-coenzyme A carboxylase

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.2.267

Crystal structure of the carboxyltransferase domain of acetyl-coenzyme A carboxylase

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.2.267

Regulation of hepatic fatty acid oxidation and ketone body production

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.2.267

The regulation of acetyl-CoA carboxylase--a potential target for the action of hypolipidemic agents

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.2.267

A mechanism for the potent inhibition of eukaryotic acetyl-coenzyme A carboxylase by soraphen A, a macrocyclic polyketide natural product.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.2.267

Molecular basis for the inhibition of the carboxyltransferase domain of acetyl-coenzyme-A carboxylase by haloxyfop and diclofop.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.2.267

Short-term regulation of acetyl CoA carboxylase in tissues of higher animals

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.2.267

Acetyl-CoA carboxylase 2 mutant mice are protected against obesity and diabetes induced by high-fat/high-carbohydrate diets

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.2.267

Purification and Characterization of Rat Skeletal Muscle Acetyl-CoA Carboxylase

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.2.267

Inhibition of Rat-Liver Acetyl-Coenzyme-A Carboxylase by Palmitoyl-Coenzyme A. Formation of Equimolar Enzyme-Inhibitor Complex

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.2.267

Evidence for an anaplerotic/malonyl-CoA pathway in pancreatic beta-cell nutrient signaling.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.2.267

The mitochondrial carnitine palmitoyltransferase system. From concept to molecular analysis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.2.267

Malonyl coenzyme A and the regulation of functional carnitine palmitoyltransferase-1 activity and fat oxidation in human skeletal muscle

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.2.267

Hypothalamic malonyl-CoA as a mediator of feeding behavior

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.2.267

More direct evidence for a malonyl-CoA-carnitine palmitoyltransferase I interaction as a key event in pancreatic beta-cell signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.2.267

Cloning of human acetyl-CoA carboxylase-beta and its unique features

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.2.267

Human acetyl-CoA carboxylase 2. Molecular cloning, characterization, chromosomal mapping, and evidence for two isoforms

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.2.267

Continuous fatty acid oxidation and reduced fat storage in mice lacking acetyl-CoA carboxylase 2

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.2.267

The subcellular localization of acetyl-CoA carboxylase 2

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.2.267

5-(Tetradecyloxy)-2-furancarboxylic acid and related hypolipidemic fatty acid-like alkyloxyarylcarboxylic acids

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.2.267

Isozyme-nonselective N-substituted bipiperidylcarboxamide acetyl-CoA carboxylase inhibitors reduce tissue malonyl-CoA concentrations, inhibit fatty acid synthesis, and increase fatty acid oxidation in cultured cells and in experimental animals

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.2.267

C75 [4-methylene-2-octyl-5-oxo-tetrahydro-furan-3-carboxylic acid] activates carnitine palmitoyltransferase-1 in isolated mitochondria and intact cells without displacement of bound malonyl CoA.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.2.267

Identification of the yeast ACC1 gene product (acetyl-CoA carboxylase) as the target of the polyketide fungicide soraphen A.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.2.267

Expression and characterization of recombinant fungal acetyl-CoA carboxylase and isolation of a soraphen-binding domain

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.2.267

An isoleucine/leucine residue in the carboxyltransferase domain of acetyl-CoA carboxylase is critical for interaction with aryloxyphenoxypropionate and cyclohexanedione inhibitors

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.2.267

Cyclohexanedione herbicides are inhibitors of rat heart acetyl-CoA carboxylase

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.2.267

Coenzyme A esters of 2-aryloxyphenoxypropionate herbicides and 2-arylpropionate antiinflammatory drugs are potent and stereoselective inhibitors of rat liver acetyl-CoA carboxylase

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.2.267

Inhibitory effects of long-chain acyl coenzyme a analogues on rat liver acetyl coenzyme a carboxylase

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.2.267

Effects of a novel dual lipid synthesis inhibitor and its potential utility in treating dyslipidemia and metabolic syndrome

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.2.267

MEDICA 16 inhibits hepatic acetyl-CoA carboxylase and reduces plasma triacylglycerol levels in insulin-resistant JCR: LA-cp rats.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.2.267

Development of insulin resistance in the JCR:LA-cp rat: role of triacylglycerols and effects of MEDICA 16.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.2.267

A bisubstrate analog inhibitor of the carboxyltransferase component of acetyl-CoA carboxylase

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.2.267

A biotin analog inhibits acetyl-CoA carboxylase activity and adipogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.2.267

Glucose and fat metabolism in adipose tissue of acetyl-CoA carboxylase 2 knockout mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.2.267

A novel mouse model of lipotoxic cardiomyopathy

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.2.267

AMP-activated protein kinase (AMPK) control of fatty acid and glucose metabolism in the ischemic heart

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.2.267

21 January 2018

Identifiers

DOI

10.1517/14728222.9.2.267

1 reference

12 August 2017

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