(Q36155580)

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Substitutions at amino acid positions 143, 148, and 155 of HIV-1 integrase define distinct genetic barriers to raltegravir resistance in vivo

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Europe PubMed Central

PMC publication ID

12 August 2017

Substitutions at amino acid positions 143, 148, and 155 of HIV-1 integrase define distinct genetic barriers to raltegravir resistance in vivo (English)

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Europe PubMed Central

PMC publication ID

12 August 2017

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Christos J Petropoulos

4

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Christos J Petropoulos

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Europe PubMed Central

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12 August 2017

author name string

Signe Fransen

1

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Europe PubMed Central

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12 August 2017

Soumi Gupta

2

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Europe PubMed Central

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12 August 2017

Arne Frantzell

3

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Europe PubMed Central

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12 August 2017

Wei Huang

5

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12 August 2017

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publication date

2 May 2012

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Europe PubMed Central

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12 August 2017

Journal of Virology

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12 August 2017

86

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Europe PubMed Central

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12 August 2017

13

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Europe PubMed Central

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12 August 2017

7249-7255

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Europe PubMed Central

PMC publication ID

12 August 2017

Switching between raltegravir resistance pathways analyzed by deep sequencing

1 reference

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2 October 2017

Effect of raltegravir resistance mutations in HIV-1 integrase on viral fitness

1 reference

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Evolution of integrase resistance during failure of integrase inhibitor-based antiretroviral therapy

1 reference

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2 October 2017

Loss of raltegravir susceptibility by human immunodeficiency virus type 1 is conferred via multiple nonoverlapping genetic pathways

1 reference

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2 October 2017

Longitudinal analysis of raltegravir susceptibility and integrase replication capacity of human immunodeficiency virus type 1 during virologic failure

1 reference

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2 October 2017

Natural polymorphisms of human immunodeficiency virus type 1 integrase and inherent susceptibilities to a panel of integrase inhibitors

1 reference

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2 October 2017

The G140S mutation in HIV integrases from raltegravir-resistant patients rescues catalytic defect due to the resistance Q148H mutation

1 reference

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2 October 2017

Resistance mutations in human immunodeficiency virus type 1 integrase selected with elvitegravir confer reduced susceptibility to a wide range of integrase inhibitors

1 reference

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2 October 2017

Drug resistance profiles for the HIV integrase gene in patients failing raltegravir salvage therapy

1 reference

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2 October 2017

Raltegravir with optimized background therapy for resistant HIV-1 infection

1 reference

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2 October 2017

Mutations associated with failure of raltegravir treatment affect integrase sensitivity to the inhibitor in vitro

1 reference

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2 October 2017

Broad antiretroviral activity and resistance profile of the novel human immunodeficiency virus integrase inhibitor elvitegravir (JTK-303/GS-9137)

1 reference

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2 October 2017

A naphthyridine carboxamide provides evidence for discordant resistance between mechanistically identical inhibitors of HIV-1 integrase

1 reference

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2 October 2017

Development of resistance against diketo derivatives of human immunodeficiency virus type 1 by progressive accumulation of integrase mutations

1 reference

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A novel phenotypic drug susceptibility assay for human immunodeficiency virus type 1

1 reference

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2 October 2017

Inhibitors of strand transfer that prevent integration and inhibit HIV-1 replication in cells

1 reference

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2 October 2017

The "megaprimer" method of site-directed mutagenesis

1 reference

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2 October 2017

Retroviral DNA integration directed by HIV integration protein in vitro

1 reference

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2 October 2017

Activities of human immunodeficiency virus (HIV) integration protein in vitro: specific cleavage and integration of HIV DNA

1 reference

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2 October 2017

In Vitro antiretroviral properties of S/GSK1349572, a next-generation HIV integrase inhibitor

1 reference

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2 July 2018

Selective-advantage profile of human immunodeficiency virus type 1 integrase mutants explains in vivo evolution of raltegravir resistance genotypes.

1 reference

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2 July 2018

Preliminary mapping of a putative inhibitor-binding pocket for human immunodeficiency virus type 1 integrase inhibitors

1 reference

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2 July 2018

Raltegravir versus Efavirenz regimens in treatment-naive HIV-1-infected patients: 96-week efficacy, durability, subgroup, safety, and metabolic analyses

1 reference

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23 September 2018

Selection and analysis of HIV-1 integrase strand transfer inhibitor resistant mutant viruses

1 reference

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23 September 2018

Quasispecies variant dynamics during emergence of resistance to raltegravir in HIV-1-infected patients

1 reference

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23 September 2018

Discovery of raltegravir, a potent, selective orally bioavailable HIV-integrase inhibitor for the treatment of HIV-AIDS infection

1 reference

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23 September 2018

Subgroup and resistance analyses of raltegravir for resistant HIV-1 infection

1 reference

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23 September 2018

Identifiers

10.1128/JVI.06618-11

1 reference

Europe PubMed Central

PMC publication ID

12 August 2017

PMC publication ID

1 reference

Europe PubMed Central

PMC publication ID

12 August 2017

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

12 August 2017

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