(Q36160990)

12 August 2017

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title

Hypoxia in head and neck cancer: how much, how important? (English)

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12 August 2017

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head and neck carcinoma

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Janssen HL

1

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12 August 2017

Haustermans KM

series ordinal

2

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12 August 2017

Balm AJ

series ordinal

3

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12 August 2017

Begg AC

series ordinal

4

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12 August 2017

publication date

1 July 2005

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12 August 2017

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12 August 2017

volume

27

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12 August 2017

issue

7

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12 August 2017

page(s)

622-638

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Imaging of hypoxia in human tumors with [F-18]fluoromisonidazole

12 August 2017

cites work

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Carbogen breathing with nicotinamide improves the oxygen status of tumours in patients

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SR 4233 (tirapazamine): a new anticancer drug exploiting hypoxia in solid tumours

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Dominant-negative hypoxia-inducible factor-1 alpha reduces tumorigenicity of pancreatic cancer cells through the suppression of glucose metabolism

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Drug and radiation resistance in spheroids: cell contact and kinetics

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7 January 2021

Hypoxia and drug resistance

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Microenvironmental control of gene expression: implications for tumor angiogenesis, progression, and metastasis

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Hypoxia modulated gene expression: angiogenesis, metastasis and therapeutic exploitation

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Relationship of hypoxia to metastatic ability in rodent tumours

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Hypoxia--a key regulatory factor in tumour growth

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Microregional fluctuations in perfusion within human tumours detected using laser Doppler flowmetry

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7 January 2021

Clinical relevance of intermittent tumour blood flow

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7 January 2021

HIF-1A, pimonidazole, and iododeoxyuridine to estimate hypoxia and perfusion in human head-and-neck tumors

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7 January 2021

Tumor hypoxia: definitions and current clinical, biologic, and molecular aspects

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7 January 2021

Investigating hypoxic tumor physiology through gene expression patterns

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7 January 2021

HIF-1, O(2), and the 3 PHDs: how animal cells signal hypoxia to the nucleus

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7 January 2021

Oxygen sensors and angiogenesis

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7 January 2021

Endothelial PAS domain protein 1 (EPAS1), a transcription factor selectively expressed in endothelial cells

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7 January 2021

Differential roles of hypoxia-inducible factor 1alpha (HIF-1alpha) and HIF-2alpha in hypoxic gene regulation

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7 January 2021

Multiple splice variants of the human HIF-3 alpha locus are targets of the von Hippel-Lindau E3 ubiquitin ligase complex

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7 January 2021

Inhibitory PAS domain protein (IPAS) is a hypoxia-inducible splicing variant of the hypoxia-inducible factor-3alpha locus

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7 January 2021

Hypoxia-inducible factor (HIF1A and HIF2A), angiogenesis, and chemoradiotherapy outcome of squamous cell head-and-neck cancer

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7 January 2021

Gene expression profiling of the hypoxia signaling pathway in hypoxia-inducible factor 1alpha null mouse embryonic fibroblasts

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7 January 2021

Role of HIF-1alpha in hypoxia-mediated apoptosis, cell proliferation and tumour angiogenesis

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7 January 2021

Endothelial cell responses to hypoxic stress

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7 January 2021

Hypoxia induces expression of the chemokines monocyte chemoattractant protein-1 (MCP-1) and IL-8 in human dermal fibroblasts

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7 January 2021

Hypoxic induction of interleukin-8 gene expression in human endothelial cells

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7 January 2021

Mechanisms of hypoxic cell radiosensitization and the development of new sensitizers.

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7 January 2021

Metabolism induced binding of 14C-misonidazole to hypoxic cells: kinetic dependence on oxygen concentration and misonidazole concentration

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7 January 2021

Chemical modifiers of cancer treatment

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7 January 2021

Pimonidazole: a novel hypoxia marker for complementary study of tumor hypoxia and cell proliferation in cervical carcinoma

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7 January 2021

Hypoxia in human intraperitoneal and extremity sarcomas

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7 January 2021

Semiquantitative immunohistochemical analysis for hypoxia in human tumors

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7 January 2021

Invasive oxygen measurements and pimonidazole labeling in human cervix carcinoma.

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7 January 2021

Vascular architecture and hypoxic profiles in human head and neck squamous cell carcinomas

1 reference

7 January 2021

Measurements of hypoxia using pimonidazole and polarographic oxygen-sensitive electrodes in human cervix carcinomas

1 reference

7 January 2021

Pretreatment oxygenation predicts radiation response in advanced squamous cell carcinoma of the head and neck

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7 January 2021

A confirmatory prognostic study on oxygenation status and loco-regional control in advanced head and neck squamous cell carcinoma treated by radiation therapy

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7 January 2021

Quantifying regional hypoxia in human tumors with positron emission tomography of [18F]fluoromisonidazole: a pretherapy study of 37 patients

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7 January 2021

In vivo evaluation of [18F]fluoroetanidazole as a new marker for imaging tumour hypoxia with positron emission tomography

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7 January 2021

[18F]-EF5, a marker for PET detection of hypoxia: synthesis of precursor and a new fluorination procedure

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7 January 2021

In vivo assessment of tumor hypoxia in lung cancer with 60Cu-ATSM

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7 January 2021

Assessing tumor hypoxia in cervical cancer by positron emission tomography with 60Cu-ATSM: relationship to therapeutic response-a preliminary report

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7 January 2021

A novel approach to overcome hypoxic tumor resistance: Cu-ATSM-guided intensity-modulated radiation therapy

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7 January 2021

Hypoxia and glucose metabolism in malignant tumors: evaluation by [18F]fluoromisonidazole and [18F]fluorodeoxyglucose positron emission tomography imaging

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7 January 2021

Tumour oxygenation assessed by 18F-fluoromisonidazole PET and polarographic needle electrodes in human soft tissue tumours

1 reference

7 January 2021

Measuring hypoxia and predicting tumor radioresistance with nuclear medicine assays

1 reference

7 January 2021

99Tc(m) labelled HL91 versus computed tomography and biopsy for the visualization of tumour recurrence of squamous head and neck carcinoma.

1 reference

7 January 2021

Phase I trial of concurrent tirapazamine, cisplatin, and radiotherapy in patients with advanced head and neck cancer

1 reference

7 January 2021

Imaging hypoxia in tumors

1 reference

7 January 2021

Phase 1 study to identify tumour hypoxia in patients with head and neck cancer using technetium-99m BRU 59-21.

1 reference

7 January 2021

Diffusion limited hypoxia estimated by vascular image analysis: comparison with pimonidazole staining in human tumors.

1 reference

7 January 2021

Use of thymidine analogues to indicate vascular perfusion in tumours

1 reference

7 January 2021

Tumor hypoxia adversely affects the prognosis of carcinoma of the head and neck

1 reference

7 January 2021

Oxygenation of head and neck cancer: changes during radiotherapy and impact on treatment outcome

1 reference

7 January 2021

Influence of the hypoxic subvolume on the survival of patients with head and neck cancer

1 reference

7 January 2021

Repeatability and prognostic impact of the pretreatment pO(2) histography in patients with advanced head and neck cancer

1 reference

7 January 2021

Predictive value of the tumor oxygenation by means of pO2 histography in patients with advanced head and neck cancer

1 reference

7 January 2021

Tumor volume and tumor hypoxia in head and neck cancers. The amount of the hypoxic volume is important.

1 reference

7 January 2021

Oxygenation of squamous cell carcinoma of the head and neck: comparison of primary tumors, neck node metastases, and normal tissue

1 reference

7 January 2021

Prognostic impact of reoxygenation in advanced cancer of the head and neck during the initial course of chemoradiation or radiotherapy alone

1 reference

7 January 2021

Glut3 expression in biopsy specimens of laryngeal carcinoma is associated with poor survival

1 reference

7 January 2021

Hypoxia and VEGF mRNA expression in human tumors

1 reference

7 January 2021

Pretreatment hemoglobin level influences local control and survival of T1-T2 squamous cell carcinomas of the glottic larynx

1 reference

7 January 2021

Anemia is associated with decreased survival and increased locoregional failure in patients with locally advanced head and neck carcinoma: a secondary analysis of RTOG 85-27.

1 reference

7 January 2021

Pre-treatment anaemia alters outcome in early squamous cell carcinoma of the larynx treated by radical radiotherapy

1 reference

7 January 2021

Anemia is associated with decreased local control of surgically treated squamous cell carcinomas of the glottic larynx

1 reference

7 January 2021

Severe anemia is associated with poor tumor oxygenation in head and neck squamous cell carcinomas

1 reference

7 January 2021

Erythropoietin to treat head and neck cancer patients with anaemia undergoing radiotherapy: randomised, double-blind, placebo-controlled trial

1 reference

7 January 2021

Accelerated radiotherapy with carbogen and nicotinamide (ARCON) for laryngeal cancer

1 reference

7 January 2021

Clinical outcome and tumour microenvironmental effects of accelerated radiotherapy with carbogen and nicotinamide

1 reference

7 January 2021

ARCON: experience in 215 patients with advanced head-and-neck cancer.

1 reference

7 January 2021

ARCON: accelerated radiotherapy with carbogen and nicotinamide in head and neck squamous cell carcinomas. The experience of the Co-operative group of radiotherapy of the european organization for research and treatment of cancer (EORTC).

1 reference

7 January 2021

A phase I/II study of the hypoxic cell sensitizer misonidazole as an adjunct to high fractional dose radiotherapy in patients with unresectable squamous cell carcinoma of the head and neck: a RTOG randomized study (#79-04).

1 reference

7 January 2021

Results of an RTOG phase III trial (RTOG 85-27) comparing radiotherapy plus etanidazole with radiotherapy alone for locally advanced head and neck carcinomas

1 reference

7 January 2021

Misonidazole combined with split-course radiotherapy in the treatment of invasive carcinoma of larynx and pharynx: report from the DAHANCA 2 study

1 reference

7 January 2021

A randomized double-blind phase III study of nimorazole as a hypoxic radiosensitizer of primary radiotherapy in supraglottic larynx and pharynx carcinoma. Results of the Danish Head and Neck Cancer Study (DAHANCA) Protocol 5-85.

1 reference

7 January 2021

Therapeutic advantage of hypoxic cells in tumors: a theoretical study

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7 January 2021

Tirapazamine: a new drug producing tumor specific enhancement of platinum-based chemotherapy in non-small-cell lung cancer

1 reference

7 January 2021

Concurrent tirapazamine and radiotherapy for advanced head and neck carcinomas: a Phase II study

1 reference

7 January 2021

AQ4N: a new approach to hypoxia-activated cancer chemotherapy

1 reference

7 January 2021

Suicide gene therapy for prostate cancer using a replication-deficient adenovirus containing the herpesvirus thymidine kinase gene

1 reference

7 January 2021

Anaerobic bacteria as a gene delivery system that is controlled by the tumor microenvironment

1 reference

7 January 2021

Anticancer efficacy of systemically delivered anaerobic bacteria as gene therapy vectors targeting tumor hypoxia/necrosis

1 reference

7 January 2021

Exploiting tumour hypoxia in cancer treatment

1 reference

7 January 2021

Specific targeting of cytosine deaminase to solid tumors by engineered Clostridium acetobutylicum.

1 reference

7 January 2021

Expression of HIF-1alpha by human macrophages: implications for the use of macrophages in hypoxia-regulated cancer gene therapy

1 reference

7 January 2021

Prognostic significance of vascular endothelial growth factor protein levels in oral and oropharyngeal squamous cell carcinoma

1 reference

7 January 2021

Intratumoral pO2 predicts survival in advanced cancer of the uterine cervix

1 reference

7 January 2021

Transcriptional response to hypoxia in human tumors

1 reference

7 January 2021

Functional genomics approach to hypoxia signaling

1 reference

7 January 2021

Reoxygenation after single irradiation in rodent tumors of different types and sizes

1 reference

7 January 2021

Identifiers

DOI

10.1002/HED.20223

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12 August 2017

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