(Q36174027)

12 August 2017

The Apaf-1-binding protein Aven is cleaved by Cathepsin D to unleash its anti-apoptotic potential (English)

1 reference

12 August 2017

0 references

Sebastian Kehrloesser

object named as

S Kehrloesser

7

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author name string

I M Melzer

1

1 reference

12 August 2017

S B M Fernández

2

1 reference

12 August 2017

S Bösser

3

1 reference

12 August 2017

K Lohrig

4

1 reference

12 August 2017

U Lewandrowski

5

1 reference

12 August 2017

D Wolters

6

1 reference

12 August 2017

M-L Brezniceanu

8

1 reference

12 August 2017

A C Theos

9

1 reference

12 August 2017

P M Irusta

10

1 reference

12 August 2017

F Impens

11

1 reference

12 August 2017

K Gevaert

12

1 reference

12 August 2017

M Zörnig

13

1 reference

12 August 2017

2 March 2012

1 reference

Cell Death & Differentiation

12 August 2017

1 reference

12 August 2017

19

1 reference

12 August 2017

9

1 reference

12 August 2017

1435-1445

1 reference

https://scigraph.springernature.com/pub.10.1038/cdd.2012.17

12 August 2017

0 references

cites work

Role of Bcl-2 family proteins and caspases in the regulation of apoptosis.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3422468

Aven blocks DNA damage-induced apoptosis by stabilising Bcl-xL.

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3422468

Pathophysiological functions of cathepsin D: Targeting its catalytic activity versus its protein binding activity?

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3422468

Novel small molecules relieve prothymosin alpha-mediated inhibition of apoptosome formation by blocking its interaction with Apaf-1.

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3422468

Mitochondrial cell death effectors.

1 October 2017

1 reference

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In vitro and in vivo protein-bound tyrosine nitration characterized by diagonal chromatography

1 October 2017

1 reference

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Overexpression of the far upstream element binding protein 1 in hepatocellular carcinoma is required for tumor growth

1 October 2017

1 reference

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Targeting the apoptosome for cancer therapy

1 October 2017

1 reference

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Cytochrome c: functions beyond respiration

1 October 2017

1 reference

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The apoptosome: emerging insights and new potential targets for drug design

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3422468

Caspase inhibitors promote alternative cell death pathways

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3422468

Apoptosome: a platform for the activation of initiator caspases

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3422468

Dual loss of ER export and endocytic signals with altered melanosome morphology in the silver mutation of Pmel17

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3422468

hTERT: a novel endogenous inhibitor of the mitochondrial cell death pathway.

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3422468

Mitomycin-C induces the apoptosis of human Tenon's capsule fibroblast by activation of c-Jun N-terminal kinase 1 and caspase-3 protease.

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3422468

Cathepsin D: newly discovered functions of a long-standing aspartic protease in cancer and apoptosis

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3422468

Apoptosome dysfunction in human cancer

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3422468

Aprotinin: a pharmacologic overview

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3422468

HMGB1 inhibits cell death in yeast and mammalian cells and is abundantly expressed in human breast carcinoma

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3422468

Distinctive roles of PHAP proteins and prothymosin-alpha in a death regulatory pathway

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3422468

Aven, a novel inhibitor of caspase activation, binds Bcl-xL and Apaf-1

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3422468

Negative regulation of cytochrome c-mediated oligomerization of Apaf-1 and activation of procaspase-9 by heat shock protein 90

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3422468

Negative regulation of the Apaf-1 apoptosome by Hsp70

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3422468

Heat-shock protein 70 inhibits apoptosis by preventing recruitment of procaspase-9 to the Apaf-1 apoptosome

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3422468

Differential modulation of apoptosis sensitivity in CD95 type I and type II cells.

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3422468

Caspase-3 is required for DNA fragmentation and morphological changes associated with apoptosis

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3422468

Cytochrome c and dATP-dependent formation of Apaf-1/caspase-9 complex initiates an apoptotic protease cascade

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3422468

Biological and clinical significance of cathepsin D in breast cancer metastasis

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3422468

Pepstatin, a new pepsin inhibitor produced by Actinomycetes

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3422468

E64 [trans-epoxysuccinyl-L-leucylamido-(4-guanidino)butane] analogues as inhibitors of cysteine proteinases: investigation of S2 subsite interactions

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3422468

Selecting protein N-terminal peptides by combined fractional diagonal chromatography.

2 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3422468

A quantitative proteomics design for systematic identification of protease cleavage events.

23 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3422468

Aven-dependent activation of ATM following DNA damage

23 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3422468

Aven overexpression: association with poor prognosis in childhood acute lymphoblastic leukemia.

23 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3422468

Survivin and aven: two distinct antiapoptotic signals in acute leukemias

23 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3422468

(p-Amidinophenyl)methanesulfonyl fluoride, an irreversible inhibitor of serine proteases

23 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3422468

Cathepsin D in breast cancer cells can digest extracellular matrix in large acidic vesicles

23 September 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/22388353

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1038/CDD.2012.17

1 reference

12 August 2017

1 reference

12 August 2017

1 reference