(Q36182579)

12 August 2017

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title

Genetics of polycystic ovary syndrome: searching for the way out of the labyrinth (English)

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polycystic ovary syndrome

12 August 2017

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1 reference

Evanthia Diamanti-Kandarakis

series ordinal

1

object named as

Evanthia Diamanti-Kandarakis

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12 August 2017

Christina Piperi

2

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12 August 2017

1 July 2005

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Human Reproduction Update

12 August 2017

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12 August 2017

11

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12 August 2017

6

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12 August 2017

631-643

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Developmental origin of polycystic ovary syndrome - a hypothesis

12 August 2017

1 reference

https://api.crossref.org/works/10.1093%2FHUMUPD%2FDMI025

Thiazolidinediones but not metformin directly inhibit the steroidogenic enzymes P450c17 and 3beta -hydroxysteroid dehydrogenase

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHUMUPD%2FDMI025

The polycystic ovary syndrome: pathogenesis and treatment

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHUMUPD%2FDMI025

Pituitary-ovarian responses to nafarelin testing in the polycystic ovary syndrome

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHUMUPD%2FDMI025

Correlation of hyperandrogenism with hyperinsulinism in polycystic ovarian disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHUMUPD%2FDMI025

The relationship between circulating androgens, obesity, and hyperinsulinemia on serum insulin-like growth factor binding protein-1 in the polycystic ovarian syndrome

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHUMUPD%2FDMI025

Insulin gene variable number of tandem repeats regulatory polymorphism is not associated with hyperandrogenism in Spanish women

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHUMUPD%2FDMI025

Difference in body weight between American and Italian women with polycystic ovary syndrome: influence of the diet

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHUMUPD%2FDMI025

Relationship between serum müllerian-inhibiting substance and other reproductive hormones in untreated women with polycystic ovary syndrome and normal women

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHUMUPD%2FDMI025

Antimüllerian hormone serum levels: a putative marker for ovarian aging

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHUMUPD%2FDMI025

Definition and significance of polycystic ovaries

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHUMUPD%2FDMI025

The polycystic ovary syndrome. Pathogenesis, metabolic implications, and therapeutic approach

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHUMUPD%2FDMI025

Presence of metabolic risk factors in non-obese PCOS sisters: evidence of heritability of insulin resistance.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHUMUPD%2FDMI025

The prevalence of 4G5G polymorphism of plasminogen activator inhibitor-1 (PAI-1) gene in polycystic ovarian syndrome and its association with plasma PAI-1 levels

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHUMUPD%2FDMI025

Increased levels of serum advanced glycation end-products in women with polycystic ovary syndrome

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHUMUPD%2FDMI025

Hyperandrogenemia is necessary but not sufficient for polycystic ovary syndrome.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHUMUPD%2FDMI025

Characterization of groups of hyperandrogenic women with acanthosis nigricans, impaired glucose tolerance, and/or hyperinsulinemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHUMUPD%2FDMI025

Profound peripheral insulin resistance, independent of obesity, in polycystic ovary syndrome

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHUMUPD%2FDMI025

Excessive insulin receptor serine phosphorylation in cultured fibroblasts and in skeletal muscle. A potential mechanism for insulin resistance in the polycystic ovary syndrome

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHUMUPD%2FDMI025

Prevalence of impaired glucose tolerance and diabetes in women with polycystic ovary syndrome.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHUMUPD%2FDMI025

Relationship of insulin receptor substrate-1 and -2 genotypes to phenotypic features of polycystic ovary syndrome

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHUMUPD%2FDMI025

Relationship of calpain-10 genotype to phenotypic features of polycystic ovary syndrome

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHUMUPD%2FDMI025

The presence of the 21-hydroxylase deficiency carrier status in hirsute women: phenotype-genotype correlations

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHUMUPD%2FDMI025

Association of polymorphisms in the interleukin 6 receptor complex with obesity and hyperandrogenism

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHUMUPD%2FDMI025

Obesity, and not insulin resistance, is the major determinant of serum inflammatory cardiovascular risk markers in pre-menopausal women.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHUMUPD%2FDMI025

Serum anti-Müllerian hormone is more strongly related to ovarian follicular status than serum inhibin B, estradiol, FSH and LH on day 3.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHUMUPD%2FDMI025

Serum anti-Müllerian hormone dynamics during controlled ovarian hyperstimulation

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHUMUPD%2FDMI025

Plasma levels of the soluble fraction of tumor necrosis factor receptor 2 and insulin resistance.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHUMUPD%2FDMI025

Candidate genes in polycystic ovary syndrome

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHUMUPD%2FDMI025

The genetic basis of polycystic ovary syndrome

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHUMUPD%2FDMI025

Association of the steroid synthesis gene CYP11a with polycystic ovary syndrome and hyperandrogenism

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHUMUPD%2FDMI025

Specific CAPN10 gene haplotypes influence the clinical profile of polycystic ovary patients

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHUMUPD%2FDMI025

Variation within the type 2 diabetes susceptibility gene calpain-10 and polycystic ovary syndrome

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHUMUPD%2FDMI025

Role of androgens in follicle maturation and atresia

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHUMUPD%2FDMI025

Effect of recombinant inhibin on androgen synthesis in cultured human thecal cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHUMUPD%2FDMI025

Human sex hormone-binding globulin variants associated with hyperandrogenism and ovarian dysfunction.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHUMUPD%2FDMI025

The role of TNFalpha and TNF receptors in obesity and insulin resistance

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHUMUPD%2FDMI025

IRS-1-mediated inhibition of insulin receptor tyrosine kinase activity in TNF-alpha- and obesity-induced insulin resistance

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHUMUPD%2FDMI025

Increased frequency of the G972R variant of the insulin receptor substrate-1 (irs-1) gene among girls with a history of precocious pubarche.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHUMUPD%2FDMI025

The follicular excess in polycystic ovaries, due to intra-ovarian hyperandrogenism, may be the main culprit for the follicular arrest.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHUMUPD%2FDMI025

Anti-Müllerian hormone serum concentrations in normoovulatory and anovulatory women of reproductive age.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHUMUPD%2FDMI025

Prevalence of polycystic ovary syndrome (PCOS) in first-degree relatives of patients with PCOS.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHUMUPD%2FDMI025

Orally absorbed reactive glycation products (glycotoxins): an environmental risk factor in diabetic nephropathy

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHUMUPD%2FDMI025

A common genetic variant of luteinizing hormone; relation to normal and aberrant pituitary-gonadal function

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHUMUPD%2FDMI025

Evidence for a genetic basis for hyperandrogenemia in polycystic ovary syndrome.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHUMUPD%2FDMI025

The paraoxonase PON1 promoter polymorphism C(-107)T is associated with increased serum glucose concentrations in non-diabetic patients

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHUMUPD%2FDMI025

Molecular scanning of the human sorbin and SH3-domain-containing-1 (SORBS1) gene: positive association of the T228A polymorphism with obesity and type 2 diabetes

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHUMUPD%2FDMI025

Insulin-like growth factor-I regulation of luteinizing hormone (LH) receptor messenger ribonucleic acid expression and LH-stimulated signal transduction in rat ovarian theca-interstitial cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHUMUPD%2FDMI025

Altered autophosphorylation of the insulin receptor in the ovary of a woman with polycystic ovary syndrome

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHUMUPD%2FDMI025

Role of hyperinsulinemia in the pathogenesis of the polycystic ovary syndrome, and its clinical implications

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHUMUPD%2FDMI025

Insulin regulation of human ovarian androgens

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHUMUPD%2FDMI025

Decreases in ovarian cytochrome P450c17 alpha activity and serum free testosterone after reduction of insulin secretion in polycystic ovary syndrome

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHUMUPD%2FDMI025

The effects of hyperinsulinemia on serum testosterone, progesterone, dehydroepiandrosterone sulfate, and cortisol levels in normal women and in a woman with hyperandrogenism, insulin resistance, and acanthosis nigricans

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHUMUPD%2FDMI025

Suppression of serum insulin by diazoxide reduces serum testosterone levels in obese women with polycystic ovary syndrome

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHUMUPD%2FDMI025

Polymorphisms in candidate obesity genes and their interaction with dietary intake of n-6 polyunsaturated fatty acids affect obesity risk in a sub-sample of the EPIC-Heidelberg cohort

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHUMUPD%2FDMI025

Comment: the methionine 196 arginine polymorphism in exon 6 of the TNF receptor 2 gene (TNFRSF1B) is associated with the polycystic ovary syndrome and hyperandrogenism

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHUMUPD%2FDMI025

Elevated serum level of anti-mullerian hormone in patients with polycystic ovary syndrome: relationship to the ovarian follicle excess and to the follicular arrest.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHUMUPD%2FDMI025

The gonadotropic function of insulin

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHUMUPD%2FDMI025

Polymorphism of glycogen synthetase gene in polycystic ovary syndrome.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHUMUPD%2FDMI025

Role of the pentanucleotide (tttta)(n) polymorphism in the promoter of the CYP11a gene in the pathogenesis of hirsutism.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHUMUPD%2FDMI025

Association of the polycystic ovary syndrome with genomic variants related to insulin resistance, type 2 diabetes mellitus, and obesity

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHUMUPD%2FDMI025

Genetic approaches to unraveling reproductive disorders: examples of bedside to bench research in the genomic era.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHUMUPD%2FDMI025

A C/T single nucleotide polymorphism at the tyrosine kinase domain of the insulin receptor gene is associated with polycystic ovary syndrome

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHUMUPD%2FDMI025

Molecular approach to common causes of female infertility

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHUMUPD%2FDMI025

Growth differentiation factor-9 stimulates rat theca-interstitial cell androgen biosynthesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHUMUPD%2FDMI025

Strategies to elucidate the mechanism of excessive theca cell androgen production in PCOS.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHUMUPD%2FDMI025

The pathophysiology of polycystic ovary syndrome

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHUMUPD%2FDMI025

Evidence for Association of Polycystic Ovary Syndrome in Caucasian Women with a Marker at the Insulin Receptor Gene Locus

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHUMUPD%2FDMI025

A genome-wide linkage scan for steroids and SHBG levels in black and white families: the HERITAGE Family Study

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHUMUPD%2FDMI025

Thirty-seven candidate genes for polycystic ovary syndrome: strongest evidence for linkage is with follistatin

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHUMUPD%2FDMI025

Variation in resistin gene promoter not associated with polycystic ovary syndrome

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHUMUPD%2FDMI025

Androgens stimulate early stages of follicular growth in the primate ovary

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHUMUPD%2FDMI025

Inconsistent effects of the proline12 --> alanine variant of the peroxisome proliferator-activated receptor-gamma2 gene on body mass index in children and adolescent girls

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHUMUPD%2FDMI025

Frequency of the T228A polymorphism in the SORBS1 gene in children with premature pubarche and in adolescent girls with hyperandrogenism

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHUMUPD%2FDMI025

The molecular phenotype of polycystic ovary syndrome (PCOS) theca cells and new candidate PCOS genes defined by microarray analysis

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHUMUPD%2FDMI025

Association of the (TAAAA)n repeat polymorphism in the sex hormone-binding globulin (SHBG) gene with polycystic ovary syndrome and relation to SHBG serum levels

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHUMUPD%2FDMI025

Administration of insulin-like growth factor I to rhesus monkeys does not augment gonadotropin-stimulated ovarian steroidogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHUMUPD%2FDMI025

Susceptibility to human type 1 diabetes at IDDM2 is determined by tandem repeat variation at the insulin gene minisatellite locus

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHUMUPD%2FDMI025

Fetal growth, length of gestation, and polycystic ovaries in adult life

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHUMUPD%2FDMI025

21 January 2018

Identifiers

DOI

10.1093/HUMUPD/DMI025

1 reference

12 August 2017

1 reference

PubMed ID

15994846