(Q36186193)

English

Efflux transporters at the blood-brain barrier limit delivery and efficacy of cyclin-dependent kinase 4/6 inhibitor palbociclib (PD-0332991) in an orthotopic brain tumor model

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Europe PubMed Central

PMC publication ID

12 August 2017

Efflux transporters at the blood-brain barrier limit delivery and efficacy of cyclin-dependent kinase 4/6 inhibitor palbociclib (PD-0332991) in an orthotopic brain tumor model (English)

1 reference

Europe PubMed Central

PMC publication ID

12 August 2017

blood–brain barrier

1 reference

based on heuristic

inferred from title

1 reference

based on heuristic

inferred from title

author name string

Karen E Parrish

1

1 reference

Europe PubMed Central

PMC publication ID

12 August 2017

Jenny Pokorny

2

1 reference

Europe PubMed Central

PMC publication ID

12 August 2017

Rajendar K Mittapalli

3

1 reference

Europe PubMed Central

PMC publication ID

12 August 2017

Katrina Bakken

4

1 reference

Europe PubMed Central

PMC publication ID

12 August 2017

Jann N Sarkaria

5

1 reference

Europe PubMed Central

PMC publication ID

12 August 2017

William F Elmquist

6

1 reference

Europe PubMed Central

PMC publication ID

12 August 2017

language of work or name

0 references

publication date

9 September 2015

1 reference

Europe PubMed Central

PMC publication ID

12 August 2017

Journal of Pharmacology and Experimental Therapeutics

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Europe PubMed Central

PMC publication ID

12 August 2017

355

1 reference

Europe PubMed Central

PMC publication ID

12 August 2017

2

1 reference

Europe PubMed Central

PMC publication ID

12 August 2017

264-271

1 reference

Europe PubMed Central

PMC publication ID

12 August 2017

Brain Exposure of Two Selective Dual CDK4 and CDK6 Inhibitors and the Antitumor Activity of CDK4 and CDK6 Inhibition in Combination with Temozolomide in an Intracranial Glioblastoma Xenograft

1 reference

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1 reference

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Molecular Pathways: Targeting the Cyclin D-CDK4/6 Axis for Cancer Treatment

1 reference

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Improving drug delivery to primary and metastatic brain tumors: strategies to overcome the blood-brain barrier

1 reference

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Targeting cyclin-dependent kinases in human cancers: from small molecules to Peptide inhibitors

1 reference

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The Efficacy of the Wee1 Inhibitor MK-1775 Combined with Temozolomide Is Limited by Heterogeneous Distribution across the Blood-Brain Barrier in Glioblastoma

1 reference

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The cyclin-dependent kinase 4/6 inhibitor palbociclib in combination with letrozole versus letrozole alone as first-line treatment of oestrogen receptor-positive, HER2-negative, advanced breast cancer (PALOMA-1/TRIO-18): a randomised phase 2 study

1 reference

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Therapeutic Considerations in Treating HER2-Positive Metastatic Breast Cancer

1 reference

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Distribution of the phosphatidylinositol 3-kinase inhibitors Pictilisib (GDC-0941) and GNE-317 in U87 and GS2 intracranial glioblastoma models-assessment by matrix-assisted laser desorption ionization imaging

1 reference

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PD-0332991, a CDK4/6 inhibitor, significantly prolongs survival in a genetically engineered mouse model of brainstem glioma

1 reference

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Blood-brain barrier structure and function and the challenges for CNS drug delivery

1 reference

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1 reference

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Regulation of miR106b cluster through the RB pathway: mechanism and functional targets

1 reference

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p16-Cdk4-Rb axis controls sensitivity to a cyclin-dependent kinase inhibitor PD0332991 in glioblastoma xenograft cells

1 reference

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1 October 2017

Impact of P-glycoprotein (ABCB1) and breast cancer resistance protein (ABCG2) on the brain distribution of a novel BRAF inhibitor: vemurafenib (PLX4032)

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4613960

1 October 2017

Brain distribution of cediranib is limited by active efflux at the blood-brain barrier

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4613960

1 October 2017

Breast cancer resistance protein and P-glycoprotein in brain cancer: two gatekeepers team up

1 reference

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Cyclin D as a therapeutic target in cancer

1 reference

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Delivery of molecularly targeted therapy to malignant glioma, a disease of the whole brain

1 reference

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The Role of the Breast Cancer Resistance Protein (ABCG2) in the Distribution of Sorafenib to the Brain

1 reference

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1 October 2017

Distribution of gefitinib to the brain is limited by P-glycoprotein (ABCB1) and breast cancer resistance protein (ABCG2)-mediated active efflux

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4613960

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Pharmacologic inhibition of cyclin-dependent kinases 4 and 6 arrests the growth of glioblastoma multiforme intracranial xenografts

1 reference

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High-grade glioma mouse models and their applicability for preclinical testing

1 reference

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Comprehensive genomic characterization defines human glioblastoma genes and core pathways

1 reference

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Radiotherapy plus concomitant and adjuvant temozolomide for glioblastoma

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4613960

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Specific inhibition of cyclin-dependent kinase 4/6 by PD 0332991 and associated antitumor activity in human tumor xenografts.

1 reference

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1 reference

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1 October 2017

P-glycoprotein and breast cancer resistance protein restrict the brain penetration of the CDK4/6 inhibitor palbociclib.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4613960

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1 reference

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1 reference

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1 reference

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Brain metastases

1 reference

https://pubmed.ncbi.nlm.nih.gov/26354993

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Quantitative targeted absolute proteomics of human blood-brain barrier transporters and receptors

1 reference

https://pubmed.ncbi.nlm.nih.gov/26354993

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1124/JPET.115.228213

1 reference

Europe PubMed Central

PMC publication ID

12 August 2017

PMC publication ID

1 reference

Europe PubMed Central

PMC publication ID

12 August 2017

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

12 August 2017

ResearchGate publication ID

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