(Q36210891)

12 August 2017

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title

Novel antitrypanosomal agents (English)

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12 August 2017

2

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12 August 2017

Dietmar Steverding

1

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language of work or name

English

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publication date

1 August 2005

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Expert Opinion on Investigational Drugs

12 August 2017

published in

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12 August 2017

volume

14

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12 August 2017

issue

8

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12 August 2017

page(s)

939-955

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Genetic epidemiology of trypanosoma cruzi infection and Chagas disease

12 August 2017

cites work

1 reference

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A critical review on Chagas disease chemotherapy

21 January 2018

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Treatment and control of human African trypanosomiasis

21 January 2018

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Resurrecting the resurrection drug

21 January 2018

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Cysteine proteinases of trypanosome parasites: novel targets for chemotherapy.

21 January 2018

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Protease trafficking in two primitive eukaryotes is mediated by a prodomain protein motif

21 January 2018

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Active site mapping, biochemical properties and subcellular localization of rhodesain, the major cysteine protease of Trypanosoma brucei rhodesiense

21 January 2018

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https://api.crossref.org/works/10.1517%2F13543784.14.8.939

Lysis of trypanosomes by peptidyl fluoromethyl ketones

21 January 2018

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https://api.crossref.org/works/10.1517%2F13543784.14.8.939

Cysteine proteinase inhibitors kill cultured bloodstream forms of Trypanosoma brucei brucei

21 January 2018

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https://api.crossref.org/works/10.1517%2F13543784.14.8.939

Trypanosoma brucei: killing of bloodstream forms in vitro and in vivo by the cysteine proteinase inhibitor Z-phe-ala-CHN2.

21 January 2018

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Cysteine protease inhibitors cure an experimental Trypanosoma cruzi infection

21 January 2018

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Aryl ureas represent a new class of anti-trypanosomal agents

21 January 2018

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Synthesis and structure-activity relationship study of potent trypanocidal thio semicarbazone inhibitors of the trypanosomal cysteine protease cruzain

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.14.8.939

Synthesis and structure-activity relationships of parasiticidal thiosemicarbazone cysteine protease inhibitors against Plasmodium falciparum, Trypanosoma brucei, and Trypanosoma cruzi

21 January 2018

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https://api.crossref.org/works/10.1517%2F13543784.14.8.939

Structure and functions of the 20S and 26S proteasomes

21 January 2018

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https://api.crossref.org/works/10.1517%2F13543784.14.8.939

Purification and characterization of proteasomes from Trypanosoma brucei

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.14.8.939

Biochemical analysis of the 20 S proteasome of Trypanosoma brucei

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.14.8.939

Antitrypanosomal activities of proteasome inhibitors

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.14.8.939

Covalent modification of the active site threonine of proteasomal beta subunits and the Escherichia coli homolog HslV by a new class of inhibitors

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.14.8.939

Substrate binding and sequence preference of the proteasome revealed by active-site-directed affinity probes

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.14.8.939

Trypanocidal activities of trileucine methyl vinyl sulfone proteasome inhibitors.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.14.8.939

Extended peptide-based inhibitors efficiently target the proteasome and reveal overlapping specificities of the catalytic beta-subunits

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.14.8.939

Trypanocidal effect of alpha',beta'-epoxyketones indicates that trypanosomes are particularly sensitive to inhibitors of proteasome trypsin-like activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.14.8.939

In vitro effect of alkaloids on bloodstream forms of Trypanosoma brucei and T. congolense

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.14.8.939

Potent and selective inhibitors of the proteasome: dipeptidyl boronic acids

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.14.8.939

Structure and mechanism of DNA topoisomerase II

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.14.8.939

Topoisomerases of kinetoplastid parasites as potential chemotherapeutic targets

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.14.8.939

An unusual type IB topoisomerase from African trypanosomes

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.14.8.939

RNA interference of Trypanosoma brucei topoisomerase IB: both subunits are essential

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.14.8.939

RNA interference of a trypanosome topoisomerase II causes progressive loss of mitochondrial DNA.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.14.8.939

Anti-trypanosomal activities of DNA topoisomerase inhibitors

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.14.8.939

Trypanocidal activity of antitumor antibiotics and other metabolic inhibitors

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.14.8.939

Evaluation of quinolone derivatives for antitrypanosomal activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.14.8.939

Antitrypanosomal activities of fluoroquinolones with pyrrolidinyl substitutions

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.14.8.939

The cytoskeleton of trypanosomatid parasites

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.14.8.939

Protist tubulins: new arrivals, evolutionary relationships and insights to cytoskeletal function

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.14.8.939

Taxol, a microtubule stabilizing agent, blocks the replication of Trypanosoma cruzi

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.14.8.939

Classical ligands bind tubulin of trypanosomes and inhibit their growth in vitro

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.14.8.939

Dinitroaniline herbicides against protozoan parasites: the case of Trypanosoma cruzi

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.14.8.939

Selective antimicrotubule activity of N1-phenyl-3,5-dinitro-N4,N4-di-n-propylsulfanilamide (GB-II-5) against kinetoplastid parasites

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.14.8.939

Synthesis and antitubulin activity of N1- and N4-substituted 3,5-dinitro sulfanilamides against African trypanosomes and Leishmania

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.14.8.939

Fatty acid and sterol metabolism: potential antimicrobial targets in apicomplexan and trypanosomatid parasitic protozoa

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.14.8.939

Host plasma low density lipoprotein particles as an essential source of lipids for the bloodstream forms of Trypanosoma brucei

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.14.8.939

Receptors for the host low density lipoproteins on the hemoflagellate Trypanosoma brucei: purification and involvement in the growth of the parasite

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.14.8.939

The interactions of amphotericin B with various sterols in relation to its possible use in anticancer therapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.14.8.939

A strategy to reduce cardiovascular disease by more than 80%

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.14.8.939

Mevinolin (lovastatin) potentiates the antiproliferative effects of ketoconazole and terbinafine against Trypanosoma (Schizotrypanum) cruzi: in vitro and in vivo studies

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.14.8.939

Kinetic properties and inhibition of Trypanosoma cruzi 3-hydroxy-3-methylglutaryl CoA reductase.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.14.8.939

Mitochondrial localization of the mevalonate pathway enzyme 3-Hydroxy-3-methyl-glutaryl-CoA reductase in the Trypanosomatidae

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.14.8.939

Bisphosphonates are potent inhibitors of Trypanosoma cruzi farnesyl pyrophosphate synthase

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.14.8.939

Bisphosphonates inhibit the growth of Trypanosoma brucei, Trypanosoma cruzi, Leishmania donovani, Toxoplasma gondii, and Plasmodium falciparum: a potential route to chemotherapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.14.8.939

Selective in vitro effects of the farnesyl pyrophosphate synthase inhibitor risedronate on Trypanosoma cruzi

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.14.8.939

Antiparasitic activity of risedronate in a murine model of acute Chagas' disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.14.8.939

Therapeutic approaches to bone diseases

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.14.8.939

Squalene synthase as a chemotherapeutic target in Trypanosoma cruzi and Leishmania mexicana

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.14.8.939

Trypanocidal activity of 2-propen-1-amine derivatives on trypomastigotes culture and in animal model

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.14.8.939

Ketoconazole Inhibition of Intracellular Multiplication of Trypanosoma cruzi and Protection of Mice Against Lethal Infection with the Organism

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.14.8.939

Activities of the triazole derivative SCH 56592 (posaconazole) against drug-resistant strains of the protozoan parasite Trypanosoma (Schizotrypanum) cruzi in immunocompetent and immunosuppressed murine hosts

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.14.8.939

In vitro antiproliferative effects and mechanism of action of the new triazole derivative UR-9825 against the protozoan parasite Trypanosoma (Schizotrypanum) cruzi

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.14.8.939

Activity of the new triazole derivative albaconazole against Trypanosoma (Schizotrypanum) cruzi in dog hosts

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.14.8.939

Parasitological cure of acute and chronic experimental Chagas disease using the long-acting experimental triazole TAK-187. Activity against drug-resistant Trypanosoma cruzi strains

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.14.8.939

In vitro and in vivo activities of ravuconazole on Trypanosoma cruzi, the causative agent of Chagas disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.14.8.939

A class of sterol 14-demethylase inhibitors as anti-Trypanosoma cruzi agents.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.14.8.939

Novel azasterols as potential agents for treatment of leishmaniasis and trypanosomiasis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.14.8.939

The activities of four anticancer alkyllysophospholipids against Leishmania donovani, Trypanosoma cruzi and Trypanosoma brucei

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.14.8.939

Proinflammatory and cytotoxic effects of hexadecylphosphocholine (miltefosine) against drug-resistant strains of Trypanosoma cruzi

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.14.8.939

Anti-proliferative synergy of lysophospholipid analogues and ketoconazole against Trypanosoma cruzi (Kinetoplastida: Trypanosomatidae): cellular and ultrastructural analysis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.14.8.939

Protein farnesyl and N-myristoyl transferases: piggy-back medicinal chemistry targets for the development of antitrypanosomatid and antimalarial therapeutics.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.14.8.939

Isothiazole dioxides: synthesis and inhibition of Trypanosoma brucei protein farnesyltransferase.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.14.8.939

Design and synthesis of peptidomimetic protein farnesyltransferase inhibitors as anti-Trypanosoma brucei agents.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.14.8.939

Quinoxaline N,N'-dioxide derivatives and related compounds as growth inhibitors of Trypanosoma cruzi. Structure-activity relationships

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.14.8.939

Glutathione derivatives active against Trypanosoma brucei rhodesiense and T. brucei brucei in vitro

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.14.8.939

Novel alkylpolyamine analogues that possess both antitrypanosomal and antimicrosporidial activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.14.8.939

Synthesis and biological evaluation of s-triazine substituted polyamines as potential new anti-trypanosomal drugs.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.14.8.939

Synthesis and evaluation of analogues of 5'-([(Z)-4-amino-2-butenyl]methylamino)-5'-deoxyadenosine as inhibitors of tumor cell growth, trypanosomal growth, and HIV-1 infectivity

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.14.8.939

In vitro and in vivo activities of aminoadamantane and aminoalkylcyclohexane derivatives against Trypanosoma brucei

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.14.8.939

Synthesis and antitrypanosomal evaluation of E-isomers of 5-nitro-2-furaldehyde and 5-nitrothiophene-2-carboxaldehyde semicarbazone derivatives. structure-activity relationships

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.14.8.939

Antitrypanosomal activities and cytotoxicity of 5-nitro-2-furancarbohydrazides.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.14.8.939

Synthesis and in vitro evaluation of potential antichagasic hydroxymethylnitrofurazone (NFOH-121): a new nitrofurazone prodrug

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.14.8.939

Trypanocidal activity of melamine-based nitroheterocycles

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.14.8.939

In vitro activity and mechanism of action against the protozoan parasite Trypanosoma cruzi of 5-nitrofuryl containing thiosemicarbazones.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.14.8.939

Synthesis and in vitro antitrypanosomal activity of novel Nifurtimox analogues

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.14.8.939

Synthesis and antiprotozoal activity of aza-analogues of furamidine

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.14.8.939

Novel dicationic imidazo[1,2-a]pyridines and 5,6,7,8-tetrahydro-imidazo[1,2-a]pyridines as antiprotozoal agents

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.14.8.939

O-alkoxyamidine prodrugs of furamidine: in vitro transport and microsomal metabolism as indicators of in vivo efficacy in a mouse model of Trypanosoma brucei rhodesiense infection

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.14.8.939

Dicationic biphenyl benzimidazole derivatives as antiprotozoal agents

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.14.8.939

The efficacy of ascofuranone in a consecutive treatment on Trypanosoma brucei brucei in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.14.8.939

Investigating the biological functions of DNA topoisomerases in eukaryotic cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.14.8.939

Biphenylquinuclidines as inhibitors of squalene synthase and growth of parasitic protozoa

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.14.8.939

10.1517/13543784.14.8.939

21 January 2018

Identifiers

DOI

1 reference

12 August 2017

1 reference