(Q36225471)

11 January 2018

title

The mTOR Complex Controls HIV Latency (English)

1 reference

11 January 2018

author

J Peter Svensson

11

1 reference

11 January 2018

Jonathan Weissman

18

Jonathan S Weissman

1 reference

11 January 2018

Robert F. Siliciano

17

Robert F Siliciano

1 reference

11 January 2018

Melanie Ott

14

Melanie Ott

1 reference

11 January 2018

Nevan Krogan

16

Nevan J Krogan

1 reference

11 January 2018

Nina N Hosmane

5

Nina N Hosmane

1 reference

11 January 2018

Emilie Besnard

1

1 reference

11 January 2018

Shweta Hakre

2

1 reference

11 January 2018

Martin Kampmann

3

1 reference

11 January 2018

Hyung W Lim

4

1 reference

11 January 2018

Alyssa Martin

6

1 reference

11 January 2018

Michael C Bassik

7

1 reference

11 January 2018

Erik Verschueren

8

1 reference

11 January 2018

Emilie Battivelli

9

1 reference

11 January 2018

Jonathan Chan

10

1 reference

11 January 2018

Andrea Gramatica

12

1 reference

11 January 2018

Ryan J Conrad

13

1 reference

11 January 2018

Warner C Greene

15

1 reference

11 January 2018

Eric Verdin

19

1 reference

11 January 2018

publication date

1 December 2016

1 reference

11 January 2018

published in

Cell Host & Microbe

1 reference

11 January 2018

volume

20

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11 January 2018

issue

6

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11 January 2018

page(s)

785-797

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11 January 2018

Compact and highly active next-generation libraries for CRISPR-mediated gene repression and activation.

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Targeting of mTOR catalytic site inhibits multiple steps of the HIV-1 lifecycle and suppresses HIV-1 viremia in humanized mice

29 June 2018

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The Tat Inhibitor Didehydro-Cortistatin A Prevents HIV-1 Reactivation from Latency

29 June 2018

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HIV reservoirs as obstacles and opportunities for an HIV cure

29 June 2018

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MicroRNA-155 Reinforces HIV Latency.

29 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5354304

COMMD1/Murr1 reinforces HIV-1 latent infection through IκB-α stabilization

29 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5354304

Autophagy restricts HIV-1 infection by selectively degrading Tat in CD4+ T lymphocytes

29 June 2018

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Genome-Scale CRISPR-Mediated Control of Gene Repression and Activation

29 June 2018

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Heat shock protein 90 controls HIV-1 reactivation from latency

29 June 2018

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New ex vivo approaches distinguish effective and ineffective single agents for reversing HIV-1 latency in vivo.

29 June 2018

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Regulation of CDK9 activity by phosphorylation and dephosphorylation.

29 June 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5354304

The Fanconi anemia pathway has a dual function in Dickkopf-1 transcriptional repression

29 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5354304

An in-depth comparison of latent HIV-1 reactivation in multiple cell model systems and resting CD4+ T cells from aviremic patients

29 June 2018

1 reference

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T cell exit from quiescence and differentiation into Th2 cells depend on Raptor-mTORC1-mediated metabolic reprogramming

29 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5354304

An integrated overview of HIV-1 latency

29 June 2018

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Calcium/calcineurin synergizes with prostratin to promote NF-κB dependent activation of latent HIV

29 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5354304

Next-generation NAMPT inhibitors identified by sequential high-throughput phenotypic chemical and functional genomic screens

29 June 2018

1 reference

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Dual-color HIV reporters trace a population of latently infected cells and enable their purification

29 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5354304

Establishment and molecular mechanisms of HIV-1 latency in T cells

29 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5354304

Integrated platform for genome-wide screening and construction of high-density genetic interaction maps in mammalian cells

29 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5354304

Phosphorylation of CDK9 at Ser175 enhances HIV transcription and is a marker of activated P-TEFb in CD4(+) T lymphocytes

29 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5354304

From reactivation of latent HIV-1 to elimination of the latent reservoir: the presence of multiple barriers to viral eradication

29 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5354304

A novel PCR assay for quantification of HIV-1 RNA.

29 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5354304

Lost in transcription: molecular mechanisms that control HIV latency

29 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5354304

Reactivation of latent HIV by histone deacetylase inhibitors.

29 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5354304

A systematic mammalian genetic interaction map reveals pathways underlying ricin susceptibility

29 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5354304

F-box protein substrate recognition: a new insight

29 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5354304

Administration of vorinostat disrupts HIV-1 latency in patients on antiretroviral therapy

29 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5354304

mTOR signaling in growth control and disease

29 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5354304

HIV latency: experimental systems and molecular models.

29 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5354304

Transcriptional and posttranscriptional regulation of HIV-1 gene expression

29 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5354304

The control of HIV transcription: keeping RNA polymerase II on track

29 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5354304

Epigenetic silencing of HIV-1 by the histone H3 lysine 27 methyltransferase enhancer of Zeste 2.

29 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5354304

Protein phosphatase-1 activates CDK9 by dephosphorylating Ser175.

29 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5354304

Epigenetic regulation of HIV latency

29 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5354304

mTOR: from growth signal integration to cancer, diabetes and ageing

29 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5354304

Mammalian target of rapamycin protein complex 2 regulates differentiation of Th1 and Th2 cell subsets via distinct signaling pathways

29 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5354304

CYCLINg through transcription: posttranslational modifications of P-TEFb regulate transcription elongation

29 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5354304

Involvement of histone H3 lysine 9 (H3K9) methyltransferase G9a in the maintenance of HIV-1 latency and its reactivation by BIX01294.

29 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5354304

Dissecting the role of mTOR: lessons from mTOR inhibitors

29 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5354304

CORUM: the comprehensive resource of mammalian protein complexes--2009

29 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5354304

Small-molecule screening using a human primary cell model of HIV latency identifies compounds that reverse latency without cellular activation

29 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5354304

CpG methylation controls reactivation of HIV from latency

29 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5354304

Epigenetic regulation of HIV-1 latency by cytosine methylation

29 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5354304

Active-site inhibitors of mTOR target rapamycin-resistant outputs of mTORC1 and mTORC2

29 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5354304

Transcriptional interference antagonizes proviral gene expression to promote HIV latency

29 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5354304

PP2B and PP1alpha cooperatively disrupt 7SK snRNP to release P-TEFb for transcription in response to Ca2+ signaling

29 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5354304

Suv39H1 and HP1gamma are responsible for chromatin-mediated HIV-1 transcriptional silencing and post-integration latency

29 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5354304

Recruitment of chromatin-modifying enzymes by CTIP2 promotes HIV-1 transcriptional silencing

29 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5354304

Effects of prostratin on Cyclin T1/P-TEFb function and the gene expression profile in primary resting CD4+ T cells

29 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5354304

Prolonged rapamycin treatment inhibits mTORC2 assembly and Akt/PKB

29 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5354304

The gene product Murr1 restricts HIV-1 replication in resting CD4+ lymphocytes

29 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5354304

Calpain facilitates GLUT4 vesicle translocation during insulin-stimulated glucose uptake in adipocytes

29 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5354304

HIV reproducibly establishes a latent infection after acute infection of T cells in vitro.

29 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5354304

Early establishment of a pool of latently infected, resting CD4(+) T cells during primary HIV-1 infection

29 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5354304

The Fanconi anemia complementation group C protein corrects DNA interstrand cross-link-specific apoptosis in HSC536N cells.

29 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5354304

Prostratin antagonizes HIV latency by activating NF-kappaB.

29 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5354304

10.1016/J.CHOM.2016.11.001

22 September 2018

Identifiers

DOI

1 reference

11 January 2018

PMC publication ID

5354304

1 reference

11 January 2018

PubMed publication ID

27978436

1 reference

11 January 2018