(Q36232545)

12 August 2017

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title

Molecular pathogenesis of MLL-associated leukemias (English)

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12 August 2017

3

Mel Greaves

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12 August 2017

Mariko Eguchi

1

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12 August 2017

Minenori Eguchi-Ishimae

series ordinal

2

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12 August 2017

publication date

1 July 2005

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International Journal of Hematology

12 August 2017

published in

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12 August 2017

volume

82

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12 August 2017

issue

1

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12 August 2017

page(s)

9-20

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The oncogenic capacity of HRX-ENL requires the transcriptional transactivation activity of ENL and the DNA binding motifs of HRX.

12 August 2017

cites work

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https://api.crossref.org/works/10.1532%2FIJH97.05042

TFG/TAF30/ANC1, a component of the yeast SWI/SNF complex that is similar to the leukemogenic proteins ENL and AF-9.

21 January 2018

1 reference

https://api.crossref.org/works/10.1532%2FIJH97.05042

DNA cleavage within the MLL breakpoint cluster region is a specific event which occurs as part of higher-order chromatin fragmentation during the initial stages of apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1532%2FIJH97.05042

Leukemic HRX fusion proteins inhibit GADD34-induced apoptosis and associate with the GADD34 and hSNF5/INI1 proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1532%2FIJH97.05042

Leukemia proto-oncoprotein MLL is proteolytically processed into 2 fragments with opposite transcriptional properties

21 January 2018

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12 December 2020

The amino terminus of the mixed lineage leukemia protein (MLL) promotes cell cycle arrest and monocytic differentiation

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12 December 2020

Oligomerization of RAR and AML1 transcription factors as a novel mechanism of oncogenic activation.

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12 December 2020

Expression of CD41 marks the initiation of definitive hematopoiesis in the mouse embryo.

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12 December 2020

A carboxy-terminal domain of ELL is required and sufficient for immortalization of myeloid progenitors by MLL-ELL.

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12 December 2020

Differential expression of Hox, Meis1, and Pbx1 genes in primitive cells throughout murine hematopoietic ontogeny

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12 December 2020

MLL-GAS7 transforms multipotent hematopoietic progenitors and induces mixed lineage leukemias in mice

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12 December 2020

Rapid intraclonal switch of lineage dominance in congenital leukaemia with a MLL gene rearrangement

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12 December 2020

Retroviral insertional mutagenesis: tagging cancer pathways

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12 December 2020

Retrovirus-mediated gene transfer of MLL-ELL transforms primary myeloid progenitors and causes acute myeloid leukemias in mice

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12 December 2020

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12 December 2020

Dimerization contributes to oncogenic activation of MLL chimeras in acute leukemias

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12 December 2020

DNA methyltransferase Dnmt1 associates with histone deacetylase activity

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12 December 2020

Modeling first-hit functions of the t(12;21) TEL-AML1 translocation in mice

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12 December 2020

Leukemia in twins: lessons in natural history

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12 December 2020

Association of CYP3A4 genotype with treatment-related leukemia

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12 December 2020

Gene expression profiling of pediatric acute myelogenous leukemia

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12 December 2020

Inhibition of FLT3 in MLL. Validation of a therapeutic target identified by gene expression based classification

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12 December 2020

Involvement of a homolog of Drosophila trithorax by 11q23 chromosomal translocations in acute leukemias

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12 December 2020

Modulation of cell cycle by graded expression of MLL-AF4 fusion oncoprotein

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12 December 2020

Infant leukaemia biology, aetiology and treatment

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12 December 2020

Novel SWI/SNF chromatin-remodeling complexes contain a mixed-lineage leukemia chromosomal translocation partner

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12 December 2020

Expression of leukemic MLL fusion proteins in Drosophila affects cell cycle control and chromosome morphology.

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12 December 2020

Lineage promiscuity in hemopoietic differentiation and leukemia

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12 December 2020

Defining roles for HOX and MEIS1 genes in induction of acute myeloid leukemia

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12 December 2020

Definitive hematopoiesis requires the mixed-lineage leukemia gene

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12 December 2020

HOX and non-HOX homeobox genes in leukemic hematopoiesis

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12 December 2020

Protracted postnatal natural histories in childhood leukemia

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12 December 2020

Maternal exposure to potential inhibitors of DNA topoisomerase II and infant leukemia (United States): a report from the Children's Cancer Group.

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12 December 2020

MLL 5 protein forms intranuclear foci, and overexpression inhibits cell cycle progression

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12 December 2020

Structure and expression pattern of human ALR, a novel gene with strong homology to ALL-1 involved in acute leukemia and to Drosophila trithorax

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12 December 2020

Prenatal and postnatal myeloid cells demonstrate stepwise progression in the pathogenesis of MLL fusion gene leukemia

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12 December 2020

Identification of a gene, MLL, that spans the breakpoint in 11q23 translocations associated with human leukemias

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12 December 2020

Myeloid or lymphoid promiscuity as a critical step in hematopoietic lineage commitment.

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12 December 2020

Concepts of human leukemic development.

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12 December 2020

Double knockout of the ALL-1 gene blocks hematopoietic differentiation in vitro

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12 December 2020

A trithorax-like gene is interrupted by chromosome 11q23 translocations in acute leukaemias

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12 December 2020

International workshop on the relationship of prior therapy to balanced chromosome aberrations in therapy-related myelodysplastic syndromes and acute leukemia: overview report

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12 December 2020

Missense mutation and defective function of ATM in a childhood acute leukemia patient with MLL gene rearrangement

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12 December 2020

BCR/ABL translocates to the nucleus and disrupts an ATR-dependent intra-S phase checkpoint

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12 December 2020

Expression of a conditional AML1-ETO oncogene bypasses embryonic lethality and establishes a murine model of human t(8;21) acute myeloid leukemia

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12 December 2020

Cloning of ALL-1, the locus involved in leukemias with the t(4;11)(q21;q23), t(9;11)(p22;q23), and t(11;19)(q23;p13) chromosome translocations

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12 December 2020

Leukemic stem cells in childhood high-risk ALL/t(9;22) and t(4;11) are present in primitive lymphoid-restricted CD34+CD19- cells.

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12 December 2020

MLL3, a new human member of the TRX/MLL gene family, maps to 7q36, a chromosome region frequently deleted in myeloid leukaemia.

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12 December 2020

Congenital leukaemia after heavy abuse of permethrin during pregnancy

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12 December 2020

The role of the MLL gene in infant leukemia

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12 December 2020

Taspase1: a threonine aspartase required for cleavage of MLL and proper HOX gene expression

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12 December 2020

Cytogenetic findings in congenital leukemia: case report and review of the literature

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12 December 2020

Gene expression signatures in MLL-rearranged T-lineage and B-precursor acute leukemias: dominance of HOX dysregulation.

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12 December 2020

MLL targets SET domain methyltransferase activity to Hox gene promoters

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12 December 2020

Classification of pediatric acute lymphoblastic leukemia by gene expression profiling

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12 December 2020

Leukemic transformation of hematopoietic progenitors by MLL-GAS7 in the absence of Hoxa7 or Hoxa9.

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12 December 2020

Perturbation of B and T cell development and predisposition to lymphomagenesis in EμBmi1 transgenic mice require the Bmi1 RING finger

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12 December 2020

Fusion genes in leukemia: an emerging network

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12 December 2020

Oncogenic transcription factors in the human acute leukemias

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12 December 2020

Tumorigenesis in mice with a fusion of the leukaemia oncogene Mll and the bacterial lacZ gene.

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12 December 2020

Growth disturbance in fetal liver hematopoiesis of Mll-mutant mice

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12 December 2020

Immortalization and leukemic transformation of a myelomonocytic precursor by retrovirally transduced HRX-ENL.

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12 December 2020

bmi-1 transgene induces lymphomas and collaborates with myc in tumorigenesis

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12 December 2020

ALL-1 is a histone methyltransferase that assembles a supercomplex of proteins involved in transcriptional regulation

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12 December 2020

Identification and characterization of EBP, a novel EEN binding protein that inhibits Ras signaling and is recruited into the nucleus by the MLL-EEN fusion protein

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12 December 2020

Biological and therapeutic aspects of infant leukemia

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12 December 2020

Transcriptional activation is a key function encoded by MLL fusion partners

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12 December 2020

Transformation of myeloid progenitors by MLL oncoproteins is dependent on Hoxa7 and Hoxa9

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12 December 2020

Two distinct gene expression signatures in pediatric acute lymphoblastic leukemia with MLL rearrangements.

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12 December 2020

The mll-AF9 gene fusion in mice controls myeloproliferation and specifies acute myeloid leukaemogenesis

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12 December 2020

The translocations, t(11;19)(q23;p13.1) and t(11;19)(q23;p13.3): a cytogenetic and clinical profile of 53 patients. European 11q23 Workshop participants

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12 December 2020

Common mechanism for oncogenic activation of MLL by forkhead family proteins

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12 December 2020

The molecular genetics of recurring chromosome abnormalities in acute myeloid leukemia

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12 December 2020

MLL5, a homolog of Drosophila trithorax located within a segment of chromosome band 7q22 implicated in myeloid leukemia

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12 December 2020

A component of the transcriptional repressor MeCP1 shares a motif with DNA methyltransferase and HRX proteins

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12 December 2020

MLL-AFX requires the transcriptional effector domains of AFX to transform myeloid progenitors and transdominantly interfere with forkhead protein function

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12 December 2020

Aetiology of acute leukaemia

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12 December 2020

Menin and MLL cooperatively regulate expression of cyclin-dependent kinase inhibitors

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12 December 2020

Chimeric MLL products with a Ras binding cytoplasmic protein AF6 involved in t(6;11) (q27;q23) leukemia localize in the nucleus

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12 December 2020

Three-dimensional structure of beta-galactosidase from E. coli

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12 December 2020

Transcriptional inhibition of p53 by the MLL/MEN chimeric protein found in myeloid leukemia.

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12 December 2020

The MT domain of the proto-oncoprotein MLL binds to CpG-containing DNA and discriminates against methylation

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12 December 2020

The human LASP1 gene is fused to MLL in an acute myeloid leukemia with t(11;17)(q23;q21).

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12 December 2020

Leukemia proto-oncoprotein MLL forms a SET1-like histone methyltransferase complex with menin to regulate Hox gene expression

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12 December 2020

Transplacental chemical exposure and risk of infant leukemia with MLL gene fusion.

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12 December 2020

Hoxa9 and Meis1 are key targets for MLL-ENL-mediated cellular immortalization

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12 December 2020

The elongation domain of ELL is dispensable but its ELL-associated factor 1 interaction domain is essential for MLL-ELL-induced leukemogenesis

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12 December 2020

Site-specific DNA cleavage within the MLL breakpoint cluster region induced by topoisomerase II inhibitors.

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12 December 2020

Bipotential precursors of B cells and macrophages in murine fetal liver

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12 December 2020

MLL and CREB bind cooperatively to the nuclear coactivator CREB-binding protein

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12 December 2020

NQO1 stabilizes p53 through a distinct pathway

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12 December 2020

Engineering de novo reciprocal chromosomal translocations associated with Mll to replicate primary events of human cancer

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12 December 2020

Cell cycle and death control: long live Forkheads

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12 December 2020

Dimerization of MLL fusion proteins immortalizes hematopoietic cells

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12 December 2020

An Mll-dependent Hox program drives hematopoietic progenitor expansion

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12 December 2020

Hoxa9 transforms primary bone marrow cells through specific collaboration with Meis1a but not Pbx1b

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12 December 2020

Conditional MLL-CBP targets GMP and models therapy-related myeloproliferative disease.

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12 December 2020

The t(4;11) chromosome translocation of human acute leukemias fuses the ALL-1 gene, related to Drosophila trithorax, to the AF-4 gene

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12 December 2020

AML1-ETO expression is directly involved in the development of acute myeloid leukemia in the presence of additional mutations

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12 December 2020

Low NAD(P)H:quinone oxidoreductase activity is associated with increased risk of leukemia with MLL translocations in infants and children

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12 December 2020

MLL2: A new mammalian member of the trx/MLL family of genes

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12 December 2020

Fetal origins of the TEL-AML1 fusion gene in identical twins with leukemia

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12 December 2020

The human formin-binding protein 17 (FBP17) interacts with sorting nexin, SNX2, and is an MLL-fusion partner in acute myelogeneous leukemia

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12 December 2020

11q23 translocations split the "AT-hook" cruciform DNA-binding region and the transcriptional repression domain from the activation domain of the mixed-lineage leukemia (MLL) gene

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12 December 2020

Molecular basis of p53 functional inactivation by the leukemic protein MLL-ELL

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12 December 2020

Expression profiles of acute lymphoblastic and myeloblastic leukemias with ALL-1 rearrangements

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12 December 2020

Protracted and variable latency of acute lymphoblastic leukemia after TEL-AML1 gene fusion in utero.

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12 December 2020

MLL2, the second human homolog of the Drosophila trithorax gene, maps to 19q13.1 and is amplified in solid tumor cell lines

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12 December 2020

Nucleolytic cleavage of the mixed lineage leukemia breakpoint cluster region during apoptosis.

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12 December 2020

A lack of a functional NAD(P)H:quinone oxidoreductase allele is selectively associated with pediatric leukemias that have MLL fusions. United Kingdom Childhood Cancer Study Investigators

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12 December 2020

Detection of leukemia-associated MLL-GAS7 translocation early during chemotherapy with DNA topoisomerase II inhibitors

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12 December 2020

MLL-ENL cooperates with SCF to transform primary avian multipotent cells.

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12 December 2020

An RNA polymerase II elongation factor encoded by the human ELL gene

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12 December 2020

Proteolytic cleavage of MLL generates a complex of N- and C-terminal fragments that confers protein stability and subnuclear localization

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12 December 2020

In vitro cleavage of the MLL gene by topoisomerase II inhibitor (etoposide) in normal cord and peripheral blood mononuclear cells

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12 December 2020

FLT3 mutations in the activation loop of tyrosine kinase domain are frequently found in infant ALL with MLL rearrangements and pediatric ALL with hyperdiploidy

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12 December 2020

Hoxa9 influences the phenotype but not the incidence of Mll-AF9 fusion gene leukemia

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12 December 2020

The MLL fusion partner AF10 binds GAS41, a protein that interacts with the human SWI/SNF complex

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12 December 2020

Menin associates with a trithorax family histone methyltransferase complex and with the hoxc8 locus

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12 December 2020

MLL repression domain interacts with histone deacetylases, the polycomb group proteins HPC2 and BMI-1, and the corepressor C-terminal-binding protein

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12 December 2020

An Mll-AF9 fusion gene made by homologous recombination causes acute leukemia in chimeric mice: a method to create fusion oncogenes

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12 December 2020

The fusion gene Cbfb-MYH11 blocks myeloid differentiation and predisposes mice to acute myelomonocytic leukaemia

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12 December 2020

Molecular mechanisms of leukemogenesis mediated by MLL fusion proteins

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12 December 2020

Protein interactions of the MLL PHD fingers modulate MLL target gene regulation in human cells

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12 December 2020

The small oligomerization domain of gephyrin converts MLL to an oncogene

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12 December 2020

Defects in yolk sac hematopoiesis in Mll-null embryos.

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12 December 2020

Lmo2 and GATA-3 associated expression in intraembryonic hemogenic sites

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12 December 2020

Human acute myeloid leukemia is organized as a hierarchy that originates from a primitive hematopoietic cell

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12 December 2020

MLL, a mammalian trithorax-group gene, functions as a transcriptional maintenance factor in morphogenesis

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12 December 2020

MLL/ENL fusion in congenital acute lymphoblastic leukemia with a unique t(11;18;19).

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12 December 2020

Characterization of purified intraembryonic hematopoietic stem cells as a tool to define their site of origin.

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12 December 2020

The mixed lineage leukemia (MLL) protein involved in 11q23 translocations contains a domain that binds cruciform DNA and scaffold attachment region (SAR) DNA.

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12 December 2020

Molecular genetics of human leukemias: new insights into therapy

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12 December 2020

Cooperative activation of Hoxa and Pbx1-related genes in murine myeloid leukaemias

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12 December 2020

Functional contribution of EEN to leukemogenic transformation by MLL-EEN fusion protein

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12 December 2020

Ten novel 11q23 chromosomal partner sites. European 11q23 Workshop participants

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12 December 2020

AT-hook motifs identified in a wide variety of DNA-binding proteins

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12 December 2020

Nuclear punctate distribution of ALL-1 is conferred by distinct elements at the N terminus of the protein

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12 December 2020

Etoposide induces chimeric Mll gene fusions

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12 December 2020

Multilineage gene expression precedes commitment in the hemopoietic system

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12 December 2020

The promiscuous MLL gene links chromosomal translocations to cellular differentiation and tumour tropism

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12 December 2020

Novel human HALR (MLL3) gene encodes a protein homologous to ALR and to ALL-1 involved in leukemia, and maps to chromosome 7q36 associated with leukemia and developmental defects.

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12 December 2020

Classification, subtype discovery, and prediction of outcome in pediatric acute lymphoblastic leukemia by gene expression profiling

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12 December 2020

Chromosomal translocations in human cancer.

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12 December 2020

Altered Hox expression and segmental identity in Mll-mutant mice

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12 December 2020

Chromosomal translocation master genes, mouse models and experimental therapeutics.

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12 December 2020

MLL translocations specify a distinct gene expression profile that distinguishes a unique leukemia

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12 December 2020

In utero rearrangements in the trithorax-related oncogene in infant leukaemias.

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12 December 2020

Oncogenesis in utero: fetal death due to acute myelogenous leukaemia with an MLL translocation

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12 December 2020

ENL, the MLL fusion partner in t(11;19), binds to the c-Abl interactor protein 1 (ABI1) that is fused to MLL in t(10;11)+.

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12 December 2020

The role of chromosome translocations in leukemogenesis.

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12 December 2020

Mll rearrangements in haematological malignancies: lessons from clinical and biological studies

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12 December 2020

Origins of chromosome translocations in childhood leukaemia

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12 December 2020

Backtracking leukemia to birth: identification of clonotypic gene fusion sequences in neonatal blood spots

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12 December 2020

The role of NUP98 gene fusions in hematologic malignancy

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12 December 2020

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12 December 2020

The AF10 leucine zipper is required for leukemic transformation of myeloid progenitors by MLL-AF10.

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12 December 2020

Loops, lineage, and leukemia

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12 December 2020

Binding to nonmethylated CpG DNA is essential for target recognition, transactivation, and myeloid transformation by an MLL oncoprotein

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12 December 2020

Secondary leukemias induced by topoisomerase-targeted drugs

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12 December 2020

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12 December 2020

Identifiers

DOI

10.1532/IJH97.05042

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Dimensions Publication ID

12 August 2017

1033955269

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Fatcat ID

release_cg4mj5d3rfftxkhpi4tf5nhtde

1 reference

Fatcat

https://api.fatcat.wiki/v0/release/cg4mj5d3rfftxkhpi4tf5nhtde

24 November 2022

mapped directly with Wikidata item

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