(Q36233848)

12 August 2017

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title

Gatekeeper pathways and cellular background in the pathogenesis and therapy of AML. (English)

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12 August 2017

Cammenga J

1

1 reference

PubMed ID

16107893

12 August 2017

language of work or name

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1 October 2005

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12 August 2017

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12 August 2017

19

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12 August 2017

10

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12 August 2017

1719-1728

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https://scigraph.springernature.com/pub.10.1038/sj.leu.2403894

12 August 2017

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Cancer-susceptibility genes. Gatekeepers and caretakers

21 January 2018

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Animal models of acute myelogenous leukaemia - development, application and future perspectives.

21 January 2018

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Disruption of differentiation in human cancer: AML shows the way.

21 January 2018

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Enhancement of hematopoietic stem cell repopulating capacity and self-renewal in the absence of the transcription factor C/EBP alpha

21 January 2018

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https://api.crossref.org/works/10.1038%2FSJ.LEU.2403894

AML-1 is required for megakaryocytic maturation and lymphocytic differentiation, but not for maintenance of hematopoietic stem cells in adult hematopoiesis

21 January 2018

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https://api.crossref.org/works/10.1038%2FSJ.LEU.2403894

Haploinsufficiency of CBFA2 causes familial thrombocytopenia with propensity to develop acute myelogenous leukaemia

21 January 2018

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https://api.crossref.org/works/10.1038%2FSJ.LEU.2403894

Extending the repertoire of the mixed-lineage leukemia gene MLL in leukemogenesis

21 January 2018

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https://api.crossref.org/works/10.1038%2FSJ.LEU.2403894

HOX and non-HOX homeobox genes in leukemic hematopoiesis

21 January 2018

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https://api.crossref.org/works/10.1038%2FSJ.LEU.2403894

The role of EVI1 in normal and leukemic cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2403894

Both AML1 and EVI1 oncogenic components are required for the cooperation of AML1/MDS1/EVI1 with BCR/ABL in the induction of acute myelogenous leukemia in mice

21 January 2018

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https://api.crossref.org/works/10.1038%2FSJ.LEU.2403894

EVI1 induces myelodysplastic syndrome in mice

21 January 2018

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https://api.crossref.org/works/10.1038%2FSJ.LEU.2403894

Human AML1/MDS1/EVI1 fusion protein induces an acute myelogenous leukemia (AML) in mice: a model for human AML

21 January 2018

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https://api.crossref.org/works/10.1038%2FSJ.LEU.2403894

Heterozygous PU.1 mutations are associated with acute myeloid leukemia.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2403894

C/EBP-beta, C/EBP-delta, PU.1, AML1 genes: mutational analysis in 381 samples of hematopoietic and solid malignancies

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2403894

pDP4, a novel glycoprotein secreted by mature granulocytes, is regulated by transcription factor PU.1

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2403894

Two critical hits for promyelocytic leukemia

21 January 2018

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https://api.crossref.org/works/10.1038%2FSJ.LEU.2403894

Core-binding factors in haematopoiesis and leukaemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2403894

AML1, the target of multiple chromosomal translocations in human leukemia, is essential for normal fetal liver hematopoiesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2403894

Embryonic lethality and impairment of haematopoiesis in mice heterozygous for an AML1-ETO fusion gene.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2403894

Disruption of the Cbfa2 gene causes necrosis and hemorrhaging in the central nervous system and blocks definitive hematopoiesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2403894

Point mutations in the RUNX1/AML1 gene: another actor in RUNX leukemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2403894

Impaired energy homeostasis in C/EBP alpha knockout mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2403894

Absence of granulocyte colony-stimulating factor signaling and neutrophil development in CCAAT enhancer binding protein alpha-deficient mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2403894

Dominant-negative mutations of CEBPA, encoding CCAAT/enhancer binding protein-alpha (C/EBPalpha), in acute myeloid leukemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2403894

A dominant-negative mutant of C/EBPalpha, associated with acute myeloid leukemias, inhibits differentiation of myeloid and erythroid progenitors of man but not mouse.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2403894

E2F repression by C/EBPalpha is required for adipogenesis and granulopoiesis in vivo

21 January 2018

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https://api.crossref.org/works/10.1038%2FSJ.LEU.2403894

McBindall--a better name for CCAAT/enhancer binding proteins?

21 January 2018

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https://api.crossref.org/works/10.1038%2FSJ.LEU.2403894

C/EBPalpha mutations in acute myeloid leukaemias

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2403894

Biallelic mutations in the CEBPA gene and low CEBPA expression levels as prognostic markers in intermediate-risk AML.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2403894

Mutations in the gene encoding the transcription factor CCAAT/enhancer binding protein alpha in myelodysplastic syndromes and acute myeloid leukemias

21 January 2018

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https://api.crossref.org/works/10.1038%2FSJ.LEU.2403894

Acquired mutations in GATA1 in the megakaryoblastic leukemia of Down syndrome

21 January 2018

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https://api.crossref.org/works/10.1038%2FSJ.LEU.2403894

Cancer genes and the pathways they control

21 January 2018

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https://api.crossref.org/works/10.1038%2FSJ.LEU.2403894

Genetic pathways in therapy-related myelodysplasia and acute myeloid leukemia

21 January 2018

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https://api.crossref.org/works/10.1038%2FSJ.LEU.2403894

Origins of chromosome translocations in childhood leukaemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2403894

Hematopoietic stem cell expansion and distinct myeloid developmental abnormalities in a murine model of the AML1-ETO translocation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2403894

AML1-ETO inhibits maturation of multiple lymphohematopoietic lineages and induces myeloblast transformation in synergy with ICSBP deficiency

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2403894

Expression of a conditional AML1-ETO oncogene bypasses embryonic lethality and establishes a murine model of human t(8;21) acute myeloid leukemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2403894

Maintaining the self-renewal and differentiation potential of human CD34+ hematopoietic cells using a single genetic element.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2403894

The AML1-ETO fusion protein promotes the expansion of human hematopoietic stem cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2403894

C/EBPalpha deficiency results in hyperproliferation of hematopoietic progenitor cells and disrupts macrophage development in vitro and in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2403894

The ETS family transcription factor PU.1 is necessary for the maintenance of fetal liver hematopoietic stem cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2403894

FLT3 internal tandem duplication mutations associated with human acute myeloid leukemias induce myeloproliferative disease in a murine bone marrow transplant model

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2403894

An activated receptor tyrosine kinase, TEL/PDGFbetaR, cooperates with AML1/ETO to induce acute myeloid leukemia in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2403894

A role for Wnt signalling in self-renewal of haematopoietic stem cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2403894

Convergence of Wnt, beta-catenin, and cadherin pathways

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2403894

Analysis of FLT3 length mutations in 1003 patients with acute myeloid leukemia: correlation to cytogenetics, FAB subtype, and prognosis in the AMLCG study and usefulness as a marker for the detection of minimal residual disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2403894

Analysis of FLT3-activating mutations in 979 patients with acute myelogenous leukemia: association with FAB subtypes and identification of subgroups with poor prognosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2403894

21 January 2018

Focus on acute leukemias

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2403894

AML1-ETO expression is directly involved in the development of acute myeloid leukemia in the presence of additional mutations

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2403894

Identification of genes that synergize with Cbfb-MYH11 in the pathogenesis of acute myeloid leukemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2403894

PML/RARalpha and FLT3-ITD induce an APL-like disease in a mouse model

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2403894

BCL-2 cooperates with promyelocytic leukemia retinoic acid receptor alpha chimeric protein (PMLRARalpha) to block neutrophil differentiation and initiate acute leukemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2403894

Differential effects of p19(Arf) and p16(Ink4a) loss on senescence of murine bone marrow-derived preB cells and macrophages

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2403894

The influence of INK4 proteins on growth and self-renewal kinetics of hematopoietic progenitor cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2403894

The t(8;21) fusion protein, AML1 ETO, specifically represses the transcription of the p14(ARF) tumor suppressor in acute myeloid leukemia.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2403894

A clonogenic common myeloid progenitor that gives rise to all myeloid lineages

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2403894

Identification of clonogenic common lymphoid progenitors in mouse bone marrow

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2403894

Normal and leukemic hematopoiesis: Are leukemias a stem cell disorder or a reacquisition of stem cell characteristics?

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2403894

Stem cells, cancer, and cancer stem cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2403894

Acute promyelocytic leukemia: where does it stem from?

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2403894

Human acute myeloid leukemia is organized as a hierarchy that originates from a primitive hematopoietic cell

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2403894

Bmi-1 determines the proliferative capacity of normal and leukaemic stem cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2403894

Bmi-1 is required for maintenance of adult self-renewing haematopoietic stem cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2403894

AML1/ETO-expressing nonleukemic stem cells in acute myelogenous leukemia with 8;21 chromosomal translocation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2403894

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2403894

Transformation of myeloid progenitors by MLL oncoproteins is dependent on Hoxa7 and Hoxa9

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2403894

Leukemic transformation of hematopoietic progenitors by MLL-GAS7 in the absence of Hoxa7 or Hoxa9.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2403894

Granulocyte-macrophage progenitors as candidate leukemic stem cells in blast-crisis CML

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2403894

Deregulated expression of HOXB4 enhances the primitive growth activity of human hematopoietic cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2403894

High-level ectopic HOXB4 expression confers a profound in vivo competitive growth advantage on human cord blood CD34+ cells, but impairs lymphomyeloid differentiation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2403894

Wnt proteins are lipid-modified and can act as stem cell growth factors

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2403894

Translocation products in acute myeloid leukemia activate the Wnt signaling pathway in hematopoietic cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2403894

Gamma-catenin contributes to leukemogenesis induced by AML-associated translocation products by increasing the self-renewal of very primitive progenitor cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2403894

The PML-RARα fusion mRNA generated by the t(15;17) translocation in acute promyelocytic leukemia encodes a functionally altered RAR

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2403894

Role of the histone deacetylase complex in acute promyelocytic leukaemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2403894

A PMLRARalpha transgene initiates murine acute promyelocytic leukemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2403894

Acute leukemia with promyelocytic features in PML/RARalpha transgenic mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2403894

A pilot study of high-throughput, sequence-based mutational profiling of primary human acute myeloid leukemia cell genomes.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2403894

Induction of C/EBPalpha activity alters gene expression and differentiation of human CD34+ cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2403894

Mutation of CEBPA in familial acute myeloid leukemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2403894

7 January 2021

Mutation analysis of the transcription factor PU.1 in younger adults (16 to 60 years) with acute myeloid leukemia: a study of the AML Study Group Ulm (AMLSG ULM)

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2403894

7 January 2021

Are PU.1 mutations frequent genetic events in acute myeloid leukemia (AML)?

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2403894

7 January 2021

Favorable prognostic significance of CEBPA mutations in patients with de novo acute myeloid leukemia: a study from the Acute Leukemia French Association (ALFA)

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2403894

7 January 2021

Aberrant crypt foci and K-ras mutations: earliest recognized players or innocent bystanders in colon carcinogenesis?

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2403894

7 January 2021

Persistence of AML1 rearrangement in peripheral blood cells in t(8;21)

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2403894

7 January 2021

Incidence and prognosis of c-KIT and FLT3 mutations in core binding factor (CBF) acute myeloid leukaemias

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2403894

7 January 2021

c-kit proto-oncogene exon 8 in-frame deletion plus insertion mutations in acute myeloid leukaemia

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2403894

7 January 2021

The fusion gene Cbfb-MYH11 blocks myeloid differentiation and predisposes mice to acute myelomonocytic leukaemia

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2403894

7 January 2021

MLL-GAS7 transforms multipotent hematopoietic progenitors and induces mixed lineage leukemias in mice

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2403894

7 January 2021

Identifiers

DOI

10.1038/SJ.LEU.2403894

1 reference

12 August 2017

1 reference

PubMed ID

16107893