(Q36255655)

13 August 2017

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title

Hypoxia-inducible factor as a physiological regulator (English)

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13 August 2017

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Patrick H Maxwell

1

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publication date

12 September 2005

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13 August 2017

published in

Experimental Physiology

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13 August 2017

volume

90

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13 August 2017

issue

6

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13 August 2017

page(s)

791-797

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Disruption of oxygen homeostasis underlies congenital Chuvash polycythemia

13 August 2017

cites work

1 reference

https://api.crossref.org/works/10.1113%2FEXPPHYSIOL.2005.030924

Differential function of the prolyl hydroxylases PHD1, PHD2, and PHD3 in the regulation of hypoxia-inducible factor

21 January 2018

1 reference

https://api.crossref.org/works/10.1113%2FEXPPHYSIOL.2005.030924

HIF prolyl-hydroxylase 2 is the key oxygen sensor setting low steady-state levels of HIF-1alpha in normoxia

21 January 2018

1 reference

https://api.crossref.org/works/10.1113%2FEXPPHYSIOL.2005.030924

Vhlh gene deletion induces Hif-1-mediated cell death in thymocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1113%2FEXPPHYSIOL.2005.030924

Heterozygous deficiency of hypoxia-inducible factor-2alpha protects mice against pulmonary hypertension and right ventricular dysfunction during prolonged hypoxia

21 January 2018

1 reference

https://api.crossref.org/works/10.1113%2FEXPPHYSIOL.2005.030924

Hearts from rodents exposed to intermittent hypoxia or erythropoietin are protected against ischemia-reperfusion injury

21 January 2018

1 reference

https://api.crossref.org/works/10.1113%2FEXPPHYSIOL.2005.030924

Progenitor cell trafficking is regulated by hypoxic gradients through HIF-1 induction of SDF-1

21 January 2018

1 reference

https://api.crossref.org/works/10.1113%2FEXPPHYSIOL.2005.030924

Contrasting effects on HIF-1alpha regulation by disease-causing pVHL mutations correlate with patterns of tumourigenesis in von Hippel-Lindau disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1113%2FEXPPHYSIOL.2005.030924

Loss of HIF-2alpha and inhibition of VEGF impair fetal lung maturation, whereas treatment with VEGF prevents fatal respiratory distress in premature mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1113%2FEXPPHYSIOL.2005.030924

HIF-1alpha is essential for myeloid cell-mediated inflammation

21 January 2018

1 reference

https://api.crossref.org/works/10.1113%2FEXPPHYSIOL.2005.030924

Defective placental vasculogenesis causes embryonic lethality in VHL-deficient mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1113%2FEXPPHYSIOL.2005.030924

Brain-specific knock-out of hypoxia-inducible factor-1alpha reduces rather than increases hypoxic-ischemic damage.

21 January 2018

1 reference

https://api.crossref.org/works/10.1113%2FEXPPHYSIOL.2005.030924

von Hippel-Lindau protein mutants linked to type 2C VHL disease preserve the ability to downregulate HIF.

21 January 2018

1 reference

https://api.crossref.org/works/10.1113%2FEXPPHYSIOL.2005.030924

HIF overexpression correlates with biallelic loss of fumarate hydratase in renal cancer: novel role of fumarate in regulation of HIF stability

21 January 2018

1 reference

https://api.crossref.org/works/10.1113%2FEXPPHYSIOL.2005.030924

Biochemical purification and pharmacological inhibition of a mammalian prolyl hydroxylase acting on hypoxia-inducible factor

21 January 2018

1 reference

https://api.crossref.org/works/10.1113%2FEXPPHYSIOL.2005.030924

Epithelial hypoxia-inducible factor-1 is protective in murine experimental colitis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1113%2FEXPPHYSIOL.2005.030924

Defective carotid body function and impaired ventilatory responses to chronic hypoxia in mice partially deficient for hypoxia-inducible factor 1 alpha

21 January 2018

1 reference

https://api.crossref.org/works/10.1113%2FEXPPHYSIOL.2005.030924

Inhibition of HIF2alpha is sufficient to suppress pVHL-defective tumor growth

21 January 2018

1 reference

https://api.crossref.org/works/10.1113%2FEXPPHYSIOL.2005.030924

Regulation of oxygen sensing by ion channels.

21 January 2018

1 reference

https://api.crossref.org/works/10.1113%2FEXPPHYSIOL.2005.030924

HIF activation identifies early lesions in VHL kidneys: evidence for site-specific tumor suppressor function in the nephron

21 January 2018

1 reference

https://api.crossref.org/works/10.1113%2FEXPPHYSIOL.2005.030924

Hypoxic induction of vascular endothelial growth factor is markedly decreased in diabetic individuals who do not develop retinopathy

21 January 2018

1 reference

https://api.crossref.org/works/10.1113%2FEXPPHYSIOL.2005.030924

Loss of skeletal muscle HIF-1alpha results in altered exercise endurance

21 January 2018

1 reference

https://api.crossref.org/works/10.1113%2FEXPPHYSIOL.2005.030924

The transcription factor EPAS-1/hypoxia-inducible factor 2alpha plays an important role in vascular remodeling

21 January 2018

1 reference

https://api.crossref.org/works/10.1113%2FEXPPHYSIOL.2005.030924

Contrasting properties of hypoxia-inducible factor 1 (HIF-1) and HIF-2 in von Hippel-Lindau-associated renal cell carcinoma.

21 January 2018

1 reference

https://api.crossref.org/works/10.1113%2FEXPPHYSIOL.2005.030924

Expression of hypoxia-inducible factor-1alpha and -2alpha in hypoxic and ischemic rat kidneys

21 January 2018

1 reference

https://api.crossref.org/works/10.1113%2FEXPPHYSIOL.2005.030924

Oxygen sensing by HIF hydroxylases

21 January 2018

1 reference

https://api.crossref.org/works/10.1113%2FEXPPHYSIOL.2005.030924

Multiple organ pathology, metabolic abnormalities and impaired homeostasis of reactive oxygen species in Epas1-/- mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1113%2FEXPPHYSIOL.2005.030924

The HIF family member EPAS1/HIF-2α is required for normal hematopoiesis in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1113%2FEXPPHYSIOL.2005.030924

HIF1alpha is a critical regulator of secretory differentiation and activation, but not vascular expansion, in the mouse mammary gland

21 January 2018

1 reference

https://api.crossref.org/works/10.1113%2FEXPPHYSIOL.2005.030924

Succinate links TCA cycle dysfunction to oncogenesis by inhibiting HIF-alpha prolyl hydroxylase

21 January 2018

1 reference

https://api.crossref.org/works/10.1113%2FEXPPHYSIOL.2005.030924

Impaired physiological responses to chronic hypoxia in mice partially deficient for hypoxia-inducible factor 1alpha

21 January 2018

1 reference

https://api.crossref.org/works/10.1113%2FEXPPHYSIOL.2005.030924

The Expression and Distribution of the Hypoxia-Inducible Factors HIF-1α and HIF-2α in Normal Human Tissues, Cancers, and Tumor-Associated Macrophages

21 January 2018

1 reference

https://api.crossref.org/works/10.1113%2FEXPPHYSIOL.2005.030924

Hypoxia-inducible factor-1alpha polymorphisms associated with enhanced transactivation capacity, implying clinical significance

21 January 2018

1 reference

https://api.crossref.org/works/10.1113%2FEXPPHYSIOL.2005.030924

The hypoxia-responsive transcription factor EPAS1 is essential for catecholamine homeostasis and protection against heart failure during embryonic development

21 January 2018

1 reference

https://api.crossref.org/works/10.1113%2FEXPPHYSIOL.2005.030924

Hypoxia-induced neutrophil survival is mediated by HIF-1alpha-dependent NF-kappaB activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1113%2FEXPPHYSIOL.2005.030924

Hypoxia-inducible factor 1 is a basic-helix-loop-helix-PAS heterodimer regulated by cellular O2 tension

21 January 2018

1 reference

https://api.crossref.org/works/10.1113%2FEXPPHYSIOL.2005.030924

HIF and oxygen sensing; as important to life as the air we breathe?

21 January 2018

1 reference

https://api.crossref.org/works/10.1113%2FEXPPHYSIOL.2005.030924

Genetic variation in the hypoxia-inducible factor-1alpha gene is associated with type 2 diabetes in Japanese.

21 January 2018

1 reference

https://api.crossref.org/works/10.1113%2FEXPPHYSIOL.2005.030924

10.1113/EXPPHYSIOL.2005.030924

21 January 2018

Identifiers

DOI

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13 August 2017

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