(Q36281646)

English

Positive and Negative Allosteric Modulation of an α1β3γ2 γ-Aminobutyric Acid Type A (GABAA) Receptor by Binding to a Site in the Transmembrane Domain at the γ+-β- Interface

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scholarly article

1 reference

Europe PubMed Central

PMC publication ID

13 August 2017

Positive and Negative Allosteric Modulation of an α1β3γ2 γ-Aminobutyric Acid Type A (GABAA) Receptor by Binding to a Site in the Transmembrane Domain at the γ+-β- Interface (English)

1 reference

Europe PubMed Central

PMC publication ID

13 August 2017

transmembrane protein

0 references

author name string

Selwyn S Jayakar

1

1 reference

Europe PubMed Central

PMC publication ID

13 August 2017

Xiaojuan Zhou

2

1 reference

Europe PubMed Central

PMC publication ID

13 August 2017

Pavel Y Savechenkov

3

1 reference

Europe PubMed Central

PMC publication ID

13 August 2017

David C Chiara

4

1 reference

Europe PubMed Central

PMC publication ID

13 August 2017

Rooma Desai

5

1 reference

Europe PubMed Central

PMC publication ID

13 August 2017

Karol S Bruzik

6

1 reference

Europe PubMed Central

PMC publication ID

13 August 2017

Keith W Miller

7

1 reference

Europe PubMed Central

PMC publication ID

13 August 2017

Jonathan B Cohen

8

1 reference

Europe PubMed Central

PMC publication ID

13 August 2017

language of work or name

0 references

publication date

30 July 2015

1 reference

Europe PubMed Central

PMC publication ID

13 August 2017

Journal of Biological Chemistry

1 reference

Europe PubMed Central

PMC publication ID

13 August 2017

290

1 reference

Europe PubMed Central

PMC publication ID

13 August 2017

38

1 reference

Europe PubMed Central

PMC publication ID

13 August 2017

23432-23446

1 reference

Europe PubMed Central

PMC publication ID

13 August 2017

The desensitization gate of inhibitory Cys-loop receptors.

1 reference

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X-ray structures of GluCl in apo states reveal a gating mechanism of Cys-loop receptors.

1 reference

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Multiple propofol-binding sites in a γ-aminobutyric acid type A receptor (GABAAR) identified using a photoreactive propofol analog.

1 reference

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Crystal structure of a human GABAA receptor

1 reference

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Identifying barbiturate binding sites in a nicotinic acetylcholine receptor with [3H]allyl m-trifluoromethyldiazirine mephobarbital, a photoreactive barbiturate.

1 reference

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Human α1β3γ2L gamma-aminobutyric acid type A receptors: High-level production and purification in a functional state

1 reference

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Asymmetric transmitter binding sites of fetal muscle acetylcholine receptors shape their synaptic response

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Specificity of intersubunit general anesthetic-binding sites in the transmembrane domain of the human α1β3γ2 γ-aminobutyric acid type A (GABAA) receptor.

1 reference

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Allyl m-trifluoromethyldiazirine mephobarbital: an unusually potent enantioselective and photoreactive barbiturate general anesthetic.

1 reference

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Ivermectin binding sites in human and invertebrate Cys-loop receptors

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Two etomidate sites in α1β2γ2 γ-aminobutyric acid type A receptors contribute equally and noncooperatively to modulation of channel gating

1 reference

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Diazepam-bound GABAA receptor models identify new benzodiazepine binding-site ligands

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Mapping general anesthetic binding site(s) in human α1β3 γ-aminobutyric acid type A receptors with [³H]TDBzl-etomidate, a photoreactive etomidate analogue

1 reference

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30 September 2017

Principles of activation and permeation in an anion-selective Cys-loop receptor

1 reference

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30 September 2017

Identification and characterization of anesthetic targets by mouse molecular genetics approaches.

1 reference

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High-level expression and purification of Cys-loop ligand-gated ion channels in a tetracycline-inducible stable mammalian cell line: GABAA and serotonin receptors

1 reference

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General anaesthesia: from molecular targets to neuronal pathways of sleep and arousal

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Stoichiometric pore mutations of the GABAAR reveal a pattern of hydrogen bonding with picrotoxin

1 reference

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30 September 2017

Emerging molecular mechanisms of general anesthetic action.

1 reference

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30 September 2017

Gating allosterism at a single class of etomidate sites on alpha1beta2gamma2L GABA A receptors accounts for both direct activation and agonist modulation

1 reference

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30 September 2017

Differential modulatory actions of the volatile convulsant flurothyl and its anesthetic isomer at inhibitory ligand-gated ion channels

1 reference

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Acetylcholine and epibatidine binding to muscle acetylcholine receptors distinguish between concerted and uncoupled models

1 reference

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30 September 2017

The interaction of the general anesthetic etomidate with the gamma-aminobutyric acid type A receptor is influenced by a single amino acid

1 reference

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30 September 2017

GABAA receptor channels

1 reference

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Physostigmine and galanthamine bind in the presence of agonist at the canonical and noncanonical subunit interfaces of a nicotinic acetylcholine receptor

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Discovery of a novel allosteric modulator of 5-HT3 receptors: inhibition and potentiation of Cys-loop receptor signaling through a conserved transmembrane intersubunit site

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Site specificity of agonist-induced opening and desensitization of the Torpedo californica nicotinic acetylcholine receptor

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Sedation and anesthesia mediated by distinct GABA(A) receptor isoforms.

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Modulation of [3H]Muscimol Binding in Rat Cerebellar and Cerebral Cortical Membranes by Picrotoxin, Pentobarbitone, and Etomidate

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Stereochemical dependence of pharmacological activity in a series of optically active N-methylated barbiturates.

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Separate site(s) of action of optical isomers of 1-methyl-5-phenyl-5-propylbarbituric acid with opposite pharmacological activities at the GABA receptor complex

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In situ chemical cleavage of proteins immobilized to glass-fiber and polyvinylidenedifluoride membranes: cleavage at tryptophan residues with 2-(2'-nitrophenylsulfenyl)-3-methyl-3'-bromoindolenine to obtain internal amino acid sequence.

1 reference

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Physiological modulation of the GABA receptor by convulsant and anticonvulsant barbiturates in cultured rat hippocampal neurons.

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Identification of a molecular target mediating the general anesthetic actions of pentobarbital

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Identification of a GABAA receptor anesthetic binding site at subunit interfaces by photolabeling with an etomidate analog.

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Anesthesia. LV. The pharmacologic response to hexafluorodiethyl ether.

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General anesthetic actions in vivo strongly attenuated by a point mutation in the GABA(A) receptor beta3 subunit.

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1 reference

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A study of the excitatory effects of barbiturates

1 reference

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https://pubmed.ncbi.nlm.nih.gov/26229099

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Identifiers

10.1074/JBC.M115.672006

1 reference

Europe PubMed Central

PMC publication ID

13 August 2017

PMC publication ID

1 reference

Europe PubMed Central

PMC publication ID

13 August 2017

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

13 August 2017

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