(Q36295481)

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The synaptic accumulation of hyperphosphorylated tau oligomers in Alzheimer disease is associated with dysfunction of the ubiquitin-proteasome system

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scholarly article

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Europe PubMed Central

PMC publication ID

13 August 2017

The synaptic accumulation of hyperphosphorylated tau oligomers in Alzheimer disease is associated with dysfunction of the ubiquitin-proteasome system (English)

1 reference

Europe PubMed Central

PMC publication ID

13 August 2017

ubiquitin-proteasome system

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Alzheimer's disease

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object named as

Hwan-Ching Tai

1

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ALBERTO SERRANO-POZO

object named as

Alberto Serrano-Pozo

2

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Tara L Spires-Jones

object named as

Tara L Spires-Jones

5

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6

object named as

Bradley T Hyman

1 reference

Europe PubMed Central

PMC publication ID

13 August 2017

4

object named as

Matthew P Frosch

1 reference

Europe PubMed Central

PMC publication ID

13 August 2017

Tadafumi Hashimoto

3

object named as

Tadafumi Hashimoto

1 reference

Europe PubMed Central

PMC publication ID

13 August 2017

language of work or name

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publication date

4 August 2012

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Europe PubMed Central

PMC publication ID

13 August 2017

number of pages

10

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based on heuristic

inferred from page(s)

The American Journal of Pathology

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Europe PubMed Central

PMC publication ID

13 August 2017

181

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Europe PubMed Central

PMC publication ID

13 August 2017

4

1 reference

Europe PubMed Central

PMC publication ID

13 August 2017

1426-1435

1 reference

Europe PubMed Central

PMC publication ID

13 August 2017

describes a project that uses

1 reference

Europe PubMed Central

11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC3463637/fullTextXML

based on heuristic

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Proteolytic degradation of amyloid β-protein

1 reference

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Apolipoprotein E4 effects in Alzheimer's disease are mediated by synaptotoxic oligomeric amyloid-β

1 reference

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The molecular basis of the frontotemporal lobar degeneration-amyotrophic lateral sclerosis spectrum

1 reference

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30 September 2017

Propagation of tau pathology in a model of early Alzheimer's disease

1 reference

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30 September 2017

Trans-synaptic spread of tau pathology in vivo

1 reference

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The toxic Aβ oligomer and Alzheimer's disease: an emperor in need of clothes

1 reference

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30 September 2017

Identification of oligomers at early stages of tau aggregation in Alzheimer's disease

1 reference

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Neuropathological alterations in Alzheimer disease

1 reference

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The many faces of tau

1 reference

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The toxicity of tau in Alzheimer disease: turnover, targets and potential therapeutics

1 reference

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Deconstruction for reconstruction: the role of proteolysis in neural plasticity and disease

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Dendritic function of tau mediates amyloid-beta toxicity in Alzheimer's disease mouse models

1 reference

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Tau pathophysiology in neurodegeneration: a tangled issue

1 reference

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Ubiquitin, the proteasome and protein degradation in neuronal function and dysfunction

1 reference

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Is tau aggregation toxic or protective?

1 reference

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Amyloid-beta protein dimers isolated directly from Alzheimer's brains impair synaptic plasticity and memory

1 reference

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Co-localization of amyloid beta and tau pathology in Alzheimer's disease synaptosomes

1 reference

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Abeta inhibits the proteasome and enhances amyloid and tau accumulation

1 reference

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Reducing endogenous tau ameliorates amyloid beta-induced deficits in an Alzheimer's disease mouse model

1 reference

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Natural oligomers of the Alzheimer amyloid-beta protein induce reversible synapse loss by modulating an NMDA-type glutamate receptor-dependent signaling pathway

1 reference

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Emerging roles for ubiquitin and protein degradation in neuronal function

1 reference

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Deletion of the ubiquitin ligase CHIP leads to the accumulation, but not the aggregation, of both endogenous phospho- and caspase-3-cleaved tau species.

1 reference

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Protein misfolding, functional amyloid, and human disease

1 reference

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Opinion: What is the role of protein aggregation in neurodegeneration?

1 reference

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Tau alteration and neuronal degeneration in tauopathies: mechanisms and models

1 reference

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Role of tau protein in both physiological and pathological conditions.

1 reference

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Neuropathology of Alzheimer's disease: what is new since A. Alzheimer?

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Presynaptic microtubules: organisation and assembly/disassembly.

1 reference

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Distribution of MAP2 in dendritic spines and its colocalization with actin. An immunogold electron-microscope study

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Physical basis of cognitive alterations in Alzheimer's disease: Synapse loss is the major correlate of cognitive impairment

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Deamidation and isoaspartate formation in smeared tau in paired helical filaments. Unusual properties of the microtubule-binding domain of tau.

1 reference

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Biochemical characterization of a filtered synaptoneurosome preparation from guinea pig cerebral cortex: cyclic adenosine 3':5'-monophosphate-generating systems, receptors, and enzymes

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Synapse loss in frontal cortex biopsies in Alzheimer's disease: correlation with cognitive severity

1 reference

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Distribution of Alzheimer-type pathologic changes in nondemented elderly individuals matches the pattern in Alzheimer's disease

1 reference

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Abnormal tau phosphorylation in the thorny excrescences of CA3 hippocampal neurons in patients with Alzheimer's disease.

1 reference

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Alzheimer disease-specific conformation of hyperphosphorylated paired helical filament-Tau is polyubiquitinated through Lys-48, Lys-11, and Lys-6 ubiquitin conjugation.

1 reference

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Microtubule-associated protein tau is a substrate of ATP/Mg(2+)-dependent proteasome protease system

1 reference

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Early Abeta accumulation and progressive synaptic loss, gliosis, and tangle formation in AD brain

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Tangle and neuron numbers, but not amyloid load, predict cognitive status in Alzheimer’s disease

1 reference

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Proteasome inhibition by paired helical filament-tau in brains of patients with Alzheimer's disease

1 reference

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The expression and distribution of the microtubule-associated proteins tau and microtubule-associated protein 2 in hippocampal neurons in the rat in situ and in cell culture

1 reference

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Characterization of pathology in transgenic mice over-expressing human genomic and cDNA tau transgenes

1 reference

https://pubmed.ncbi.nlm.nih.gov/22867711

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based on heuristic

inferred from PubMed ID database lookup

Serotonin uptake and release by biochemically characterized nerve endings isolated from rat brain by concomitant flotation and sedimentation centrifugation

1 reference

https://pubmed.ncbi.nlm.nih.gov/22867711

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Differential subcellular localization of tubulin and the microtubule-associated protein MAP2 in brain tissue as revealed by immunocytochemistry with monoclonal hybridoma antibodies

1 reference

https://pubmed.ncbi.nlm.nih.gov/22867711

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Hydrofluoric acid-treated tau PHF proteins display the same biochemical properties as normal tau

1 reference

https://pubmed.ncbi.nlm.nih.gov/22867711

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Ubiquitin is conjugated with amino-terminally processed tau in paired helical filaments

1 reference

https://pubmed.ncbi.nlm.nih.gov/22867711

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1016/J.AJPATH.2012.06.033

1 reference

Europe PubMed Central

PMC publication ID

13 August 2017

PMC publication ID

1 reference

Europe PubMed Central

PMC publication ID

13 August 2017

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

13 August 2017

ResearchGate publication ID

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