(Q36301359)

English

Ethosuximide Induces Hippocampal Neurogenesis and Reverses Cognitive Deficits in an Amyloid-β Toxin-induced Alzheimer Rat Model via the Phosphatidylinositol 3-Kinase (PI3K)/Akt/Wnt/β-Catenin Pathway

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scholarly article

1 reference

Europe PubMed Central

PMC publication ID

13 August 2017

Ethosuximide Induces Hippocampal Neurogenesis and Reverses Cognitive Deficits in an Amyloid-β Toxin-induced Alzheimer Rat Model via the Phosphatidylinositol 3-Kinase (PI3K)/Akt/Wnt/β-Catenin Pathway (English)

1 reference

Europe PubMed Central

PMC publication ID

13 August 2017

Alzheimer's disease

0 references

1 reference

based on heuristic

inferred from title

1 reference

based on heuristic

inferred from title

Shashi Kant Tiwari

object named as

Shashi Kant Tiwari

1

0 references

Shailendra K. Gupta

object named as

Shailendra Kumar Gupta

6

0 references

Rajnish Kumar Chaturvedi

object named as

Rajnish Kumar Chaturvedi

9

0 references

object named as

Abhay Sharma

8

0 references

author name string

Brashket Seth

2

1 reference

Europe PubMed Central

PMC publication ID

13 August 2017

Swati Agarwal

3

1 reference

Europe PubMed Central

PMC publication ID

13 August 2017

Anuradha Yadav

4

1 reference

Europe PubMed Central

PMC publication ID

13 August 2017

Madhumita Karmakar

5

1 reference

Europe PubMed Central

PMC publication ID

13 August 2017

Vinay Choubey

7

1 reference

Europe PubMed Central

PMC publication ID

13 August 2017

language of work or name

0 references

publication date

29 September 2015

1 reference

Europe PubMed Central

PMC publication ID

13 August 2017

Journal of Biological Chemistry

1 reference

Europe PubMed Central

PMC publication ID

13 August 2017

290

1 reference

Europe PubMed Central

PMC publication ID

13 August 2017

47

1 reference

Europe PubMed Central

PMC publication ID

13 August 2017

28540-28558

1 reference

Europe PubMed Central

PMC publication ID

13 August 2017

Ketamine affects the neurogenesis of rat fetal neural stem progenitor cells via the PI3K/Akt-p27 signaling pathway

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4653709

30 September 2017

Role of wnt signaling in the control of adult hippocampal functioning in health and disease: therapeutic implications.

1 reference

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30 September 2017

Induction of neuronal differentiation of rat muscle-derived stem cells in vitro using basic fibroblast growth factor and ethosuximide

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4653709

30 September 2017

Levetiracetam suppresses neuronal network dysfunction and reverses synaptic and cognitive deficits in an Alzheimer's disease model

1 reference

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30 September 2017

Adult neurogenesis in Parkinson's disease

1 reference

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30 September 2017

Transducer of regulated CREB-binding proteins (TORCs) transcription and function is impaired in Huntington's disease

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4653709

30 September 2017

Vascular endothelial growth factor regulates adult hippocampal cell proliferation through MEK/ERK- and PI3K/Akt-dependent signaling

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4653709

30 September 2017

Reduction of hippocampal hyperactivity improves cognition in amnestic mild cognitive impairment

1 reference

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30 September 2017

Histone H3 phosphorylation - a versatile chromatin modification for different occasions.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4653709

30 September 2017

Adult hippocampal neurogenesis and its role in Alzheimer's disease

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4653709

30 September 2017

Adult hippocampal neurogenesis buffers stress responses and depressive behaviour

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4653709

30 September 2017

Antiepileptic drugs in the treatment of psychiatric disorders

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4653709

30 September 2017

Neurodegenerative disease and adult neurogenesis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4653709

30 September 2017

Proliferative neural stem cells have high endogenous ROS levels that regulate self-renewal and neurogenesis in a PI3K/Akt-dependant manner

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4653709

30 September 2017

Nestin is required for the proper self-renewal of neural stem cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4653709

30 September 2017

When neurogenesis encounters aging and disease

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4653709

30 September 2017

Impairment of PGC-1alpha expression, neuropathology and hepatic steatosis in a transgenic mouse model of Huntington's disease following chronic energy deprivation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4653709

30 September 2017

Hippocampal neurogenesis as a target for the treatment of mental illness: a critical evaluation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4653709

30 September 2017

Inhibition of PI3K-Akt signaling blocks exercise-mediated enhancement of adult neurogenesis and synaptic plasticity in the dentate gyrus

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4653709

30 September 2017

Wnt-mediated activation of NeuroD1 and retro-elements during adult neurogenesis.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4653709

30 September 2017

Role of Akt and ERK signaling in the neurogenesis following brain ischemia

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4653709

30 September 2017

A functional role for adult hippocampal neurogenesis in spatial pattern separation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4653709

30 September 2017

Impaired PGC-1alpha function in muscle in Huntington's disease.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4653709

30 September 2017

Beta-catenin-mediated Wnt signaling regulates neurogenesis in the ventral telencephalon

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4653709

30 September 2017

Wnt-mediated self-renewal of neural stem/progenitor cells.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4653709

30 September 2017

The anticonvulsant ethosuximide disrupts sensory function to extend C. elegans lifespan

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4653709

30 September 2017

Mechanisms and functional implications of adult neurogenesis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4653709

30 September 2017

PI3K/Akt and CREB regulate adult neural hippocampal progenitor proliferation and differentiation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4653709

30 September 2017

Ethosuximide: from bench to bedside

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4653709

30 September 2017

Adult hippocampal neurogenesis as target for the treatment of depression.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4653709

30 September 2017

Adult neurogenesis and neurodegenerative disease

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4653709

30 September 2017

Wnt signalling regulates adult hippocampal neurogenesis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4653709

30 September 2017

Adult neurogenesis in the mammalian central nervous system

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4653709

30 September 2017

Beta-catenin signaling is required for neural differentiation of embryonic stem cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4653709

30 September 2017

Requirement of hippocampal neurogenesis for the behavioral effects of antidepressants

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4653709

30 September 2017

Functional neurogenesis in the adult hippocampus

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4653709

30 September 2017

Specific petit mal anticonvulsants reduce calcium currents in thalamic neurons

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4653709

30 September 2017

Characterization of ethosuximide reduction of low-threshold calcium current in thalamic neurons

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4653709

30 September 2017

Different action of ethosuximide on low- and high-threshold calcium currents in rat sensory neurons

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4653709

30 September 2017

Bisphenol-A impairs myelination potential during development in the hippocampus of the rat brain

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4653709

29 June 2018

Prenatal carbofuran exposure inhibits hippocampal neurogenesis and causes learning and memory deficits in offspring

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4653709

29 June 2018

Effects of lamotrigine and topiramate on hippocampal neurogenesis in experimental temporal-lobe epilepsy

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4653709

29 June 2018

Ethosuximide in the treatment of absence (peptit mal) seizures

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4653709

29 June 2018

Valproic acid, a histone deacetylase inhibitor, regulates cell proliferation in the adult zebrafish optic tectum

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4653709

22 September 2018

Lamotrigine attenuates deficits in synaptic plasticity and accumulation of amyloid plaques in APP/PS1 transgenic mice

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4653709

22 September 2018

Curcumin-loaded nanoparticles potently induce adult neurogenesis and reverse cognitive deficits in Alzheimer's disease model via canonical Wnt/β-catenin pathway

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4653709

22 September 2018

Effects of allantoin on cognitive function and hippocampal neurogenesis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4653709

22 September 2018

Valproate recovers the inhibitory effect of dexamethasone on the proliferation of the adult dentate gyrus-derived neural precursor cells via GSK-3β and β-catenin pathway

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4653709

22 September 2018

Evaluation of longevity enhancing compounds against transactive response DNA-binding protein-43 neuronal toxicity.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4653709

22 September 2018

Intrahippocampal injection of Aβ1-42 inhibits neurogenesis and down-regulates IFN-γ and NF-κB expression in hippocampus of adult mouse brain

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4653709

22 September 2018

Age-dependent effects of hippocampal neurogenesis suppression on spatial learning.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4653709

22 September 2018

BDNF promotes EGF-induced proliferation and migration of human fetal neural stem/progenitor cells via the PI3K/Akt pathway.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4653709

22 September 2018

Long-term effectiveness of ethosuximide, valproic acid, and lamotrigine in childhood absence epilepsy.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4653709

22 September 2018

Effects of mood stabilizers on adult dentate gyrus-derived neural precursor cells.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4653709

22 September 2018

Ethosuximide converts ictogenic neurons initiating absence seizures into normal neurons in a genetic model

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4653709

22 September 2018

Mood stabilizing drugs expand the neural stem cell pool in the adult brain through activation of notch signaling.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4653709

22 September 2018

The effects of chronic administration of ethosuximide on learning and memory: a behavioral and biochemical study on nonepileptic rats

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4653709

22 September 2018

Discovery of novel hippocampal neurogenic agents by using an in vivo stable isotope labeling technique

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4653709

22 September 2018

Behavioral and neurochemical effects induced by pyrethroid-based mosquito repellent exposure in rat offsprings during prenatal and early postnatal period

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4653709

22 September 2018

Evaluation of gabapentin and ethosuximide for treatment of acute nonconvulsive seizures following ischemic brain injury in rats

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4653709

22 September 2018

Activation of the Akt/GSK3beta signaling pathway mediates survival of vulnerable hippocampal neurons after transient global cerebral ischemia in rats

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4653709

22 September 2018

Corticosterone-induced inhibition of gliogenesis in rat hippocampus is counteracted by electroconvulsive seizures

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4653709

22 September 2018

The mood stabilizer valproic acid stimulates GABA neurogenesis from rat forebrain stem cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4653709

22 September 2018

Phosphatidylinositol 3-kinase signaling is involved in neurogenesis during Xenopus embryonic development

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4653709

22 September 2018

Two Distinct Subpopulations of Nestin-Positive Cells in Adult Mouse Dentate Gyrus

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4653709

22 September 2018

Long-term cultivation of multipotential neural stem cells from adult rat subependyma

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4653709

22 September 2018

Seizures decrease postnatal neurogenesis and granule cell development in the human fascia dentata

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4653709

22 September 2018

Regulation of neurogenesis in adult mouse hippocampus by cAMP and the cAMP response element-binding protein.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4653709

22 September 2018

The pharmacokinetics of ethosuximide enantiomers in the rat.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4653709

22 September 2018

Two models of epileptic spike-and-wave rhythm in rats are differently influenced by ethosuximide

1 reference

https://pubmed.ncbi.nlm.nih.gov/26420483

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Comparative study of ethosuximide and sodium valproate in the treatment of typical absence seizures (petit mal)

1 reference

https://pubmed.ncbi.nlm.nih.gov/26420483

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Neurogenin 1 mediates erythropoietin enhanced differentiation of adult neural progenitor cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/26420483

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Lamotrigine increases the number of BrdU-labeled cells in the rat hippocampus

1 reference

https://pubmed.ncbi.nlm.nih.gov/26420483

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Improved Control of Epilepsy by Monitoring Plasma Ethosuximide

1 reference

https://pubmed.ncbi.nlm.nih.gov/26420483

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Ontogeny of ethosuximide action against two seizure models in rats is different

1 reference

https://pubmed.ncbi.nlm.nih.gov/26420483

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Neurodegenerative diseases: Anti-epileptic drug shows benefit in AD mouse model

1 reference

https://pubmed.ncbi.nlm.nih.gov/26420483

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

[Therapeutic drug monitoring of ethosuximide]

1 reference

https://pubmed.ncbi.nlm.nih.gov/26420483

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Hypotension, mental disorders and changes in catecholamine excretion observed during the administration of disulfiram in a case of pheochromocytoma

1 reference

https://pubmed.ncbi.nlm.nih.gov/26420483

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1074/JBC.M115.652586

1 reference

Europe PubMed Central

PMC publication ID

13 August 2017

PMC publication ID

1 reference

Europe PubMed Central

PMC publication ID

13 August 2017

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

13 August 2017

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