(Q24624879)

23 June 2017

title

Levetiracetam suppresses neuronal network dysfunction and reverses synaptic and cognitive deficits in an Alzheimer's disease model (English)

1 reference

23 June 2017

1 reference

1 reference

3

Laure Verret

1 reference

23 June 2017

11

Lennart Mucke

1 reference

23 June 2017

Pascal E Sanchez

1

1 reference

23 June 2017

Lei Zhu

2

1 reference

23 June 2017

Keith A Vossel

4

1 reference

23 June 2017

Anna G Orr

5

1 reference

23 June 2017

John R Cirrito

6

1 reference

23 June 2017

Nino Devidze

7

1 reference

23 June 2017

Kaitlyn Ho

8

1 reference

23 June 2017

Gui-Qiu Yu

9

1 reference

23 June 2017

Jorge J Palop

10

1 reference

23 June 2017

language of work or name

English

0 references

publication date

6 August 2012

1 reference

Proceedings of the National Academy of Sciences of the United States of America

23 June 2017

published in

1 reference

23 June 2017

volume

109

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23 June 2017

issue

42

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23 June 2017

page(s)

E2895-903

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Inhibitory interneuron deficit links altered network activity and cognitive dysfunction in Alzheimer model

23 June 2017

cites work

1 reference

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Reversing EphB2 depletion rescues cognitive functions in Alzheimer model

7 April 2017

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Amyloid-beta-induced neuronal dysfunction in Alzheimer's disease: from synapses toward neural networks

7 April 2017

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Soluble oligomers of amyloid Beta protein facilitate hippocampal long-term depression by disrupting neuronal glutamate uptake

7 April 2017

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SV2 renders primed synaptic vesicles competent for Ca2+ -induced exocytosis

7 April 2017

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The synaptic vesicle protein SV2A is the binding site for the antiepileptic drug levetiracetam

7 April 2017

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Synaptic vesicle protein 2 enhances release probability at quiescent synapses

7 April 2017

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Effect of levetiracetam on molecular regulation of hippocampal glutamate and GABA transporters in rats with chronic seizures induced by amygdalar FeCl3 injection

7 April 2017

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Reducing endogenous tau ameliorates amyloid beta-induced deficits in an Alzheimer's disease mouse model

7 April 2017

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APP processing and synaptic function

7 April 2017

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High-level neuronal expression of abeta 1-42 in wild-type human amyloid protein precursor transgenic mice: synaptotoxicity without plaque formation

7 April 2017

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Aberrant excitatory neuronal activity and compensatory remodeling of inhibitory hippocampal circuits in mouse models of Alzheimer's disease

7 April 2017

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Reduction of hippocampal hyperactivity improves cognition in amnestic mild cognitive impairment

26 May 2017

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3479491

Hippocampal hyperactivation associated with cortical thinning in Alzheimer's disease signature regions in non-demented elderly adults

27 September 2017

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Opposing synaptic regulation of amyloid-β metabolism by NMDA receptors in vivo

27 September 2017

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3479491

A new mechanism for antiepileptic drug action: vesicular entry may mediate the effects of levetiracetam

27 September 2017

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3479491

Neuronal activity regulates the regional vulnerability to amyloid-β deposition

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3479491

Levetiracetam: a review of its use in epilepsy

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3479491

Anti-aβ therapeutics in Alzheimer's disease: the need for a paradigm shift

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3479491

Amyloid-β/Fyn-induced synaptic, network, and cognitive impairments depend on tau levels in multiple mouse models of Alzheimer's disease.

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3479491

Transsynaptic progression of amyloid-β-induced neuronal dysfunction within the entorhinal-hippocampal network

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3479491

Hippocampal interictal spikes disrupt cognition in rats

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3479491

The dysregulation of intracellular calcium in Alzheimer disease

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3479491

Functional alterations in memory networks in early Alzheimer's disease

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3479491

Many neuronal and behavioral impairments in transgenic mouse models of Alzheimer's disease are independent of caspase cleavage of the amyloid precursor protein

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3479491

Key factors in the discovery and development of new antiepileptic drugs

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3479491

Treatment strategies targeting excess hippocampal activity benefit aged rats with cognitive impairment

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3479491

Abnormal neuronal networks and seizure susceptibility in mice overexpressing the APP intracellular domain.

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3479491

Targeting Abeta and tau in Alzheimer's disease, an early interim report

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3479491

Amyloid deposition is associated with impaired default network function in older persons without dementia

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3479491

Calcium signaling and neurodegenerative diseases

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3479491

Epilepsy and cognitive impairments in Alzheimer disease

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3479491

Endocytosis is required for synaptic activity-dependent release of amyloid-beta in vivo

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3479491

Levetiracetam: part II, the clinical profile of a novel anticonvulsant drug

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3479491

Levetiracetam: the profile of a novel anticonvulsant drug-part I: preclinical data.

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3479491

A network dysfunction perspective on neurodegenerative diseases

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3479491

Experimental and clinical evidence for loss of effect (tolerance) during prolonged treatment with antiepileptic drugs

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3479491

Increased hippocampal activation in mild cognitive impairment compared to normal aging and AD

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3479491

Cognitive impairment during epileptiform discharges: is it ever justifiable to treat the EEG?

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3479491

Seizures in elderly patients with dementia: epidemiology and management

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3479491

Neuronal depletion of calcium-dependent proteins in the dentate gyrus is tightly linked to Alzheimer's disease-related cognitive deficits

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3479491

Neuropsychological effects of epilepsy and antiepileptic drugs

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3479491

Amyloid precursor protein processing and A beta42 deposition in a transgenic mouse model of Alzheimer disease

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3479491

Soluble Aβ oligomers inhibit long-term potentiation through a mechanism involving excessive activation of extrasynaptic NR2B-containing NMDA receptors

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3479491

Spontaneous epileptiform discharges in a mouse model of Alzheimer's disease are suppressed by antiepileptic drugs that block sodium channels

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3479491

Levetiracetam has a time- and stimulation-dependent effect on synaptic transmission

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3479491

Development of tolerance during chronic treatment of kindled rats with the novel antiepileptic drug levetiracetam.

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3479491

Neuroscience: Alzheimer's disease

30 May 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1121081109

Alterations in memory networks in mild cognitive impairment and Alzheimer's disease: an independent component analysis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1121081109

Amyloid beta-induced neuronal hyperexcitability triggers progressive epilepsy.

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1121081109

Fyn kinase induces synaptic and cognitive impairments in a transgenic mouse model of Alzheimer's disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1121081109

Accelerating amyloid-beta fibrillization reduces oligomer levels and functional deficits in Alzheimer disease mouse models.

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1121081109

Effects of the novel antiepileptic drug levetiracetam on spontaneous recurrent seizures in the rat pilocarpine model of temporal lobe epilepsy

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1121081109

Development of tolerance to levetiracetam in rats with chronic epilepsy

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1121081109

Evidence for sustained efficacy of levetiracetam as add-on epilepsy therapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1121081109

Toll-like receptor 4 and high-mobility group box-1 are involved in ictogenesis and can be targeted to reduce seizures

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1121081109

Levetiracetam, lamotrigine, and phenobarbital in patients with epileptic seizures and Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1121081109

Amyloid-beta as a positive endogenous regulator of release probability at hippocampal synapses.

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1121081109

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1121081109

Levetiracetam reduces caffeine-induced Ca2+ transients and epileptiform potentials in hippocampal neurons

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1121081109

EEG-triggered functional MRI of interictal epileptiform activity in patients with partial seizures

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1121081109

EEG-fMRI of epileptic spikes: concordance with EEG source localization and intracranial EEG.

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1121081109

Temporal and extratemporal BOLD responses to temporal lobe interictal spikes.

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1121081109

Levels and alternative splicing of amyloid beta protein precursor (APP) transcripts in brains of APP transgenic mice and humans with Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1121081109

Quantifying biomarkers of cognitive dysfunction and neuronal network hyperexcitability in mouse models of Alzheimer's disease: depletion of calcium-dependent proteins and inhibitory hippocampal remodeling

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1121081109

Synaptic activity regulates interstitial fluid amyloid-beta levels in vivo.

21 January 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3479491

Effects of distinct classes of N-methyl-D-aspartate receptor antagonists on seizures, axonal sprouting and neuronal loss in vitro: suppression by NR2B-selective antagonists

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3479491

In VivoAssessment of Brain Interstitial Fluid with Microdialysis Reveals Plaque-Associated Changes in Amyloid-β Metabolism and Half-Life

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3479491

28 November 2018

Identifiers

DOI

10.1073/PNAS.1121081109

1 reference

OpenCitations bibliographic resource ID

23 June 2017

0 references

1721352

1 reference

Consolidated OpenCitations Corpus – April 2017

OpenCitations bibliographic resource ID

1 reference

Consolidated OpenCitations Corpus – April 2017

OpenCitations bibliographic resource ID

1721352

1 reference