(Q36323352)

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IκBα deficiency in brain leads to elevated basal neuroinflammation and attenuated response following traumatic brain injury: implications for functional recovery

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scholarly article

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Europe PubMed Central

PMC publication ID

13 August 2017

IκBα deficiency in brain leads to elevated basal neuroinflammation and attenuated response following traumatic brain injury: implications for functional recovery (English)

1 reference

Europe PubMed Central

PMC publication ID

13 August 2017

traumatic brain injury

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author name string

Hong Lian

1

1 reference

Europe PubMed Central

PMC publication ID

13 August 2017

David J Shim

2

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Europe PubMed Central

PMC publication ID

13 August 2017

Samson S K Gaddam

3

1 reference

Europe PubMed Central

PMC publication ID

13 August 2017

Jennifer Rodriguez-Rivera

4

1 reference

Europe PubMed Central

PMC publication ID

13 August 2017

Brittany R Bitner

5

1 reference

Europe PubMed Central

PMC publication ID

13 August 2017

Robia G Pautler

6

1 reference

Europe PubMed Central

PMC publication ID

13 August 2017

Claudia S Robertson

7

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Europe PubMed Central

PMC publication ID

13 August 2017

Hui Zheng

8

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Europe PubMed Central

PMC publication ID

13 August 2017

publication date

19 September 2012

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Europe PubMed Central

PMC publication ID

13 August 2017

Molecular Neurodegeneration

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Europe PubMed Central

PMC publication ID

13 August 2017

7

1 reference

Europe PubMed Central

PMC publication ID

13 August 2017

47

1 reference

Europe PubMed Central

PMC publication ID

13 August 2017

describes a project that uses

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Europe PubMed Central

11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC3473257/fullTextXML

based on heuristic

inferred from PubMed Central ID database lookup

https://scigraph.springernature.com/pub.10.1186/1750-1326-7-47

0 references

Astrocyte-derived GDNF is a potent inhibitor of microglial activation.

1 reference

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Cautionary notes on the use of NF-κB p65 and p50 antibodies for CNS studies

1 reference

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Attenuated neurological deficit, cell death and lesion volume in Fas-mutant mice is associated with altered neuroinflammation following traumatic brain injury

1 reference

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Increase in blood-brain barrier permeability, oxidative stress, and activated microglia in a rat model of blast-induced traumatic brain injury

1 reference

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Soluble amyloid precursor protein (APP) regulates transthyretin and Klotho gene expression without rescuing the essential function of APP

1 reference

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Blood-brain barrier breakdown as a therapeutic target in traumatic brain injury

1 reference

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Traumatic brain injury and amyloid-β pathology: a link to Alzheimer's disease?

1 reference

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30 September 2017

Involvement of pro- and anti-inflammatory cytokines and chemokines in the pathophysiology of traumatic brain injury

1 reference

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Neurological autoimmunity targeting aquaporin-4.

1 reference

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Unique aspects of transcriptional regulation in neurons - nuances in NFkappaB and Sp1-related factors

1 reference

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c-Rel, an NF-kappaB family transcription factor, is required for hippocampal long-term synaptic plasticity and memory formation

1 reference

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30 September 2017

Suppression of acute proinflammatory cytokine and chemokine upregulation by post-injury administration of a novel small molecule improves long-term neurologic outcome in a mouse model of traumatic brain injury

1 reference

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Systemic inflammation exacerbates behavioral and histopathological consequences of isolated traumatic brain injury in rats

1 reference

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The blood-brain barrier in health and chronic neurodegenerative disorders

1 reference

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Dysfunctional astrocytes as key players in the pathogenesis of central nervous system disorders.

1 reference

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30 September 2017

The epidemiology and impact of traumatic brain injury: a brief overview

1 reference

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Inflammation and brain edema: new insights into the role of chemokines and their receptors

1 reference

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30 September 2017

NF-kappaB regulates spatial memory formation and synaptic plasticity through protein kinase A/CREB signaling

1 reference

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Roles for NF-kappaB in nerve cell survival, plasticity, and disease

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IgG marker of optic-spinal multiple sclerosis binds to the aquaporin-4 water channel

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Stroma-mediated dysregulation of myelopoiesis in mice lacking I kappa B alpha

1 reference

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30 September 2017

A bioinformatics analysis of memory consolidation reveals involvement of the transcription factor c-rel

1 reference

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30 September 2017

NF-kappa B functions in synaptic signaling and behavior

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3473257

30 September 2017

The IkappaB-NF-kappaB signaling module: temporal control and selective gene activation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3473257

30 September 2017

Inflammatory response in acute traumatic brain injury: a double-edged sword

1 reference

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Astrocyte-specific inactivation of the neurofibromatosis 1 gene (NF1) is insufficient for astrocytoma formation.

1 reference

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The duality of the inflammatory response to traumatic brain injury

1 reference

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A review and rationale for the use of genetically engineered animals in the study of traumatic brain injury

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3473257

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IkappaB family members function by different mechanisms

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3473257

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Disruption of the glucocorticoid receptor gene in the nervous system results in reduced anxiety

1 reference

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IkappaBalpha deficiency results in a sustained NF-kappaB response and severe widespread dermatitis in mice

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3473257

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Brain synapses contain inducible forms of the transcription factor NF-kappa B.

1 reference

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30 September 2017

Autoregulation of I kappa B alpha activity

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3473257

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Constitutive NF-kappa B activity in neurons

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3473257

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Signal-induced site-specific phosphorylation targets I kappa B alpha to the ubiquitin-proteasome pathway

1 reference

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1 reference

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Stimulation of ionotropic glutamate receptors activates transcription factor NF-kappa B in primary neurons

1 reference

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Stimulation-dependent I kappa B alpha phosphorylation marks the NF-kappa B inhibitor for degradation via the ubiquitin-proteasome pathway

1 reference

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Lack of NF-kappaB p50 exacerbates degeneration of hippocampal neurons after chemical exposure and impairs learning

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Chronic ibuprofen administration worsens cognitive outcome following traumatic brain injury in rats.

1 reference

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Astrocyte-targeted expression of IL-6 protects the CNS against a focal brain injury.

1 reference

https://api.crossref.org/works/10.1186%2F1750-1326-7-47

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NF-kappaB and IkappaBalpha expression following traumatic brain injury to the immature rat brain.

1 reference

https://api.crossref.org/works/10.1186%2F1750-1326-7-47

21 January 2018

Delayed neuronal death after brain trauma involves p53-dependent inhibition of NF-kappaB transcriptional activity.

1 reference

https://api.crossref.org/works/10.1186%2F1750-1326-7-47

21 January 2018

NF-kappaB is activated and promotes cell death in focal cerebral ischemia.

1 reference

https://api.crossref.org/works/10.1186%2F1750-1326-7-47

21 January 2018

Neuronal activation of NF-kappaB contributes to cell death in cerebral ischemia.

1 reference

https://api.crossref.org/works/10.1186%2F1750-1326-7-47

21 January 2018

Astrocytes are GABAergic cells that modulate microglial activity.

1 reference

https://api.crossref.org/works/10.1186%2F1750-1326-7-47

21 January 2018

Hypoxia/reoxygenation differentially modulates NF-kappaB activation and iNOS expression in astrocytes and microglia.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3473257

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Forebrain-specific neuronal inhibition of nuclear factor-kappaB activity leads to loss of neuroprotection.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3473257

22 September 2018

Activation of the nuclear factor-kappaB is a key event in brain tolerance.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3473257

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Interleukin-6 promotes post-traumatic healing in the central nervous system

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3473257

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Expression of nuclear factor kappaB and tumor necrosis factor alpha in the mouse brain after experimental thermal ablation injury.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3473257

22 September 2018

NF-kappa B signaling promotes both cell survival and neurite process formation in nerve growth factor-stimulated PC12 cells.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3473257

22 September 2018

Regulation of Cu/Zn-Superoxide Dismutase Expression via the Phosphatidylinositol 3 Kinase/Akt Pathway and Nuclear Factor- B

1 reference

https://api.crossref.org/works/10.1186%2F1750-1326-7-47

21 January 2018

Prolonged activation of NF-kappaB following traumatic brain injury in rats

1 reference

https://pubmed.ncbi.nlm.nih.gov/22992283

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Constitutive NF-kappa B activity is modulated via neuron-astroglia interaction

1 reference

https://pubmed.ncbi.nlm.nih.gov/22992283

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Effect of systemic LPS injection on cortical NF-kappaB activity and inflammatory response following traumatic brain injury in rats

1 reference

https://pubmed.ncbi.nlm.nih.gov/22992283

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1186/1750-1326-7-47

1 reference

Europe PubMed Central

PMC publication ID

13 August 2017

Dimensions Publication ID

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PMC publication ID

1 reference

Europe PubMed Central

PMC publication ID

13 August 2017

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

13 August 2017

ResearchGate publication ID

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