(Q36331722)

13 October 2017

CRISPR-Cas9 epigenome editing enables high-throughput screening for functional regulatory elements in the human genome (English)

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13 October 2017

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4

Alexias Safi

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13 October 2017

7

Gregory E Crawford

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13 October 2017

5

Lingyun Song

1 reference

13 October 2017

Tyler S Klann

1

1 reference

13 October 2017

Joshua B Black

2

1 reference

13 October 2017

Malathi Chellappan

3

1 reference

13 October 2017

Isaac B Hilton

6

1 reference

13 October 2017

Timothy E Reddy

8

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13 October 2017

Charles A Gersbach

9

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13 October 2017

3 April 2017

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13 October 2017

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13 October 2017

35

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13 October 2017

6

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13 October 2017

561-568

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https://scigraph.springernature.com/pub.10.1038/nbt.3853

13 October 2017

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High-resolution interrogation of functional elements in the noncoding genome

29 June 2018

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Systematic mapping of functional enhancer-promoter connections with CRISPR interference

29 June 2018

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Editing DNA Methylation in the Mammalian Genome

29 June 2018

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Applications of CRISPR technologies in research and beyond

29 June 2018

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Direct GR Binding Sites Potentiate Clusters of TF Binding across the Human Genome

29 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5462860

A CRISPR-based approach for targeted DNA demethylation

29 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5462860

CRISPR-dCas9 mediated TET1 targeting for selective DNA demethylation at BRCA1 promoter.

29 June 2018

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Repurposing the CRISPR-Cas9 system for targeted DNA methylation

29 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5462860

Editing the epigenome: technologies for programmable transcription and epigenetic modulation

29 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5462860

A new class of temporarily phenotypic enhancers identified by CRISPR/Cas9-mediated genetic screening

29 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5462860

High-throughput mapping of regulatory DNA.

29 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5462860

Functional genetic screens for enhancer elements in the human genome using CRISPR-Cas9.

29 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5462860

Highly specific epigenome editing by CRISPR-Cas9 repressors for silencing of distal regulatory elements

29 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5462860

BCL11A enhancer dissection by Cas9-mediated in situ saturating mutagenesis

29 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5462860

Functional footprinting of regulatory DNA.

29 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5462860

Massively parallel quantification of the regulatory effects of noncoding genetic variation in a human cohort

29 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5462860

Epigenome editing by a CRISPR-Cas9-based acetyltransferase activates genes from promoters and enhancers.

29 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5462860

Functional annotation of native enhancers with a Cas9-histone demethylase fusion.

29 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5462860

Moderated estimation of fold change and dispersion for RNA-seq data with DESeq2

29 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5462860

Genome-scale transcriptional activation by an engineered CRISPR-Cas9 complex

29 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5462860

Genome-Scale CRISPR-Mediated Control of Gene Repression and Activation

29 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5462860

Comparison of TALE designer transcription factors and the CRISPR/dCas9 in regulation of gene expression by targeting enhancers

29 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5462860

Saturation editing of genomic regions by multiplex homology-directed repair

29 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5462860

Improved vectors and genome-wide libraries for CRISPR screening

29 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5462860

GT-Scan: identifying unique genomic targets

29 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5462860

Genome-wide recessive genetic screening in mammalian cells with a lentiviral CRISPR-guide RNA library

29 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5462860

Genome-scale CRISPR-Cas9 knockout screening in human cells

29 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5462860

Genetic screens in human cells using the CRISPR-Cas9 system

29 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5462860

Reprogramming to pluripotency using designer TALE transcription factors targeting enhancers

29 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5462860

CAS9 transcriptional activators for target specificity screening and paired nickases for cooperative genome engineering

29 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5462860

CRISPR-mediated modular RNA-guided regulation of transcription in eukaryotes

29 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5462860

Repurposing CRISPR as an RNA-guided platform for sequence-specific control of gene expression

29 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5462860

Targeted genome engineering in human cells with the Cas9 RNA-guided endonuclease

29 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5462860

Genome-wide quantitative enhancer activity maps identified by STARR-seq

29 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5462860

RNA-guided human genome engineering via Cas9

29 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5462860

Multiplex genome engineering using CRISPR/Cas systems

29 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5462860

The accessible chromatin landscape of the human genome

29 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5462860

An integrated encyclopedia of DNA elements in the human genome

29 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5462860

A Programmable Dual-RNA-Guided DNA Endonuclease in Adaptive Bacterial Immunity

29 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5462860

Trastuzumab: updated mechanisms of action and resistance in breast cancer

29 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5462860

Fast gapped-read alignment with Bowtie 2

29 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5462860

Open chromatin defined by DNaseI and FAIRE identifies regulatory elements that shape cell-type identity

29 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5462860

HER2-amplified breast cancer: mechanisms of trastuzumab resistance and novel targeted therapies

29 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5462860

The NIH Roadmap Epigenomics Mapping Consortium

29 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5462860

EGF-induced Grb7 recruits and promotes Ras activity essential for the tumorigenicity of Sk-Br3 breast cancer cells

29 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5462860

DNase-seq: a high-resolution technique for mapping active gene regulatory elements across the genome from mammalian cells

29 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5462860

Regulation of ERBB2 by oestrogen receptor-PAX2 determines response to tamoxifen

29 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5462860

Production and titration of lentiviral vectors.

29 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5462860

High-resolution mapping and characterization of open chromatin across the genome

29 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5462860

Use of chemotherapy plus a monoclonal antibody against HER2 for metastatic breast cancer that overexpresses HER2.

29 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5462860

Locus control regions of mammalian beta-globin gene clusters: combining phylogenetic analyses and experimental results to gain functional insights

29 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5462860

Developmental regulation of the vertebrate globin multigene family.

29 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5462860

Inducible transcription of five globin genes in K562 human leukemia cells

29 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5462860

Genome-scale mapping of DNase I sensitivity in vivo using tiling DNA microarrays.

29 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5462860

22 September 2018

Identifiers

DOI

10.1038/NBT.3853

1 reference

13 October 2017

1 reference

13 October 2017

1 reference