Home
Random
Nearby
Log in
Settings
Donate
About Wikidata
Disclaimers
Search
(Q36348378)
Watch
English
Re-replication induced by geminin depletion occurs from G2 and is enhanced by checkpoint activation.
scientific article
In more languages
edit
Statements
instance of
scholarly article
1 reference
stated in
Europe PubMed Central
PMC publication ID
3481538
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22366459%20AND%20SRC:MED&resulttype=core&format=json
retrieved
24 January 2020
title
Re-replication induced by geminin depletion occurs from G2 and is enhanced by checkpoint activation
(English)
1 reference
stated in
Europe PubMed Central
PMC publication ID
3481538
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22366459%20AND%20SRC:MED&resulttype=core&format=json
retrieved
24 January 2020
author
Nicholas Schurch
series ordinal
3
1 reference
stated in
Europe PubMed Central
PMC publication ID
3481538
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22366459%20AND%20SRC:MED&resulttype=core&format=json
retrieved
24 January 2020
J. Julian Blow
series ordinal
5
1 reference
stated in
Europe PubMed Central
PMC publication ID
3481538
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22366459%20AND%20SRC:MED&resulttype=core&format=json
retrieved
24 January 2020
author name string
Kathleen Klotz-Noack
series ordinal
1
1 reference
stated in
Europe PubMed Central
PMC publication ID
3481538
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22366459%20AND%20SRC:MED&resulttype=core&format=json
retrieved
24 January 2020
Debbie McIntosh
series ordinal
2
1 reference
stated in
Europe PubMed Central
PMC publication ID
3481538
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22366459%20AND%20SRC:MED&resulttype=core&format=json
retrieved
24 January 2020
Norman Pratt
series ordinal
4
1 reference
stated in
Europe PubMed Central
PMC publication ID
3481538
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22366459%20AND%20SRC:MED&resulttype=core&format=json
retrieved
24 January 2020
language of work or name
English
0 references
publication date
24 February 2012
1 reference
stated in
Europe PubMed Central
PMC publication ID
3481538
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22366459%20AND%20SRC:MED&resulttype=core&format=json
retrieved
24 January 2020
published in
Journal of Cell Science
1 reference
stated in
Europe PubMed Central
PMC publication ID
3481538
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22366459%20AND%20SRC:MED&resulttype=core&format=json
retrieved
24 January 2020
volume
125
1 reference
stated in
Europe PubMed Central
PMC publication ID
3481538
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22366459%20AND%20SRC:MED&resulttype=core&format=json
retrieved
24 January 2020
issue
Pt 10
1 reference
stated in
Europe PubMed Central
PMC publication ID
3481538
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22366459%20AND%20SRC:MED&resulttype=core&format=json
retrieved
24 January 2020
page(s)
2436-2445
1 reference
stated in
Europe PubMed Central
PMC publication ID
3481538
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22366459%20AND%20SRC:MED&resulttype=core&format=json
retrieved
24 January 2020
cites work
Dynamic interactions of high Cdt1 and geminin levels regulate S phase in early Xenopus embryos.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3481538
retrieved
30 September 2017
How dormant origins promote complete genome replication
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3481538
retrieved
30 September 2017
Inhibition of NEDD8-activating enzyme induces rereplication and apoptosis in human tumor cells consistent with deregulating CDT1 turnover
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3481538
retrieved
30 September 2017
Chk1 inhibits replication factory activation but allows dormant origin firing in existing factories.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3481538
retrieved
30 September 2017
NEDD8-targeting drug MLN4924 elicits DNA rereplication by stabilizing Cdt1 in S phase, triggering checkpoint activation, apoptosis, and senescence in cancer cells
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3481538
retrieved
30 September 2017
Preferential re-replication of Drosophila heterochromatin in the absence of geminin
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3481538
retrieved
30 September 2017
Cell type-dependent requirement for PIP box-regulated Cdt1 destruction during S phase
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3481538
retrieved
30 September 2017
High-resolution whole-genome sequencing reveals that specific chromatin domains from most human chromosomes associate with nucleoli
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3481538
retrieved
30 September 2017
G2 phase chromatin lacks determinants of replication timing.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3481538
retrieved
30 September 2017
A double-hexameric MCM2-7 complex is loaded onto origin DNA during licensing of eukaryotic DNA replication
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3481538
retrieved
30 September 2017
Quaternary structure of the human Cdt1-Geminin complex regulates DNA replication licensing
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3481538
retrieved
30 September 2017
Concerted loading of Mcm2-7 double hexamers around DNA during DNA replication origin licensing
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3481538
retrieved
30 September 2017
Selective killing of cancer cells by suppression of geminin activity
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3481538
retrieved
30 September 2017
An inhibitor of NEDD8-activating enzyme as a new approach to treat cancer
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3481538
retrieved
30 September 2017
Replication licensing and cancer--a fatal entanglement?
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3481538
retrieved
30 September 2017
Cdt1 and Cdc6 are destabilized by rereplication-induced DNA damage.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3481538
retrieved
30 September 2017
Dormant origins licensed by excess Mcm2-7 are required for human cells to survive replicative stress.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3481538
retrieved
30 September 2017
The ATR-mediated S phase checkpoint prevents rereplication in mammalian cells when licensing control is disrupted.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3481538
retrieved
30 September 2017
ATR pathway is the primary pathway for activating G2/M checkpoint induction after re-replication
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3481538
retrieved
30 September 2017
The Mre11/Rad50/Nbs1 complex plays an important role in the prevention of DNA rereplication in mammalian cells
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3481538
retrieved
30 September 2017
Strength in numbers: preventing rereplication via multiple mechanisms in eukaryotic cells
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3481538
retrieved
30 September 2017
A Cdt1-geminin complex licenses chromatin for DNA replication and prevents rereplication during S phase in Xenopus
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3481538
retrieved
30 September 2017
An ATR- and BRCA1-mediated Fanconi anemia pathway is required for activating the G2/M checkpoint and DNA damage repair upon rereplication
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3481538
retrieved
30 September 2017
Regulating the licensing of DNA replication origins in metazoa
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3481538
retrieved
30 September 2017
Two E3 ubiquitin ligases, SCF-Skp2 and DDB1-Cul4, target human Cdt1 for proteolysis.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3481538
retrieved
30 September 2017
Genome-wide mapping of DNA synthesis in Saccharomyces cerevisiae reveals that mechanisms preventing reinitiation of DNA replication are not redundant
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3481538
retrieved
30 September 2017
PCNA is a cofactor for Cdt1 degradation by CUL4/DDB1-mediated N-terminal ubiquitination
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3481538
retrieved
30 September 2017
Preventing re-replication of chromosomal DNA.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3481538
retrieved
30 September 2017
Cdt1 downregulation by proteolysis and geminin inhibition prevents DNA re-replication in Xenopus
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3481538
retrieved
30 September 2017
Loss of rereplication control in Saccharomyces cerevisiae results in extensive DNA damage
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3481538
retrieved
30 September 2017
Rereplication by depletion of geminin is seen regardless of p53 status and activates a G2/M checkpoint
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3481538
retrieved
30 September 2017
Human geminin promotes pre-RC formation and DNA replication by stabilizing CDT1 in mitosis
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3481538
retrieved
30 September 2017
Loss of Geminin induces rereplication in the presence of functional p53
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3481538
retrieved
30 September 2017
Cdt1 phosphorylation by cyclin A-dependent kinases negatively regulates its function without affecting geminin binding
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3481538
retrieved
30 September 2017
Non-proteolytic inactivation of geminin requires CDK-dependent ubiquitination.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3481538
retrieved
30 September 2017
The SCF(Skp2) ubiquitin ligase complex interacts with the human replication licensing factor Cdt1 and regulates Cdt1 degradation
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3481538
retrieved
30 September 2017
A p53-dependent checkpoint pathway prevents rereplication
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3481538
retrieved
30 September 2017
Geminin becomes activated as an inhibitor of Cdt1/RLF-B following nuclear import.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3481538
retrieved
30 September 2017
Control of DNA replication and chromosome ploidy by geminin and cyclin A
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3481538
retrieved
30 September 2017
Reconstitution of licensed replication origins on Xenopus sperm nuclei using purified proteins
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3481538
retrieved
30 September 2017
Repression of origin assembly in metaphase depends on inhibition of RLF-B/Cdt1 by geminin
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3481538
retrieved
30 September 2017
Inhibition of eukaryotic DNA replication by geminin binding to Cdt1
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3481538
retrieved
30 September 2017
Geminin, an inhibitor of DNA replication, is degraded during mitosis
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3481538
retrieved
30 September 2017
Geminin escapes degradation in G1 of mouse pluripotent cells and mediates the expression of Oct4, Sox2, and Nanog
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3481538
retrieved
29 June 2018
MCM2-7 form double hexamers at licensed origins in Xenopus egg extract
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3481538
retrieved
29 June 2018
Loss of DNA Replication Control Is a Potent Inducer of Gene Amplification
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3481538
retrieved
29 June 2018
Deregulated replication licensing causes DNA fragmentation consistent with head-to-tail fork collision.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3481538
retrieved
22 September 2018
Drosophila double-parked is sufficient to induce re-replication during development and is regulated by cyclin E/CDK2.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3481538
retrieved
22 September 2018
Proteolysis of DNA replication licensing factor Cdt1 in S-phase is performed independently of geminin through its N-terminal region
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3481538
retrieved
22 September 2018
CUL-4 ubiquitin ligase maintains genome stability by restraining DNA-replication licensing
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3481538
retrieved
22 September 2018
Recombinant Cdt1 induces rereplication of G2 nuclei in Xenopus egg extracts
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/22366459
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
PCNA functions as a molecular platform to trigger Cdt1 destruction and prevent re-replication
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/22366459
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Identifiers
DOI
10.1242/JCS.100883
1 reference
stated in
Europe PubMed Central
PMC publication ID
3481538
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22366459%20AND%20SRC:MED&resulttype=core&format=json
retrieved
24 January 2020
PMC publication ID
3481538
1 reference
stated in
Europe PubMed Central
PMC publication ID
3481538
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22366459%20AND%20SRC:MED&resulttype=core&format=json
retrieved
24 January 2020
PubMed publication ID
22366459
1 reference
stated in
Europe PubMed Central
PMC publication ID
3481538
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22366459%20AND%20SRC:MED&resulttype=core&format=json
retrieved
24 January 2020
ResearchGate publication ID
221862767
0 references
Sitelinks
Wikipedia
(0 entries)
edit
Wikibooks
(0 entries)
edit
Wikinews
(0 entries)
edit
Wikiquote
(0 entries)
edit
Wikisource
(0 entries)
edit
Wikiversity
(0 entries)
edit
Wikivoyage
(0 entries)
edit
Wiktionary
(0 entries)
edit
Multilingual sites
(0 entries)
edit