(Q36348804)

13 August 2017

Microtubule destabilization and nuclear entry are sequential steps leading to toxicity in Huntington's disease (English)

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13 August 2017

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12

Cynthia T McMurray

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13 August 2017

1

Eugenia Trushina

1 reference

13 August 2017

Michael P Heldebrant

2

1 reference

13 August 2017

Carmen M Perez-Terzic

3

1 reference

13 August 2017

Ryan Bortolon

4

1 reference

13 August 2017

Irina V Kovtun

5

1 reference

13 August 2017

John D Badger

6

1 reference

13 August 2017

Andre Terzic

7

1 reference

13 August 2017

Alvaro Estévez

8

1 reference

13 August 2017

Anthony J Windebank

9

1 reference

13 August 2017

Roy B Dyer

10

1 reference

13 August 2017

Janet Yao

11

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13 August 2017

language of work or name

English

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publication date

3 October 2003

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Proceedings of the National Academy of Sciences of the United States of America

13 August 2017

1 reference

13 August 2017

100

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13 August 2017

21

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13 August 2017

12171-12176

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Sp1 and TAFII130 transcriptional activity disrupted in early Huntington's disease

13 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=218731

Perinuclear localization of huntingtin as a consequence of its binding to microtubules through an interaction with beta-tubulin: relevance to Huntington's disease

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=218731

Huntingtin is present in the nucleus, interacts with the transcriptional corepressor C-terminal binding protein, and represses transcription

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=218731

Histone deacetylase inhibitors arrest polyglutamine-dependent neurodegeneration in Drosophila

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=218731

Mutant protein in Huntington disease is resistant to proteolysis in affected brain

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=218731

Polyglutamine expansions cause decreased CRE-mediated transcription and early gene expression changes prior to cell death in an inducible cell model of Huntington's disease

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=218731

Transcriptional dysregulation in Huntington's disease

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=218731

Inhibiting caspase cleavage of huntingtin reduces toxicity and aggregate formation in neuronal and nonneuronal cells

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=218731

Long glutamine tracts cause nuclear localization of a novel form of huntingtin in medium spiny striatal neurons in HdhQ92 and HdhQ111 knock-in mice

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=218731

Structural plasticity of the cardiac nuclear pore complex in response to regulators of nuclear import

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=218731

In vitro evidence for both the nucleus and cytoplasm as subcellular sites of pathogenesis in Huntington's disease.

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=218731

Synergistic activation of the N-methyl-D-aspartate receptor subunit 1 promoter by myocyte enhancer factor 2C and Sp1

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=218731

Huntingtin interacts with a family of WW domain proteins

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=218731

Aggregation of huntingtin in neuronal intranuclear inclusions and dystrophic neurites in brain

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=218731

Nucleocytoplasmic transport

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=218731

Mouse Huntington's disease gene homolog (Hdh).

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=218731

Expanded polyglutamine peptides alone are intrinsically cytotoxic and cause neurodegeneration in Drosophila

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=218731

Behavioural abnormalities and selective neuronal loss in HD transgenic mice expressing mutated full-length HD cDNA.

29 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=218731

Inhibition of axonal growth from sensory neurons by excess nerve growth factor

29 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=218731

Quantitative analysis of morphological features in Huntington's disease.

29 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=218731

Taxol stabilization of microtubules in vitro: dynamics of tubulin addition and loss at opposite microtubule ends

29 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=218731

Abnormalities of striatal projection neurons and N-methyl-D-aspartate receptors in presymptomatic Huntington's disease

29 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=218731

Amyloid-like inclusions in Huntington's disease.

29 June 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.2034961100

Axonal transport of N-terminal huntingtin suggests early pathology of corticostriatal projections in Huntington disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.2034961100

Early transcriptional profiles in huntingtin-inducible striatal cells by microarray analyses

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.2034961100

Huntingtin inclusions do not deplete polyglutamine-containing transcription factors in HD mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.2034961100

A YAC mouse model for Huntington's disease with full-length mutant huntingtin, cytoplasmic toxicity, and selective striatal neurodegeneration.

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.2034961100

Huntington's disease gene product, huntingtin, associates with microtubules in vitro

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.2034961100

Nuclear targeting of mutant Huntingtin increases toxicity

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.2034961100

Microtubule reconfiguration during axonal retraction induced by nitric oxide.

21 January 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=218731

Huntingtin aggregate-associated axonal degeneration is an early pathological event in Huntington's disease mice.

22 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=218731

Toxicity of dopamine to striatal neurons in vitro and potentiation of cell death by a mitochondrial inhibitor

22 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=218731

Interference by huntingtin and atrophin-1 with cbp-mediated transcription leading to cellular toxicity

22 September 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.2034961100

Toxicity of Dopamine to Striatal Neurons In Vitro and Potentiation of Cell Death by a Mitochondrial Inhibitor

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.2034961100

21 January 2018

Identifiers

DOI

10.1073/PNAS.2034961100

1 reference

13 August 2017

0 references

1 reference

13 August 2017

PubMed publication ID

14527999

1 reference