(Q36353626)

English

Quantitative comparison of the efficacy of various compounds in lowering intracellular cholesterol levels in Niemann-Pick type C fibroblasts

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scholarly article

1 reference

Europe PubMed Central

PMC publication ID

13 August 2017

Quantitative comparison of the efficacy of various compounds in lowering intracellular cholesterol levels in Niemann-Pick type C fibroblasts (English)

1 reference

Europe PubMed Central

PMC publication ID

13 August 2017

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Holly Goodson

7

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Kevin T. Vaughan

4

object named as

Kevin T Vaughan

1 reference

Europe PubMed Central

PMC publication ID

13 August 2017

5

object named as

Olaf Wiest

1 reference

Europe PubMed Central

PMC publication ID

13 August 2017

6

object named as

Paul Helquist

1 reference

Europe PubMed Central

13 August 2017

PMC publication ID

author name string

Zachary T Wehrmann

1

1 reference

Europe PubMed Central

PMC publication ID

13 August 2017

Tyler W Hulett

2

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Europe PubMed Central

PMC publication ID

13 August 2017

Kara L Huegel

3

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Europe PubMed Central

PMC publication ID

13 August 2017

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publication date

29 October 2012

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Europe PubMed Central

PMC publication ID

13 August 2017

1 reference

Europe PubMed Central

PMC publication ID

13 August 2017

7

1 reference

Europe PubMed Central

PMC publication ID

13 August 2017

10

1 reference

Europe PubMed Central

PMC publication ID

13 August 2017

e48561

1 reference

Europe PubMed Central

PMC publication ID

13 August 2017

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Creative Commons Attribution 4.0 International

29 October 2012

1 reference

April 2022 Public Data File from Crossref

copyright status

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describes a project that uses

1 reference

Europe PubMed Central

11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC3483179/fullTextXML

based on heuristic

inferred from PubMed Central ID database lookup

Activation mobilizes the cholesterol in the late endosomes-lysosomes of Niemann Pick type C cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3483179

30 September 2017

Niemann-Pick type C 1 function requires lumenal domain residues that mediate cholesterol-dependent NPC2 binding

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3483179

30 September 2017

Histone deacetylase inhibitor treatment dramatically reduces cholesterol accumulation in Niemann-Pick type C1 mutant human fibroblasts

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3483179

30 September 2017

Niemann-Pick disease type C

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3483179

30 September 2017

Defective cholesterol trafficking in Niemann-Pick C-deficient cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3483179

30 September 2017

Endocytosis of beta-cyclodextrins is responsible for cholesterol reduction in Niemann-Pick type C mutant cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3483179

30 September 2017

mTORC1 activates SREBP-1c and uncouples lipogenesis from gluconeogenesis.

1 reference

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Pharmacology of epigenetics in brain disorders

1 reference

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30 September 2017

Structure of N-Terminal Domain of NPC1 Reveals Distinct Subdomains for Binding and Transfer of Cholesterol

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3483179

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Targeting mTOR with rapamycin: one dose does not fit all

1 reference

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30 September 2017

Reversal of defective lysosomal transport in NPC disease ameliorates liver dysfunction and neurodegeneration in the npc1-/- mouse

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3483179

30 September 2017

Therapeutic application of histone deacetylase inhibitors for central nervous system disorders

1 reference

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30 September 2017

Rab8-dependent recycling promotes endosomal cholesterol removal in normal and sphingolipidosis cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3483179

30 September 2017

Automated microscopy screening for compounds that partially revert cholesterol accumulation in Niemann-Pick C cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3483179

30 September 2017

Effects of sirolimus on mesangial cell cholesterol homeostasis: a novel mechanism for its action against lipid-mediated injury in renal allografts

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3483179

30 September 2017

SREBP transcription factors: master regulators of lipid homeostasis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3483179

30 September 2017

Targeting the mammalian target of rapamycin (mTOR): a new approach to treating cancer

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3483179

30 September 2017

Upstream and downstream of mTOR

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3483179

30 September 2017

Suberoylanilide hydroxamic acid, a histone deacetylase inhibitor, ameliorates motor deficits in a mouse model of Huntington's disease

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3483179

30 September 2017

The Niemann-Pick C proteins and trafficking of cholesterol through the late endosomal/lysosomal system

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3483179

30 September 2017

Rab proteins mediate Golgi transport of caveola-internalized glycosphingolipids and correct lipid trafficking in Niemann-Pick C cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3483179

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3483179

30 September 2017

Niemann-Pick C1 disease: the I1061T substitution is a frequent mutant allele in patients of Western European descent and correlates with a classic juvenile phenotype

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3483179

30 September 2017

Sterol transfer between cyclodextrin and membranes: similar but not identical mechanism to NPC2-mediated cholesterol transfer

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3483179

29 June 2018

Hydroxypropylcyclodextrins in parenteral use. I: Lipid dissolution and effects on lipid transfers in vitro

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3483179

29 June 2018

Rapamycin down-regulates LDL-receptor expression independently of SREBP-2.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3483179

22 September 2018

Niemann-Pick type C1 I1061T mutant encodes a functional protein that is selected for endoplasmic reticulum-associated degradation due to protein misfolding

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3483179

22 September 2018

Critical role for glycosphingolipids in Niemann-Pick disease type C.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3483179

22 September 2018

Effect of cytarabine and decitabine in combination in human leukemic cell lines

1 reference

https://pubmed.ncbi.nlm.nih.gov/23144769

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Calmodulin antagonists chlorpromazine and W-7 inhibit exogenous cholesterol esterification and sphingomyelinase activity in human skin fibroblast cultures. Similarities between drug-induced and Niemann-Pick type C lipidoses

1 reference

https://pubmed.ncbi.nlm.nih.gov/23144769

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cholesterol homeostasis. Modulation by amphiphiles

1 reference

https://pubmed.ncbi.nlm.nih.gov/23144769

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cyclodextrin Drug Carrier Systems

1 reference

https://pubmed.ncbi.nlm.nih.gov/23144769

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1371/JOURNAL.PONE.0048561

1 reference

Europe PubMed Central

PMC publication ID

13 August 2017

2012PLoSO...748561W

0 references

PMC publication ID

1 reference

Europe PubMed Central

PMC publication ID

13 August 2017

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

13 August 2017

ResearchGate publication ID

0 references

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