(Q36369556)

http://europepmc.org/abstract/PMC/6453127

30 June 2019

title

Targeting the Hsp90 C-terminal domain to induce allosteric inhibition and selective client downregulation (English)

1 reference

http://europepmc.org/abstract/PMC/6453127

30 June 2019

author

Pete E Pascuzzi

5

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28495207%20AND%20SRC:MED&resulttype=core&format=json

10 June 2020

Tony R. Hazbun

8

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28495207%20AND%20SRC:MED&resulttype=core&format=json

10 June 2020

Vincent Jo Davisson

7

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28495207%20AND%20SRC:MED&resulttype=core&format=json

10 June 2020

author name string

Kourtney M Goode

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28495207%20AND%20SRC:MED&resulttype=core&format=json

10 June 2020

Dino P Petrov

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28495207%20AND%20SRC:MED&resulttype=core&format=json

10 June 2020

Renee E Vickman

3

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28495207%20AND%20SRC:MED&resulttype=core&format=json

10 June 2020

Scott A Crist

4

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28495207%20AND%20SRC:MED&resulttype=core&format=json

10 June 2020

Tim L Ratliff

6

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28495207%20AND%20SRC:MED&resulttype=core&format=json

10 June 2020

language of work or name

1 reference

8 May 2017

1 reference

http://europepmc.org/abstract/PMC/6453127

30 June 2019

published in

BBA - General Subjects

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28495207%20AND%20SRC:MED&resulttype=core&format=json

10 June 2020

volume

1861

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28495207%20AND%20SRC:MED&resulttype=core&format=json

10 June 2020

issue

8

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28495207%20AND%20SRC:MED&resulttype=core&format=json

10 June 2020

page(s)

1992-2006

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28495207%20AND%20SRC:MED&resulttype=core&format=json

Mice lacking HSP90beta fail to develop a placental labyrinth

10 June 2020

cites work

1 reference

12 December 2020

Novobiocin and related coumarins and depletion of heat shock protein 90-dependent signaling proteins

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12 December 2020

Geldanamycin as a potential anti-cancer agent: its molecular target and biochemical activity

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12 December 2020

The heat shock protein 90 antagonist novobiocin interacts with a previously unrecognized ATP-binding domain in the carboxyl terminus of the chaperone

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Gene expression profiling of human colon cancer cells following inhibition of signal transduction by 17-allylamino-17-demethoxygeldanamycin, an inhibitor of the hsp90 molecular chaperone.

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12 December 2020

Modulation of Akt kinase activity by binding to Hsp90

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12 December 2020

C-terminal regions of Hsp90 are important for trapping the nucleotide during the ATPase cycle

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12 December 2020

Binding of ATP to heat shock protein 90: evidence for an ATP-binding site in the C-terminal domain

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Studies on prostatic cancer: I. The effect of castration, of estrogen and of androgen injection on serum phosphatases in metastatic carcinoma of the prostate. 1941.

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12 December 2020

A structure-based mutational analysis of cyclophilin 40 identifies key residues in the core tetratricopeptide repeat domain that mediate binding to Hsp90

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12 December 2020

Comparative analysis of the ATP-binding sites of Hsp90 by nucleotide affinity cleavage: a distinct nucleotide specificity of the C-terminal ATP-binding site

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12 December 2020

A high-affinity conformation of Hsp90 confers tumour selectivity on Hsp90 inhibitors

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12 December 2020

Structure and functional relationships of Hsp90.

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12 December 2020

Irreversible formation of intermediate BSA oligomers requires and induces conformational changes

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12 December 2020

Increased expression of the major heat shock protein Hsp72 in human prostate carcinoma cells is dispensable for their viability but confers resistance to a variety of anticancer agents.

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12 December 2020

Formation of 17-allylamino-demethoxygeldanamycin (17-AAG) hydroquinone by NAD(P)H:quinone oxidoreductase 1: role of 17-AAG hydroquinone in heat shock protein 90 inhibition

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12 December 2020

Pharmacological induction of Hsp70 protects apoptosis-prone cells from doxorubicin: comparison with caspase-inhibitor- and cycle-arrest-mediated cytoprotection

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12 December 2020

New insights about HERG blockade obtained from protein modeling, potential energy mapping, and docking studies

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12 December 2020

Novel procedure for modeling ligand/receptor induced fit effects.

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12 December 2020

Modulation of chaperone function and cochaperone interaction by novobiocin in the C-terminal domain of Hsp90: evidence that coumarin antibiotics disrupt Hsp90 dimerization

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12 December 2020

Use of an induced fit receptor structure in virtual screening

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12 December 2020

Crystal structure of an Hsp90-nucleotide-p23/Sba1 closed chaperone complex

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12 December 2020

Structure and mechanism of the Hsp90 molecular chaperone machinery

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12 December 2020

Development of 17-allylamino-17-demethoxygeldanamycin hydroquinone hydrochloride (IPI-504), an anti-cancer agent directed against Hsp90.

1 reference

12 December 2020

Up-regulation of heat shock protein 27 induces resistance to 17-allylamino-demethoxygeldanamycin through a glutathione-mediated mechanism

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12 December 2020

Overexpression of the heat-shock protein 70 is associated to imatinib resistance in chronic myeloid leukemia

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12 December 2020

Drugging the cancer chaperone HSP90: combinatorial therapeutic exploitation of oncogene addiction and tumor stress

1 reference

12 December 2020

Mechanistic studies on Hsp90 inhibition by ansamycin derivatives

1 reference

12 December 2020

Epik: a software program for pK( a ) prediction and protonation state generation for drug-like molecules

1 reference

12 December 2020

Development of novobiocin analogues that manifest anti-proliferative activity against several cancer cell lines

1 reference

12 December 2020

Molecular characterization of macbecin as an Hsp90 inhibitor

1 reference

12 December 2020

The Hsp90 chaperone machinery

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12 December 2020

Novobiocin and additional inhibitors of the Hsp90 C-terminal nucleotide-binding pocket

1 reference

12 December 2020

Targeting HSP90 for cancer therapy

1 reference

12 December 2020

(-)-Epigallocatechin-3-gallate inhibits Hsp90 function by impairing Hsp90 association with cochaperones in pancreatic cancer cell line Mia Paca-2.

1 reference

12 December 2020

Tanespimycin: the opportunities and challenges of targeting heat shock protein 90.

1 reference

12 December 2020

The 90-kDa heat shock protein (hsp-90) possesses an ATP binding site and autophosphorylating activity.

1 reference

12 December 2020

Detection of the ATPase activity of the molecular chaperones Hsp90 and Hsp72 using the TranscreenerTM ADP assay kit.

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12 December 2020

Biochemical and biophysical characterization of the Mg2+-induced 90-kDa heat shock protein oligomers.

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12 December 2020

Towards the comprehensive, rapid, and accurate prediction of the favorable tautomeric states of drug-like molecules in aqueous solution.

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12 December 2020

Feasibility of a high-flux anticancer drug screen using a diverse panel of cultured human tumor cell lines

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12 December 2020

Targeting the dynamic HSP90 complex in cancer

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12 December 2020

Exploring the binding site of C-terminal hsp90 inhibitors

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12 December 2020

Elucidation of the Hsp90 C-terminal inhibitor binding site

1 reference

12 December 2020

The hexameric structures of human heat shock protein 90

1 reference

12 December 2020

Targeting heat shock proteins 70/90 and proteasome for cancer therapy.

1 reference

12 December 2020

Development and characterization of a novel C-terminal inhibitor of Hsp90 in androgen dependent and independent prostate cancer cells

1 reference

12 December 2020

Target identification using drug affinity responsive target stability (DARTS).

1 reference

12 December 2020

Synthesis and evaluation of novologues as C-terminal Hsp90 inhibitors with cytoprotective activity against sensory neuron glucotoxicity

1 reference

12 December 2020

CellMiner: a web-based suite of genomic and pharmacologic tools to explore transcript and drug patterns in the NCI-60 cell line set.

1 reference

12 December 2020

Bovine serum albumin oligomers in the E- and B-forms at low protein concentration and ionic strength

1 reference

12 December 2020

HSP90 inhibitors: current development and potential in cancer therapy

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12 December 2020

The HSP70 family and cancer

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12 December 2020

Protein and ligand preparation: parameters, protocols, and influence on virtual screening enrichments

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12 December 2020

A heat shock protein 90 inhibitor that modulates the immunophilins and regulates hormone receptors without inducing the heat shock response

1 reference

12 December 2020

Exploiting conformational dynamics in drug discovery: design of C-terminal inhibitors of Hsp90 with improved activities

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12 December 2020

Differences in Conformational Dynamics between Plasmodium falciparum and Human Hsp90 Orthologues Enable the Structure-Based Discovery of Pathogen-Selective Inhibitors

1 reference

12 December 2020

19-substituted benzoquinone ansamycin heat shock protein-90 inhibitors: biological activity and decreased off-target toxicity

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12 December 2020

Heat shock proteins at the crossroads between cancer and Alzheimer's disease

1 reference

12 December 2020

Concentration-dependent reversible self-oligomerization of serum albumins through intermolecular β-sheet formation

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12 December 2020

The heat shock protein 90 inhibitor, (-)-epigallocatechin gallate, has anticancer activity in a novel human prostate cancer progression model

1 reference

12 December 2020

The FTMap family of web servers for determining and characterizing ligand-binding hot spots of proteins

1 reference

12 December 2020

KU675, a Concomitant Heat-Shock Protein Inhibitor of Hsp90 and Hsc70 that Manifests Isoform Selectivity for Hsp90α in Prostate Cancer Cells

1 reference

12 December 2020

Synthesis and Evaluation of a Novel Deguelin Derivative, L80, which Disrupts ATP Binding to the C-terminal Domain of Heat Shock Protein 90.

1 reference

12 December 2020

Hsp90 Oligomers Interacting with the Aha1 Cochaperone: An Outlook for the Hsp90 Chaperone Machineries.

1 reference

12 December 2020

Deguelin inhibits vasculogenic function of endothelial progenitor cells in tumor progression and metastasis via suppression of focal adhesion

1 reference

12 December 2020

Deguelin Analogue SH-1242 Inhibits Hsp90 Activity and Exerts Potent Anticancer Efficacy with Limited Neurotoxicity

1 reference

12 December 2020

Design and biological testing of peptidic dimerization inhibitors of human Hsp90 that target the C-terminal domain.

1 reference

12 December 2020

Molecular Dynamics Simulations Reveal the Mechanisms of Allosteric Activation of Hsp90 by Designed Ligands

1 reference

12 December 2020

CellMiner Companion: an interactive web application to explore CellMiner NCI-60 data.

1 reference

12 December 2020

Cholesterol Sulfonation Enzyme, SULT2B1b, Modulates AR and Cell Growth Properties in Prostate Cancer

1 reference

12 December 2020

Gambogic acid identifies an isoform-specific druggable pocket in the middle domain of Hsp90β

1 reference

12 December 2020

A Novel Class of Hsp90 C-Terminal Modulators Have Pre-Clinical Efficacy in Prostate Tumor Cells Without Induction of a Heat Shock Response

1 reference

12 December 2020

Allosteric Regulation Points Control the Conformational Dynamics of the Molecular Chaperone Hsp90.

1 reference

12 December 2020

Identification of the key structural elements of a dihydropyrimidinone core driving toward more potent Hsp90 C-terminal inhibitors.

1 reference

12 December 2020

In silico identification and computational analysis of the nucleotide binding site in the C-terminal domain of Hsp90.

1 reference

12 December 2020

C0818, a novel curcumin derivative, interacts with Hsp90 and inhibits Hsp90 ATPase activity

1 reference

12 December 2020

A Chemogenomic Screening Platform Used to Identify Chemotypes Perturbing HSP90 Pathways

1 reference

12 December 2020

Mechanism of Dimer Formation of the 90‐kDa Heat‐Shock Protein

1 reference

12 December 2020

Polyubiquitination and proteasomal degradation of the p185c-erbB-2 receptor protein-tyrosine kinase induced by geldanamycin

1 reference

12 December 2020

Modulation of the chaperone-like activity of bovine alpha-crystallin

1 reference

12 December 2020

Oligomeric forms of the 90-kDa heat shock protein

1 reference

12 December 2020

Structural basis for inhibition of the Hsp90 molecular chaperone by the antitumor antibiotics radicicol and geldanamycin

1 reference

12 December 2020

The charged region of Hsp90 modulates the function of the N-terminal domain

1 reference

12 December 2020

10.1016/J.BBAGEN.2017.05.006

Identifiers

DOI

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28495207%20AND%20SRC:MED&resulttype=core&format=json

10 June 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28495207%20AND%20SRC:MED&resulttype=core&format=json

10 June 2020

PubMed publication ID

28495207

1 reference