(Q36371939)

13 August 2017

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title

MAPKAP kinases - MKs - two's company, three's a crowd (English)

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13 August 2017

1

Matthias Gaestel

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publication date

1 February 2006

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Nature Reviews Molecular Cell Biology

13 August 2017

published in

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13 August 2017

volume

7

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13 August 2017

issue

2

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13 August 2017

page(s)

120-130

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The protein kinase complement of the human genome

13 August 2017

cites work

1 reference

The mouse kinome: discovery and comparative genomics of all mouse protein kinases

31 March 2020

1 reference

Evolution of protein kinase signaling from yeast to man

31 March 2020

1 reference

MSK2 and MSK1 mediate the mitogen- and stress-induced phosphorylation of histone H3 and HMG-14

31 March 2020

1 reference

Mitogen-activated protein kinases activate the serine/threonine kinases Mnk1 and Mnk2

31 March 2020

1 reference

MNK1, a new MAP kinase-activated protein kinase, isolated by a novel expression screening method for identifying protein kinase substrates

31 March 2020

1 reference

The p38 MAP kinase pathway signals for cytokine-induced mRNA stabilization via MAP kinase-activated protein kinase 2 and an AU-rich region-targeted mechanism.

31 March 2020

1 reference

MAPKAP kinase 2 is essential for LPS-induced TNF-alpha biosynthesis

31 March 2020

1 reference

The kaposin B protein of KSHV activates the p38/MK2 pathway and stabilizes cytokine mRNAs.

31 March 2020

1 reference

MAPKAP kinase 2 phosphorylates tristetraprolin on in vivo sites including Ser178, a site required for 14-3-3 binding

31 March 2020

1 reference

MK2-induced tristetraprolin:14-3-3 complexes prevent stress granule association and ARE-mRNA decay

31 March 2020

1 reference

MAPKAP kinase-2 is a cell cycle checkpoint kinase that regulates the G2/M transition and S phase progression in response to UV irradiation

31 March 2020

1 reference

HDM2 phosphorylation by MAPKAP kinase 2.

31 March 2020

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Genome-wide survey of protein kinases required for cell cycle progression.

31 March 2020

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MAPKAP kinase 3pK phosphorylates and regulates chromatin association of the polycomb group protein Bmi1

31 March 2020

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Scaffolding by ERK3 regulates MK5 in development

31 March 2020

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Activation of MK5/PRAK by the atypical MAP kinase ERK3 defines a novel signal transduction pathway

31 March 2020

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The substrate specificity and structure of mitogen-activated protein (MAP) kinase-activated protein kinase-2

31 March 2020

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The MAP kinase-activated protein kinase 2 contains a proline-rich SH3-binding domain.

31 March 2020

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Interleukin-1 activates a novel protein kinase cascade that results in the phosphorylation of Hsp27.

31 March 2020

1 reference

A novel kinase cascade triggered by stress and heat shock that stimulates MAPKAP kinase-2 and phosphorylation of the small heat shock proteins

31 March 2020

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Identification of mitogen-activated protein (MAP) kinase-activated protein kinase-3, a novel substrate of CSBP p38 MAP kinase

31 March 2020

1 reference

3pK, a new mitogen-activated protein kinase-activated protein kinase located in the small cell lung cancer tumor suppressor gene region

31 March 2020

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PRAK, a novel protein kinase regulated by the p38 MAP kinase

31 March 2020

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MAPKAPK5, a novel mitogen-activated protein kinase (MAPK)-activated protein kinase, is a substrate of the extracellular-regulated kinase (ERK) and p38 kinase

31 March 2020

1 reference

Identification of MAPKAPK homolog (MAPKAPK-4) as a myosin II regulatory light-chain kinase in sea urchin egg extracts

31 March 2020

1 reference

The RCK1 and RCK2 protein kinase genes from Saccharomyces cerevisiae suppress cell cycle checkpoint mutations in Schizosaccharomyces pombe

31 March 2020

1 reference

Characterization of the proline-rich region of mouse MAPKAP kinase 2: influence on catalytic properties and binding to the c-abl SH3 domain in vitro.

31 March 2020

1 reference

Characterization of an autoinhibitory domain in human mitogen-activated protein kinase-activated protein kinase 2.

31 March 2020

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Constitutive activation of mitogen-activated protein kinase-activated protein kinase 2 by mutation of phosphorylation sites and an A-helix motif

31 March 2020

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A conserved docking motif in MAP kinases common to substrates, activators and regulators

31 March 2020

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Catalysis and function of the p38 alpha.MK2a signaling complex

31 March 2020

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Anisomycin-activated protein kinases p45 and p55 but not mitogen-activated protein kinases ERK-1 and -2 are implicated in the induction of c-fos and c-jun

31 March 2020

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Two distinct forms of MAPKAP kinase-2 in adult cardiac ventricular myocytes.

31 March 2020

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The primary structure of a human MAP kinase activated protein kinase 2

31 March 2020

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3pK, a novel mitogen-activated protein (MAP) kinase-activated protein kinase, is targeted by three MAP kinase pathways

31 March 2020

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Identification of novel phosphorylation sites required for activation of MAPKAP kinase-2

31 March 2020

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A protein kinase involved in the regulation of inflammatory cytokine biosynthesis

31 March 2020

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A comparison of the substrate specificity of MAPKAP kinase-2 and MAPKAP kinase-3 and their activation by cytokines and cellular stress

31 March 2020

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Deficiency of the stress kinase p38alpha results in embryonic lethality: characterization of the kinase dependence of stress responses of enzyme-deficient embryonic stem cells

31 March 2020

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Nuclear export of the stress-activated protein kinase p38 mediated by its substrate MAPKAP kinase-2

31 March 2020

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Distinct cellular functions of MK2.

31 March 2020

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p38 mitogen-activated protein kinase plays a key role in regulating MAPKAPK2 expression

31 March 2020

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Serine/Threonine kinases 3pK and MAPK-activated protein kinase 2 interact with the basic helix-loop-helix transcription factor E47 and repress its transcriptional activity

31 March 2020

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Leptomycin B-sensitive nuclear export of MAPKAP kinase 2 is regulated by phosphorylation

31 March 2020

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Regulation of PRAK subcellular location by p38 MAP kinases

31 March 2020

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Identification of a docking groove on ERK and p38 MAP kinases that regulates the specificity of docking interactions

31 March 2020

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Both binding and activation of p38 mitogen-activated protein kinase (MAPK) play essential roles in regulation of the nucleocytoplasmic distribution of MAPK-activated protein kinase 5 by cellular stress

31 March 2020

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Structure of mitogen-activated protein kinase-activated protein (MAPKAP) kinase 2 suggests a bifunctional switch that couples kinase activation with nuclear export

31 March 2020

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Catalytically active MAP KAP kinase 2 structures in complex with staurosporine and ADP reveal differences with the autoinhibited enzyme

31 March 2020

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FRET-based detection of different conformations of MK2.

31 March 2020

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Elimination of protein kinase MK5/PRAK activity by targeted homologous recombination

31 March 2020

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Rapid turnover of extracellular signal-regulated kinase 3 by the ubiquitin-proteasome pathway defines a novel paradigm of mitogen-activated protein kinase regulation during cellular differentiation

31 March 2020

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Nuclear export of ERK3 by a CRM1-dependent mechanism regulates its inhibitory action on cell cycle progression

31 March 2020

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Activation of the tumour suppressor kinase LKB1 by the STE20-like pseudokinase STRAD

31 March 2020

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Identification of MAPKAP kinase 2 as a major enzyme responsible for the phosphorylation of the small mammalian heat shock proteins

31 March 2020

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Participation of a stress-activated protein kinase cascade in the activation of tyrosine hydroxylase in chromaffin cells

31 March 2020

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5-lipoxygenase is phosphorylated by p38 kinase-dependent MAPKAP kinases

31 March 2020

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Phosphorylation of alphaB-crystallin in mitotic cells and identification of enzymatic activities responsible for phosphorylation.

31 March 2020

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Inhibition of SAPK2a/p38 prevents hnRNP A0 phosphorylation by MAPKAP-K2 and its interaction with cytokine mRNAs

31 March 2020

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Affinity purification of ARE-binding proteins identifies poly(A)-binding protein 1 as a potential substrate in MK2-induced mRNA stabilization

31 March 2020

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MAPKAP kinase 2 phosphorylates serum response factor in vitro and in vivo

31 March 2020

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Cell type-specific inhibition of the ETS transcription factor ER81 by mitogen-activated protein kinase-activated protein kinase 2

31 March 2020

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Proteomic identification of Bcl2-associated athanogene 2 as a novel MAPK-activated protein kinase 2 substrate

31 March 2020

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Regulation of Hsp27 oligomerization, chaperone function, and protective activity against oxidative stress/tumor necrosis factor alpha by phosphorylation

31 March 2020

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Binding of non-native protein to Hsp25 during heat shock creates a reservoir of folding intermediates for reactivation.

31 March 2020

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LSP1 is the major substrate for mitogen-activated protein kinase-activated protein kinase 2 in human neutrophils

31 March 2020

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The phosphorylation of CapZ-interacting protein (CapZIP) by stress-activated protein kinases triggers its dissociation from CapZ

31 March 2020

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Identification of the p16-Arc subunit of the Arp 2/3 complex as a substrate of MAPK-activated protein kinase 2 by proteomic analysis

31 March 2020

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A Role for p38MAPK/HSP27 Pathway in Smooth Muscle Cell Migration

31 March 2020

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Abnormal migration phenotype of mitogen-activated protein kinase-activated protein kinase 2-/- neutrophils in Zigmond chambers containing formyl-methionyl-leucyl-phenylalanine gradients

31 March 2020

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Cloning and characterization of mouse extracellular-signal-regulated protein kinase 3 as a unique gene product of 100 kDa.

31 March 2020

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Initiation of a G2/M checkpoint after ultraviolet radiation requires p38 kinase

31 March 2020

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Inactivation of the Cdc25 phosphatase by the stress-activated Srk1 kinase in fission yeast

31 March 2020

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Phosphorylation of human p53 by p38 kinase coordinates N-terminal phosphorylation and apoptosis in response to UV radiation

31 March 2020

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P66(ShcA) interacts with MAPKAP kinase 2 and regulates its activity

31 March 2020

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Division of labor in polycomb group repression

31 March 2020

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Mitogen-activated 3p kinase is active in the nucleus

31 March 2020

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Bmi-1 determines the proliferative capacity of normal and leukaemic stem cells

31 March 2020

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Mitogen-activated protein kinase-activated protein kinase 2-deficient mice show increased susceptibility to Listeria monocytogenes infection

31 March 2020

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Genetic dissection of the cellular pathways and signaling mechanisms in modeled tumor necrosis factor-induced Crohn's-like inflammatory bowel disease

31 March 2020

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MK2 targets AU-rich elements and regulates biosynthesis of tumor necrosis factor and interleukin-6 independently at different post-transcriptional levels

31 March 2020

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Feedback inhibition of macrophage tumor necrosis factor-alpha production by tristetraprolin

31 March 2020

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Rac1-MKK3-p38-MAPKAPK2 pathway promotes urokinase plasminogen activator mRNA stability in invasive breast cancer cells

31 March 2020

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Regulation of cyclooxygenase 2 mRNA stability by the mitogen-activated protein kinase p38 signaling cascade

31 March 2020

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Stabilization of Urokinase and Urokinase Receptor mRNAs by HuR Is Linked to Its Cytoplasmic Accumulation Induced by Activated Mitogen-Activated Protein Kinase-Activated Protein Kinase 2

31 March 2020

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Phaeochromycins A-E, anti-inflammatory polyketides isolated from the soil actinomycete Streptomyces phaeochromogenes LL-P018.

31 March 2020

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Discovery and characterization of a substrate selective p38alpha inhibitor

31 March 2020

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Aminocyanopyridine inhibitors of mitogen activated protein kinase-activated protein kinase 2 (MK-2).

31 March 2020

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Nuclear export inhibitors and kinase inhibitors identified using a MAPK-activated protein kinase 2 redistribution screen

31 March 2020

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Herpes simplex virus 1 induces cytoplasmic accumulation of TIA-1/TIAR and both synthesis and cytoplasmic accumulation of tristetraprolin, two cellular proteins that bind and destabilize AU-rich RNAs

31 March 2020

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Transducible heat shock protein 20 (HSP20) phosphopeptide alters cytoskeletal dynamics

31 March 2020

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Convergent actions of I kappa B kinase beta and protein kinase C delta modulate mRNA stability through phosphorylation of 14-3-3 beta complexed with tristetraprolin

31 March 2020

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The p38 and MK2 kinase cascade phosphorylates tuberin, the tuberous sclerosis 2 gene product, and enhances its interaction with 14-3-3

31 March 2020

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Proteomic identification of 14-3-3zeta as a mitogen-activated protein kinase-activated protein kinase 2 substrate: role in dimer formation and ligand binding

31 March 2020

1 reference

The Mnks are novel components in the control of TNF alpha biosynthesis and phosphorylate and regulate hnRNP A1

31 March 2020

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Nuclear localization of NF-ATc by a calcineurin-dependent, cyclosporin-sensitive intramolecular interaction

31 March 2020

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The cAMP-dependent protein kinase site (Ser312) enhances dorsal nuclear import through facilitating nuclear localization sequence/importin interaction

31 March 2020

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In vivo binding pattern of a trans-regulator of homoeotic genes in Drosophila melanogaster

31 March 2020

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Posterior transformation, neurological abnormalities, and severe hematopoietic defects in mice with a targeted deletion of the bmi-1 proto-oncogene

31 March 2020

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Stem cells and cancer; the polycomb connection

31 March 2020

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A conserved AU sequence from the 3' untranslated region of GM-CSF mRNA mediates selective mRNA degradation

31 March 2020

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AU-rich elements: characterization and importance in mRNA degradation

31 March 2020

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The AU-rich transcriptome: more than interferons and cytokines, and its role in disease.

31 March 2020

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p38 Mitogen-activated protein kinase-dependent and -independent signaling of mRNA stability of AU-rich element-containing transcripts

31 March 2020

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Mkp1 and Mkp2, two MAPKAP-kinase homologues in Schizosaccharomyces pombe, interact with the MAP kinase Sty1

31 March 2020

1 reference

inferred from DOI database lookup

7 January 2021

based on heuristic

Identifiers

DOI

10.1038/NRM1834

1 reference

13 August 2017

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